Article
Cardiac & Cardiovascular Systems
Anxin Wang, Guangyao Wang, Qian Liu, Yingting Zuo, Shuohua Chen, Boni Tao, Xue Tian, Penglian Wang, Xia Meng, Shouling Wu, Yongjun Wang, Yilong Wang
Summary: Elevated levels of both baseline and long-term updated cumulative average TyG index can independently predict stroke and ischemic stroke but not intracerebral hemorrhage in the general population during an 11-year follow-up. The study found a linear association between TyG index and stroke outcomes, with higher TyG index associated with increased risk of stroke.
CARDIOVASCULAR DIABETOLOGY
(2021)
Article
Clinical Neurology
Yoo Jeong Lee, Sooyeon Lee, In Cheol Hwang, Hong Yup Ahn
Summary: This study investigated the relationship between insulin resistance and suicidal ideation, and found that the TyG index was significantly associated with suicidal ideation in women, especially in the low-risk group for suicide.
JOURNAL OF AFFECTIVE DISORDERS
(2024)
Article
Nutrition & Dietetics
Feifei Wang, Ting He, Guoliang Wang, Tuo Han, Zhongqiang Yao
Summary: This study suggests that TyG-BMI is a useful tool for assessing the risk of NSCLC. Individuals with high TyG-BMI should be monitored and lifestyle modifications are needed to prevent the occurrence of NSCLC.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Analie Nunes Couto, Hildegard Hedwig Pohl, Moises Evandro Bauer, Carla Helena Augustin Schwanke
Summary: This study verified the performance of the TyG index in predicting MetS in healthy individuals living in rural areas and estimated the cutoff points for different criteria. The results showed that the TyG index performed well in diagnosing MetS.
Review
Cardiac & Cardiovascular Systems
Li-Chan Tao, Jia-ni Xu, Ting-ting Wang, Fei Hua, Jian-Jun Li
Summary: This review summarizes the history of the use of the TyG index as a surrogate marker for insulin resistance (IR) and explores its application value in various types of cardiovascular disease (CVD), as well as the potential limitations of using this index as a predictor for cardiovascular events. The aim is to provide more extensive and precise supporting evidence to improve its application value in CVD.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Yoonkyung Chang, Jimin Jeon, Tae-Jin Song, Jinkwon Kim
Summary: The TyG index, a surrogate marker for insulin resistance, is associated with an increased risk of severe complications in COVID-19 infected patients.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2022)
Article
Clinical Neurology
Canlin Liao, Haixiong Xu, Tao Jin, Ke Xu, Zhennan Xu, Lingzhen Zhu, Mingfa Liu
Summary: This study systematically assessed the association between the triglyceride-glucose (TyG) index and stroke through a meta-analysis. The results showed that a higher TyG index was independently associated with a higher risk of stroke. These findings need to be further verified by a large-scale prospective cohort study.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Yang Zhao, Haohang Sun, Weidong Zhang, Yuanlin Xi, Xuezhong Shi, Yongli Yang, Jie Lu, Ming Zhang, Liang Sun, Dongsheng Hu
Summary: This study aimed to investigate the association between triglyceride-glucose (TyG) and incident ischemic stroke, as well as assess the potential modification effect by known risk factors of stroke. The results showed that elevated TyG index is an independent predictor of ischemic stroke in the general population, and insulin resistance may be positively associated with future stroke risk.
DIABETES & METABOLISM
(2021)
Article
Nutrition & Dietetics
Hind A. Beydoun, Ted K. S. Ng, May A. Beydoun, Aladdin H. Shadyab, Su Yon Jung, Christy Costanian, Nazmus Saquib, Farha S. Ikramuddin, Kathy Pan, Alan B. Zonderman, JoAnn E. Manson
Summary: This study found that obesity and central obesity markers were associated with COVID-19 outcomes among postmenopausal women, and glucose concentration and TyG partly mediated these associations.
CLINICAL NUTRITION
(2023)
Article
Oncology
Lijie Wang, Shucheng Si, Jiqing Li, Yunxia Li, Xiaolu Chen, Fuzhong Xue, Wangang Ren
Summary: The study based on the UK Biobank involving 324,334 individuals found no association between the TyG index and lung cancer risk. The results suggest limited evidence that IR is not correlated with the risk of lung cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Mengxing Wang, Lerong Mei, Aoming Jin, Xueli Cai, Jing Jing, Suying Wang, Xia Meng, Shan Li, Tiemin Wei, Yongjun Wang, Yuesong Pan
Summary: The study found that in patients without diabetes, a high triglyceride glucose (TyG) index was associated with increased atherosclerotic burden and plaques in coronary, intra- and extracranial arteries. Compared with the homeostasis model assessment of insulin resistance (HOMA-IR), the TyG index was more strongly associated with intracranial atherosclerosis.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Zegui Huang, Xiong Ding, Qing Yue, Xianxuan Wang, Zekai Chen, Zefeng Cai, Weijian Li, Zhiwei Cai, Guanzhi Chen, Yulong Lan, Weiqiang Wu, Shouling Wu, Youren Chen
Summary: This study investigated the association between TyG index trajectory and stroke risk among hypertensive patients. The findings suggest that a long-term elevated TyG index is associated with an increased risk of stroke, especially ischemic stroke, in hypertensive patients.
