Article
Cell Biology
Sachin Shetty, U. Anushree, Rajesh Kumar, Sanjay Bharati
Summary: Targeting mitochondrial oxidative stress at the early stages of hepatocarcinogenesis with mito-TEMPO showed promising results in preventing HCC. Mito-TEMPO pre-treatment protected mice from NDEA-induced damage by normalizing liver injury markers.
Article
Biochemistry & Molecular Biology
Sachin Shetty, Vinoth Kumar, Vasumathi Ramesh, Sanjay Bharati
Summary: The study suggests that the mitochondria-targeted antioxidant mito-TEMPO can protect against testicular damage induced by BPA. Pretreatment with mito-TEMPO normalizes sperm parameters, preserves testicular histopathology, and repairs oxidative stress and dysfunction in mitochondria.
FREE RADICAL RESEARCH
(2022)
Article
Immunology
Prasad Kisan Tambe, H. S. Qsee, Sanjay Bharati
Summary: This study investigated the protective effect of Mito-TEMPO against 5-FU-induced intestinal toxicity. The results showed that Mito-TEMPO pre-treatment improved intestinal histopathological alterations, reduced inflammatory cell infiltration and apoptotic cell death, and improved mitochondrial function and oxidative stress. Therefore, Mito-TEMPO may be used as an adjuvant therapy in 5-FU chemotherapy.
INFLAMMOPHARMACOLOGY
(2023)
Article
Oncology
Prasad Kisan Tambe, A. Jesil Mathew, Sanjay Bharati
Summary: This study investigated the cardioprotective potential of mito-TEMPO against 5-FU-induced cardiotoxicity. The results showed that mito-TEMPO could decrease the levels of cardiac injury markers, improve histopathology, and preserve mitochondrial function. It also reduced mitochondrial oxidative stress and apoptotic cell death.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Simone Patergnani, Esmaa Bouhamida, Sara Leo, Paolo Pinton, Alessandro Rimessi
Summary: The decline in mitochondrial redox homeostasis is associated with the development of inflammatory-related diseases, with mitochondria playing a key role in triggering inflammation and enhancing the inflammatory response. Evidence supports the concept of mito-inflammation, where mitochondrial-derived reactive oxygen species exacerbate inflammation in various diseases.
Article
Andrology
Abhishek Kumar, Subrata Kumar Ghosh, Rahul Katiyar, Amare Eshetu Gemeda, Rupali Rautela, Amarjeet Bisla, Neeraj Srivastava, Sanjeev Kumar Bhure, Huidrom Lakshmi Devi, Vikash Chandra
Summary: This study investigated the effects of Mito TEMPO and acetovanillone on the freezability of buffalo spermatozoa. The results showed that the addition of these compounds, either individually or in combination, significantly improved post-thaw semen quality.
Article
Cell Biology
Peng-Fei Wang, Ke Xie, Yun-Xing Cao, An Zhang
Summary: The mitochondria-specific superoxide scavenger Mito-TEMPO showed anti-inflammatory effects, alleviated liver injury, enhanced antioxidative capability, and improved mitochondrial function in lipopolysaccharide-induced septic mice.
MEDIATORS OF INFLAMMATION
(2022)
Article
Multidisciplinary Sciences
Sirirak Mukem, Tipsuda Thongbuakaew, Kanjana Khornchatri
Summary: This study aimed to investigate the neuroprotective effects of MitoTempo on glutamate-induced neurotoxicity and found that MitoTempo can improve neuronal properties against glutamate cytotoxicity through its direct free radical scavenging activity and inhibit excessive autophagy signaling pathway.
