Article
Clinical Neurology
Markus Bock, Falk Steffen, Frauke Zipp, Stefan Bittner
Summary: This study investigated the impact of adapted ketogenic diet (AKD) and caloric restriction (CR) on neuroaxonal damage in patients with multiple sclerosis (MS), and found that AKD significantly reduced serum neurofilament light chain (sNfL) levels.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2022)
Article
Nutrition & Dietetics
Ilias Attaye, Sophie van Oppenraaij, Moritz V. Warmbrunn, Max Nieuwdorp
Summary: The ketogenic diet focuses on reducing carbohydrate intake and increasing fat intake to promote weight loss, improve insulin sensitivity, and reduce dyslipidaemia. The interactions between diet and gut microbiota play a crucial role in influencing host health and metabolic effects.
Article
Neurosciences
Rebecca Bornstein, Katerina James, Julia Stokes, Kyung Yeon Park, Ernst-Bernhard Kayser, John Snell, Angela Bard, Yihan Chen, Franck Kalume, Simon C. Johnson
Summary: Genetic mitochondrial diseases are a common cause of inherited metabolic disorders, with Leigh syndrome being the most common clinical presentation in children. While there are no proven therapies for mitochondrial diseases, a ketogenic diet has shown some success in managing mitochondrial epilepsies. mTOR inhibition is being explored as a potential therapeutic target for seizures related to primary mitochondrial dysfunction.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Biochemistry & Molecular Biology
Ricardo Mario Arida
Summary: The review discusses the significant contribution of the ketogenic diet and physical exercise in reducing seizure susceptibility and improving the condition of epilepsy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Clinical Neurology
Emine Tekin, Filiz Mihci Serdaroglu, Serife Sahin, Haydar Ali Tasdemir
Summary: The ketogenic diet (KD) is effective in treating metabolic disorders, epilepsy, and improving social behavior of patients. However, challenges such as weight loss, infections, and family issues may lead some patients to discontinue the treatment. Increasing awareness and support may help expand the use of KD in various patient populations.
NEUROLOGICAL SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ping Jia, Bi Huang, Yuehua You, Hong Su, Lingyun Gao
Summary: A ketogenic diet has effects on metabolism and renal fibrosis in spontaneously hypertensive rats, leading to decreased glucose tolerance, activation of the renin-angiotensin-aldosterone system, and reduced renal autophagy levels; however, it has no significant effect on hypertensive renal fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Clinical Neurology
Zehong Lin, Tian Sang, Ying Yang, Yuan Wu, Yan Dong, Taoyun Ji, Yuehua Zhang, Ye Wu, Kai Gao, Yuwu Jiang
Summary: This study evaluated the efficacy of quinidine, ketogenic diet therapy (KDT), and anti-seizure medications (ASMs) for KCNT1-related epilepsy. The results showed that KDT may be a more effective treatment option compared to quinidine, while ASMs were found to be the least effective. The study also highlighted the importance of genotype in determining treatment efficacy for functional domain variant-related epilepsy.
FRONTIERS IN NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yue Zhou, Luqiang Sun, Haichuan Wang
Summary: The prevalence of neonatal hypoxic-ischemic encephalopathy (HIE) is increasing, leading to the need for effective treatments and preventions. Research has focused on understanding the underlying pathology and the potential of dietary interventions, such as a ketogenic diet (KD). The KD has shown promising effects in animal models and brain injury patients, including potential neuroprotection and improvement of mitochondrial function.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Nutrition & Dietetics
Robert P. Carson, Donna L. Herber, Zhaoxing Pan, Fenna Phibbs, Alexandra P. Key, Arnaud Gouelle, Patience Ergish, Eric A. Armour, Shital Patel, Jessica Duis
Summary: This study compared an exogenous medical food ketone formulation with placebo for the dietary management of Angelman syndrome. The results suggest that the exogenous KF appears safe, but more data are needed to determine its utility in children with AS.
JOURNAL OF NUTRITION
(2021)
Article
Nutrition & Dietetics
Elizabeth A. Felton, Bobbie J. Henry-Barron, Amanda K. Jan, Abigail Shegelman, Kelly Faltersack, Diane Vizthum, Mackenzie C. Cervenka
Summary: The study aimed to evaluate the feasibility and tolerability of adding a medium chain triglyceride emulsion to the modified Atkins diet for treating catamenial seizures in pre-menopausal women with epilepsy. Results showed high adherence and acceptable tolerability of the emulsion, indicating potential for future studies on ketogenic diet therapies for catamenial seizures.
Review
Neurosciences
Ebru Cicek, Nevin Sanlier
Summary: The ketogenic diet is commonly used for the treatment of drug-resistant epilepsy, showing positive effects in seizure control and improvement in quality of life. However, the sustainability of the diet and potential side effects should be taken into consideration.
NUTRITIONAL NEUROSCIENCE
(2023)
Article
Neurosciences
Daniela Liskiewicz, Arkadiusz Liskiewicz, Marta M. Nowacka-Chmielewska, Mateusz Grabowski, Natalia Pondel, Konstancja Grabowska, Sebastian Student, Jaroslaw J. Barski, Andrzej Malecki
Summary: Experimental and clinical data support the neuroprotective properties of the ketogenic diet and ketone bodies, with autophagy being a key mechanism for maintaining cell homeostasis. Recent studies suggest possible interconnections between ketone body metabolism and autophagy, indicating that the stimulation of autophagy may contribute to the neuroprotection provided by the ketogenic diet.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Nutrition & Dietetics
Valeria Calcaterra, Hellas Cena, Francesca Sottotetti, Chiara Hruby, Nagaia Madini, Noemi Zelaschi, Gianvincenzo Zuccotti
Summary: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age and is mainly driven by hyperandrogenism, hyperinsulinism, and insulin resistance. Lifestyle and dietary interventions, particularly the quality and quantity of carbohydrates consumed, play a crucial role in the management of PCOS, and the ketogenic diet (KD) has shown promise in improving insulin resistance and carbohydrate metabolism. Further studies are needed to determine the specific effects of the very low-calorie ketogenic diet (LCKD) in adolescents with PCOS and excessive body weight. Rating: 8/10
Review
Endocrinology & Metabolism
Vincenzo Garofalo, Federica Barbagallo, Rossella Cannarella, Aldo Eugenio Calogero, Sandro La Vignera, Rosita Angela Condorelli
Summary: This systematic review found no significant effect of different types of ketogenic diet on bone health, including bone mass density, bone formation, and overall bone turnover. Only in female subjects after a 10% weight loss, an increase in bone resorption and a decrease in new bone synthesis were observed, without increasing the risk of osteoporosis. Additionally, ketogenic diet was associated with weight loss, increased vitamin D levels, and reduced parathyroid hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Wael Abu Dayyih, Raghad Layth, Mohammad Hailat, Bayan Alkhawaja, Lina Al Tamimi, Zainab Zakaraya, Aseel Aburumman, Nisreen Al Dmour, Mohamed J. Saadh, Hisham Al-Matubsi, Saed M. Aldalaen
Summary: In this study, it was found that administering date molasses to rats significantly decreased the pharmacokinetic parameters of levetiracetam, which could increase the risk of epileptic seizures.
SCIENTIFIC REPORTS
(2023)