Article
Geriatrics & Gerontology
Jana Kynast, Maryna Polyakova, Eva Maria Quinque, Andreas Hinz, Arno Villringer, Matthias L. Schroeter
Summary: This study calculated standard scores for the German version of the RMET using a large sample of healthy adults, showing differences in scores between age and gender groups. These results contribute to standardized assessment of socio-cognitive abilities in clinical diagnostics.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychiatry
Tai-Shan Li, Susan Shur-Fen Gau, Tai-Li Chou
Summary: This study examined the differences in underlying mechanisms of socioemotional processes between males with autism spectrum disorder (ASD) and healthy control males using the Taiwanese version of the Reading the Mind in the Eyes test (RMET) and network analysis methods. The results showed that ASD males performed poorer on the RMET and had higher network density and in-degree scores, especially in negative words, compared to control males.
Article
Psychiatry
Steven H. Woodward, Andrea L. Jamison, Christina Khan, Sasha Gala, Chloe Bhowmick, Diana Villasenor, Gisselle Tamayo, Melissa Puckett, Karen J. Parker
Summary: This study assessed the performance of U.S. military veterans with PTSD in the Reading the Mind in the Eyes Test (RMET). The presence of a service dog did not improve their social cognitive abilities.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Neurosciences
Ruud Hortensius, Michaela Kent, Kohinoor M. Darda, Laura Jastrzab, Kami Koldewyn, Richard Ramsey, Emily S. Cross
Summary: This study investigated the relationship between anthropomorphism and theory-of-mind, finding that while these two concepts may overlap in certain situations, they remain separate at the personality level.
HUMAN BRAIN MAPPING
(2021)
Article
Psychiatry
Se Jun Koo, Ye Jin Kim, Jung Hwa Han, Eunchong Seo, Hye Yoon Park, Minji Bang, Jin Young Park, Eun Lee, Suk Kyoon An
Summary: The study developed a Korean version of the RMET using Korean eye stimuli and found acceptable psychometric properties, with good internal consistency and test-retest reliability, but less ideal results in confirmatory factor analysis.
PSYCHIATRY INVESTIGATION
(2021)
Article
Biology
Derry Taylor, Gokhan Gonul, Cameron Alexander, Klaus Zueberbuehler, Fabrice Clement, Hans-Johann Glock
Summary: Understanding the origins of human social cognition is a central challenge in contemporary science. The 'Theory of Mind' (ToM) has been the most popular explanation for human social cognition, but recent research on 'implicit' ToM has questioned its validity. Our article introduces 'script theory' as a new theoretical framework to overcome the limitations of ToM-based frameworks and provide a plausible account of how individuals make sense of others' behavior.
BIOLOGICAL REVIEWS
(2023)
Article
Psychiatry
Kah Kheng Goh, Mong-Liang Lu
Summary: The study suggests that oxytocin levels are associated with social cognition and social dysfunction in patients with schizophrenia. Patients with schizophrenia have more deficits in social cognition and social dysfunction, along with lower plasma oxytocin levels. Plasma oxytocin levels are positively correlated with affective Theory of Mind (ToM) in patients with schizophrenia, and the effects of oxytocin on social functioning are partially mediated by affective ToM.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychiatry
Clare M. Eddy
Summary: The Reading the Mind in the Eyes test (RMET) is a widely used test of social cognition that measures mental state judgments based on photographs of human eyes. The test can identify impairments in individuals with psychiatric and neurological disorders. However, the interpretation of task performance is limited without the use of control tasks. A new Non-human Animal RMET (NARMET) was developed using photographs of domestic cat and dog eyes, showing promise as an assessment tool for social cognitive skills in neuropsychiatric populations.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Psychiatry
Rachal R. Hegde, Synthia Guimond, Deepthi Bannai, Victor Zeng, Shezal Padani, Shaun M. Eack, Matcheri S. Keshavan
Summary: This study validated the False Belief task as a measure of Theory of Mind in schizophrenia and found that individuals with schizophrenia exhibited reduced brain activation in the bilateral TPJ during the task, which was positively associated with ToM abilities. Lower neural activity in the bilateral TPJ was associated with ToM impairments observed in individuals with early course schizophrenia.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Psychiatry
Tatia M. C. Lee, Li Liang, Wai Kai Hou, Alicia H. Y. Tse, Chetwyn C. H. Chan
Summary: A Chinese Eyes Test was developed and tested for its psychometric properties. The test showed good validity, discrimination, and consistency. The identified cutoff score can be useful for identifying social cognitive deficits in high-functioning adults with autism or Asperger syndrome.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Behavioral Sciences
Yiting Weng, Jingxia Lin, Daniel Kwasi Ahorsu, Hector W. H. Tsang
Summary: In this study, a systematic literature search was conducted to identify studies using neuroimaging to measure theory of mind (ToM) in schizophrenia. The results showed that patients with schizophrenia exhibited hyperactivations in the superior longitudinal fasciculus II and hypoactivations in the superior frontal gyrus, precuneus and cuneus, and precentral gyrus during ToM tasks. The primary brain regions involved in the potential neuropathways in schizophrenia were the middle temporal gyrus, superior and inferior frontal gyrus, and supplementary motor areas.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Psychology, Multidisciplinary
Sara Isernia, Sarah E. E. MacPherson, R. Asaad Baksh, Niels Bergsland, Antonella Marchetti, Francesca Baglio, Davide Massaro
Summary: This study translated and adapted the ESCoT social cognition assessment tool for an adult Italian population and demonstrated its reliability and validity in evaluating social cognition. Results showed the ESCoT total score was associated with age, and the subscore for intrapersonal social norm understanding was associated with education.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Psychiatry
Laura M. -L. Dorn, Nele Struck, Florian Bitsch, Irina Falkenberg, Tilo Kircher, Winfried Rief, Stephanie Mehl
Summary: Patients with psychosis showed more pronounced deficits in Cognitive and Affective ToM compared to non-clinical controls, while there were no significant differences in Hyper-ToM errors. Deficits in Cognitive ToM were associated with general delusions, while problems in Affective ToM were linked to negative and disorganized symptoms. Furthermore, there was no association between Hyper-ToM errors and any symptoms when controlling for educational level.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Mathematical
Anne C. Krendl, Kurt Hugenberg, Daniel P. Kennedy
Summary: Nearly half of psychology research uses online samples that heavily rely on self-report measures. This study validates the quality of data from an online sample by comparing its performance with an in-lab sample on two dynamic measures of theory of mind. The results suggest that crowdsourcing platforms can reliably capture performance on novel, dynamic, and complex tasks.
