期刊
CHEMICAL ENGINEERING JOURNAL
卷 424, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.cej.2021.130356
关键词
Yolk-shell nanocomposites; Enzymatic; Photothermal performance; Magnetic resonance imaging; Synergistic therapy
资金
- National Natural Science Foundation of China [21505118]
- Postdoctoral Research Funding Program of Jiangsu Province of China [1701133C]
This study successfully prepared a novel nanotherapeutic agent with excellent targeted tumor therapy effect, including O-2 generation, MRI property, enzymatic activity, and photothermal conversion effect, and achieved the synergistic effects of chemotherapy, chemodynamic therapy, and photothermal therapy.
The preparation and construction of novel nanostructures as targeting theranostic is of great significance for diagnosis and treatment of tumor. Herein, a novel PANI/PPy@Au@MnO2 (PPAuMns) yolk-shell enzymatic theranostic agent was fabricated firstly via in situ deposition of Au nanoparticles (Au NPs) and reduction of KMnO4 on the surface of PANI/PPy nanocomposites. In addition to high biocompatible and biodegraded performance, PPAuMns possessed amazing tumor microenvironment (TME)-responsive O-2 generation capacity, magnetic resonance imaging (MRI) property, enzymatic activity and excellent photothermal conversion effect. Chemotherapeutics doxorubicin and folic acid (FA) were further loaded and decorated on it for targeted tumor therapy. Experiments in vitro and in vivo indicated that DOX-loaded PPAuMns@FA demonstrated excellent synergistic anti-tumor effect combining chemotherapy (CT), chemo-dynamic therapy (CDT) and photothermal therapy (PTT). This work offers a paradigm to design and construct tumor diagnosis and therapy platforms employing TME-responsive synergistic strategy of photothermal ablation, chemo-dynamic and chemotherapy.
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