Review
Radiology, Nuclear Medicine & Medical Imaging
Valeria Romeo, Thomas H. Helbich, Katja Pinker
Summary: The recent introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI) as a promising imaging modality for breast cancer assessment has sparked extensive research on its clinical applications. This state-of-the-art review provides an overview of advanced MRI techniques, PET tracers, and the use of radiomics and artificial intelligence techniques in hybrid breast PET/MRI. The strengths and limitations of hybrid PET/MRI in the real world are also discussed.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Clinical Neurology
Fengzhao Zhu, Yulong Wang, Xiangchuang Kong, Yuan Liu, Lian Zeng, Xirui Jing, Sheng Yao, Kaifang Chen, Lian Yang, Xiaodong Guo
Summary: The combination of conventional MRI with DTI-DTT is a valid diagnostic approach for acute traumatic cervical SCI. Lower intramedullary lesion length and intramedullary hemorrhage length, and higher fractional anisotropy value and connection rates of fiber tractography are linked to better neurological outcomes.
EUROPEAN SPINE JOURNAL
(2022)
Review
Medicine, General & Internal
Natalia Garcia-Casares, Amanda Barros-Cano, Juan A. Garcia-Arnes
Summary: This review focuses on studying the rehabilitation effects of Melodic Intonation Therapy (MIT) on non-fluent aphasic patients using neuroimaging and neurophysiological techniques. The results indicate that MIT can promote right-hemisphere involvement in language processing, but the specific activation mechanism is influenced by individual factors.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Emanuele Monda, Marta Rubino, Giuseppe Palmiero, Federica Verrillo, Michele Lioncino, Gaetano Diana, Annapaola Cirillo, Adelaide Fusco, Francesca Dongiglio, Martina Caiazza, Ippolita Altobelli, Alfredo Mauriello, Natale Guarnaccia, Alessandra Scatteia, Arturo Cesaro, Giuseppe Pacileo, Berardo Sarubbi, Giulia Frisso, Barbara Bauce, Antonello D'Andrea, Santo Dellegrottaglie, Maria Giovanna Russo, Paolo Calabro, Giuseppe Limongelli
Summary: Arrhythmogenic cardiomyopathy (ACM) is a broad term for myocardial diseases characterized by progressive fibrotic or fibrofatty replacement, which leads to ventricular tachyarrhythmias and ventricular dysfunction. Arrhythmogenic left ventricular cardiomyopathy (ALVC) is a specific subtype that exclusively affects the left ventricle. Diagnosis of ALVC requires a combination of family history, clinical, electrocardiographic, and imaging features, with genetic testing for confirmation. Multimodality imaging techniques, such as echocardiography, cardiac magnetic resonance, and cardiac nuclear imaging, are essential for diagnosis, differential diagnosis, risk stratification, and management of ALVC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Christian Philipp Reinert, Cecilia Liang, Matthias Weissinger, Jonas Vogel, Andrea Forschner, Konstantin Nikolaou, Christian la Fougere, Ferdinand Seith
Summary: The purpose of this study was to compare the diagnostic performance of whole-body MRI and CT with PET/CT and PET/MRI as the reference standard. The results showed that whole-body MRI had comparable diagnostic accuracy and confidence to CT across most regions. However, CT had a higher detection rate in the lungs, while MRI had a higher detection rate in the bones.
Review
Medicine, General & Internal
Frank A. Flachskampf, Tomasz Baron
Summary: Heart failure is a central issue in cardiology, with cardiac imaging playing a crucial role in its identification and monitoring. While echocardiography is the first diagnostic step, other imaging techniques are often needed for further clarification of the underlying diseases.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Clinical Neurology
Christopher Hollen, Lee E. Neilson, Ramon F. Barajas, Ian Greenhouse, Rebecca I. Spain
Summary: Conventional MRI is important for evaluating patients with multiple sclerosis, but its role in detecting the underlying pathophysiology of neurodegeneration is limited. Biomarkers that identify processes underlying neurodegeneration before irreversible damage occurs are needed. Oxidative stress is believed to play a major role in the pathogenesis of multiple neurodegenerative diseases, including multiple sclerosis. Non-invasive imaging techniques offer real-time assessment of oxidative stress within the brain, which is an area of unrealized potential.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Robert Burns, Sebastien Mule, Paul Blanc-Durand, Mojdeh Tofighi, Karim Belhadj, Pierre Zerbib, Fabien Le Bras, Laurence Baranes, Corinne Haioun, Emmanuel Itti, Alain Luciani
Summary: The WB-PET/MRI dataset, including T1 and T2 Dixon, WB-DWI, and PET images, provides the optimal diagnostic performance for detecting both focal lesions and diffuse bone marrow involvement. WB-PET/MRI and WB-DCE-PET/MRI show superior sensitivity for focal bone marrow involvement compared to PET alone, while WB-MRI performs best for detecting diffuse bone marrow involvement.
EUROPEAN RADIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Loredana G. G. Marcu, Leyla Moghaddasi, Eva Bezak
Summary: Cancer stem cells are crucial in tumor development, growth, and spread. Their unique properties make them resistant to treatment, often leading to therapy failure. Research into identifying, targeting, and eliminating these cells is believed to revolutionize oncology treatment. This review discusses state-of-the-art functional imaging techniques for identifying cancer stem cells through various pathways and mechanisms. It presents in vivo molecular techniques that are currently available or awaiting clinical implementation while highlighting challenges and future prospects for cancer stem cell imaging.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Giulia Ferrarazzo, Silvia Chiola, Selene Capitanio, Maria Isabella Donegani, Alberto Miceli, Stefano Raffa, Alberto Stefano Tagliafico, Silvia Morbelli, Matteo Bauckneht
Summary: This article summarizes the clinical value of FDG PET/CT in the assessment and monitoring of therapy responses in multiple myeloma (MM), and discusses the potential role of non-FDG PET tracers in the future.
Review
Radiology, Nuclear Medicine & Medical Imaging
Pedram Keshavarz, Sara Haseli, Fereshteh Yazdanpanah, Fateme Bagheri, Negar Raygani, Mahboobeh Karimi-Galougahi
Summary: This systematic review of imaging data in COVID-19-induced anosmia found that normal morphology and T2/FLAIR signal intensity in olfactory bulb and obstruction of olfactory cleft were common, while paranasal sinuses were mostly normal. Olfactory cleft obstruction may be the mechanism for olfactory dysfunction in COVID-19, and abnormalities in olfactory bulb signal intensity and atrophy suggest central mechanisms may also play a role in late stage COVID-19-induced anosmia.
ACADEMIC RADIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Petra Hnilicova, Ema Kantorova, Stanislav Sutovsky, Milan Grofik, Kamil Zelenak, Egon Kurca, Norbert Zilka, Petra Parvanovova, Martin Kolisek
Summary: Alzheimer's disease (AD) is an incurable neurodegenerative disease characterized by perturbed cerebral perfusion and metabolism, induced proinflammatory processes, and the aggregation of amyloid beta and hyperphosphorylated Tau proteins. Various imaging methods can detect subclinical AD changes, and new insights suggest a link between brain insulin resistance and AD pathogenesis. This article discusses the use of non-neuronal imaging modalities to assess AD-related structural changes in the liver and pancreas, which may be clinically important during the prodromal phase of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Osamu Manabe, Noriko Oyama-Manabe, Tadao Aikawa, Satonori Tsuneta, Nagara Tamaki
Summary: Sarcoidosis, a systemic granulomatous disease, can affect various organs with cardiac involvement being a leading cause of mortality. The clinical manifestations of cardiac sarcoidosis are diverse, ranging from asymptomatic to life-threatening conditions. Imaging techniques, including positron emission tomography and cardiac magnetic resonance imaging, play a crucial role in diagnosing and evaluating cardiac sarcoidosis.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Sung Soo Ahn, Soonmee Cha
Summary: Advances in molecular and genetic characterization of CNS tumors have led to a new era of tumor classification and imaging plays a critical role in preoperative diagnosis, surgical planning, molecular marker prediction, targeted treatment planning, and post-therapy assessment.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yoshiharu Ohno, Yuji Kishida, Shinichiro Seki, Hisanobu Koyama, Masao Yui, Kota Aoyagi, Takeshi Yoshikawa
Summary: This study compared the interobserver agreements and diagnostic accuracies for different imaging examinations in the staging of thymic epithelial tumors. The results showed that co-registered FDG-PET/MRI, MRI, and PET/CT had better interobserver agreements and diagnostic accuracies for the new IASLC/ITMIG thymic epithelial tumor staging.
ACADEMIC RADIOLOGY
(2022)
Review
Neurosciences
Peter Kochunov, L. Elliot Hong, Emily L. Dennis, Rajendra A. Morey, David F. Tate, Elisabeth A. Wilde, Mark Logue, Sinead Kelly, Gary Donohoe, Pauline Favre, Josselin Houenou, Christopher R. K. Ching, Laurena Holleran, Ole A. Andreassen, Laura S. van Velzen, Lianne Schmaal, Julio E. Villalon-Reina, Carrie E. Bearden, Fabrizio Piras, Gianfranco Spalletta, Odile A. van den Heuvel, Dick J. Veltman, Dan J. Stein, Meghann C. Ryan, Yunlong Tan, Theo G. M. van Erp, Jessica A. Turner, Liz Haddad, Talia M. Nir, David C. Glahn, Paul M. Thompson, Neda Jahanshad
Summary: The ENIGMA-DTI workgroup investigates the effects of psychiatric, neurological, and developmental disorders on white matter pathways in the human brain. They have identified patterns of white matter deficits in various disorders and demonstrated their reproducibility across different cohorts. Applying the regional vulnerability index (RVI) to individual subjects, they have shown the similarity of deficit patterns among different disorders and discussed the differences between idiopathic schizophrenia and 22q11 deletion syndrome. These findings emphasize the importance of collaborative large-scale research in understanding individual vulnerability and cross-diagnosis features.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
Inga K. Koerte, Carrie Esopenko, Sidney R. Hinds, Martha E. Shenton, Elena M. Bonke, Jeffrey J. Bazarian, Kevin C. Bickart, Erin D. Bigler, Sylvain Bouix, Thomas A. Buckley, Meeryo C. Choe, Paul S. Echlin, Jessica Gill, Christopher C. Giza, Jasmeet Hayes, Cooper B. Hodges, Andrei Irimia, Paula K. Johnson, Kimbra Kenney, Harvey S. Levin, Alexander P. Lin, Hannah M. Lindsey, Michael L. Lipton, Jeffrey E. Max, Andrew R. Mayer, Timothy B. Meier, Kian Merchant-Borna, Tricia L. Merkley, Brian D. Mills, Mary R. Newsome, Tara Porfido, Jaclyn A. Stephens, Maria Carmela Tartaglia, Ashley L. Ware, Ross D. Zafonte, Michael M. Zeineh, Paul M. Thompson, David F. Tate, Emily L. Dennis, Elisabeth A. Wilde, David Baron
Summary: Research on sport-related brain injury is often limited by small sample sizes and variation in neuroimaging techniques and analysis tools. The ENIGMA Sports Injury working group aims to address these limitations by promoting data sharing and collaborative data analysis, with a focus on reproducibility and enhancing data quality for future prospective studies.
BRAIN IMAGING AND BEHAVIOR
(2021)
Review
Neurosciences
Emily L. Dennis, David Baron, Brenda Bartnik-Olson, Karen Caeyenberghs, Carrie Esopenko, Frank G. Hillary, Kimbra Kenney, Inga K. Koerte, Alexander P. Lin, Andrew R. Mayer, Stefania Mondello, Alexander Olsen, Paul M. Thompson, David F. Tate, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is a leading cause of global disability, but predicting patient outcomes is challenging due to the heterogeneous nature of TBI in terms of injury severity and other factors. Neuroimaging research has been limited by small sample sizes, and the development of reliable biomarkers for mild TBI or repeated subconcussive impacts has been slow.
HUMAN BRAIN MAPPING
(2022)
Article
Neuroimaging
R. Jarrett Rushmore, Sylvain Bouix, Marek Kubicki, Yogesh Rathi, Douglas L. Rosene, Edward H. Yeterian, Nikos Makris
Summary: Research on the rhesus monkey brain has provided insights into primate brain function and structure, offering valuable references for studying the human brain. The macaque Harvard-Oxford Atlas (mHOA) is a novel parcellation system based on the human Harvard-Oxford Atlas (HOA), utilizing an ontological and taxonomic framework to categorize anatomical features. This system of parcellation provides a foundation for interpreting results from various experimental studies, such as functional magnetic resonance imaging (fMRI), physiology, connectivity, and graph theory.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neuroimaging
Alexander Olsen, Talin Babikian, Erin D. Bigler, Karen Caeyenberghs, Virginia Conde, Kristen Dams-O'Connor, Ekaterina Dobryakova, Helen Genova, Jordan Grafman, Asta K. Haberg, Ingrid Heggland, Torgeir Hellstrom, Cooper B. Hodges, Andrei Irimia, Ruchira M. Jha, Paula K. Johnson, Vassilis E. Koliatsos, Harvey Levin, Lucia M. Li, Hannah M. Lindsey, Abigail Livny, Marianne Lovstad, John Medaglia, David K. Menon, Stefania Mondello, Martin M. Monti, Virginia Fj Newcombe, Agustin Petroni, Jennie Ponsford, David Sharp, Gershon Spitz, Lars T. Westlye, Paul M. Thompson, Emily L. Dennis, David F. Tate, Elisabeth A. Wilde, Frank G. Hillary
Summary: Traumatic brain injury (TBI) poses a significant global burden of mortality and morbidity. The ENIGMA Adult moderate/severe TBI (AMS-TBI) working group aims to drive new discoveries in AMS-TBI through large-scale cross-border collaboration and data sharing. By promoting transparency, rigor, and reproducibility, the group facilitates the development of harmonized analysis pipelines for neuroimaging data in AMS-TBI.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neuroimaging
Brenda L. Bartnik-Olson, Jeffry R. Alger, Talin Babikian, Ashley D. Harris, Barbara Holshouser, Ivan I. Kirov, Andrew A. Maudsley, Paul M. Thompson, Emily L. Dennis, David F. Tate, Elisabeth A. Wilde, Alexander Lin
Summary: Proton magnetic resonance spectroscopy is a non-invasive method for quantitatively measuring brain metabolites, particularly in traumatic brain injury research. However, the technique is currently underutilized, primarily being conducted at centers with MR research support.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neuroimaging
David F. Tate, Emily L. Dennis, John T. Adams, Maheen M. Adamson, Heather G. Belanger, Erin D. Bigler, Heather C. Bouchard, Alexandra L. Clark, Lisa M. Delano-Wood, Seth G. Disner, Blessen C. Eapen, Carol E. Franz, Elbert Geuze, Naomi J. Goodrich-Hunsaker, Kihwan Han, Jasmeet P. Hayes, Sidney R. Hinds, Cooper B. Hodges, Elizabeth S. Hovenden, Andrei Irimia, Kimbra Kenney, Inga K. Koerte, William S. Kremen, Harvey S. Levin, Hannah M. Lindsey, Rajendra A. Morey, Mary R. Newsome, John Ollinger, Mary Jo Pugh, Randall S. Scheibel, Martha E. Shenton, Danielle R. Sullivan, Brian A. Taylor, Maya Troyanskaya, Carmen Velez, Benjamin S. C. Wade, Xin Wang, Ashley L. Ware, Ross Zafonte, Paul M. Thompson, Elisabeth A. Wilde
Summary: Traumatic brain injury (TBI) is common in military and civilian populations, leading to a range of clinical, cognitive, behavioral, mood, and neuroimaging changes. The inconsistent presentation of TBI poses challenges in establishing biological and imaging markers, although big data approaches offer opportunities to better understand its impact in military populations.
