期刊
BRITISH JOURNAL OF NEUROSURGERY
卷 36, 期 3, 页码 307-315出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/02688697.2021.1903390
关键词
Choroid plexus; blood-cerebrospinal fluid barrier; cerebrospinal fluid; circadian clock; taste and olfactory signalling; chemical surveillance; immune surveillance; brain disorders; normal pressure hydrocephalus; Alzheimer’ s disease
The choroid plexus plays a crucial role in CSF secretion, renewal, absorption, circadian rhythm regulation, chemical and immune surveillance, and disruption of the ChP may have functional implications in neurodegenerative disorders.
In this article, we review the available literature about the functions of the choroid plexus (ChP), including its basic role in cerebrospinal fluid (CSF) secretion, renewal and absorption. We discuss more recently described, lesser-known functions of the ChP, such as its role in circadian rhythm regulation, chemical and immune surveillance and functional implications of ChP disruption, as occurs in neurodegenerative disorders.
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