Exosome-mediated delivery of RNA and DNA for gene therapy

Functionalized Folate-Modified Graphene Oxide/PEI siRNA Nanocomplexes for Targeted Ovarian Cancer Gene Therapy

(2020) Yunfei Wang et al.   Nanoscale Research Letters

Synergistic combinations of paclitaxel and withaferin A against human non-small cell lung cancer cells

(2020) Al Hassan Kyakulaga et al.   Oncotarget

Luxturna: FDA documents reveal the value of a costly gene therapy

(2019) Jonathan J. Darrow   DRUG DISCOVERY TODAY

Milk exosomes - Natural nanoparticles for siRNA delivery

(2019) Farrukh Aqil et al.   CANCER LETTERS

Folic acid functionalized nanoparticles as pharmaceutical carriers in drug delivery systems

(2019) Asghar Narmani et al.   DRUG DEVELOPMENT RESEARCH

Mesenchymal stem cell-derived exosomes for clinical use

(2019) Mayela Mendt et al.   BONE MARROW TRANSPLANTATION

Real-Time Monitoring of Exosome Enveloped-AAV Spreading by Endomicroscopy Approach: A New Tool for Gene Delivery in the Brain

(2019) Nicola Salvatore Orefice et al.   Molecular Therapy-Methods & Clinical Development

Folate-displaying exosome mediated cytosolic delivery of siRNA avoiding endosome trapping

(2019) Zhen Zheng et al.   JOURNAL OF CONTROLLED RELEASE

The approved gene therapy drugs worldwide: from 1998 to 2019

(2019) Cui-Cui Ma et al.   BIOTECHNOLOGY ADVANCES

Comparison of Biological Responses of Polymers Based on Imine and Disulfide Backbones for siRNA Delivery

(2018) Junyi Che et al.   ACS Applied Materials & Interfaces

Nasal delivery of H5N1 avian influenza vaccine formulated with GenJet™ or in vivo-jetPEI® induces enhanced serological, cellular and protective immune responses

(2018) Weiping Cao et al.   DRUG DELIVERY

Advanced physical techniques for gene delivery based on membrane perforation

(2018) Xiaofan Du et al.   DRUG DELIVERY

First CAR to Pass the Road Test: Tisagenlecleucel's Drive to FDA Approval

(2018) Mark B. Geyer   CLINICAL CANCER RESEARCH

Exosomes: natural nanoparticles as bio shuttles for RNAi delivery

(2018) Saber Ghazizadeh Darband et al.   JOURNAL OF CONTROLLED RELEASE

Entering the Modern Era of Gene Therapy

(2018) Xavier M. Anguela et al.   Annual Review of Medicine

A phase I trial of intraperitoneal GEN-1, an IL-12 plasmid formulated with PEG-PEI-cholesterol lipopolymer, administered with pegylated liposomal doxorubicin in patients with recurrent or persistent epithelial ovarian, fallopian tube or primary peritoneal cancers: An NRG Oncology/Gynecologic Oncology Group study

(2017) Premal H. Thaker et al.   GYNECOLOGIC ONCOLOGY

Exosomes as novel bio-carriers for gene and drug delivery

(2017) Xin-Chi Jiang et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Exosomes: Nanoparticulate tools for RNA interference and drug delivery

(2017) Fahimeh Shahabipour et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Nano-based delivery of RNAi in cancer therapy

(2017) Yong Xin et al.   Molecular Cancer

Milk-derived exosomes for oral delivery of paclitaxel

(2017) Ashish K. Agrawal et al.   Nanomedicine-Nanotechnology Biology and Medicine

Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles in mice via different administration routes

(2017) Jie Yu et al.   Nanoscale

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Exosomal delivery of berry anthocyanidins for the management of ovarian cancer

(2017) Farrukh Aqil et al.   Food & Function

Exosome-associated AAV2 vector mediates robust gene delivery into the murine retina upon intravitreal injection

(2017) Sarah J. Wassmer et al.   Scientific Reports

Codelivery of sorafenib and GPC3 siRNA with PEI-modified liposomes for hepatoma therapy

