期刊
BMC CANCER
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12885-021-08222-8
关键词
Head and neck cancer; Tumor-stroma ratio; Tumor-stroma; Clinical relevance; Marker; Systematic review and meta-analysis
类别
资金
- Turku University Hospital Fund
- Helsinki University Hospital Research Fund
- Finnish Cancer Society
- Finska Lakaresallskapet
- Maritza and Reino Salonen Foundation
The assessment of tumor-stroma ratio in head and neck cancer shows promising prognostic value, particularly in oral cancer where it is significantly associated with cancer-related mortality and disease-free survival.
Background The clinical significance of tumor-stroma ratio (TSR) has been examined in many tumors. Here we systematically reviewed all studies that evaluated TSR in head and neck cancer. Methods Four databases (Scopus, Medline, PubMed and Web of Science) were searched using the term tumo(u)r-stroma ratio. The preferred reporting items for systematic reviews and meta-analyses (PRISMA) were followed. Results TSR was studied in nine studies of different subsites (including cohorts of nasopharyngeal, oral, laryngeal and pharyngeal carcinomas). In all studies, TSR was evaluated using hematoxylin and eosin staining. Classifying tumors based on TSR seems to allow for identification of high-risk cases. In oral cancer, specifically, our meta-analysis showed that TSR is significantly associated with both cancer-related mortality (HR 2.10, 95%CI 1.56-2.84) and disease-free survival (HR 1.84, 95%CI 1.38-2.46). Conclusions The assessment of TSR has a promising prognostic value and can be implemented with minimum efforts in routine head and neck pathology.
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