Article
Medicine, General & Internal
Richard J. Perry, Arina Tamborska, Bhagteshwar Singh, Brian Craven, Richard Marigold, Peter Arthur-Farraj, Jing Ming Yeo, Liqun Zhang, Ghaniah Hassan-Smith, Matthew Jones, Christopher Hutchcroft, Esther Hobson, Dana Warcel, Daniel White, Phillip Ferdinand, Alastair Webb, Tom Solomon, Marie Scully, David J. Werring, Christine Roffe
Summary: The study documented cases of cerebral venous thrombosis after COVID-19 vaccination, finding that patients with VITT were younger, had more intracranial and extracranial thrombosis, and experienced worse outcomes compared to non-VITT patients. Treatments with non-heparin anticoagulants and intravenous immunoglobulin may improve outcomes in VITT-associated cerebral venous thrombosis.
Article
Hematology
David J. Kuter
Summary: A study found that COVID-19 vaccination may have varying effects on ITP patients, with some experiencing significant platelet count drops and new bleeding symptoms post-vaccination, but platelets recovered after rescue treatment.
BRITISH JOURNAL OF HAEMATOLOGY
(2021)
Review
Immunology
Prachi Saluja, F. N. U. Amisha, Nitesh Gautam, Harmeen Goraya
Summary: A systematic review on patients with immune thrombocytopenia (ITP) after COVID-19 vaccination revealed a higher association with mRNA vaccines and promising outcomes without reported deaths.
Article
Oncology
Syed Raza Ali Shah, Sherpa Dolkar, Jacob Mathew, Prakash Vishnu
Summary: This study reports three cases of severe immune thrombocytopenia (ITP) following COVID-19 vaccination and their clinical course. Treatment with oral immunoglobulin and dexamethasone resulted in improvement in platelet counts for all cases, indicating a potential effective management approach for vaccine-induced ITP.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Toshiaki Iba, Jerrold H. Levy
Summary: Thrombosis is a serious complication in COVID-19, which may be caused by platelet activation and immune system dysregulation. Vaccination is effective but can also lead to rare side effects like vaccine-induced immune thrombotic thrombocytopenia. Accurate diagnosis and differentiation are crucial.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Immunology
Patricia Mouta Nunes de Oliveira, Daniela P. Mendes-de-Almeida, Victor Bertollo Gomes Porto, Catherine Crespo Cordeiro, Gabriellen Vitiello Teixeira, Renata Saraiva Pedro, Paulo Roberto Gomes Takey, Leticia Kegele Lignani, Janaina Reis Xavier, Vitor Cardoso Doria da Gamaa, Luiz Amorim Filho, Barbara Emoingt Furtado, Andre Santa Maria, Tiago Dahrug Barros, Livia Neves Waite Freitas, Taina dos Santos Pereira, Debora Lima Abreu, Michael Bernardes Ramos, Caroline Gabe, Donald Arnold, James William Smith, Ishac Nazy, Maria de Lourdes de Sousa Maia
Summary: This case series study describes vaccine-induced immune thrombotic thrombocytopenia (VITT) cases following COVID-19 vaccination in Brazil, including ChAdOx1 nCoV-19, Ad26.COV2.S, and BNT162b2 vaccines, and describes their clinical and laboratory characteristics. The study findings suggest that VITT is a very rare but serious adverse event following COVID-19 immunization.
Review
Biochemistry & Molecular Biology
Katharina Guetl, Reinhard Bernd Raggam, Thomas Gary
Summary: COVID-19 vaccines may lead to vaccine-induced thrombotic complications, specifically vaccine-induced thrombotic thrombocytopenia (VITT). This condition, similar to other thrombotic events, requires different diagnostic and therapeutic strategies. The review provides a concise overview of these strategies.
