Article
Endocrinology & Metabolism
Milana A. Bochkur Dratver, Juliana Arenas, Tanayott Thaweethai, Chu Yu, Kaitlyn James, Emily A. Rosenberg, Michael J. Callahan, Melody Cayford, Jessica S. Tangren, Sarah N. Bernstein, Marie France Hivert, Ravi Thadhani, Camille E. Powe
Summary: In pregnant women with diabetes risk factors, fasting glucose levels decrease in the first trimester while post-load glucose levels increase later in pregnancy. These findings could help establish criteria for diagnosing hyperglycaemia early in pregnancy.
Review
Biochemistry & Molecular Biology
Bei Liu, Qiong Dai, Pei Liu, Subash C. B. Gopinath, Lihong Zhang
Summary: Gestational diabetes refers to elevated blood glucose levels during pregnancy, affecting approximately 10% of women in the USA annually. Researchers are focusing on using nanomaterials to develop high-performance glucose sensors for improved detection of gestational diabetes.
PROCESS BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Durga Parkhi, Nishanthi Periyathambi, Yonas Ghebremichael-Weldeselassie, Vinod Patel, Nithya Sukumar, Rahul Siddharthan, Leelavati Narlikar, Ponnusamy Saravanan
Summary: This study aims to predict the risk of postpartum prediabetes in women diagnosed with gestational diabetes. By using a sparse logistic regression approach and selecting only two variables as relevant factors, the study achieved a good predictive performance.
Article
Medicine, General & Internal
Delia Bogdanet, Michelle Toth Castillo, Helen Doheny, Louise Dervan, Miguel-Angel Luque-Fernandez, Jose A. Halperin, Paula M. O'Shea, Fidelma P. Dunne
Summary: This study aimed to evaluate the ability of second trimester plasma glycated CD59 (pGCD59) as a predictor for the results of the oral glucose tolerance test in gestational diabetes. The study found that pGCD59 levels were significantly higher in women with GDM and could accurately predict GDM status, especially in subjects with a higher BMI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Isabelle R. Jardine, Hannah E. Christie, Kate Oetsch, Angelo Sabag, Meredith Kennedy, Barbara J. Meyer, Monique E. Francois
Summary: Maintaining blood glucose within the target range is the primary treatment goal for women with gestational diabetes mellitus. This pilot study explored the associations of glycaemic load, carbohydrates, and physical activity parameters on blood glucose concentrations in free-living women with GDM. The study found that physical activity, specifically the total stepping time, had a significant relationship with lower 24-hour glucose iAUC and nocturnal glucose, suggesting it may be an effective strategy to improve maternal blood glucose concentrations.
Article
Microbiology
Yuan Ren, Lilan Hao, Juntao Liu, Pei Wang, Qiuxia Ding, Chen Chen, Yingna Song
Summary: In this study, the changes in gut microbiota composition in pregnant women with and without pregestational type 2 diabetes mellitus (PGDM) were investigated. The results showed that the gut microbiota in the PGDM group decreased as the pregnancies progressed, and certain bacteria taxa were enriched in the PGDM group. Moreover, the gut microbiota in the PGDM group was correlated with blood glucose levels during pregnancy. This study is important for understanding the relationship between PGDM and gut microbiota.
Article
Endocrinology & Metabolism
Elena Flowers, Bradley E. Aouizerat, Alka M. Kanaya, Jose C. Florez, Xingyue Gong, Li Zhang
Summary: This study identified 5 miRs (miR-144, miR-186, miR-203a, miR-205, miR-206) that can effectively predict the incidence of type 2 diabetes. After adjusting for covariates, the HR for the highest quartile risk group compared with the lowest quartile risk group was 5.91. There was significant interaction between the intensive lifestyle and metformin groups compared with placebo. These findings may have potential clinical utility for risk stratification of individuals with prediabetes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Katrien Benhalima, Diane D. Ma, Annouschka Laenen, Chantal Mathieu, Jose A. Halperin
Summary: The study found that women with higher postpartum plasma glycated CD59 (pGCD59) levels were more likely to develop glucose intolerance, with a 0.5-unit increase in pGCD59 associated with a 3.3-fold increase in risk of glucose intolerance postpartum. pGCD59 measured during pregnancy was a poor predictor for glucose intolerance postpartum.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2021)
Article
Environmental Sciences
Mohammad Miri, Hossein Rezaei, Seyed Mojtaba Momtaz, Moslem Lari Najafi, Abolfazl Adli, Nasim Sadat Pajohanfar, Mina Abroudi, Malihe Sadat Bazghandi, Zahra Razavi, Lucia Alonso, Cathryn Tonne, Xavier Basagana, Mark J. Nieuwenhuijsen, Jordi Sunyer, Tim S. Nawrot, Payam Dadvand
Summary: This study aimed to assess the determinants of airway macrophages carbon loading (AMCL) during pregnancy in Iran and found that personal, indoor, and outdoor factors related to air pollution were associated with AMCL levels.
ENVIRONMENTAL POLLUTION
(2022)
Article
Nutrition & Dietetics
Hannah E. Christie, Courtney R. Chang, Isabelle R. Jardine, Monique E. Francois
Summary: The study aimed to determine if postmeal walking is an effective alternative for managing gestational diabetes. The results showed that short bouts of walking after meals can improve glycemic control in women with gestational diabetes and may be more feasible to adhere to compared to continuous walking. Therefore, postmeal walking may be a promising alternative for managing gestational diabetes.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2022)
Article
Oncology
Akram Abolbaghaei, Marc-Andre Langlois, Helen R. Murphy, Denice S. Feig, Dylan Burger
Summary: Extracellular vesicle levels in pregnant women with type 1 diabetes are associated with glucose fluctuations and may impact neonatal outcomes. Assessing extracellular vesicles could offer a new personalized care approach for type 1 diabetes pregnancies.
BIOMARKER RESEARCH
(2021)
Review
Endocrinology & Metabolism
Grenye O'Malley, Ally Wang, Selassie Ogyaadu, Carol J. Levy
Summary: The use of CGM during pregnancy can reduce the risk of neonatal complications, detect blood glucose fluctuations, and guide pharmacological interventions, and has been shown to benefit pregnant women with type 1, type 2, and gestational diabetes.
CURRENT DIABETES REPORTS
(2021)
Article
Endocrinology & Metabolism
Samuel Furse, Albert Koulman, Susan E. Ozanne, Lucilla Poston, Sara L. White, Claire L. Meek
Summary: Gestational diabetes in obese women is associated with elevated levels of specific lipids related to de novo lipogenesis, which are also correlated with measures of offspring adiposity. These findings suggest that the effects of GDM on neonatal body composition may not be solely due to hyperglycemia, but may involve other pathways.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Mette B. Andersen, Jens Fuglsang, Eva B. Ostenfeld, Charlotte W. Poulsen, Merete Daugaard, Per G. Ovesen
Summary: This study found that conducting 20 minutes of postprandial interval walking can help women with gestational diabetes mellitus control postprandial glucose excursions.
AMERICAN JOURNAL OF OBSTETRICS & GYNECOLOGY MFM
(2021)
Article
Multidisciplinary Sciences
David Salcedo-Tacuma, Leonardo Bonilla, Maria Cristina Geney Montes, Jorge Ernesto Nino Gonzalez, Sandra Milena Sanchez Gutierrez, Miguel Chirivi, G. Andres Contreras
Summary: In this study, RNA-seq was used to analyze the transcriptomic profile of adipose tissues in patients with gestational diabetes. The results revealed differences based on anatomical location and provided whole-transcriptome data for further exploration of unique gene expression patterns in gestational diabetes patients.
Article
Medical Laboratory Technology
Anna Maria Ciaccio, Luisa Agnello, Bruna Lo Sasso, Rosaria Vincenza Giglio, Alessandro Iacona, Caterina Maria Gambino, Concetta Scazzone, Antonino Tuttolomondo, Marcello Ciaccio
Summary: Monocyte Distribution Width (MDW) is a new cell blood count parameter that measures the anisocytosis of monocytes. It has emerged as a reliable biomarker for sepsis in emergency departments and intensive care units. MDW has advantages such as low-cost and quick measurement compared to other sepsis biomarkers.
CLINICA CHIMICA ACTA
(2023)
Editorial Material
Neurosciences
Giulia Bivona, Concetta Scazzone, Bruna Lo Sasso, Rosaria Vincenza Giglio, Caterina Maria Gambino, Luisa Agnello, Marcello Ciaccio
Summary: Recent literature has discussed the role of vitamin D, Epstein Barr Virus (EBV), and endogenous retrovirus (ERV) in the pathogenesis of multiple sclerosis (MS). Some authors suggest a synergistic interplay between these factors that could contribute to the onset and progression of the disease. However, further research is needed to better understand this important topic.
JOURNAL OF INTEGRATIVE NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Simona Terzo, Antonella Amato, Antonio Magan-Fernandez, Giuseppa Castellino, Pasquale Calvi, Roberta Chianetta, Rosaria V. Giglio, Angelo M. Patti, Dragana Nikolic, Alberto Firenze, Flavia Mule, Marcello Ciaccio, Manfredi Rizzo
Summary: Pre-obesity is a condition that increases the risk of obesity, cardiovascular diseases, and diabetes. A study found that Altilix(R), a nutraceutical containing chlorogenic acid and luteolin extracts, can improve hepatic and cardio-metabolic parameters. In a post-hoc analysis, Altilix(R) was shown to effectively improve anthropometry, glucose metabolism, lipid profile, hepatic functionality, carotid-media thickness, and endothelial function in pre-obesity subjects.
Review
Medicine, General & Internal
Caterina Maria Gambino, Anna Maria Ciaccio, Bruna Lo Sasso, Rosaria Vincenza Giglio, Matteo Vidali, Luisa Agnello, Marcello Ciaccio
Summary: A systematic review and meta-analysis were conducted to evaluate the diagnostic performance of TDP-43 as a biomarker for ALS. The results showed that CSF TDP-43 levels are higher in ALS patients compared with control groups. CSF TDP-43 could potentially serve as a biomarker for ALS, but more research is needed before definitive conclusions can be drawn.
Review
Biochemistry & Molecular Biology
Rosaria Vincenza Giglio, Angelo Maria Patti, Ali Abbas Rizvi, Anca Panta Stoian, Marcello Ciaccio, Nikolaos Papanas, Andrej Janez, Alper Sonmez, Maciej Banach, Amirhossein Sahebkar, Manfredi Rizzo
Summary: Diabetic nephropathy is the leading cause of end-stage renal disease globally, and its pathogenesis involves increased pressure, activity of the renin-angiotensin system, and oxidative stress. Current treatment options focus on optimizing blood pressure and blood glucose targets, but new drug classes such as GLP-1 RAs, SGLT-2is, and inhibitors of mineralocorticoid receptor-mediated sodium reabsorption show positive effects on kidney function in individuals with type 2 diabetes mellitus. This review aims to provide an update on therapeutic options for preventing or slowing the onset and progression of diabetic nephropathy.
Article
Medical Laboratory Technology
Daniela Ligi, Bruna Lo Sasso, Chiara Della Franca, Rosaria Vincenza Giglio, Luisa Agnello, Marcello Ciaccio, Ferdinando Mannello
Summary: The study investigated the role of extracellular histones on monocyte distribution width (MDW) and their effect on the release of cytokines by blood cells. The results showed that extracellular histones can induce changes in MDW and promote heterogeneity in monocytes. They also lead to the release of cytokines, especially G-CSF, IL-1 beta, IL-6, MIP-1 beta, and IL-8. These findings may have significant implications for predicting the risk of severe outcomes.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medicine, General & Internal
Caterina Maria Gambino, Luisa Agnello, Anna Maria Ciaccio, Concetta Scazzone, Matteo Vidali, Vincenzo Di Stefano, Salvatore Milano, Filippo Brighina, Giuseppina Candore, Bruna Lo Sasso, Marcello Ciaccio
Summary: This study compares the sensitivity of two methods for detecting serum anti-acetylcholine receptor antibodies, finding that competitive ELISA has higher sensitivity compared to indirect ELISA and fixed cell-based assay (F-CBA), while the concordance between iELISA and F-CBA is higher.
