Parallel genome-wide RNAi screens identify lymphocyte-specific protein tyrosine kinase (LCK) as a targetable vulnerability of cell proliferation and chemoresistance in nasopharyngeal carcinoma

Mitochondrial DNA alterations may influence the cisplatin responsiveness of oral squamous cell carcinoma

(2020) Amnani Aminuddin et al.   Scientific Reports

Phosphoinositide‐dependent Kinase‐1 (PDPK1) regulates serum/glucocorticoid‐regulated Kinase 3 (SGK3) for prostate cancer cell survival

(2020) Geetha Nalairndran et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Genome-wide CRISPR-based gene knockout screens reveal cellular factors and pathways essential for nasopharyngeal carcinoma

(2019) Chong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Beyond TCR Signaling: Emerging Functions of Lck in Cancer and Immunotherapy

(2019) Bommhardt et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Nasopharyngeal carcinoma

(2019) Yu-Pei Chen et al.   LANCET

Management of locally recurrent nasopharyngeal carcinoma

(2019) Anne W.M. Lee et al.   CANCER TREATMENT REVIEWS

Histone deacetylase (HDAC) inhibitors and doxorubicin combinations target both breast cancer stem cells and non-stem breast cancer cells simultaneously

(2019) Ling-Wei Hii et al.   BREAST CANCER RESEARCH AND TREATMENT

Alterations in cellular expression in EBV infected epithelial cell lines and tumors

(2019) Rachel Hood Edwards et al.   PLoS Pathogens

Identification of inhibitors synergizing gemcitabine sensitivity in the squamous subtype of pancreatic ductal adenocarcinoma (PDAC)

(2018) Jia Lin Er et al.   APOPTOSIS

YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells is Regulated by LCK and Independent of LATS Activity

(2018) Takaaki Sugihara et al.   MOLECULAR CANCER RESEARCH

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Exploration of the therapeutic aspects of Lck: A kinase target in inflammatory mediated pathological conditions

(2018) Pankaj Kumar Singh et al.   BIOMEDICINE & PHARMACOTHERAPY

Regulation of human glioma cell migration, tumor growth, and stemness gene expression using a Lck targeted inhibitor

(2018) J. P. Zepecki et al.   ONCOGENE

High-throughput RNAi screen in Ewing sarcoma cells identifies leucine rich repeats and WD repeat domain containing 1 (LRWD1) as a regulator of EWS-FLI1 driven cell viability

(2017) Tao He et al.   GENE

CD55 regulates self-renewal and cisplatin resistance in endometrioid tumors

(2017) Caner Saygin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Bis-benzopyrroloisoquinoline Alkaloid Incorporating a Cyclobutane Core and a Chlorophenanthroindolizidine Alkaloid with Cytotoxic Activity from Ficus fistulosa var. tengerensis

(2017) Amjad Ayad Qatran Al-Khdhairawi et al.   JOURNAL OF NATURAL PRODUCTS

A genome-wide siRNA screen for regulators of tumor suppressor p53 activity in human non-small cell lung cancer cells identifies components of the RNA splicing machinery as targets for anticancer treatment

(2017) Ellen Siebring-van Olst et al.   Molecular Oncology

Transcriptome evolution from breast epithelial cells to basal-like tumors

(2017) Gabriel Santpere et al.   Oncotarget

Jerantinine A induces tumor-specific cell death through modulation of splicing factor 3b subunit 1 (SF3B1)

(2017) Felicia Fei-Lei Chung et al.   Scientific Reports

The Src family kinase LCK cooperates with oncogenic FLT3/ITD in cellular transformation

(2017) Alissa Marhäll et al.   Scientific Reports

Combenefit: an interactive platform for the analysis and visualization of drug combinations

(2016) Giovanni Y. Di Veroli et al.   BIOINFORMATICS

Global trends in incidence and mortality of nasopharyngeal carcinoma

(2016) Ling-Ling Tang et al.   CANCER LETTERS

Functional genomics reveals that tumors with activating phosphoinositide 3-kinase mutations are dependent on accelerated protein turnover

(2016) Teresa Davoli et al.   GENES & DEVELOPMENT

Nasopharyngeal carcinoma

(2016) Melvin L K Chua et al.   LANCET

Fibroblast growth factor receptor 4 (FGFR4) and fibroblast growth factor 19 (FGF19) autocrine enhance breast cancer cells survival

(2016) Kai Hung Tiong et al.   Oncotarget

Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

(2016) James Campbell et al.   Cell Reports

Antitumour benzothiazoles. Part 32: DNA adducts and double strand breaks correlate with activity; synthesis of 5F203 hydrogels for local delivery

(2015) Erica L. Stone et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity

(2015) YEE-LIN VOON et al.   ONCOLOGY REPORTS

LCK over-expression drives STAT5 oncogenic signaling in PAX5 translocated BCP-ALL patients

(2015) Valeria Cazzaniga et al.   Oncotarget

A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells

(2014) Zhenfeng Duan et al.   BMC CANCER

CYP2S1 and CYP2W1 Mediate 2-(3,4-Dimethoxyphenyl)-5-Fluorobenzothiazole (GW-610, NSC 721648) Sensitivity in Breast and Colorectal Cancer Cells

(2011) B. S. Tan et al.   MOLECULAR CANCER THERAPEUTICS

High-throughput RNA interference screening using pooled shRNA libraries and next generation sequencing

(2011) David Sims et al.   GENOME BIOLOGY

Role of lymphocyte-specific protein tyrosine kinase (LCK) in the expansion of glioma-initiating cells by fractionated radiation

(2010) Rae-Kwon Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BRCA1-Associated Epigenetic Regulation of p73 Mediates an Effector Pathway for Chemosensitivity in Ovarian Carcinoma

(2010) N. Ibrahim et al.   CANCER RESEARCH

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored

(2010) D. Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

(2009) Robert J. Salmond et al.   IMMUNOLOGICAL REVIEWS

Small Molecule Inhibitors of Lck: The Search for Specificity within a Kinase Family

(2008) Malcolm Meyn III et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Highly parallel identification of essential genes in cancer cells

(2008) B. Luo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA