期刊
CARBOHYDRATE POLYMERS
卷 260, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2021.117769
关键词
Bilayered tissue guided membranes; Seamlessly integrated layer structure; Mechanical properties; Biocompatibility; Osteoconductivity; Periodontal defect regeneration
资金
- National Natural Science Foundation of China [11632013, 11502158, 11802197]
- Shanxi Provincial Key Research and Development Project, China [201803D421060, 201903D421064, 201803D421076]
- Natural Science Foundation of Shanxi Province, China [201901D111078, 201901D111077]
The novel PA6/CS@n-HA/PA6 bilayered tissue guided membranes show good physical and mechanical properties, biological compatibility, and osteoconductivity. Through a series of tests, it is confirmed that the membranes have good porosity and bioactivity.
Periodontal defect poses a significant challenge in orthopedics. Guided Bone Regeneration (GBR) membrane is considered as one of the most successful methods applied to reconstruct alveolar bone and then to achieve periodontal defect repair/regeneration. In this paper, a novel polyamide-6/chitosan@nano-hydroxyapatite/ polyamide-6 (PA6/CS@n-HA/PA6) bilayered tissue guided membranes by combining a solvent casting and an electrospinning technique was designed. The developed PA6/CS@n-HA/PA6 composites were characterized by a series of tests. The results show that n-HA/PA6 and electrospun PA6/CS layers are tightly bound by molecular interaction and chemical bonding, which enhances the bonding strength between two distinct layers. The porosity and adsorption average pore diameter of the PA6/CS@n-HA/PA6 membranes are 36.90 % and 22.61 nm, respectively. The tensile strength and elastic modulus of PA6/CS@n-HA/PA6 composites are 1.41 ? 0.18 MPa and 7.15 ? 1.09 MPa, respectively. In vitro cell culture studies demonstrate that PA6/CS@n-HA/PA6 bilayered scaffolds have biological safety, good bioactivity, biocompatibility and osteoconductivity.
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