Structural hallmarks of lung surfactant: Lipid-protein interactions, membrane structure and future challenges

Pulmonary Surfactant Lipid Reorganization Induced by the Adsorption of the Oligomeric Surfactant Protein B Complex

(2020) Juho Liekkinen et al.   JOURNAL OF MOLECULAR BIOLOGY

Pulmonary surfactant protein SP-B nanorings induce the multilamellar organization of surfactant complexes

(2020) Marta Martinez-Calle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Polarized light microscopy reveals physiological and drug-induced changes in surfactant membrane assembly in alveolar type II pneumocytes

(2018) Thomas Haller et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pulmonary surfactant protein SP-B promotes exocytosis of lamellar bodies in alveolar type II cells

(2018) Marta Martínez-Calle et al.   FASEB JOURNAL

Homo- and hetero-oligomerization of hydrophobic pulmonary surfactant proteins SP-B and SP-C in surfactant phospholipid membranes

(2018) Elisa J. Cabré et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Supramolecular Assembly of Human Pulmonary Surfactant Protein SP-D

(2018) R. Arroyo et al.   JOURNAL OF MOLECULAR BIOLOGY

The Lγ Phase of Pulmonary Surfactant

(2018) Kamlesh Kumar et al.   LANGMUIR

Controlled hypothermia may improve surfactant function in asphyxiated neonates with or without meconium aspiration syndrome

(2018) Chiara Autilio et al.   PLoS One

Inhibition and counterinhibition of Surfacen, a clinical lung surfactant of natural origin

(2018) Yuliannis Lugones et al.   PLoS One

The Impact of Nonequilibrium Conditions in Lung Surfactant: Structure and Composition Gradients in Multilamellar Films

(2018) Jenny Marie Andersson et al.   ACS Central Science

Interfacial curvature effects on the monolayer morphology and dynamics of a clinical lung surfactant

(2017) Amit Kumar Sachan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A small key unlocks a heavy door: The essential function of the small hydrophobic proteins SP-B and SP-C to trigger adsorption of pulmonary surfactant lamellar bodies

(2016) Nina Hobi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Effect of Lung Surfactant Protein SP-C and SP-C-Promoted Membrane Fragmentation on Cholesterol Dynamics

(2016) Nuria Roldan et al.   BIOPHYSICAL JOURNAL

Using electron microscopes to look into the lung

(2016) Matthias Ochs et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Palmitoylation as a key factor to modulate SP-C–lipid interactions in lung surfactant membrane multilayers

(2015) Nuria Roldan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Pneumocytes Assemble Lung Surfactant as Highly Packed/Dehydrated States with Optimal Surface Activity

(2015) Alejandro Cerrada et al.   BIOPHYSICAL JOURNAL

Hydrophobic Surfactant Proteins Strongly Induce Negative Curvature

(2015) Mariya Chavarha et al.   BIOPHYSICAL JOURNAL

A model for the structure and mechanism of action of pulmonary surfactant protein B

(2015) Bárbara Olmeda et al.   FASEB JOURNAL

Structure-function relationships in pulmonary surfactant membranes: From biophysics to therapy

(2014) Elena Lopez-Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The Mechanism of Collapse of Heterogeneous Lipid Monolayers

(2014) Svetlana Baoukina et al.   BIOPHYSICAL JOURNAL

Human Decidua-Derived Mesenchymal Stem Cells Differentiate into Functional Alveolar Type II-Like Cells that Synthesize and Secrete Pulmonary Surfactant Complexes

(2014) Alejandro Cerrada et al.   PLoS One

An Anionic Phospholipid Enables the Hydrophobic Surfactant Proteins to Alter Spontaneous Curvature

(2013) Mariya Chavarha et al.   BIOPHYSICAL JOURNAL

Hydrophobic Pulmonary Surfactant Proteins SP-B and SP-C Induce Pore Formation in Planar Lipid Membranes: Evidence for Proteolipid Pores

(2013) Elisa Parra et al.   BIOPHYSICAL JOURNAL

Transient Exposure of Pulmonary Surfactant to Hyaluronan Promotes Structural and Compositional Transformations into a Highly Active State

(2013) Elena Lopez-Rodriguez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bidirectional Surface Analysis of Monomolecular Membrane Harboring Nanoscale Reversible Collapse Structures

(2013) Amit K. Sachan et al.   NANO LETTERS

Effect of cholesterol nanodomains on monolayer morphology and dynamics

(2013) K. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interfacial behavior and structural properties of a clinical lung surfactant from porcine source

(2012) Odalys Blanco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Exposure to Polymers Reverses Inhibition of Pulmonary Surfactant by Serum, Meconium, or Cholesterol in the Captive Bubble Surfactometer

(2012) Elena López-Rodríguez et al.   BIOPHYSICAL JOURNAL

Visualizing the Analogy between Competitive Adsorption and Colloid Stability to Restore Lung Surfactant Function

(2012) Ian C. Shieh et al.   BIOPHYSICAL JOURNAL

Lipid-Protein Interactions Alter Line Tensions and Domain Size Distributions in Lung Surfactant Monolayers

(2012) Prajnaparamita Dhar et al.   BIOPHYSICAL JOURNAL

Structure–function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins

(2012) Bárbara Olmeda et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Phase-field model for the morphology of monolayer lipid domains

(2012) F. Campelo et al.   EUROPEAN PHYSICAL JOURNAL E

Segregated ordered lipid phases and protein-promoted membrane cohesivity are required for pulmonary surfactant films to stabilize and protect the respiratory surface

(2012) Jorge Bernardino de la Serna et al.   FARADAY DISCUSSIONS

Molecular View of Phase Coexistence in Lipid Monolayers

(2012) Svetlana Baoukina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Differential Effects of the Hydrophobic Surfactant Proteins on the Formation of Inverse Bicontinuous Cubic Phases

