期刊
CARBOHYDRATE POLYMERS
卷 260, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117703
关键词
Oseltamivir phosphate; Maltodextrin; Molecular dynamics; Influenza; Viral pandemic; Pediatric formulations
资金
- UGC, New Delhi, India
This study successfully masked the bitter taste of the antiviral drug Oseltamivir phosphate through computational assessment and experimental methods, and prepared orally dispersible mini tablets with the assistance of pea starch maltodextrin. Various characterization techniques confirmed the results of computational simulations, and taste assessment in human volunteers showed a significant reduction in bitterness of the prepared tablets.
Present research work was aimed at masking the bitter taste of anti- viral drug Oseltamivir phosphate (Ost) by complexing it with pea starch maltodextrin- Kleptose Linecaps (R) (Mid). The Ost groups involved in triggering the bitter sensation were identified by computationally assessing its interaction with human bitter taste receptor hTAS2R 38. A series of exhaustive molecular dynamics (MD) simulation was run using Schrodinger (R) suite to understand the type of interaction of Ost with Mld. Experimentally, complexes of Ost with Mld were realized by solution method. The complexes were characterized using differential scanning colorimetry (DSC), fourier transform-infrared spectroscopy (FT-IR), powder X-ray diffraction (PXRD), hot stage microscopy (HSM), scanning electron microscopy (SEM), proton NMR (H-1-NMR) and Carbon-13 nuclear magnetic resonance (C-13-NMR). Ost-oral dispersible mini tablets (ODMT) were prepared by direct compression and optimised using mixture designs. Finally, bitter taste perception of Ost-ODMT was evaluated in healthy human volunteers of either sex. Computational assessment, involving interaction of Ost with bitter receptor, predicted the involvement of free amino group of Ost in triggering the bitter response whereas, MD simulation predicted the formation of stable complex between Ost and double helical confirmation of Mld. Different characterization techniques confirmed the findings of MD simulation. Results from the taste assessment in human volunteers revealed a significant reduction in bitter taste of prepared Ost-ODMT
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