BEHAVIOR RESEARCH METHODS
(2023)
Article
Psychiatry
Selima Jelili, Soumeyya Halayem, Olfa Rajhi, Zeineb Abbes, Hajer Ben Mansour, Sami Ouanes, Amal Taamallah, Selima Ennaifer, Houda Ben Yahia, Melek Ghazzei, Ahmed Nabli, Malek Hajri, Radhouane Fakhfakh, Ali Mrabet, Asma Bouden
Summary: This study examined the Theory of Mind (ToM) performance in Arabic-speaking verbal children with Autism Spectrum Disorder (ASD) and compared them to neurotypical controls. The findings showed impairments in ToM in children with ASD, particularly in affective and advanced ToM. Future studies could focus on identifying the most impaired subdomains and developing specific tools to target these specific impairments.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Anesthesiology
Martin F. Bjurstrom, Mikael Bodelsson, Michael R. Irwin, Camilla Orbjorn, Oskar Hansson, Niklas Mattsson-Carlgren
Summary: The study evaluated the associations among alterations in CSF IP-10, Flt-1, MCP-1, and pain sensitization following THA. Long-term postoperative results showed decreased pain sensitivity and an increase in CSF IP-10 may be linked to altered pain phenotype.
Article
Psychology, Clinical
Dominique Piber, Richard Olmstead, Joshua H. Cho, Miguel Guzman, Michael R. Irwin
Summary: This study found that both poor sleep maintenance and higher levels of IFN-gamma were associated with depressed mood in older adults. Moreover, IFN-gamma moderated the relationship between poor sleep maintenance and depressed mood, indicating that older adults with higher IFN-gamma are at a heightened risk for depressive symptoms following sleep disturbance.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Mark A. Straccia, Adam R. Teed, Perri L. Katzman, Kevin M. Tan, Michael H. Parrish, Michael R. Irwin, Naomi Eisenberger, Matthew D. Lieberman, Benjamin A. Tabak
Summary: Although there are theoretical grounds, this study fails to demonstrate the effects of oxytocin (OT) and vasopressin (AVP) on social cognition in healthy individuals, suggesting that the impact of these neuropeptides may be more limited than initially assumed.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Denise R. Purdie, Myke Federman, Alan Chin, Diana Winston, Brenda Bursch, Richard Olmstead, Yonca Bulut, Michael R. Irwin
Summary: Physicians are facing high levels of work-related stress and burnout. This study found that a hybrid mindfulness meditation intervention can help reduce perceived stress in pediatric residents.
JOURNAL OF CLINICAL PSYCHOLOGY IN MEDICAL SETTINGS
(2023)
Article
Oncology
Julienne E. Bower, Ann H. Partridge, Antonio C. Wolff, Steve W. Cole, Michael R. Irwin, Elissa D. Thorner, Hadine Joffe, Laura Petersen, Catherine M. Crespi, Patricia A. Ganz
Summary: This study examined the effects of interventions on younger breast cancer survivors and found that mindful awareness practices (MAPs) had beneficial effects on psychological and immune outcomes, indicating its potential for enhancing biobehavioral health.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2023)
Article
Anesthesiology
Michael R. Irwin, Richard Olmstead, Martin F. Bjurstrom, Patrick H. Finan, Michael T. Smith
Summary: Sleep loss increases pain sensitivity, and this study aimed to explore the mechanisms behind this association. By disrupting sleep and inducing inflammation and loss of slow wave, N3 sleep, the researchers found that sleep disruption led to decreased pain threshold. A causal mediation analysis revealed that the effect of sleep disruption on pain sensitivity was mediated by decreased N3 sleep and subsequent inflammation.