CARDIOVASCULAR DIABETOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Yin Yuan, Simiao Chen, Chunjin Lin, Xiaoming Huang, Siyang Lin, Feng Huang, Pengli Zhu
Summary: This study aimed to investigate the association between the triglyceride-glucose (TyG) index and frailty. The cross-sectional analysis found that individuals with a higher TyG index had an increased risk of frailty. The retrospective and prospective analysis also confirmed the association between the TyG index and frailty risk.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Endocrinology & Metabolism
Zhaoxiang Wang, Han Qian, Shao Zhong, Tian Gu, Mengjiao Xu, Qichao Yang
Summary: The purpose of this study was to investigate the relationship between the triglyceride-glucose (TyG) index and albuminuria in the adult population in the United States. The study found that there was a positive correlation between TyG index and albuminuria, which persisted even after adjusting for other factors. In addition, the TyG index was compared with insulin resistance and metabolic syndrome, and it was found that TyG index had a better predictive effect. Subgroup analysis showed that the relationship between TyG index and albuminuria was more significant in terms of age, weight, diabetes, and metabolic syndrome.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Huijie Huang, Ai Wang, Li Cong, Yingjuan Zeng
Summary: This study investigated the association between osteocalcin and insulin resistance in men with type 2 diabetes. The results showed an inverse correlation between osteocalcin and the TyG index, particularly in younger patients with lower BMI, poorer glycemic control, without hypertension or smoking.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Allergy
Parisa Kaviany, Emily P. Brigham, Joseph M. Collaco, Jessica L. Rice, Han Woo, Megan Wood, Rachelle Koehl, Tianshi D. Wu, Michelle N. Eakin, Kirsten Koehler, Nadia N. Hansel, Meredith C. McCormack
Summary: In this home intervention study, children used air purifiers 80% of the time and were adherent to high or turbo settings for 60% of the time. Season was identified as the major determinant of air purifier adherence, with lower use in the winter attributed to the draft generated by the machine. Improving air purifier adherence among children with asthma living in low-income, urban households may require addressing practical barriers to consistent use, such as draft during the winter, in addition to financial barriers.
Letter
Critical Care Medicine
Meredith C. McCormack, Aparna Balasubramanian, Elizabeth C. Matsui, Roger D. Peng, Robert A. Wise, Corinne A. Keet
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Critical Care Medicine
Stefanie E. Mason, Rafael Moreta-Martinez, Wassim W. Labaki, Matthew J. Strand, Elizabeth A. Regan, Jessica Bon, Ruben San Jose Estepar, Richard Casaburi, Merry-Lynn McDonald, Harry B. Rossiter, Barry Make, Mark T. Dransfield, MeiLan K. Han, Kendra Young, Jeffrey L. Curtis, Kathleen Stringer, Greg Kinney, John E. Hokanson, Raul San Jose Estepar, George R. Washko
Summary: The longitudinal loss of fat-free mass (FFM) is associated with increased all-cause mortality, regardless of initial body composition metrics, including BMI or muscle mass. This finding may improve risk stratification and identify novel therapeutic targets for patients with chronic obstructive pulmonary disease.
Article
Respiratory System
Sanja Stanojevic, David A. Kaminsky, Martin R. Miller, Bruce Thompson, Andrea Aliverti, Igor Barjaktarevic, Brendan G. Cooper, Bruce Culver, Eric Derom, Graham L. Hall, Teal S. Hallstrand, Joerg D. Leuppi, Neil MacIntyre, Meredith McCormack, Margaret Rosenfeld, Erik R. Swenson
Summary: This article emphasizes the importance of accurately interpreting pulmonary function test results and updates the new standards and strategies for interpreting pulmonary function tests. It is necessary to combine clinical expertise and biological variability for interpretation to ensure an accurate understanding of individual pulmonary function measurements.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Subhashini A. Sellers, Andrew Edmonds, Catalina Ramirez, Sushma K. Cribbs, Igho Ofotokun, Laurence Huang, Alison Morris, Meredith C. Mccormack, Ken M. Kunisaki, Gypsyamber D'souza, M. Patricia Rivera, M. Bradley Drummond, Adaora A. Adimora
Summary: This study evaluated the screening criteria for patients with HIV, and found that the new 2021 criteria improved the sensitivity of lung cancer screening in this population. Additionally, lowering the age and tobacco exposure thresholds further increased the screening sensitivity in women. Further research is needed to determine the optimal screening criteria for patients with HIV, particularly in women.