(2012) Mariya Chavarha et al.   LANGMUIR

Interfacial Behavior of Recombinant Forms of Human Pulmonary Surfactant Protein SP-C

(2012) Dunja Lukovic et al.   LANGMUIR

A combined action of pulmonary surfactant proteins SP-B and SP-C modulates permeability and dynamics of phospholipid membranes

(2011) Elisa Parra et al.   BIOCHEMICAL JOURNAL

Pulmonary surfactant proteins and polymer combinations reduce surfactant inhibition by serum

(2011) Karen W. Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Comparative study of clinical pulmonary surfactants using atomic force microscopy

(2011) Hong Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Atomic force microscopy analysis of rat pulmonary surfactant films

(2011) Xiujun Jiao et al.   BIOPHYSICAL CHEMISTRY

Meconium Impairs Pulmonary Surfactant by a Combined Action of Cholesterol and Bile Acids

(2011) Elena Lopez-Rodriguez et al.   BIOPHYSICAL JOURNAL

Lung Surfactant Protein SP-B Promotes Formation of Bilayer Reservoirs from Monolayer and Lipid Transfer between the Interface and Subphase

(2011) Svetlana Baoukina et al.   BIOPHYSICAL JOURNAL

The Accelerated Late Adsorption of Pulmonary Surfactant

(2011) Ryan W. Loney et al.   LANGMUIR

On the Low Surface Tension of Lung Surfactant

(2011) Hong Zhang et al.   LANGMUIR

Restoring the charge and surface activity of bovine lung extract surfactants with cationic and anionic polysaccharides

(2010) Edgar J. Acosta et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Direct Simulation of Protein-Mediated Vesicle Fusion: Lung Surfactant Protein B

(2010) Svetlana Baoukina et al.   BIOPHYSICAL JOURNAL

Hydrophobic Surfactant Proteins Induce a Phosphatidylethanolamine to Form Cubic Phases

(2010) Mariya Chavarha et al.   BIOPHYSICAL JOURNAL

Palmitoylation of Pulmonary Surfactant Protein SP-C Is Critical for Its Functional Cooperation with SP-B to Sustain Compression/Expansion Dynamics in Cholesterol-Containing Surfactant Films

(2010) Florian Baumgart et al.   BIOPHYSICAL JOURNAL

Combined and Independent Action of Proteins SP-B and SP-C in the Surface Behavior and Mechanical Stability of Pulmonary Surfactant Films

(2010) David Schürch et al.   BIOPHYSICAL JOURNAL

Lamellar body ultrastructure revisited: high-pressure freezing and cryo-electron microscopy of vitreous sections

(2010) Dimitri Vanhecke et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Lamellar Bodies Form Solid Three-dimensional Films at the Respiratory Air-Liquid Interface

(2010) Andrea Ravasio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms of polyelectrolyte enhanced surfactant adsorption at the air–water interface

(2009) Patrick C. Stenger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cholesterol modulates the exposure and orientation of pulmonary surfactant protein SP-C in model surfactant membranes

(2009) L. Gómez-Gil et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Surfactant Protein SP-B Strongly Modifies Surface Collapse of Phospholipid Vesicles: Insights from a Quartz Crystal Microbalance with Dissipation

(2009) Elisa J. Cabré et al.   BIOPHYSICAL JOURNAL

Pulmonary Surfactant Protein SP-C Counteracts the Deleterious Effects of Cholesterol on the Activity of Surfactant Films under Physiologically Relevant Compression-Expansion Dynamics

(2009) Leticia Gómez-Gil et al.   BIOPHYSICAL JOURNAL

Calcium Ions as “Miscibility Switch”: Colocalization of Surfactant Protein B with Anionic Lipids under Absolute Calcium Free Conditions

(2009) Mohammed Saleem et al.   BIOPHYSICAL JOURNAL

X-Ray Diffraction and Reflectivity Validation of the Depletion Attraction in the Competitive Adsorption of Lung Surfactant and Albumin

(2009) Patrick C. Stenger et al.   BIOPHYSICAL JOURNAL

Segregated Phases in Pulmonary Surfactant Membranes Do Not Show Coexistence of Lipid Populations with Differentiated Dynamic Properties

(2009) Jorge Bernardino de la Serna et al.   BIOPHYSICAL JOURNAL

The Closer we Look the more we See? Quantitative Microscopic Analysis of the Pulmonary Surfactant System

(2009) Matthias Ochs   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Perturbation of DPPC/POPG bilayers by the N-terminal helix of lung surfactant protein SP-B: a 2H NMR study

(2009) Bretta Russell-Schulz et al.   EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS

Molecular weight dependence of the depletion attraction and its effects on the competitive adsorption of lung surfactant

(2008) Patrick C. Stenger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Structure of pulmonary surfactant membranes and films: The role of proteins and lipid–protein interactions

(2008) Jesús Pérez-Gil   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Effect of acylation on the interaction of the N-Terminal segment of pulmonary surfactant protein SP-C with phospholipid membranes

(2008) I. Plasencia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Influence of Lipid Saturation Grade and Headgroup Charge: A Refined Lung Surfactant Adsorption Model

(2008) U. Klenz et al.   BIOPHYSICAL JOURNAL

Atomic Force Microscopy Studies of Functional and Dysfunctional Pulmonary Surfactant Films. I. Micro- and Nanostructures of Functional Pulmonary Surfactant Films and the Effect of SP-A

(2008) Yi Y. Zuo et al.   BIOPHYSICAL JOURNAL

A comparative study of mechanisms of surfactant inhibition

(2007) Lasantha Gunasekara et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES