Article
Biochemistry & Molecular Biology
Ling-Ling Qian, Xiaojing Sun, Jingchun Yang, Xiao-Li Wang, Michael J. Ackerman, Ru-Xing Wang, Xiaolei Xu, Hon-Chi Lee, Tong Lu
Summary: Loss of SORBS2 protein can lead to abnormal cardiac ion channels, causing cardiac structural and electrical remodeling, leading to cardiac conduction delays and arrhythmias.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Cardiac & Cardiovascular Systems
Jin Li, Ane M. Salvador, Guoping Li, Nedyalka Valkov, Olivia Ziegler, Ashish Yeri, Chun Yang Xiao, Bessie Meechoovet, Eric Alsop, Rodosthenis S. Rodosthenous, Piyusha Kundu, Tianxiao Huan, Daniel Levy, John Tigges, Alexander R. Pico, Ionita Ghiran, Michael G. Silverman, Xiangmin Meng, Robert Kitchen, Jiahong Xu, Kendall Van Keuren-Jensen, Ravi Shah, Junjie Xiao, Saumya Das
Summary: miR-30d can improve cardiac function and reduce fibrosis by targeting MAP4K4 and integrin alpha 5, showing a protective effect in ischemic heart failure. The communication of extracellular vesicle-contained miRNAs may provide a novel therapeutic target in heart failure treatment.
CIRCULATION RESEARCH
(2021)
Article
Veterinary Sciences
Patrick Roynard, Ann Bilderback, Curtis Wells Dewey
Summary: Ketamine 5 mg/kg IV bolus may be successful in treating RSE in dogs, but its efficacy in handling CS is limited. The incidence of adverse effects is low, but timing of administration should be carefully considered.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Endocrinology & Metabolism
Zi Ye, Xiaomin Guan, Wenyuan Shan, Baojun Ma
Summary: This study aimed to evaluate the effect of Tripchlorolide (T4) on microglial activation and the STING-NLRP3 signaling pathway in epilepsy treatment. The results showed that T4 treatment improved the latency to SE and mortality, and significantly reduced the levels of inflammatory factors. T4 also had an impact on the expression of proteins associated with inflammation and the STING-NLRP3 signaling pathway in mouse brain tissue. In cell experiments, T4 inhibited the expression of STING and NLRP3 in SE-induced cells. These findings provide new insights for the treatment of epilepsy.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Review
Clinical Neurology
Lena-Luise Becker, Alexander Gratopp, Christine Prager, Christian E. Elger, Angela M. Kaindl
Summary: Status epilepticus is a life-threatening neurological emergency in childhood, particularly in the first 5 years of life, with high mortality and morbidity rates. Current treatments for convulsive status epilepticus in children may be delayed and inadequate. This study summarizes the current knowledge on treatment options and proposes a treatment algorithm. Benzodiazepines are recommended as first-line treatment, and for refractory status epilepticus, no superiority was found in fosphenytoin, levetiracetam, or phenobarbital. Limited data is available on third-line treatments for refractory status epilepticus lasting >30 min. The proposed algorithm aims to address treatment delay and reduce potential permanent neuronal damage.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Michael C. Jin, Jonathon J. Parker, Michael Zhang, Zack A. Medress, Casey H. Halpern, Gordon Li, John K. Ratliff, Gerald A. Grant, Robert S. Fisher, Stephen Skirboll
Summary: The occurrence of early and late PNSE was associated with specific neurosurgical pathologies and increased mortality. These findings provide a foundation for validating clinical and perioperative risk factors prospectively and help identify patients who require heightened diagnostic suspicion for PNSE.
JOURNAL OF NEUROSURGERY
(2021)
Review
Clinical Neurology
Pia De Stefano, Peter W. Kaplan, Herve Quintard, Margitta Seeck, Raoul Sutter
Summary: Seizures and status epilepticus (SE) are common in comatose cardiac arrest survivors, but little is known about nonconvulsive SE (NCSE). This study aimed to compile evidence from the literature on the frequency and outcome of NCSE in adult patients remaining in coma after resuscitation. The results showed that NCSE occurred in a small percentage of patients, and the favorable outcome after NCSE was observed in approximately one-fourth of the patients. However, the limited quality of data calls for further investigation on the effects of NCSE on outcome.
JOURNAL OF NEUROLOGY
(2023)
Review
Behavioral Sciences
Marco de Curtis, Andrea O. Rossetti, Diogo Vila Verde, Erwin A. van Vliet, Christine T. Ekdahl
Summary: Status Epilepticus (SE) is a neurological emergency characterized by abnormally sustained seizures, which can result in long-term consequences for the brain. However, the specific effects of different types of SE on brain pathology and long-term deficits in patients are still not clearly understood.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Veterinary Sciences
Giulia Cagnotti, Sara Ferrini, Giorgia Di Muro, Eleonora Avilii, Alessandra Favole, Antonio D'Angelo
Summary: The aim of this study was to determine the effect of duration of anesthetic constant rate infusion (CRI) on outcome and length of hospital stay in dogs with refractory seizure activity of different etiology. There was no statistically significant difference found in outcomes between the experimental group and the control group. Shorter duration of anesthetic CRI did not have a clear superiority on outcome or length of hospital stay in dogs with refractory seizure activity of different etiology.
FRONTIERS IN VETERINARY SCIENCE
(2023)
Article
Clinical Neurology
Marc Rodrigo-Gisbert, Laura Gomez-Dabo, Manuel Quintana, Daniel Campos-Fernandez, Sofia Lallana, Elena Fonseca, Laura Abraira, Manuel Toledo, Estevo Santamarina
Summary: This study aimed to evaluate the risk of long-term seizure recurrence after status epilepticus (SE) and the potential risk factors associated with it. The results showed that progressive symptomatic etiology, delay in treatment initiation, and superrefractory SE were associated with a higher risk of seizure recurrence. On the other hand, older patients and acute symptomatic etiology had a lower risk of seizure recurrence.
Article
Neurosciences
Nicholas H. Varvel, Claudia Espinosa-Garcia, Sarah Hunter-Chang, Di Chen, Ariel Biegel, Allison Hsieh, Lisa Blackmer-Raynolds, Thota Ganesh, Raymond Dingledine
Summary: The study shows that blocking the activation of EP2 receptors on immune myeloid cells plays a role in alleviating post-seizure inflammatory responses and BBB breakdown, but does not significantly affect neurodegeneration.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Llaurado Arnau, Manuel Quintana, Alejandro Ballve, Daniel Campos, Elena Fonseca, Laura Abraira, Manuel Toledo, Estevo Santamarina
Summary: The study showed that factors like etiology and symptomatology of SE influence the response to BZD treatment. Prompt administration was associated with faster resolution in patients with prominent motor symptoms, chronic structural lesions, or history of epilepsy.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Review
Cell Biology
Camille E. Blandin, Basile J. Gravez, Stephane N. Hatem, Elise Balse
Summary: Both inherited and acquired cardiac arrhythmias are often linked to abnormal functional expression of ion channels at the cellular level, with mutations in genes encoding ion channels being a major factor in inherited cases. Disruption of normal channel trafficking due to factors like fibrosis and altered myocyte contacts is common in acquired cardiac arrhythmias. Channel availability, particularly in hERG and K(V)1.5 channels, may be another significant arrhythmogenic mechanism. Knowledge of these molecular mechanisms could lead to novel antiarrhythmic strategies.
Article
Critical Care Medicine
Henning R. Stetefeld, Alexander Schaal, Franziska Scheibe, Julia Nichtweiss, Felix Lehmann, Marcus Mueller, Stefan T. Gerner, Hagen B. Huttner, Sebastian Luger, Hannah Fuhrer, Julian Boesel, Silvia Schoenenberger, Konstantinos Dimitriadis, Bernhard Neumann, Kornelius Fuchs, Gereon R. Fink, Michael P. Malter
Summary: Isoflurane was effective in stopping RSE/SRSE, but achieving remission remained difficult. Side effects, such as hypotension and infection, were common but did not impact discharge outcomes.
