期刊
EPILEPSY & BEHAVIOR
卷 58, 期 -, 页码 91-96出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.yebeh.2016.03.006
关键词
Temporal lobe epilepsy; Histopathology; FCD; Hippocampal sclerosis; Cognition; Handedness; Status epilepticus
资金
- Faculty of Arts, Charles University, Prague, Czech Republic [GAUK 1162/13]
- MH CZ-DRO, University Hospital Motol, Prague, Czech Republic [00064203]
This study evaluated language organization in children with intractable epilepsy caused by temporal lobe focal cortical dysplasia (FCD) alone or dual pathology (temporal lobe FCD and hippocampal sclerosis, HS). We analyzed clinical, neurological, fMRI, neuropsychological, and histopathologic data in 46 pediatric patients with temporal lobe lesions who underwent excisional epilepsy surgery. The frequency of atypical language representation was similar in both groups, but children with dual pathology were more likely to be left-handed. Atypical receptive language cortex correlated with lower intellectual capacity, verbal abstract conceptualization, receptive language abilities, verbal working memory, and a history of status epilepticus but did not correlate with higher seizure frequency or early seizure onset. Histopathologic substrate had only a minor influence on neuropsychological status. Greater verbal comprehension deficits were noted in children with atypical receptive language representation, a risk factor for cognitive morbidity. (C) 2016 Elsevier Inc. All rights reserved.
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