(2017) Weitong Sun et al.   Biomaterials Science

Bio-inspired polymer envelopes around adenoviral vectors to reduce immunogenicity and improve in vivo kinetics

(2016) Gerui Fan et al.   Acta Biomaterialia

Therapeutic nucleic acids: current clinical status

(2016) Kannan Sridharan et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Bovine milk-derived exosomes for drug delivery

(2016) Radha Munagala et al.   CANCER LETTERS

Target gene delivery from targeting ligand conjugated chitosan–PEI copolymer for cancer therapy

(2016) Joung-Pyo Nam et al.   CARBOHYDRATE POLYMERS

Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes

(2016) Kasper Bendix Johnsen et al.   CYTOTECHNOLOGY

Folic acid functionalized long-circulating co-encapsulated docetaxel and curcumin solid lipid nanoparticles:In vitroevaluation, pharmacokinetic and biodistribution in rats

(2016) Harish Pawar et al.   DRUG DELIVERY

Alnylam terminates revusiran program, stock plunges

(2016) Ken Garber   NATURE BIOTECHNOLOGY

Production and clinical development of nanoparticles for gene delivery

(2016) Jie Chen et al.   Molecular Therapy-Methods & Clinical Development

First-in-man Phase 1 Clinical Trial of Gene Therapy for Advanced Pancreatic Cancer: Safety, Biodistribution, and Preliminary Clinical Findings

(2015) Louis Buscail et al.   MOLECULAR THERAPY

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Phosphorothioate Oligonucleotides: Effectiveness and Toxicity

(2014) Tommaso Iannitti et al.   CURRENT DRUG TARGETS

Non-viral vectors for gene-based therapy

(2014) Hao Yin et al.   NATURE REVIEWS GENETICS

Current Progress in Gene Delivery Technology Based on Chemical Methods and Nano-carriers

(2014) Lian Jin et al.   Theranostics

MicroRNA ‘signature’ during estrogen-mediated mammary carcinogenesis and its reversal by ellagic acid intervention

(2013) Radha Munagala et al.   CANCER LETTERS

Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles

(2013) Sander A.A. Kooijmans et al.   JOURNAL OF CONTROLLED RELEASE

DNA Based Therapy with Diphtheria Toxin-A BC-819: A Phase 2b Marker Lesion Trial in Patients with Intermediate Risk Nonmuscle Invasive Bladder Cancer

(2013) Ofer N. Gofrit et al.   JOURNAL OF UROLOGY

Physical Non-Viral Gene Delivery Methods for Tissue Engineering

(2012) Adam J. Mellott et al.   ANNALS OF BIOMEDICAL ENGINEERING

Tumor-targeting drug delivery of new-generation taxoids

(2011) Iwao Ojima et al.   Future Medicinal Chemistry

DNA delivery to ‘ex vivo’ human liver segments

(2011) M J Herrero et al.   GENE THERAPY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Mechanism-Based Tumor-Targeting Drug Delivery System. Validation of Efficient Vitamin Receptor-Mediated Endocytosis and Drug Release

(2010) Shuyi Chen et al.   BIOCONJUGATE CHEMISTRY

Stable isotope resolved metabolomics of lung cancer in a SCID mouse model

(2010) Teresa W.-M. Fan et al.   Metabolomics

The use of folate-PEG-grafted-hybranched-PEI nonviral vector for the inhibition of glioma growth in the rat

(2009) Bing Liang et al.   BIOMATERIALS

Effect of Yeast-derived β-glucan in Conjunction With Bevacizumab for the Treatment of Human Lung Adenocarcinoma in Subcutaneous and Orthotopic Xenograft Models

(2009) Wangjian Zhong et al.   JOURNAL OF IMMUNOTHERAPY

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Innate immune response induced by gene delivery vectors

(2007) Haruna Sakurai et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Adenovirus vector induced innate immune responses: Impact upon efficacy and toxicity in gene therapy and vaccine applications

(2007) Zachary C. Hartman et al.   VIRUS RESEARCH