Article
Psychology, Clinical
Erica N. Grodin, Lindsay R. Meredith, Elizabeth M. Burnette, Karen Miotto, Michael R. Irwin, Lara A. Ray
Summary: This study investigated CRP as a predictor of treatment response to ibudilast and suggests that a baseline proinflammatory profile may enhance clinical efficacy.
AMERICAN JOURNAL OF DRUG AND ALCOHOL ABUSE
(2023)
Article
Clinical Neurology
Danny Rahal, Julienne E. Bower, Michael R. Irwin, Andrew J. Fuligni, Jessica J. Chiang
Summary: The study found that higher resting RSA can enhance the emotional response to social-evaluative stress in adolescents, possibly due to active engagement and active response to stimuli. Higher resting RSA may promote flexible emotional responses to the social environment, thereby improving mental health.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Sport Sciences
Danny J. Yu, Angus P. Yu, Shirley X. Li, Rachel N. Y. Chan, Daniel Y. Fong, Derwin K. C. Chan, Stanley S. Hui, Ka Fai Chung, Jean Woo, Chenchen Wang, Michael R. Irwin, Parco M. Siu
Summary: This study aims to compare the efficacy and long-term outcomes of Tai Chi and cognitive behavioral therapy for insomnia (CBT-I) in older adults. The participants will be randomly assigned to either the Tai Chi or CBT-I group, and the severity of insomnia will be assessed at 3 months and 15 months. This study is of clinical importance as it supports the use of Tai Chi as an alternative non-pharmacological approach for insomnia treatment.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Psychology, Clinical
John O. Brooks III, Jennifer L. Kruse, Antoni Kubicki, Gerhard Hellemann, Randall T. Espinoza, Michael R. Irwin, Katherine L. Narr
Summary: This study followed 20 subjects with treatment-resistant depression for six months after an index ECT course and found significant decreases in gray matter volume in multiple regions. Reduced IL-8 level was significantly related to decreased depressive symptoms, while decreased volume in the right insula and Brodmann's Area 22 was related to increased depressive symptoms over six months.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Emil F. Coccaro, Royce Lee, Elizabeth C. Breen, Michael R. Irwin
Summary: Growing evidence suggests that individuals with aggressive behavior have chronic, low-level inflammation indicated by elevated levels of acute phase reactant proteins and pro-inflammatory cytokines. While animal studies show that pro-inflammatory proteins in the brain increase aggression, there is no data on this relationship in humans. This study found that aggressive individuals with Intermittent Explosive Disorder (IED) have elevated plasma, but not cerebrospinal fluid, levels of proinflammatory markers, suggesting that proinflammatory proteins may influence brain-based behavior in a manner not reflected in lumbar cerebrospinal fluid.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Alejandro D. Meruelo, Matthew A. Timmins, Michael R. Irwin, Emil F. Coccaro
Summary: This study found that morning salivary cortisol levels were significantly lower in individuals with Intermittent Explosive Disorder (IED) compared with controls. Salivary cortisol levels were inversely correlated with trait anger, trait aggression, and plasma C-Reactive Protein (CRP), a marker of systemic inflammation. This suggests a complex interaction between chronic-low level inflammation, the hypothalamic-pituitary-adrenal (HPA) axis, and IED.
PSYCHONEUROENDOCRINOLOGY
(2023)
Article
Geriatrics & Gerontology
Judith E. Carroll, Richard Olmstead, Steve W. Cole, Elizabeth C. Breen, Jesusa M. Arevalo, Michael R. Irwin
Summary: Late life insomnia may increase the risk of biological aging. Treating insomnia with cognitive behavioral therapy (CBT-I) may reduce the expression of p16(INK4a), a marker of cellular senescence. This study found that CBT-I treatment reduced the increase in p16(INK4a) expression over 24 months, and sustained remission of insomnia led to a decrease in p16(INK4a) expression.
Article
Immunology
Michael R. Irwin, Chloe C. Boyle, Joshua H. Cho, Dominique Piber, Elizabeth C. Breen, Nina Sadeghi, Daisy Castillo, Michael Smith, Naomi I. Eisenberger, Richard Olmstead
Summary: Depression is a common disease in older adults, posing significant risks for morbidity and mortality. Due to the large population of older adults, the burden of late-life depression, and the limited effectiveness of current antidepressants, it is important to develop biologically plausible models that lead to selective depression prevention strategies. Insomnia is a predictor of depression recurrence and can be targeted to prevent depression in older adults. However, the mechanisms by which insomnia contributes to depression and the molecular targets for interventions are not yet understood.
BRAIN, BEHAVIOR, & IMMUNITY - HEALTH
(2023)
Review
Rheumatology
Michael R. Irwin, Rainer H. Straub, Michael T. Smith
Summary: Sleep has a homeostatic role in immune system regulation and can help control inflammation and pain sensitivity. In rheumatoid arthritis (RA) patients, sleep-wake activity dysregulation due to a misaligned inflammatory profile leads to excessive inflammation and increased pain sensitivity. Understanding these risk mechanisms may offer prevention and treatment opportunities for insomnia in RA, potentially improving pain and disease outcomes.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)