Effect of dermatological consultation on survival in patients with checkpoint inhibitor-associated cutaneous toxicity

Background Cutaneous immune-related adverse events (cirAEs) are a common side-effect of immune checkpoint inhibitors (ICIs). However, prior work examining these toxicities in detail has considered only the fraction of events evaluated by dermatologists. Associations between dermatology referral, cirAE treatment and survival outcomes remain underexplored across care settings. Objectives To comprehensively categorize cirAE patterns among all patients treated with immunotherapy at our institution, and to evaluate: (i) the effect of dermatology referral on cirAE treatment and (ii) the impact of cirAE treatment on survival. Methods This was a retrospective cohort analysis of patients with cancer who initiated ICI therapy between 1 January 2016 and 8 March 2019 and developed one or more cirAEs, as screened for using International Classification of Diseases 10th revision codes and confirmed via manual chart review (n = 358). All relevant information documented prior to 31 March 2020 was included. Results CirAEs evaluated by dermatologists were significantly more likely to be treated than cirAEs that were not referred (odds ratio 6 center dot 08, P < 0 center dot 001). Patients who received any cirAE treatment had improved progression-free survival [hazard ratio (HR) 0 center dot 59, P = 0 center dot 001] and overall survival (HR 0 center dot 58, P = 0 center dot 007) compared with those who did not. Conclusions CirAEs evaluated by dermatologists were significantly more likely to be treated than cirAEs that were not referred, and patients who received any treatment for a cirAE had improved survival outcomes.

Automated summary

Dermatologist-evaluated cirAEs were more likely to receive treatment than non-referred cirAEs, and patients receiving any cirAE treatment showed improved survival outcomes.