BRAIN IMAGING AND BEHAVIOR
(2021)
Article
Neurosciences
Emily L. Dennis, Brian A. Taylor, Mary R. Newsome, Maya Troyanskaya, Tracy J. Abildskov, Aaron M. Betts, Erin D. Bigler, James Cole, Nicholas Davenport, Timothy Duncan, Jessica Gill, Vivian Guedes, Sidney R. Hinds, Elizabeth S. Hovenden, Kimbra Kenney, Mary Jo Pugh, Randall S. Scheibel, Pashtun-Poh Shahim, Robert Shih, William C. Walker, J. Kent Werner, Gerald E. York, David X. Cifu, David F. Tate, Elisabeth A. Wilde
Summary: This study investigates the association between history of mild traumatic brain injury (mTBI) and accelerated brain aging among United States military Service Members and Veterans. The results showed that males with a history of deployment-related mTBI had advanced brain age compared to those without, while this association was not significant in females. Additionally, severity of posttraumatic stress disorder (PTSD), depression symptoms, and alcohol misuse were also associated with advanced brain aging in male participants.
Article
Neurosciences
Eimear M. Foley, Yorghos Tripodis, Eukyung Yhang, Inga K. Koerte, Brett M. Martin, Joseph Palmisano, Nikos Makris, Vivian Schultz, Chris Lepage, Marc Muehlmann, Pawel P. Wrobel, Jeffrey P. Guenette, Robert C. Cantu, Alexander P. Lin, Michael Coleman, Jesse Mez, Sylvain Bouix, Martha E. Shenton, Robert A. Stern, Michael L. Alosco
Summary: This study examines the association between reserve metrics and cognitive and neuropsychiatric functioning in former professional football players. The study finds that reading ability is associated with attention, episodic memory, fluency, and behavioral regulation. The residual variance in episodic memory and executive functioning is also associated with cognitive performance. Traditional reserve proxies may not be suitable for elite athlete samples, and alternative approaches are needed to quantify reserve.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Madeline Uretsky, Sylvain Bouix, Ronald J. Killiany, Yorghos Tripodis, Brett Martin, Joseph Palmisano, Asim Z. Mian, Karen Buch, Chad Farris, Daniel H. Daneshvar, Brigid Dwyer, Lee Goldstein, Douglas Katz, Christopher Nowinski, Robert Cantu, Neil Kowall, Bertrand Russell Huber, Robert A. Stern, Victor E. Alvarez, Thor D. Stein, Ann McKee, Jesse Mez, Michael L. Alosco
Summary: This study investigated the neuropathologic correlates of white matter hyperintensities (WMH) in brain donors exposed to repetitive head impacts. The results suggest that WMH may capture long-term white matter pathologies from repetitive head impacts, including white matter rarefaction and p-tau accumulation, in addition to microvascular disease. Prospective imaging-pathologic correlation studies are needed to further understand these associations.
Article
Clinical Neurology
James J. Gugger, Eamonn Kennedy, Samin Panahi, David F. Tate, Ali Roghani, Anne C. Van Cott, M. Raquel Lopez, Hamada Altalib, Ramon Diaz-Arrastia, Mary Jo Pugh
Summary: This study investigates the impact of quality of life (QOL) across different epilepsy phenotypes in a cohort of post-9/11 veterans with high rates of traumatic brain injury (TBI). It aims to understand the interplay between comorbid conditions and QOL among epilepsy patients.
