期刊
BLOOD CELLS MOLECULES AND DISEASES
卷 88, 期 -, 页码 -出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bcmd.2021.102536
关键词
Iron; Supplementation; RET-He; Erythropoietin; Erythroferrone; Hepcidin
类别
资金
- US Public Health Service [U54DK110858]
- Department of Pediatrics, University of Utah Health, Salt Lake City, UT
The study assessed elements of the principal hormonal pathway regulating iron homeostasis in human neonates, finding that the Epo/ERFE/hepcidin axis is intact during the newborn period.
In a two-part process, we assessed elements of the principal hormonal pathway regulating iron homeostasis in human neonates. Part 1: Quantifying erythropoietin (Epo), erythroferrone (ERFE), hepcidin, and relevant serum and erythrocytic iron-related metrics in umbilical cord blood from term (n = 13) and preterm (n = 10) neonates, and from neonates born to mothers with diabetes and obesity (n = 13); Part 2: Quantifying serum Epo, ERFE, and hepcidin before and following darbepoetin administration. Part 1: We measured Epo, ERFE and hepcidin in all cord blood samples. Epo and ERFE levels did not differ between the three groups. Preterm neonates had the lowest hepcidin levels, while neonates born to diabetic women with a very high BMI had the lowest ferritin and RET-He levels. Part 2: Following darbepoetin dosing, ERFE levels generally increased (p < 0.05) and hepcidin levels generally fell (p < 0.05). Our observations suggest that the Epo/ERFE/hepcidin axis is intact in the newborn period.
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