JOURNAL OF CLINICAL MEDICINE
(2023)
Meeting Abstract
Urology & Nephrology
D. Baiamonte, I. Lampasona, S. Altomare, P. Mannone, N. Pavan, G. Tulone, R. Giaimo, L. Agnello, B. Lo Sasso, R. V. Giglio, C. M. Gambino, M. Ciaccio, A. Simonato
Article
Medical Laboratory Technology
Matteo Vidali, Federico Giacchetti, Andrea Sangiorgio, Chiara Vantaggiato, Giulia Rodari, Chiara Orsenigo, Adriana Di Modugno, Filomena Napolitano, Daniela Morniroli, Lorenzo Colombo, Eriselda Profka, Giulia Vizzari, Fabio Mosca, Ferruccio Ceriotti, Giovanna Mantovani, Maura Arosio, Maria L. Gianni, Claudia Giavoli
Summary: This study developed a new analytical method using dried blood spots (DBS) to estimate the reference values for growth hormone (GH) in newborns. The reference values obtained using this method were consistent with previous studies using ELISA, and can help confirm the clinical suspicion of GH deficiency in neonates.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Medical Laboratory Technology
Luisa Agnello, Salvatore Buscemi, Giuseppe Di Buono, Matteo Vidali, Bruna Lo Sasso, Antonino Agrusa, Marcello Ciaccio
Summary: In this study, drainage fluid LDH and NLR were identified as promising biomarkers for predicting postoperative complications and anastomotic leakage in colorectal surgery patients.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Endocrinology & Metabolism
Luisa Agnello, Rosaria Vincenza Giglio, Bruna Lo Sasso, Matteo Vidali, Silvia Pedone, Davide Massa, Anna Maria Ciaccio, Caterina Maria Gambino, Marcello Ciaccio
ACTA DIABETOLOGICA
(2023)
Article
Medicine, Research & Experimental
Bruna Lo Sasso, Luisa Agnello, Rosaria Vincenza Giglio, Concetta Scazzone, Davide Massa, Anna Maria Ciaccio, Caterina Maria Gambino, Matteo Vidali, Marcello Ciaccio
Summary: Serology surveillance of SARS-CoV-2 antibodies is a valuable tool for monitoring protective immunity in the population. This study compared the performance of three different serological immunoassays for detecting anti-SARS-CoV-2 antibodies in 600 vaccinated subjects. The results showed that all three assays can effectively detect post-vaccine humoral immune response. The methods also demonstrated high specificity and correlation, making them suitable for monitoring IgG titers over time in vaccinated individuals.
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Jiansheng Lin, Weihua Lin, Yiming Lin, Weilin Peng, Zhenzhu Zheng
Summary: This study retrospectively analyzed the cases of Chinese infants with NICCD and identified multiple genetic mutations. The study also found comorbidity of NICCD and other inborn errors of metabolism in some patients.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Lihua Guan, Wei Su, Jian Zhong, Ling Qiu
Summary: Multiple myeloma is characterized by excessive production of monoclonal immunoglobulins. Routine screening methods are insufficient for detecting low levels of M proteins, but advances in mass spectrometry enable reliable detection of low abundance serum biomarkers for minimal residual disease assessment in multiple myeloma.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Liya Zhu, Chao Zhu, Jialie Jin, Jinxin Wang, Xiaojing Zhao, Rongxi Yang
Summary: This study found an association between blood-based ITGB2 methylation and coronary heart disease (CHD), with hypomethylation of ITGB2 being a risk factor for CHD. Additionally, the combination of ITGB2 methylation and conventional CHD risk factors could efficiently discriminate CHD patients from controls.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
H. Al Habobe, E. B. Haverkort, K. Nazmi, A. P. Van Splunter, R. H. H. Pieters, F. J. Bikker
Summary: Saliva diagnostics have become popular due to their non-invasive nature and patient-friendly collection process. However, the choice of saliva collection method can affect the measured levels of various biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Valentinus Besin, Farizky Martriano Humardani, Trilis Yulianti, Matthew Justyn
Summary: The study of Parkinson's Disease in Asian populations has revealed the impact of genetic variants on multiple biological pathways and highlighted shared genetic susceptibility with other diseases. These findings emphasize the importance of personalized treatment based on individual genetic profiles.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Simona Ferraro, Sara Benedetti, Savina Mannarino, Santica Marcovina, Elia Mario Biganzoli, Gianvincenzo Zuccotti