Review
Immunology
Fatma Elrashdy, Murtaza M. Tambuwala, Sk Sarif Hassan, Parise Adadi, Murat Seyran, Tarek Mohamed Abd El-Aziz, Nima Rezaei, Amos Lal, Alaa A. A. Aljabali, Ramesh Kandimalla, Nicolas G. Bazan, Gajendra Kumar Azad, Samendra P. Sherchan, Pabitra Pal Choudhury, Angel Serrano-Aroca, Kazuo Takayama, Gaurav Chauhan, Damiano Pizzol, Debmalya Barh, Pritam Kumar Panda, Yogendra K. Mishra, Giorgio Palu, Kenneth Lundstrom, Elrashdy M. Redwan, Vladimir N. Uversky
Summary: Vaccine-induced immune thrombotic thrombocytopenia (VITT) can be triggered by certain types of vaccines, with the main pathogenic mechanisms still unclear but likely involving interactions between host and vaccine factors, with some of the pathology related to the vaccine-triggered autoimmune reaction.
AUTOIMMUNITY REVIEWS
(2021)
Article
Medicine, General & Internal
Andreas Greinacher, Thomas Thiele, Theodore E. Warkentin, Karin Weisser, Paul A. Kyrle, Sabine Eichinger
Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
M. De Michele, M. Iacobucci, A. Chistolini, E. Nicolini, F. Pulcinelli, B. Cerbelli, E. Merenda, O. G. Schiavo, E. Sbardella, I. Berto, L. Petraglia, N. Caracciolo, M. Chiara, S. Truglia, D. Toni
Summary: Two cases of malignant middle cerebral artery infarct occurred within 9-10 days following ChAdOx1 nCoV-19 vaccination, presenting with thrombocytopenia, pulmonary, and portal vein thrombosis.
NATURE COMMUNICATIONS
(2021)
Article
Hematology
C. Schaefers, F. -O. Paulsen, C. Frenzel, K. Weisel, C. Bokemeyer, C. Seidel
Summary: We conducted a retrospective single-center analysis to compare the cases of immune thrombocytopenia (ITP) detected in 2021 with previous years. A significant increase in ITP cases, including those related to COVID-19 vaccines, was observed in 2021 compared to the pre-vaccination years. Further studies globally are necessary to explore this finding.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Editorial Material
Biochemistry & Molecular Biology
Allyson M. Pishko, James B. Bussel, Douglas B. Cines
Summary: A study suggests a potential link between the AstraZeneca vaccine and an autoimmune disorder, immune thrombocytopenia, but further research is needed to establish causality.
Article
Immunology
Patricia Mouta Nunes de Oliveira, Daniela P. Mendes-de-Almeida, Victor Bertollo Gomes Porto, Catherine Crespo Cordeiro, Gabriellen Vitiello Teixeira, Renata Saraiva Pedro, Paulo Roberto Gomes Takey, Leticia Kegele Lignani, Janaina Reis Xavier, Vitor Cardoso Doria da Gama, Luiz Amorim Filho, Barbara Emoingt Furtado, Andre Santa Maria, Tiago Dahrug Barros, Livia Neves Waite Freitas, Taina Dos Santos Pereira, Debora Lima Abreu, Michael Bernardes Ramos, Caroline Gabe, Donald Arnold, James William Smith, Ishac Nazy, Maria de Lourdes de Sousa Maia
Summary: This case series study described the clinical and laboratory characteristics of VITT cases following COVID-19 vaccination in Brazil. Most cases occurred in women with central nervous system as the main site of thrombosis, and the median onset of symptoms was 8 days post-vaccination.
Review
Surgery
Avinash Mani, Vineeta Ojha
Summary: Thromboembolic events can occur after COVID-19 vaccination, most commonly after the AstraZeneca vaccine. Cerebral sinus thrombosis is the most common manifestation noted in vaccinated individuals.
ANNALS OF VASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Jimin Hwang, Seung Hyun Park, Seung Won Lee, Se Bee Lee, Min Ho Lee, Gwang Hun Jeong, Min Seo Kim, Jong Yeob Kim, Ai Koyanagi, Louis Jacob, Se Yong Jung, Jaewoo Song, Dong Keon Yon, Jae Il Shin, Lee Smith
Summary: Fibrinogen levels, age, platelet count, and the presence of intracerebral hemorrhage and cerebral venous thrombosis were found to be significantly associated with mortality in adenoviral vaccine-associated thrombosis with thrombocytopenia syndrome (TTS). The newly developed FAPIC scoring system incorporating these risk factors showed promising predictive value for mortality in patients with TTS.
EUROPEAN HEART JOURNAL
(2021)
Article
Hematology
Diego A. Pereira-Martins, Juan L. Coelho-Silva, Isabel Weinhauser, Pedro L. Franca-Neto, Douglas R. Silveira, Cesar Ortiz, Amanda Moreira-Aguiar, Marinus M. Lima, Luisa C. Koury, Raul A. de Melo, Ana B. Gloria, Evandro M. Fagundes, Bruno K. Lino, Katia Pagnano, Rosane Bittencourt, Elenaide Nunes, Fabiola Traina, Lorena Figueiredo-Pontes, Armand Keating, Martin S. Tallman, Raul C. Ribeiro, Richard Dilon, Arnold Ganser, Miguel A. Sanz, Nancy Berliner, Peter Valk, Bob Lowenberg, Tiziana Ottone, Nelida Noguera, Maria T. Voso, Francesca Paoloni, Paola Fazi, Emanuele Ammatuna, Gerwin Huls, Jan Jacob Schuringa, Eduardo M. Rego, Antonio R. Lucena-Araujo
Summary: A growing body of evidence indicates that higher-than-normal mitochondrial DNA content (mtDNAc) is associated with better prognosis in acute promyelocytic leukemia (APL) patients, regardless of tumor burden. This effect is more pronounced in low-risk patients. The multivariate Cox proportional hazard model reveals that high mtDNAc is independently associated with a decreased cumulative incidence of relapse. These findings highlight the potential role of mitochondrial metabolism in APL patients treated with ATRA.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Oncology
Hendrik Eggers, Lea Haebel, Arnold Ganser, Viktor Gruenwald, Roland Merten, Athanasia Warnecke, Martin Durisin, Philipp Ivanyi
Summary: The application of cetuximab in palliative first-line therapy for R/M HNSCC patients can significantly improve overall survival, according to the study.
CANCER INVESTIGATION
(2023)
Article
Gastroenterology & Hepatology
Carlos Oltmanns, Zhaoli Liu, Jasmin Mischke, Jan Tauwaldt, Yonatan Ayalew Mekonnen, Melanie Urbanek-Quaing, Jennifer Debarry, Benjamin Maasoumy, Heiner Wedemeyer, Anke R. M. Kraft, Cheng-Jian Xu, Markus Comberg
Summary: This study investigates the association between chronic hepatitis C virus (HCV) infection and epigenetic changes and biological age acceleration, as well as the reversibility of these changes after sustained virologic response (SVR). The results show that patients with chronic HCV infection have significant epigenetic age acceleration, which partially reverses after SVR. However, some patients still show incomplete reversal of biological age after treatment.
JOURNAL OF HEPATOLOGY
(2023)
Article
Hematology
Piroska Klement, Walter Fiedler, Razif Gabdoulline, Louisa-Kristin Dallmann, Clara Philine Wienecke, Johannes Schiller, Christian Kandziora, Katrin Teich, Bennett Heida, Konstantin Buttner, Maximilian Brandes, Carolin Funke, Martin Wichmann, Basem Othman, Joerg Chromik, Stefanie Amberg, Maxim Kebenko, Vera Schlipfenbacher, Anne Christine Wilke, Franziska Modemann, Melanie Janning, Hubert Serve, Carsten Bokemeyer, Susann Theile, Ute Deppermann, Anne L. Kranich, Arnold Ganser, Felicitas Thol, Michael Heuser
Summary: Relapse is common in AML patients and has a poor prognosis. Treatment options are limited and understanding the molecular response patterns is challenging. In this study, we analyzed the response patterns of relapsed/refractory AML patients treated with selinexor and identified subclonal patterns. One patient showed a long-term course of remission with selinexor maintenance treatment after relapse following alloHCT. This exploratory study provides insights into the effects of selinexor in AML patients.
ANNALS OF HEMATOLOGY
(2023)
Editorial Material
Hematology
Arnold Ganser
Summary: In this study, Sorror et al demonstrate that allogeneic hematopoietic cell transplantation does not provide any benefits for older and medically infirm patients with acute myeloid leukemia.