Article
Neurosciences
Lu Lin, Zhou Chen, Cuihua Huang, Yubin Wu, Lishan Huang, Lijing Wang, Sujie Ke, Libin Liu
Summary: This study aims to investigate the mechanism of severe hypoglycemia leading to cognitive dysfunction. The results show that BBB leakage after hypoglycemia is associated with oxidative stress and mitochondrial dysfunction. Further research shows that using a mitochondria-targeted antioxidant can improve brain damage, reduce cell loss and BBB leakage, ultimately improving cognitive function.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Siarhei A. Dabravolski, Varvara A. Orekhova, Mirza S. Baig, Evgeny E. Bezsonov, Antonina Starodubova, Tatyana Popkova, Alexander N. Orekhov
Summary: Diabetes mellitus and related disorders are closely related to mitochondrial dysfunction. Specific types of mitochondrial diabetes, such as MIDD and DAD, have been identified. Mutations in mitochondrial DNA cause hereditary mitochondrial disorders, with tissue-specific phenotypes depending on the level of heteroplasmy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Josh Allen, Hector J. Caruncho, Lisa E. Kalynchuk
Summary: This study explores how chronic stress can induce depressive symptoms by affecting mitochondrial function, and how targeting mitochondrial defects may be a promising avenue for the development of more effective antidepressants.
Review
Biochemistry & Molecular Biology
Jeong-Su Park, Nodir Rustamov, Yoon-Seok Roh
Summary: Chronic liver disease (CLD) is a global health issue that causes a significant number of deaths each year. Non-alcoholic fatty liver disease (NAFLD) and alcoholic fatty liver disease (ALD) are two distinct forms of CLD, but they both share oxidative stress as a common pathology. Mitochondria, which are vital for liver metabolism, are compromised in diseases like NAFLD, ALD, and liver fibrosis due to inflammation, toxins, and metabolic irregularities. Nuclear factor erythroid 2-related factor 2 (NRF2) emerges as a cellular protector that regulates antioxidant genes and maintains mitochondrial health. The synergy between NRF2 modulation and mitochondrial function provides new therapeutic potentials for CLD by preserving mitochondrial integrity against oxidative threats.
Review
Chemistry, Multidisciplinary
Xiaolu Guo, Naidi Yang, Wenhui Ji, Hang Zhang, Xiao Dong, Zhiqiang Zhou, Lin Li, Han-Ming Shen, Shao Q. Yao, Wei Huang
Summary: Traditional cancer therapies such as surgery, chemotherapy, and radiotherapy have limited effectiveness, while photodynamic therapy, photothermal therapy, and chemodynamic therapy have shown promising results in cancer treatment due to their high selectivity, minimal resistance, and minimal toxicity.
ADVANCED MATERIALS
(2021)
Article
Cell Biology
Dinesh Kumar Chellappan, Keshav Raj Paudel, Nian Wan Tan, Ka Seng Cheong, Samantha Sert Qi Khoo, Su Min Seow, Jestin Chellian, Mayuren Candasamy, Vyoma K. Patel, Poonam Arora, Pankaj Kumar Singh, Sachin Kumar Singh, Gaurav Gupta, Brian G. Oliver, Philip M. Hansbro, Kamal Dua
Summary: Mitochondria play a crucial role in respiratory diseases, impacting airway morphology and epithelial function. Targeting dysfunctional mitochondria could be a promising treatment strategy for asthma, COPD, and lung cancer.
Article
Nutrition & Dietetics
Miyuki Kobara, Nessa Naseratun, Hiroe Toba, Tetsuo Nakata
Summary: The study found that preconditioning with short-term dietary restriction can attenuate chronic pressure overload-induced cardiac hypertrophy and associated oxidative stress, ultimately improving heart function.
Article
Biochemistry & Molecular Biology
Iwona Piatkowska-Chmiel, Mariola Herbet, Monika Gawronska-Grzywacz, Marta Ostrowska-Lesko, Jaroslaw Dudka
Summary: The brain is the most vulnerable organ to glucose fluctuations and inflammation. Studies have found a strong association between hyperglycemia, hyperinsulinemia, neuroinflammation, and cognitive dysfunction in diabetic mice models. Changes in Arc and Egr1 gene expression in early stage diabetes may be used to track the progression of central nervous system dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Iwona Piatkowska-Chmiel, Mariola Herbet, Monika Gawronska-Grzywacz, Jaroslaw Dudka
Summary: Untreated diabetes can lead to the development of neuroinflammation and cognitive impairment. The study investigated the anti-inflammatory potential of pioglitazone in a mouse model of neuroinflammation related to diabetes and found that pioglitazone reduced inflammatory markers and improved memory and exploratory activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Nutrition & Dietetics
Lucja Justyna Walczak-Nowicka, Mariola Herbet
Summary: There are conflicting research results on the safety of sodium benzoate, with some studies suggesting its potential use in treating various diseases and others pointing out its harmful effects.
