Article
Clinical Neurology
Shirui Cheng, Xiaohui Dong, Jun Zhou, Chenjian Tang, Wenhua He, Yang Chen, Xinyue Zhang, Peihong Ma, Tao Yin, Yimei Hu, Fang Zeng, Zhengjie Li, Fanrong Liang
Summary: Patients with knee osteoarthritis (KOA) exhibit structural and functional alterations in white matter, as revealed by magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI). Extensive white matter changes are observed in sensorimotor and pain-related regions in KOA patients. Additionally, a negative correlation is found between disease severity and white matter abnormalities in KOA.
FRONTIERS IN NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Benjamin Yeske, Jiancheng Hou, Nagesh Adluru, Veena A. Nair, Vivek Prabhakaran
Summary: This study revealed significant structural differences in white matter regions associated with language production in young adults, compared to older adults who showed significant correlations between language production and MD values. This suggests that white matter structures play a crucial role in age-related changes in language production.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Clinical Neurology
Jian Yang, Xiaowei Jiang, Shengnan Wei, Xin Deng, Yue Zhu, Miao Chang, Zhiyang Yin, Haiyang Geng, Yanqing Tang, Xu Dai
Summary: Compared to DTI parameters, DKI parameters showed more sensitivity and stability in probing the local microstructure, especially in exploring cerebral alterations in BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Geriatrics & Gerontology
Yahui Ouyang, Dong Cui, Zilong Yuan, Zhipeng Liu, Qing Jiao, Tao Yin, Jianfeng Qiu
Summary: Population aging has led to a focus on changes in elderly brains, particularly in white matter fibers. This study used various parameters to analyze age-related changes in white matter fibers, finding significant differences in FA, MD, AD, and RD between young and middle-age groups. Deterministic fiber tracking showed a correlation between fiber length and age, with specific fibers identified as potential image markers for age-related white matter changes.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neuroimaging
Longfei Li, Wei Yang, Yu Wan, Hailong Shen, Ting Wang, Liangliang Ping, Chuanxin Liu, Min Chen, Hao Yu, Shushu Jin, Yuqi Cheng, Xiufeng Xu, Cong Zhou
Summary: This study used diffusion tensor imaging (DTI) to examine white matter microarchitecture alterations in patients with mild cognitive impairment (MCI). The results showed significant changes in multiple regions of the brain, including the corpus callosum and left striatum. These findings contribute to our understanding of the neuropathological mechanism underlying MCI.
BRAIN IMAGING AND BEHAVIOR
(2023)
Article
Neurosciences
Yufeng Tang, Xiaoqin Yuan, Jinfeng Duan, Xianwen Zhang, Jiao Chen, Ying Zhou, Fangzhou Song, Dong Zhou
Summary: This study systematically evaluated DTI-derived parameters in iNPH patients with different responses to the tap test and found a correlation between cognitive impairment and white matter degeneration. The TT responders showed lower FA values in certain white matter regions, while cognitive improvement was associated with specific white matter changes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Chaofan Sui, Hongwei Wen, Shengpei Wang, Mengmeng Feng, Haotian Xin, Yian Gao, Jing Li, Lingfei Guo, Changhu Liang
Summary: CSVD patients with cerebral microbleeds (CMBs) have extensive white matter microstructural deterioration. Using DTI-derived diffusivity and anisotropy metrics, we found that CSVD patients with CMBs showed significant FA decrease and AD, RD, and MD increases in cognitive and sensorimotor-related white matter tracts.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Review
Geriatrics & Gerontology
Xia Wei, Chunyan Luo, Qian Li, Na Hu, Yuan Xiao, Nian Liu, Su Lui, Qiyong Gong
Summary: This study utilized meta-analysis to identify the most prominent and replicable white matter abnormalities in Parkinson's disease patients. Results showed FA reduction in the body of the corpus callosum and the left inferior fronto-occipital fasciculus. Additionally, a positive correlation between the percentage of male PD patients and FA values in the corpus callosum body was found.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neuroimaging
Tania M. Setiadi, Sander Martens, Esther M. Opmeer, Jan-Bernard C. Marsman, Shankar Tumati, Fransje E. Reesink, Peter P. De Deyn, Andre Aleman, Branislava Curcic-Blake
Summary: Apathy in amnestic Mild Cognitive Impairment is associated with lower FA in various white matter pathways, suggesting a relationship between the severity of apathy and white matter integrity.
NEUROIMAGE-CLINICAL
(2021)
Article
Geriatrics & Gerontology
Hikaru Sugimoto, Mihoko Otake-Matsuura
Summary: Diffusion tensor imaging (DTI) is used to investigate white matter properties in the brain. This study aims to examine the effects of a cognitive intervention program (PICMOR) on older adults' cognitive function and white matter fiber health. Results showed improved verbal fluency task scores in the intervention group compared to the control group. Tract-based spatial statistics analyses revealed higher FA values and lower MD, AD, or RD values in the intervention group across various fiber tracts. The findings suggest left frontal white matter structures may be responsible for the enhancement of verbal fluency.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychiatry
Taro Mizobe, Keisuke Ikari, Hirofumi Tomiyama, Keitaro Murayama, Kenta Kato, Suguru Hasuzawa, Osamu Togao, Akio Hiwatashi, Tomohiro Nakao
Summary: This study found widespread white matter abnormalities in the brains of patients with hoarding disorder, which are associated with the severity of hoarding symptoms and cognitive dysfunction.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Geriatrics & Gerontology
Emma L. Ducca, Gabriela T. Gomez, Priya Palta, Kevin J. Sullivan, Clifford R. Jack, David S. Knopman, Rebecca F. Gottesman, Jeremy Walston, B. Gwen Windham, Keenan A. Walker
Summary: The study found a strong association between cerebral white matter structure and current and future frailty. Specifically, white matter hyperintensity volume was significantly associated with frailty. However, measures of white matter microstructure were not generally associated with progression from nonfrail to frail status.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Lin Mei, Xiaodan Li, Guifei Zhou, Tingting Ji, Jun Chen, Zhifei Xu, Yun Peng, Yue Liu, Hongbin Li, Jie Zhang, Shengcai Wang, Yamei Zhang, Wentong Ge, Yongli Guo, Yue Qiu, Xinbei Jia, Jinghong Tian, Li Zheng, Jiangang Liu, Jun Tai, Xin Ni
Summary: The study found that male children with severe OSA demonstrated more severe issues in neurocognition, attention, sleep quality, and brain white matter integrity compared to those with mild OSA, while no significant differences were observed in female children.
Article
Geriatrics & Gerontology
Stephanie Matijevic, Lee Ryan
Summary: The study found that age and sex have an impact on the cerebral white matter integrity of older adults, with a more significant effect on certain white matter tracts. Females exhibited lower global FA compared to males, but had higher MD in the anterior cingulum and superior longitudinal fasciculus. Age influenced both global FA and specific tract FA, while APOE epsilon 4 status did not show predictive power.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Donglai Jing, Yaojing Chen, Kexin Xie, Yue Cui, Chunlei Cui, Li Liu, Hui Lu, Jing Ye, Ran Gao, Lin Wang, Zhigang Liang, Zhanjun Zhang, Liyong Wu
Summary: The study aimed to explore white matter alterations in preclinical familial Creutzfeldt-Jakob disease using DTI. Results showed integrity changes in multiple WM tracts during preclinical stage of fCJD, with no neurological symptoms observed during follow-up. Increased MD in various WM tracts in carriers overlapped patterns observed in symptomatic CJD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Health Care Sciences & Services
Celia Domingos, Patricio Costa, Nadine Correia Santos, Jose Miguel Pego
Summary: This study assessed the acceptability, usability, and user satisfaction of the Xiaomi Mi Band 2 among Portuguese community-dwelling older adults. The results showed that usability is a determinant of satisfaction with the technology and confirmed the suitability of the Xiaomi Mi Band 2 for older adults.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Psychiatry
Catia Ribeiro da Costa, Jose M. Soares, Patricia Oliveira-Silva, Adriana Sampaio, Joana F. Coutinho
Summary: Social cognition relies on two main subsystems, the default mode network (DMN) and the salience network (SN), to construct the understanding of others. The functional connectivity (FC) patterns of DMN and SN change during the transition from resting state to social task performance. The anterior and posterior regions of DMN exhibit increased FC during social task performance, while the SN connectivity is more limited in the Other condition compared to the Self and Rest conditions.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Neurosciences
Ana Coelho, Ricardo Magalhaes, Pedro S. Moreira, Liliana Amorim, Carlos Portugal-Nunes, Teresa Castanho, Nadine Correia Santos, Nuno Sousa, Henrique M. Fernandes
Summary: This study proposes a new CBP method based on diffusion MRI data and demonstrates its potential to accurately characterize the longitudinal alterations in brain network topology occurring during aging. The method successfully generates highly homogeneous parcels and provides a robust anatomical framework to assess aging-related changes in the brain's structural network.
HUMAN BRAIN MAPPING
(2022)
Article
Chemistry, Multidisciplinary
Andre Ferreira, Ricardo Magalhaes, Sebastien Meriaux, Victor Alves
Summary: The study successfully generated realistic MRI scans of the rat brain using an adapted Generative Adversarial Networks architecture. The generated scans were evaluated using various quantitative metrics, a Turing test, and a segmentation test, demonstrating their realism and applicability. The research also showed that using the generated data improved the segmentation model more than traditional data augmentation.
APPLIED SCIENCES-BASEL
(2022)
Article
Neurosciences
Ines Caetano, Liliana Amorim, Teresa Costa Castanho, Ana Coelho, Sonia Ferreira, Carlos Portugal-Nunes, Jose Miguel Soares, Nuno Goncalves, Rui Sousa, Joana Reis, Catarina Lima, Paulo Marques, Pedro Silva Moreira, Ana Joao Rodrigues, Nadine Correia Santos, Pedro Morgado, Madalena Esteves, Ricardo Magalhaes, Maria Pico-Perez, Nuno Sousa
Summary: Daily life is becoming more stressful, and research has found a correlation between stress perception and amygdala volume. Stress is no longer limited to a specific age group and should be considered as a continuous factor throughout life.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Ines Caetano, Sonia Ferreira, Ana Coelho, Liliana Amorim, Teresa Costa Castanho, Carlos Portugal-Nunes, Jose Miguel Soares, Nuno Goncalves, Rui Sousa, Joana Reis, Catarina Lima, Paulo Marques, Pedro Silva Moreira, Ana Joao Rodrigues, Nadine Correia Santos, Pedro Morgado, Ricardo Magalhaes, Maria Pico-Perez, Joana Cabral, Nuno Sousa
Summary: The association between stress and psychiatric disorders has prompted research on stress's impact on the brain. In this study, perceived stress was found to be directly associated with increased connectivity between the amygdala and frontal cortical regions, indicating that stress may lead to altered functional connectivity patterns.
MOLECULAR PSYCHIATRY
(2022)
Article
Behavioral Sciences
Liliana Amorim, Sandro Da Mesquita, Luis Jacinto, Magda J. Castelhano-Carlos, Nadine Correia Santos, Hugo Leite-Almeida, Nuno Sousa
Summary: This study examines the social interactions of a group of rats under different conditions of resource access. The results show that reductions in food availability lead to increased heterogeneity in behaviors such as sniffing, chasing, and fighting/struggling. Introducing the possibility of interaction with a female rat leads to a consistent increase in sniffing and fighting/struggling. These findings demonstrate how variations in access to reinforcers modulate social behavior in rats.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychiatry
Ana Veronica Domingues, Barbara Coimbra, Raquel Correia, Catarina Deseyve, Natacha Vieitas-Gaspar, Stan B. Floresco, Nuno Sousa, Carina Soares-Cunha, Ana Joao Rodrigues
Summary: In utero exposure to synthetic glucocorticoids leads to motivation and decision-making deficits associated with dysfunctional ACC-NAc circuit.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Diana Rodrigues, Luis Jacinto, Margarida Falcao, Ana Carolina Castro, Alexandra Cruz, Catia Santa, Bruno Manadas, Fernanda Marques, Nuno Sousa, Patricia Monteiro
Summary: Chronic stress can trigger or worsen motor symptoms in neuropsychiatric disorders, and SOM interneurons in the striatum are involved in stress-induced motor behaviors.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Joana Martins-Macedo, Antonio Mateus-Pinheiro, Catia Alves, Fernando Veloso, Eduardo D. Gomes, Ines Ribeiro, Joana S. Correia, Tiago Silveira-Rosa, Nuno D. Alves, Ana J. Rodrigues, Joao M. Bessa, Nuno Sousa, Joao F. Oliveira, Patricia Patricio, Luisa Pinto
Summary: This study developed an automated system for exposing rodents to a standard unpredictable chronic mild stress (uCMS) protocol. Comparing manual (uCMS) and automated (auCMS) stress-exposure protocols, the data showed similar impacts on behavioral and physiological measurements. This automated method represents a step forward in preclinical research with advantages in time and standardization.
Article
Health Care Sciences & Services
Anna Quialheiro, Andre Miranda, Miguel Garcia Jr, Adriana Camargo de Carvalho, Margarida Correia-Neves, Nadine Correia Santos
Summary: This study aimed to develop and evaluate the impact of a digital inclusion program on digital and health literacy among community dwellers in northern Portugal. The findings showed that the program led to significant improvement in digital literacy, which was sustained one month after the intervention. However, there was no significant change in health literacy during the project period.
JMIR FORMATIVE RESEARCH
(2023)
Article
Cell Biology
Sofia Pereira das Neves, Joao Carlos Sousa, Ricardo Magalhaes, Fuying Gao, Giovanni Coppola, Sebatien Meriaux, Fawzi Boumezbeur, Nuno Sousa, Joao Jose Cerqueira, Fernanda Marques
Summary: Multiple sclerosis is a chronic inflammatory disease of the central nervous system. Recent research has shown that reactive astrocytes in MS lesions undergo metabolic alterations and exhibit increased reactivity, potentially contributing to the progression of the disease.
Article
Psychiatry
Victor De la Pena-Arteaga, Pedro Morgado, Beatriz Couto, Sonia Ferreira, Ines Castro, Nuno Sousa, Carles Soriano-Mas, Maria Pico-Perez
Summary: This study aims to investigate the brain networks and their dysfunctions related to emotion regulation alterations during cognitive reappraisal in patients with OCD. The results demonstrate that patients with OCD show decreased activation in specific networks involving the frontal cortex during cognitive reappraisal.
EUROPEAN PSYCHIATRY
(2022)
Article
Health Care Sciences & Services
Keenan A. Ramsey, Carel G. M. Meskers, Marijke C. Trappenburg, Maria Giulia Bacalini, Massimo Delledonne, Paolo Garagnani, Carolyn Greig, Victor Kallen, Nico van Meeteren, Natal van Riel, Nadine Correia Santos, Sarianna Sipila, Janice L. Thompson, Anna C. Whittaker, Andrea B. Maier
Summary: The PANINI Toolkit aims to provide a standardized assessment tool for evaluating multiple domains of health in older adults, with a focus on nutrition and physical activity. It was developed through consensus of experts within the PANINI consortium and has been implemented successfully in various countries and populations.
Article
Endocrinology & Metabolism
Maria Lopes-Pereira, Anna Quialheiro, Patricio Costa, Susana Roque, Nadine Correia Santos, Margarida Correia-Neves, Ana Goios, Ivone Carvalho, Tim I. M. Korevaar, Laura Vilarinho, Joana Almeida Palha
Summary: The study found that the use of iodine supplements among pregnant women in Portugal increased from 25% before the recommendation to 81% after the recommendation, mostly due to an increase in the use of supplements containing iodine only. Iodine supplementation was protective for adverse obstetric outcomes and neonatal morbidities. The recommendation seems to have succeeded in implementing iodine supplementation during pregnancy.
EUROPEAN THYROID JOURNAL
(2022)