Letter
Gastroenterology & Hepatology
Lisa Sandmann, Tammo Lambert Tergast, Heiner Wedemeyer, Katja Deterding, Benjamin Maasoumy
JOURNAL OF HEPATOLOGY
(2023)
Article
Hematology
Alexandros Spyridonidis, Myriam Labopin, Bipin Savani, Sebastian Giebel, Gesine Bug, Stefan Schoenland, Nicolaus Kroeger, Matthias Stelljes, Thomas Schroeder, Andrew McDonald, Igor-Wolfgang Blau, Martin Bornhaeuser, Montse Rovira, Wolfgang Bethge, Andreas Neubauer, Arnold Ganser, Jean Henri Bourhis, Matthias Edinger, Bruno Lioure, Gerald Wulf, Kerstin Schaefer-Eckart, Mutlu Arat, Zinaida Peric, Christoph Schmid, Ali Bazarbachi, Fabio Ciceri, Arnon Nagler, Mohamad Mohty
Summary: In this registry-based study, the outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) in adult patients with acute lymphoblastic leukemia (ALL) were compared. The study found that the total dose of total body irradiation (TBI) did not influence the survival outcomes for patients, regardless of whether they received a standard 12-Gray or lower 8-Gray dose.
Editorial Material
Gastroenterology & Hepatology
Lisa Sandmann, Benjamin Maasoumy
LIVER INTERNATIONAL
(2023)
Letter
Gastroenterology & Hepatology
Valerie Ohlendorf, Benjamin Maasoumy
LIVER INTERNATIONAL
(2023)
Article
Clinical Neurology
Martin Klietz, Nima Mahmoudi, Andrew A. Maudsley, Sulaiman Sheriff, Paul Bronzlik, Mohammad Almohammad, Patrick Noesel, Florian Wegner, Guenter U. Hoeglinger, Heinrich Lanfermann, Xiao-Qi Ding
Summary: In this study, the metabolic profile of patients with clinically diagnosed PSP was analyzed using wbMRSI and compared with matched healthy volunteers and PD patients. The results showed that PSP patients had a significant increase in the fractional volume of cerebrospinal fluid and a significant reduction in N-acetyl-aspartate (NAA) in all brain lobes compared to PD and healthy volunteers. This suggests that PSP patients have more neuronal degeneration and cerebral atrophy, and the decrease in NAA in the brain lobes is partially correlated with clinical symptoms.
MOVEMENT DISORDERS
(2023)
Article
Hematology
Peter Hokland, Isolda I. Fernandez, Sylvie D. Freeman, Bjorn T. Gjertsen, Jie Jin, Vidh Murthy, Masamitsu Yanada, Arnold Ganser
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Editorial Material
Gastroenterology & Hepatology
Benjamin Maasoumy, Pietro Lampertico
LIVER INTERNATIONAL
(2023)
Letter
Immunology
Yannick Stahl, Iyad Kabar, Hauke Heinzow, Benjamin Maasoumy, Birgit Bremer, Heiner Wedemeyer, Hartmut H. -J. Schmidt, Thomas Pietschmann, Bernhard Schlevogt, Patrick Behrendt
Summary: Urine-based antigen testing appears to be superior to measuring antibodies or viral RNA for diagnosing and monitoring HEV infection.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Clinical Neurology
Frank Donnerstag, Christopher Werlein, Friedrich Goetz, Omar Abu Fares, Peter Raab, Enrico Calvino Iglesias, Heinrich Lanfermann, Mike P. Wattjes, Danny Jonigk
Summary: This retrospective study aimed to investigate the involvement and role of the stentriever in vessel wall injury by analyzing the composition of adherent tissue to the stentriever during combined aspiration thrombectomy with stentriever. The results showed that parts of the vessel wall were detected in 33% of the samples analyzed, and all specimens revealed fresh thrombus material without signs of organization or atheromatous tissue. No vascular tissue was found in free clots of the aspiration samples.
INTERVENTIONAL NEURORADIOLOGY
(2023)
Article
Clinical Neurology
Roxanne Lofredi, Ute Scheller, Aurika Mindermann, Lucia K. Feldmann, Joachim K. Krauss, Assel Saryyeva, Gerd-Helge Schneider, Andrea A. Kuehn
Summary: Pallidal deep brain stimulation (DBS) can alleviate symptoms in dystonia patients, but it may also cause movement slowness. This study found that after the cessation of pallidal stimulation, the movement speed of dystonia patients increased over time. The beta oscillations in the pallidum were found to be associated with the variance in movement speed.
MOVEMENT DISORDERS
(2023)