Article
Multidisciplinary Sciences
Iwona Piatkowska-Chmiel, Monika Gawronska-Grzywacz, Lukasz Popiolek, Mariola Herbet, Jaroslaw Dudka
Summary: The study demonstrates that newly synthesized adamantane derivatives can alleviate diabetes-induced cognitive impairment and improve memory performance by inhibiting inflammatory response. This finding provides new insights into the prevention and treatment of cognitive impairment in patients with diabetes or related diseases.
SCIENTIFIC REPORTS
(2022)
Article
Neurosciences
Mariola Herbet, Iwona Piatkowska-Chmiel, Monika Motylska, Monika Gawronska-Grzywacz, Barbara Nieradko-Iwanicka, Jaroslaw Dudka
Summary: Exposure to chronic stress can lead to disruptions in brain glucose metabolism and changes in neural functioning during depression. This study aimed to investigate the expression of selected genes involved in cerebral glucose metabolism in a validated animal model of chronic stress. The results suggest that changes in cerebral glucose metabolism may be an adaptive response to stress and could potentially inform new therapeutic strategies for chronic stress-related depression.
Article
Medicine, General & Internal
Mariola Herbet, Jaroslaw Widelski, Iwona Piatkowska-Chmiel, Kamil Pawlowski, Aleksandra Dymek, Tomasz Mroczek
Summary: This study evaluated the safety and pharmacological activity of compounds obtained from various plant extracts, and found that these compounds have a high safety profile and significantly improve rodent memory.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Aleksandra Szopa, Mariola Herbet, Ewa Poleszak, Karolina Bogatko, Marta Ostrowska-Lesko, Katarzyna Swiader, Jaroslaw Szponar, Anna Serefko
Summary: The study determined that the co-administration of sodium selenite with selective adenosine A1 and A2A antagonists has antidepressant-like potential in mice, enhancing efficacy and altering gene expression levels. This combination may provide a new therapeutic strategy for patients with depression.
Article
Chemistry, Medicinal
Monika Gawronska-Grzywacz, Iwona Piatkowska-Chmiel, Lukasz Popiolek, Mariola Herbet, Jaroslaw Dudka
Summary: This study tested the anti-angiogenic potential of a compound with anti-cancer activity in a zebrafish model. The compound also demonstrated moderate toxicity and shows promise for the treatment of malignant neoplasms and other diseases related to pathological angiogenesis.
Review
Biochemistry & Molecular Biology
Bartosz Twarowski, Mariola Herbet
Summary: Alzheimer's disease is an incurable form of senile dementia and a leading cause of death. Inflammation, specifically the release of mediators by inflammatory cells, can contribute to neuronal degeneration and disease progression in Alzheimer's. The pathomechanism of neuroinflammation in Alzheimer's disease is still not fully understood, but studying it could lead to the development of early diagnostic methods and new therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Antonina Kurowska, Wojciech Ziemichod, Mariola Herbet, Iwona Piatkowska-Chmiel
Summary: Neurological diseases are a leading cause of disability and mortality worldwide. Scientists are researching new interventions for diseases like Alzheimer's, Parkinson's, Schizophrenia, Depression, and Multiple Sclerosis. Evidence suggests that inflammation and gut microbiome imbalance play a critical role in these diseases, and dietary interventions can have beneficial effects. Consuming an anti-inflammatory diet abundant in fruits, vegetables, nuts, herbs, spices, and legumes while avoiding pro-inflammatory foods may reduce the risk of neurological diseases.
Article
Biochemistry & Molecular Biology
Aleksandra Szopa, Mariola Herbet, Ewa Poleszak, Anna Serefko, Agnieszka Czylkowska, Iwona Piatkowska-Chmiel, Kamila Kasperek, Andrzej Wrobel, Paulina Prewencka, Bernadeta Szewczyk
Summary: The study evaluated the antidepressant-like effects of an IMI-Zn complex compound on mice and compared its efficacy with separate administration of imipramine and zinc. The results showed that the IMI-Zn complex exhibited dose-dependent antidepressant potential similar to individual treatments of imipramine and zinc. The study also found that acute stress did not significantly affect oxidative stress parameters. Developing the IMI-Zn complex could simplify treatment and improve patient compliance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Magdalena Dziewa, Bartosz Banka, Mariola Herbet, Iwona Piatkowska-Chmiel
Summary: Eating disorders and diabetes are closely linked, requiring comprehensive understanding and specialized care to address the challenges they present.
Review
Biochemistry & Molecular Biology
Magdalena Zlotek, Antonina Kurowska, Mariola Herbet, Iwona Piatkowska-Chmiel
Summary: This review comprehensively assesses the potential therapeutic applications of new-generation anti-diabetic drugs in the context of Alzheimer's disease, highlighting the well-documented correlation and shared mechanisms between diabetes and Alzheimer's disease.
Article
Behavioral Sciences
Radwa H. Lutfy, Sherine Abdel Salam, Haitham S. Mohammed, Marwa M. Shakweer, Amina E. Essawy
Summary: Insufficient sleep is associated with impaired hypothalamic activity and declined attentional performance. This study found that near-infrared (NIR) laser therapy can alleviate the effects of sleep deprivation on the hypothalamus, enhance antioxidant status, suppress neuroinflammation, and regulate cellular activity.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Durmus Ali Aslanlar, Emin Fatih Visneci, Mehmet Oz, K. Esra Nurullahoglu Atalik
Summary: Mood disorders caused by chemotherapy have become more important as cancer patients' survival increases. This study used methotrexate to induce mood disorders in rats and found that treatment with the antioxidant N-acetylcysteine (NAC) can alleviate anxiety and depression-like behaviors, increase antioxidant capacity, reduce oxidative stress and inflammatory response, and regulate brain chemistry. The findings suggest that NAC treatment could be an effective strategy in revising the treatment for individuals suffering from chemotherapy-induced mood disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Yunfan Zhang, Yunbin Zhang, Zhuangfei Chen, Ping Ren, Yu Fu
Summary: This study systematically investigated the effects of extremely low intensity HF-rTMS on cognition in mice and found that 40 Hz rTMS significantly impaired exploratory behavior and spatial memory at both 10 mT and 1 mT conditions. Additionally, 40 Hz stimulation had remarkably different effects on exploratory behavior depending on intensity, compared to 10 Hz stimulation.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xuan Xuan, Guangling Zheng, Wenjia Zhu, Qionghua Sun, Yawei Zeng, Juan Du, Xusheng Huang
Summary: This study examines the functional characteristics of the cerebellum in individuals with sALS and their correlation with clinical data. The results show changes in both local and global functional connectivity in the cerebellum of sALS patients, suggesting a pathophysiological role of the cerebellum in sALS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Mehdi Rezaei, Mohammad Mahdi Shariat Bagheri
Summary: This study examined the efficacy of tDCS for PTSD and related symptoms, as well as the factors that may predict response to tDCS. The results showed that tDCS had a positive effect in reducing symptoms of PTSD, depression, anxiety, and anhedonia. The severity of symptoms at baseline may also predict the response to tDCS.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Huimin Wu, Yiqun Guo, Yaoyao Zhang, Le Zhao, Cheng Guo
Summary: Aggression can have serious consequences, but little is known about its personality and neurological origins in children. This study investigated the relationship between self-esteem, aggression, and brain structure in healthy children, and found that self-esteem was negatively associated with aggression. The study also revealed that increased cortical thickness in certain brain areas may be a potential mechanism linking low self-esteem to aggression in children.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xinmei Deng, Kexin Chen, Xiaoming Chen, Lin Zhang, Mingping Lin, Xiaoqing Li, Qiufeng Gao
Summary: Parental involvement affects the relationship and communication between parents and adolescents. This study found that high parental involvement is associated with stronger brain-to-brain synchrony during shared positive emotional experiences, while low parental involvement is associated with stronger synchrony during shared negative emotional experiences.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Xin Deng, I. -Shuo Huang, Kourtlin Williams, Marcy L. Wainwright, Paul Zimba, Riccardo Mozzachiodi
Summary: Food deprivation can lead to neurological dysfunctions, including memory impairment. This study used Aplysia as an animal model to investigate the memory deficits caused by prolonged food deprivation. The results showed that 14 days of food deprivation decreased the level of 5-HT in the hemolymph, which contributed to the lack of sensitization and its cellular correlates. However, exogenous application of 5-HT partially induced sensitization in the food deprived animals.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Ihori Kobayashi, Patrick A. Forcelli
Summary: The study found that intervention with the dual orexin receptor antagonist suvorexant did not have the expected effects on extinction memory and sleep. Higher percentages of REM sleep were associated with poorer extinction memory recall and stronger fear responses. Additionally, the fear extinction training protocol used in this study did not lead to complete fear extinction.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Jiyan Xu, Xinlu Chen, Shuai Liu, Ziqi Wei, Minhui Xu, Linhao Jiang, Xue Han, Liangyu Peng, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the effects of nicotinamide mononucleotide (NMN) on oxidative stress and cognitive function in postoperative cognitive dysfunction (POCD) mice. The results showed that NMN pretreatment reduced oxidative stress damage and alleviated cognitive impairment in POCD mice.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Song Liu, Qiang Wu, Liyue Wang, Cong Xing, Junrui Guo, Baicao Li, Hongpeng Ma, Hao Zhong, Mi Zhou, Shibo Zhu, Rusen Zhu, Guangzhi Ning
Summary: In this study, a systematic assessment indicator was developed to objectively evaluate hindlimb motor function recovery in rats after thoracic contusion SCI. By screening CatWalk XT gait parameters and using exploratory factor analysis, 38 suitable parameters for assessing motor function were identified. A reliable Coordinated Function Index (CFI) was proposed based on these parameters and simplified for improved assessment efficacy.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Kyosuke Shiga, Shota Miyaguchi, Yasuto Inukai, Naofumi Otsuru, Hideaki Onishi
Summary: This study aimed to investigate the effects of transcranial alternating current stimulation (tACS) on microscale learning in implicit motor tasks. Contrary to expectations, the results showed that the stimulation protocol had no significant effects on microscale learning, revealing a novel aspect of microscale learning in implicit motor tasks.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Cahide Aslan, Rahime Aslankoc, Ozlem Ozmen, Buse Nur Suluk, Oguzhan Kavrik, Nurhan Gumral
Summary: This study examined the negative effects of high fructose corn syrup on prefrontal cortex damage in adolescent rats, as well as the protective role of vitamin D.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Matin Baghani, Arad Bolouri-Roudsari, Reyhaneh Askari, Abbas Haghparast
Summary: The study suggests that the orexinergic system in the dentate gyrus region of the brain may act as an endogenous pain control system and a potential target for treating stress-related disorders.
BEHAVIOURAL BRAIN RESEARCH
(2024)
Article
Behavioral Sciences
Sen Zhou, Yang Liu, Binbin Xue, Peigen Yuan
Summary: This study confirmed that low-dose Esketamine alleviates LPS-induced depressive symptoms by regulating the GSK-3 beta/NLRP3 pathway. Appropriate doses of Esketamine are essential for the treatment of depression in the clinical setting.
BEHAVIOURAL BRAIN RESEARCH
(2024)
