期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 43, 期 -, 页码 203-208出版社
ELSEVIER
DOI: 10.1016/j.etap.2016.03.014
关键词
Bisphenol A; Developmental exposure; Adrenal gland; Steroidogenesis
资金
- Canadian Institutes of Health Research [MOP-79484]
The present study sought to determine if prenatal exposure to bisphenol A (BPA) alters adrenal steroidogenesis in adult offspring. Pregnant mice were exposed to BPA (25 mg BPA/kg food pellet) via diet from day 7 to the end of pregnancy. At eight weeks of age, offsprings were sacrificed, blood samples and adrenal glands were collected for hormone assays and western blot analysis, respectively. We found that: (1) BPA increased adrenal gland weight in both males and females; (2) although BPA elevated plasma corticosterone levels in both sexes, it stimulated the expression of StAR and cyp11A1, the two rate-limiting factors in the steroidogenic pathway, only in female adrenal glands; and interestingly (3)BPA did not alter plasma ACTH levels or adrenal expression of the key steroidogenic transcription factor SF-1 in either sex. Taken together, the present study provides novel insights into the long-term consequences of developmental BPA exposure on adrenal steroidogenesis. (C) 2016 Elsevier B.V. All rights reserved.
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