Article
Medicine, General & Internal
Bosanka Jocic-Jakubi, Darina Jocic, Rajesh P. Poothrikovil, Amna Al-Futaisi
Summary: This study analyzed the electrographic and clinical features of patients with CAE who had concurrent or subsequent EEG features of BECTs. The results showed that this overlap in electrographic features is rare and can occur concurrently or subsequently.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2022)
Article
Clinical Neurology
Beatrice S. Goad, Christopher Lee-Messer, Zihuai He, Brenda E. Porter, Fiona M. Baumer
Summary: This study investigated the impact of interictal spikes on brain connectivity in patients with Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS). The results showed that SeLECTS patients had increased connectivity during sleep, with further elevation during spike and perispike periods. The study is significant in determining whether increased connectivity affects cognition or seizure susceptibility in SeLECTS and more severe epilepsies.
CLINICAL NEUROPHYSIOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wenwen Cheng, Yan Yang, Ying Chen, Sharui Shan, Changhui Li, Ling Fang, Weiguo Zhang, Song Lan, Xiong Zhang
Summary: This study identified discrepancies in efficacy and tolerability among ASMs used in patients with BECTS. More RCTs with larger populations are needed to determine the optimal antiepileptic drug treatment to guide clinicians.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Mei-Gang Ma, Xiao-Rong Liu, Yuan Wu, Jie Wang, Bing-Mei Li, Yi-Wu Shi, Tao Su, Bin Li, De-Tian Liu, Yong-Hong Yi, Wei-Ping Liao
Summary: This study identified RYR2 mutations in five cases with BECTS, including frameshift, missense, and compound heterozygous mutations. These mutations showed a higher frequency in the BECTS cohort compared to control populations and were associated with arrhythmia and mild cardiac structural abnormalities in affected individuals.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Cell Biology
Jens G. Klinzing, Lilian Tashiro, Susanne Ruf, Markus Wolff, Jan Born, Hong-Viet V. Ngo
Summary: BECTS, a common form of childhood epilepsy, is associated with cognitive abnormalities and focal interictal epileptic spikes. Auditory stimulation during NonREM sleep has been shown to reduce spike rates in BECTS patients, with the most significant reductions occurring 1.5 to 3.5 seconds after the tones are presented.
CELL REPORTS MEDICINE
(2021)
Article
Behavioral Sciences
Xinyu Yang, Lulu Wu, Dandan Zheng, Bin Yang, De Wu
Summary: This study evaluated the symptoms and seizure control of patients with childhood epilepsy with centrotemporal spikes (BECTS) after COVID-19 vaccination. The results suggest that COVID-19 vaccination is well tolerated and safe in BECTS patients below 18 years of age.
EPILEPSY & BEHAVIOR
(2022)
Article
Behavioral Sciences
Orhan Coskun, Osman Kipoglu, Burcin Nazli Karacabey, Mehmet Akif Kilic, Derya Simsek Ceran, Edibe Pembegul Yildiz, Nur Aydinli, Mine Caliskan
Summary: The study found no significant differences in eating habits between patients with CECTS and healthy controls, including CEBQ scores and BMI.
EPILEPSY & BEHAVIOR
(2021)
Article
Neurosciences
Yichen Ji, Jun Zhang, Hongjuan Lu, Haoran Yang, Xuan Zhang, Huixin Liu, Wenjian Liu, Wei Zhou, Xiaoling Zhang, Wei Sun
Summary: This study aimed to investigate whether high-frequency oscillations (HFOs) could predict seizure risk and atypical manifestations of benign epilepsy of childhood with centrotemporal spikes (BECTS). The study found that the number of sleep spike ripples was an independent risk factor for the active period of the disease and atypical forms of BECTS. These findings may assist in the diagnosis and treatment of BECTS.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Clinical Neurology
Miriam Kessi, Fangling Yan, Langui Pan, Baiyu Chen, Eleonore Olatoutou, Dong Li, Fang He, Tibera Rugambwa, Lifen Yang, Jing Peng, Fei Yin
Summary: This study evaluated the efficacy of levetiracetam and sodium valproate on cognition in BECTS patients, finding that levetiracetam is a good first-line therapy for normalizing EEG and preventing cognitive decline, while the administration of sodium valproate is associated with poor cognition and should be avoided.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Mark A. Kramer, Sally M. Stoyell, Dhinakaran Chinappen, Lauren M. Ostrowski, Elizabeth R. Spencer, Amy K. Morgan, Britt Carlson Emerton, Jin Jing, M. Brandon Westover, Uri T. Eden, Robert Stickgold, Dara S. Manoach, Catherine J. Chu
Summary: Childhood epilepsy with centrotemporal spikes (CECTS) is a common focal epilepsy syndrome, with unknown cause. Research shows a focal deficit in sleep spindles during active phase of the disease, an inverse correlation between spindle rate and spike rate, and that spindle rate predicts cognitive task performance. These findings suggest thalamocortical circuit dysfunction in CECTS, providing insights for potential treatment targets.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Computer Science, Information Systems
Siqi Zhang, Jihong Tang, Jing Huang, Guihai Suo, Zhiyong Zhou, Bo You, Yakang Dai, Yan Liu
Summary: Benign epilepsy with centrotemporal spikes (BECTS), the most common type of epilepsy among children, is associated with static resting-state functional network (SFN) alterations. However, these alterations are not significant when calculated in the scalp space using low-density EEG recordings. Therefore, we propose a whole-brain dynamic resting-state functional network (DFN) computation method based on low-density EEG recordings, which can reveal more accurate differences between individuals with BECTS and healthy controls.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Biotechnology & Applied Microbiology
Zhenhong Li, Hong Ni, Yueying Liu, Fei Li, Haijiang Zeng
Summary: This study investigated the association of VBECT with zinc, MRS, EEG, and IQ tests. The results showed that the patients with VBECT had significantly decreased zinc, MRS, and IQ test results, as well as an upward trend in spinal slow wave results. Linear correlation analysis revealed significant negative correlations between zinc and MRS, EEG, and IQ tests.
Article
Pediatrics
Yang Yang, Fuqin Wang, Rene Andrade-Machado, Andrea De Vito, Jiaojian Wang, Tijiang Zhang, Heng Liu
Summary: The study found abnormal connectivity patterns in BECTS patients within the subregions of the LIFG, with increased or decreased connectivity between specific regions, suggesting different subregions may be involved in distinct neural circuits associated with language function in BECTS.
TRANSLATIONAL PEDIATRICS
(2022)
Article
Clinical Neurology
Guangyuan Jin, Jia Chen, Jialin Du, Liu He, Lei Qi, Di Wu, Yuping Wang, Hua Lin, Liankun Ren
Summary: The study demonstrates that low-frequency repetitive transcranial magnetic stimulation (rTMS) has positive effects on patients with benign epilepsy with centrotemporal spikes (BECTS), reducing seizure frequency and improving attention deficit. Moreover, the treatment is safe and well-tolerated.
Article
Behavioral Sciences
Lulu Wu, Xinyu Yang, Kaili Zhang, Xiaocui Wang, Bin Yang
Summary: In our study, newly diagnosed BECT patients exhibited emotion discrimination dysfunction, mainly related to sadness, fear, and disgust, and this dysfunction was more severe the younger the age of onset was. However, after BECT remission, the ability to discriminate emotions returned to normal.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Willemiek J. E. M. Zweiphenning, Hanneke M. Keijzer, Eric van Diessen, Maryse A. van't Klooster, Nicole E. C. van Klink, Frans S. S. Leijten, Peter C. van Rijen, Michel J. A. M. van Putten, Kees P. J. Braun, Maeike Zijlmans
Editorial Material
Clinical Neurology
Nicole van Klink, Maeike Zijlmans
Letter
Clinical Neurology
Lotte Noorlag, Nicole van Klink, Geertjan Huiskamp, Maeike Zijlmans
CLINICAL NEUROPHYSIOLOGY
(2019)
Article
Clinical Neurology
Dongqing Sun, Maryse A. van 't Klooster, Monique M. J. van Schooneveld, Willemiek J. E. M. Zweiphenning, Nicole E. C. van Klink, Cyrille H. Ferrier, Peter H. Gosselaar, Kees P. J. Braun, Maeike Zijlmans
CLINICAL NEUROPHYSIOLOGY
(2020)
Letter
Clinical Neurology
Willemiek J. E. M. Zweiphenning, Eric van Diessen, Erik J. Aarnoutse, Frans S. S. Leijten, Peter C. van Rijen, Kees P. J. Braun, Maeike Zijlmans
CLINICAL NEUROPHYSIOLOGY
(2020)
Article
Clinical Neurology
Julia Jacobs, Maeike Zijlmans
Article
Multidisciplinary Sciences
Matteo Demuru, Stiliyan Kalitzin, Willemiek Zweiphenning, Dorien van Blooijs, Maryse van't Klooster, Pieter Van Eijsden, Frans Leijten, Maeike Zijlmans
SCIENTIFIC REPORTS
(2020)
Article
Clinical Neurology
Nicole E. C. van Klink, Willemiek J. E. M. Zweiphenning, Cyrille H. Ferrier, Peter H. Gosselaar, Kai J. Miller, Eleonora Aronica, Kees P. J. Braun, Maeike Zijlmans
Summary: In patients with low-grade brain tumors, fast ripples occur more frequently in tumors and peritumoral tissue, with glioma and extraventricular neurocytoma showing higher rates. Post-resection ECoG ripples are associated with seizure outcomes, while fast ripples outside the resection bed and in post-ECoG seem to be related to seizure recurrence.
Article
Clinical Neurology
Lotte Noorlag, Maryse A. van 't Klooster, Alexander C. van Huffelen, Nicole E. C. van Klink, Manon J. N. L. Benders, Linda S. de Vries, Frans S. S. Leijten, Floor E. Jansen, Kees P. J. Braun, Maeike Zijlmans
Summary: The study found that neonatal seizures can co-occur with high-frequency oscillations (HFOs), but the relationship between them and outcome is not clear yet.
CLINICAL NEUROPHYSIOLOGY
(2021)
Editorial Material
Clinical Neurology
Maeike Zijlmans, Sandra M. A. van der Salm, Maryse van't Klooster
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Paula Agudelo Valencia, Nicole E. C. van Klink, Maryse A. van 't Klooster, Willemiek J. E. M. Zweiphenning, Banu Swampillai, Pieter van Eijsden, Tineke Gebbink, Martine J. E. van Zandvoort, Maeike Zijlmans
Summary: The study demonstrates that high frequency oscillations in pre-resection ioECoG may be valuable in assessing hippocampal sclerosis, hippocampal volume, and cognitive impairments in patients with temporal lobe epilepsy.
FRONTIERS IN NEUROLOGY
(2021)
Editorial Material
Clinical Neurology
Nicole van Klink, Simon Tousseyn, Olaf Schijns, Pieter van Eijsden, Pieter Vos, Danny Hilkman, Joep Killestein, Frans Leijten
Summary: This article presents two successful cases of epilepsy surgery in patients with both pharmacoresistant epilepsy and multiple sclerosis. The patients experienced seizure relief after surgery, but one patient developed a new lesion related to multiple sclerosis. The risk-benefit ratio of epilepsy surgery compared to the potential for multiple sclerosis relapse is discussed.
EPILEPTIC DISORDERS
(2023)