Synthesis and anti-trypanosomal activity of 3′-fluororibonucleosides derived from 7-deazapurine nucleosides

Antiviral Activity of 7-Substituted 7-Deazapurine Ribonucleosides, Monophosphate Prodrugs, and Triphoshates against Emerging RNA Viruses

(2021) Nemanja Milisavljevic et al.   ACS Infectious Diseases

C6–O-alkylated 7-deazainosine nucleoside analogues: Discovery of potent and selective anti-sleeping sickness agents

(2020) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Purine and pyrimidine transporters of pathogenic protozoa – conduits for therapeutic agents

(2020) Gustavo D. Campagnaro et al.   MEDICINAL RESEARCH REVIEWS

Structure–Activity Relationship Exploration of 3′-Deoxy-7-deazapurine Nucleoside Analogues as Anti-Trypanosoma brucei Agents

(2020) Fabian Hulpia et al.   ACS Infectious Diseases

Synthesis and evaluation of a collection of purine-like C-nucleosides as antikinetoplastid agents

(2020) Jakob Bouton et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Combining tubercidin and cordycepin scaffolds results in highly active candidates to treat late-stage sleeping sickness

(2019) Fabian Hulpia et al.   Nature Communications

Evaluation of the Trypanosoma brucei 6-oxopurine salvage pathway as a potential target for drug discovery

(2018) Eva Doleželová et al.   PLoS Neglected Tropical Diseases

Discovery of novel 7-aryl 7-deazapurine 3’-deoxy-ribofuranosyl nucleosides with potent activity against Trypanosoma cruzi

(2018) Fabian Hulpia et al.   JOURNAL OF MEDICINAL CHEMISTRY

Challenges and recent progress in drug discovery for tropical diseases

(2018) Manu De Rycker et al.   NATURE

Revisiting tubercidin against kinetoplastid parasites: Aromatic substitutions at position 7 improve activity and reduce toxicity

(2018) Fabian Hulpia et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolo[2,3-d ]pyrimidine (7-deazapurine) as a privileged scaffold in design of antitumor and antiviral nucleosides

(2017) Pavla Perlíková et al.   MEDICINAL RESEARCH REVIEWS

Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need

(2017) Mark C. Field et al.   NATURE REVIEWS MICROBIOLOGY

Versatile synthesis and biological evaluation of novel 3’-fluorinated purine nucleosides

(2015) Hang Ren et al.   Beilstein Journal of Organic Chemistry

Synthesis and biological profiling of 6- or 7-(het)aryl-7-deazapurine 4′-C-methylribonucleosides

(2015) Petr Nauš et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of 3′-Fluoro-tRNA Analogues for Exploring Non-ribosomal Peptide Synthesis in Bacteria

(2015) Laura Iannazzo et al.   CHEMBIOCHEM

Investigation and Conformational Analysis of Fluorinated Nucleoside Antibiotics Targeting Siderophore Biosynthesis

(2015) Surendra Dawadi et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis, Cytostatic, Antimicrobial, and Anti-HCV Activity of 6-Substituted 7-(Het)aryl-7-deazapurine Ribonucleosides

(2014) Petr Nauš et al.   JOURNAL OF MEDICINAL CHEMISTRY

Sugar-modified derivatives of cytostatic 7-(het)aryl-7-deazaadenosines: 2′-C-methylribonucleosides, 2′-deoxy-2′-fluoroarabinonucleosides, arabinonucleosides and 2′-deoxyribonucleosides

(2012) Petr Nauš et al.   BIOORGANIC & MEDICINAL CHEMISTRY

S-Adenosylhomocysteine hydrolase of the protozoan parasite Trichomonas vaginalis: Potent inhibitory activity of 9-(2-deoxy-2-fluoro-β,d-arabinofuranosyl)adenine

(2012) Ajit Shokar et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2′-deoxy-2′-fluororibo- and 2′-deoxy-2′,2′-difluororibonucleosides derived from 6-(het)aryl-7-deazapurines

(2012) Pavla Perlíková et al.   TETRAHEDRON

Synthesis and Significant Cytostatic Activity of 7-Hetaryl-7-deazaadenosines

(2011) Aurelie Bourderioux et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inhibitors of the Purine Salvage Pathway: A Valuable Approach for Antiprotozoal Chemotherapy?

(2010) M. Berg et al.   CURRENT MEDICINAL CHEMISTRY