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2022)
Article
Critical Care Medicine
Robert A. Wise, Janet T. Holbrook, Robert H. Brown, Gerard J. Criner, Mark T. Dransfield, Jiaxian He, Robert J. Henderson, David A. Kaminsky, Robert J. Kaner, Stephen C. Lazarus, Barry J. Make, Meredith C. McCormack, Enid R. Neptune, Loretta G. Que
Summary: This study aimed to evaluate the efficacy of losartan in reducing emphysema progression in COPD patients, and the results showed that losartan did not prevent emphysema progression.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Letter
Critical Care Medicine
Meredith McCormack, Aparna Balasubramanian, Robert A. Wise, Corinne A. Keet, Elizabeth C. Matsui, Roger D. Peng
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2022)
Article
Physiology
Chenjuan Gu, Jeff Loube, Rachel Lee, Shannon Bevans-Fonti, Tianshi David Wu, Jessica H. Barmine, Jonathan C. Jun, Meredith C. McCormack, Nadia N. Hansel, Wayne Mitzner, Vsevolod Y. Polotsky
Summary: The study aimed to investigate the effect of metformin on airway hyperresponsiveness (AHR) in a mouse model of obese asthma. The results showed that metformin can alleviate AHR without affecting body weight or blood glucose levels.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Allergy
Olivia Johnson, Lynn B. Gerald, Jean Harvey, Gem Roy, Heather Hazucha, Chelsey Large, Alyce Burke, Meredith McCormack, Robert A. Wise, Janet T. Holbrook, Anne E. Dixon
Summary: This study pilot-tested an online weight loss intervention and found that weight loss of at least 5% was associated with clinically significant improvements in asthma control, quality of life, and overall health-related quality of life.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Torie L. Grant, Meredith C. McCormack, Roger D. Peng, Corinne A. Keet, Ana M. Rule, Meghan F. Davis, Michelle Newman, Susan Balcer-Whaley, Elizabeth C. Matsui
Summary: This study aimed to investigate the effectiveness of home environmental control strategies on persistent asthma in low-income, Black children. The results showed that the addition of home environmental control strategies did not reduce indoor allergen concentrations or the need for controller medication compared to controller medication titration alone.
Article
Respiratory System
Michelle Sharp, Kevin J. Psoter, Aparna Balasubramanian, Anuhya Pulapaka, Edward S. Chen, Stacey-Ann Whittaker Brown, Stephen C. Mathai, Nisha A. Gilotra, Jonathan Chrispin, Rebecca Bascom, Richard Bernstein, Michelle N. Eakin, Robert A. Wise, David R. Moller, Meredith C. McCormack
Summary: This study investigated the pulmonary function phenotypes of a large and diverse cohort of patients with sarcoidosis. Less than half of the patients with pulmonary involvement demonstrated a restrictive phenotype. There were significant differences in pulmonary function phenotypes by race and sex.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Apama Balasubramanian, Nirupama Putcha, Neil R. MacIntyre, Robert L. Jensen, Gregory Kinney, William W. Stlinger, Craig P. Hersh, Russell P. Bowler, Richard Casaburi, MeiLan K. Han, Janos Porszasz, R. Graham Barr, Elizabeth Regan, Barry J. Make, Nadia N. Hansel, Robert A. Wise, Meredith C. McCormack
Summary: DLCO is a potential predictor of mortality in COPD patients, independent of BODE index and CT evidence. For every 10% decrease in DLCO percent predicted, mortality increases by 28%. Adding DLCO to BODE improves the predictive accuracy of the model for COPD.
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2023)
Article
Respiratory System
Wendy Lorizio, Han Woo, Meredith C. McCormack, Chen Liu, Nirupama Putcha, Megan Wood, Timothy Green, Parisa Kaviany, Daniel Belz, Ashraf Fawzy, Sara Carson, Michelle N. Eakin, Kirsten Koehler, Nadia N. Hansel
Summary: This study found that cold weather, gas heating, and lower annual income have a negative impact on adherence to air cleaner use among adults with COPD. Poor quality of life and worse disease control may also decrease adherence.
CHRONIC OBSTRUCTIVE PULMONARY DISEASES-JOURNAL OF THE COPD FOUNDATION
(2022)
Review
Respiratory System
Aisling McGowan, Pierantonio Laveneziana, Sam Bayat, Nicole Beydon, P. W. Boros, Felip Burgos, Matjaz Flezar, Monika Franczuk, Maria-Alejandra Galarza, Adrian H. Kendrick, Enrico Lombardi, Jellien Makonga-Braaksma, Meredith C. McCormack, Laurent Plantier, Sanja Stanojevic, Irene Steenbruggen, Bruce Thompson, Allan L. Coates, Jack Wanger, Donald W. Cockcroft, Bruce Culver, Karl Sylvester, Frans De Jongh
Summary: The COVID-19 pandemic has adversely affected respiratory diagnostic services worldwide. An international consensus statement by experts in the field of lung function and respiratory physiology presents strategies for the safe delivery of lung function testing services during and beyond the pandemic.