Article
Psychiatry
Liangsuo Ma, Kathryn A. Cunningham, Noelle C. Anastasio, James M. Bjork, Brian A. Taylor, Albert J. Arias, Brien P. Riley, Andrew D. Snyder, F. Gerard Moeller
Summary: Patients with Cocaine Use Disorder (CUD) exhibit diverse symptoms and unpredictable responses to treatment, emphasizing the importance of identifying biobehavioral signatures to predict success in clinical trials. This study utilized a task-based behavioral and pharmacogenetic-fMRI approach to investigate craving and attentional bias in CUD patients. The findings suggest that the wild-type 5-HT2CR gene is necessary for the efficacy of the serotonin antagonist mirtazapine in reducing activated effective connectivity in CUD patients.
TRANSLATIONAL PSYCHIATRY
(2022)
Review
Clinical Neurology
Ashley D. Harris, Houshang Amiri, Mariana Bento, Ronald Cohen, Christopher R. K. Ching, Christina Cudalbu, Emily L. Dennis, Arne Doose, Stefan Ehrlich, Ivan I. Kirov, Ralf Mekle, Georg Oeltzschner, Eric Porges, Roberto Souza, Friederike I. Tam, Brian Taylor, Paul M. Thompson, Yann Quide, Elisabeth A. Wilde, John Williamson, Alexander P. Lin, Brenda Bartnik-Olson
Summary: Magnetic resonance spectroscopy (MRS) is a powerful and non-invasive imaging technique that quantitatively measures brain metabolites and has utility in diagnosing and characterizing neurological diseases. However, its impact has been limited by small sample sizes, methodological variability, and intrinsic limitations. This manuscript provides an overview of MRS data harmonization, including key considerations for retrospective and prospective studies, and various approaches to harmonization. The goal is to provide knowledge for conducting MRS data harmonization studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Medicine, General & Internal
Philine Rojczyk, Johanna Seitz-Holland, Elisabeth Kaufmann, Valerie J. Sydnor, Cara L. Kim, Lisa F. Umminger, Tim L. T. Wiegand, Jeffrey P. Guenette, Fan Zhang, Yogesh Rathi, Sylvain Bouix, Ofer Pasternak, Catherine B. Fortier, David Salat, Sidney R. Hinds, Florian Heinen, Lauren J. O'Donnell, William P. Milberg, Regina E. McGlinchey, Martha E. Shenton, Inga K. Koerte
Summary: Sleep disturbances are strongly associated with mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD), and poor sleep quality has a compounding effect on white matter (WM) microstructure in veterans with comorbid PTSD+mTBI. Veterans with PTSD and comorbid PTSD+mTBI reported poorer sleep quality than those with mTBI or no history of PTSD or mTBI. Poor sleep quality fully mediated the association between greater PTSD symptom severity and impaired WM microstructure. Sleep-targeted interventions are necessary for improving brain health in veterans with PTSD+mTBI.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Lara Pankatz, Philine Rojczyk, Johanna Seitz-Holland, Sylvain Bouix, Leonard B. Jung, Tim L. T. Wiegand, Elena M. Bonke, Nico Sollmann, Elisabeth Kaufmann, Holly Carrington, Twishi Puri, Yogesh Rathi, Michael J. Coleman, Ofer Pasternak, Mark S. George, Thomas W. Mcallister, Ross Zafonte, Murray B. Stein, Christine E. Marx, Martha E. Shenton, Inga K. Koerte
Summary: This study analyzed diffusion and structural MRI data of 278 participants with and without military background, and found microstructural alterations at the gray matter/white matter boundary of the brain after mild traumatic brain injury (mTBI) that were associated with post-concussive symptom severity, functional, and cognitive impairment. These findings suggest that microstructural changes at the gray matter/white matter boundary may be sensitive markers of adverse long-term outcomes following mTBI.
JOURNAL OF CLINICAL MEDICINE
(2023)