NEUROCRITICAL CARE
(2021)
Review
Pediatrics
T. Foiadelli, A. Santangelo, G. Costagliola, E. Costa, M. Scacciati, A. Riva, G. Volpedo, M. Smaldone, A. Bonuccelli, A. M. Clemente, A. Ferretti, S. Savasta, P. Striano, A. Orsini
Summary: Status epilepticus (SE) is a medical emergency that can lead to long-term consequences such as neuronal death and impaired neuronal networks. Inflammation has been shown to contribute to seizure onset and recurrence in SE. Understanding the molecular mechanisms of neuroinflammation is crucial for improving SE treatment. Currently, the main approach to SE treatment is the use of medication for symptom control.
FRONTIERS IN PEDIATRICS
(2023)
Article
Neurosciences
Suleman Hussain, Daniel Lawer Egbenya, Yi-Chen Lai, Zita J. Dosa, Jakob B. Sorensen, Anne E. Anderson, Svend Davanger
Article
Biochemistry & Molecular Biology
Yi-Chen Lai, J. Scott Baker, Taraka Donti, Brett H. Graham, William J. Craigen, Anne E. Anderson
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2017)
Article
Clinical Neurology
Ravindra Arya, Katrina Peariso, Marina Gainza-Lein, Jessica Harvey, Ann Bergin, J. Nicholas Brenton, Brian T. Burrows, Tracy Glauser, Howard P. Goodkin, Yi-Chen Lai, Mohamad A. Mikati, Ivan Sanchez Fernandez, Dmitry Tchapyjnikov, Angus A. Wilfong, Korwyn Williams, Tobias Loddenkemper
Article
Clinical Neurology
I. Sanchez Fernandez, M. Gainza-Lein, N. S. Abend, A. E. Anderson, R. Arya, J. N. Brenton, J. L. Carpenter, K. E. Chapman, J. Clark, W. D. Gaillard, T. A. Glauser, J. L. Goldstein, H. P. Goodkin, A. R. Helseth, M. C. Jackson, K. Kapur, Y. -C. Lai, T. L. McDonough, M. A. Mikati, A. Nayak, K. Peariso, J. J. Riviello, R. C. Tasker, D. Tchapyjnikov, A. A. Topjian, M. S. Wainwright, A. Wilfong, K. Williams, T. Loddenkemper
Article
Clinical Neurology
Alejandra Vasquez, Marina Gainza-Lein, Ivan Sanchez Fernandez, Nicholas S. Abend, Anne Anderson, J. Nicholas Brenton, Jessica L. Carpenter, Kevin Chapman, Justice Clark, William D. Gaillard, Tracy Glauser, Joshua Goldstein, Howard P. Goodkin, Yi-Chen Lai, Tobias Loddenkemper, Tiffani L. McDonough, Mohamad A. Mikati, Anuranjita Nayak, Eric Payne, James Riviello, Dmitry Tchapyjnikov, Alexis A. Topjian, Mark S. Wainwright, Robert C. Tasker
PEDIATRIC NEUROLOGY
(2018)
Article
Neurosciences
Daniel L. Egbenya, Suleman Hussain, Yi-Chen Lai, Jun Xia, Anne E. Anderson, Svend Davanger
MOLECULAR AND CELLULAR NEUROSCIENCE
(2018)
Article
Clinical Neurology
Arnold J. Sansevere, Ravindra Arya, Ivan Sanchez Fernandez, William D. Gaillard, Robert C. Tasker, Yi-Chen Lai, Anne E. Anderson, Dmitry Tchapyjnikov, Kevin E. Chapman, J. Nicholas Brenton, Jessica L. Carpenter, Marina Gainza-Lein, Joshua L. Goldstein, Howard P. Goodkin, Michele C. Jackson, Kush Kapur, Mohamad A. Mikati, Katrina Peariso, Tracy A. Glauser, Alexis A. Topjian, Mark Wainwright, Angus A. Wilfong, Korwyn L. Williams, Tobias Loddenkemper, Nicholas S. Abend
JOURNAL OF CLINICAL NEUROPHYSIOLOGY
(2019)
Article
Clinical Neurology
Ivan Sanchez Fernandez, Marina Gainza-Lein, Nicholas S. Abend, Marta Amengual-Gual, Anne Anderson, Ravindra Arya, J. Nicholas Brenton, Jessica L. Carpenter, Kevin E. Chapman, Justice Clark, Raquel Farias-Moeller, William Davis Gaillard, Tracy A. Glauser, Joshua Goldstein, Howard P. Goodkin, Rejean M. Guerriero, Kurt Hecox, Michele Jackson, Kush Kapur, Sarah A. Kelley, Eric H. W. Kossoff, Yi-Chen Lai, Tiffani L. McDonough, Mohamad A. Mikati, Lindsey A. Morgan, Edward J. Novotny, Adam P. Ostendorf, Eric T. Payne, Katrina Peariso, Juan Piantino, James J. Riviello, Kumar Sannagowdara, Carl E. Stafstrom, Robert C. Tasker, Dmitry Tchapyjnikov, Alexis A. Topjian, Alejandra Vasquez, Mark S. Wainwright, Angus Wilfong, Korwyn Williams, Tobias Loddenkemper
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2019)
Article
Multidisciplinary Sciences
Amber T. Levine, Heather A. Born, Andrew P. Landstrom, Samuel Larson, Wai Ling Lee, An T. Dao, Xander H. Wehrens, Yi-Chen Lai, Anne E. Anderson
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Yi-Chen Lai, Eyal Muscal, Elizabeth Wells, Nikita Shukla, Krista Eschbach, Ki Hyeong Lee, Marios Kaliakatsos, Nevedita Desai, Ronny Wickstrom, Maurizio Viri, Elena Freri, Tiziana Granata, Srishti Nangia, Robertino Dilena, Andreas Brunklaus, Mark S. Wainwright, Mark P. Gorman, Coral M. Stredny, Abdurhman Asiri, Khalid Hundallah, Asif Doja, Eric Payne, Elaine Wirrell, Sookyong Koh, Jessica L. Carpenter, James Riviello
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2020)
Article
Critical Care Medicine
Isabella Herman, Thao Nguyen, See Wai Chan, Jennifer Erklauer, James J. Riviello, Yi-Chen Lai
Summary: This study aims to investigate the adherence to continuous electroencephalogram (cEEG) monitoring for status epilepticus (SE) as part of a pediatric neurocritical care (PNCC) program. The results showed that implementing initiatives in care delivery, resource allocation, and education can improve adherence to best care practices for the management of SE.
PEDIATRIC CRITICAL CARE MEDICINE
(2022)
Article
Microbiology
Kari Brossard A. Stoos, Jennifer Ren, Robin R. Shields-Cutler, Kelly L. Sams, Shannon Caldwell, Marvin B. Ho, Gregg Rivara, Cheryl A. Whistler, Stephen H. Jones, Martin Wiedmann, Jamie DeMent, Rodman G. Getchell, Helene Marquis
Summary: This study suggests that bacteriophages in coastal waters could be used to monitor the presence of specific V. parahaemolyticus STs associated with foodborne outbreaks, as evidenced by the testing of 29 bacterial isolates which revealed the presence of four distinct phages.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Clinical Neurology
Yi-Chen Lai, Gabriella Abou-El-Kheir, Thao Nguyen, Margo Hanerhoff, James J. Riviello, Eyal Muscal
Summary: In this retrospective case series, the early clinical course and potential biomarkers following anakinra initiation were investigated in 10 children with cryptogenic FIRES. Six children achieved anesthetic withdrawal within 3 weeks of therapy, and one in week four. Temporal changes were observed in highly epileptiform bursts, CRP, IL-6, and IL-10 levels, which may serve as candidate biomarkers for monitoring clinical progression and therapeutic interventions including anakinra. Further investigation is warranted.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Clinical Neurology
See Wai Chan, Leslie A. Dervan, Robert Scott Watson, Anne E. Anderson, Yi-Chen Lai
Summary: Cardiac alterations may become more common with increasing epilepsy duration in select pediatric epilepsy patients. Future studies are needed to determine the potential clinical implications and the generalizability of these observations.