Summary: Risk stratification for cardio-vascular disease should be implemented in childhood to promote early prevention strategies, as atherosclerotic lesions can be present even in very young individuals. Evaluating pediatric CV risk factors/clinical conditions and conducting lipid profile and genetic testing can help identify children at risk of future CV events and guide appropriate therapeutic options.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Ahmad Mobed, Bita Abdi, Sajjad Masoumi, Mohammad Mikaeili, Elham Shaterian, Hamed Shaterian, Esmat Sadat Kazemi, Mahdiye Shirafkan
Summary: Reproductive biomarkers play important regulatory roles in women. The discovery and quantification of these biomarkers are clinically significant. Various detection strategies, including nanotechnology-based methods, have been developed. This article provides an in-depth introduction to the latest advances in biosensor and nanosensor research for detecting and quantitatively identifying reproductive biomarkers.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Chengfang Tang, Fang Tang, Yanna Cai, Minyi Tan, Sichi Liu, Ting Xie, Xiang Jiang, Yonglan Huang
Summary: This study proposes an effective method for screening X-ALD and evaluates the performance of newborn screening for X-ALD in Guangzhou. The LC-MS/MS method can accurately identify X-ALD through analysis of C26:0-LPC.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Lan Liu, Jiamin Wang, Xijing Liu, Jing Wang, Lin Chen, Hongmei Zhu, Jingqun Mai, Ting Hu, Shanling Liu
Summary: The 16p11.2 deletion is a common genetic cause of neurodevelopmental disorders, with prenatal and postnatal presentations including vertebral malformations and language impairment. The majority of deletions are de novo and may be associated with MAPK3 and histidine-associated metabolism.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Sneha Venkatesalu, Shanmugapriya Dilliyappan, Avanthika Satish Kumar, Thirunavukkarasu Palaniyandi, Gomathy Baskar, Maddaly Ravi, Asha Sivaji
Summary: Microfluidics is a science and technology that deals with less sample-to-more precision in vitro analysis. It has wide applications in cancer theranostics, enabling precise diagnosis and personalized treatment.
CLINICA CHIMICA ACTA
(2024)
Review
Medical Laboratory Technology
Yuanqin Zhao, Wei Deng, Zhaoyue Wang, Yanxia Wang, Hongyu Zheng, Kun Zhou, Qian Xu, Le Bai, Huiting Liu, Zhong Ren, Zhisheng Jiang
Summary: The cardiovascular system and the central nervous system exhibit a coordinated developmental process during embryonic development. Congenital heart disease (CHD) is the most common congenital disorder, and neurodevelopmental disorders (NDD) are common complications in CHD patients. Both genetic and non-genetic factors contribute to the co-occurrence of CHD and NDD. Further research should focus on identifying common molecular mechanisms underlying this co-occurrence and promoting the research and treatment of developmental disorders related to the cardiovascular and central nervous systems.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Karol Gostomczyk, Ewelina Lukaszewska, Jedrzej Borowczak, Anita Bator, Marek Zdrenka, Magdalena Bodnar, Lukasz Szylberg
Summary: Flow cytometry improves the detection of epithelial cancer cells in peritoneal and pleural fluids compared to conventional cytology. Due to similar speciflcity and higher sensitivity, flow cytometry offers a promising alternative to cytology for patient screening.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Heping Tian, Genghuan Wang, Qi Zhong, Haihang Zhou
Summary: This study found that the decline of serum ITIH4 concentrations during the early phase after aneurysmal subarachnoid hemorrhage (aSAH) was closely related to the severity and poor prognosis of the disease. Serum ITIH4 may represent a promising prognostic biomarker of aSAH.
CLINICA CHIMICA ACTA
(2024)
Article
Medical Laboratory Technology
Xueting Zhu, Yang Yu, Jun Zhang, Yuxia Zhan, Guanghua Luo, Lu Zheng
Summary: This study successfully established a 2D-PCR method for identifying HLA-B*15:02 through a two-tube reaction. This method can distinguish HLA-B*15:02 from 16 highly homologous HLA-B*15 alleles. Among 1830 samples from the clinical general population, 3 HLA-B*15:02 homozygotes and 84 HLA-B*15:02 heterozygotes were detected.
CLINICA CHIMICA ACTA
(2024)