Review
Pharmacology & Pharmacy
Toshio Kanno, Takahiro Nakajima, Keisuke Miyako, Yusuke Endo
Summary: Th17 cells play a crucial role in the pathogenesis of autoimmune disorders, and their differentiation is regulated by lipid metabolism and the activation of ROR?t. Inhibition of lipid biosynthesis suppresses Th17 cell differentiation. Manipulating cellular lipid metabolism provides a novel therapeutic approach for treating autoimmune disorders.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Biology
Tsan-Tzu Yang, Ming-Feng Chiang, Che-Chang Chang, Shii-Yi Yang, Shih-Wen Huang, Nan-Shih Liao, Hsiu-Ming Shih, Wei Hsu, Kuo- Lin
Summary: SENP2 is involved in regulating post-translational modification of Smad4 in Th17 cells and intestinal bowel diseases. Lack of Senp2 exacerbates the severity of experimental colitis and leads to elevated levels of pathogenic Th17 cells and dysbiosis of the intestinal microbiome. SENP2 enzymatic activity is important for deSUMOylation of Smad4 and regulates the pathogenicity of Th17 cells.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xuyan Tian, Lipeng Tang, Fengjiao Wei, Huanpeng Chen, Longxiang Sheng, Yuying Yang, Xiaoqing Zhou, Yongchao Li, Xiaoting Xu, Boyang Zhang, Zhonghua Liu, Yu Lei, Bolan Yu, Chuan Bai, Xixin He, Zhaofeng Huang
Summary: The study demonstrates the potent therapeutic effects of three pentacyclic triterpene compounds isolated from loquat leaves on psoriasis, alleviating skin inflammation, abnormal keratinocyte proliferation, and immune cell infiltration. These compounds show promising potential for drug development in treating psoriasis with better performance than steroids.
MOLECULAR IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ankitha Shetty, Santosh D. Bhosale, Subhash Kumar Tripathi, Tanja Buchacher, Rahul Biradar, Omid Rasool, Robert Moulder, Sanjeev Galande, Riitta Lahesmaa
Summary: Dysregulated function of Th17 cells is associated with immunodeficiencies and autoimmune disorders. FOSL1 and FOSL2 modulate the effector functions of Th17 cells, with new mechanistic links discovered through the first interactomes study in human Th17 cells.
Article
Immunology
Imke Lingel, Adrienne N. Wilburn, Julie Hargis, Jaclyn W. McAlees, Yves Laumonnier, Claire A. Chougnet, Hitesh Deshmukh, Peter Koenig, Ian P. Lewkowich, Inken Schmudde
Summary: Changes in microbiome contribute to severity of allergic asthma. Prenatal antibiotic-induced dysbiosis leads to long-term immunological effects in offspring and increases asthma severity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Riping Xiao, Kawai Lei, Hioha Kuok, Wende Deng, Yuxin Zhuang, Yanqing Tang, Zhengyang Guo, Hongyan Qin, Li-Ping Bai, Ting Li
Summary: Primary bile acids (BAs), byproducts of cholesterol metabolism, are closely associated with the pathogenesis of cholestatic liver diseases. In this study, a synthesized sulfated product of lithocholic acid (LCA) was found to selectively inhibit the differentiation of Th17 cells, without affecting other types of T cells. This finding provides clues for further exploration of the relationship between bile acid metabolites and T lymphocytes.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Dehui Chang, Hao Zhang, Jing Ge, Qi Xing, Xinyi Guo, Xiaohu Wang, Chen Dong
Summary: This study identifies CNS9 as an essential cis-regulatory element controlling the lineage stability and plasticity of ILC3s through modulating expression levels of ROR gamma t protein.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Manman Wang, Tiantian Su, Hanfei Sun, Huijuan Cheng, Chunru Jiang, Paipai Guo, Zhenduo Zhu, Ruhong Fang, Feng He, Mingli Ge, Qiuyun Guan, Wei Wei, Qingtong Wang
Summary: This study investigated the therapeutic effect and primary pharmacological mechanism of Ziyuglycoside I on collagen-induced arthritis mice. The results showed that Ziyuglycoside I effectively improved arthritis symptoms by inhibiting mTOR activation and regulating Th17/Treg balance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Xiancai Zhong, Hongmin Wu, Wencan Zhang, Yousang Gwack, Weirong Shang, Kyle O. Lee, Noah Isakov, Zhiheng He, Zuoming Sun
Summary: This research reveals that RORyt not only regulates the differentiation of TH17 cells, but also plays a role in their effector function. By mutating K256R, which prevents ubiquitination of RORyt, the distinct functions of RORyt in TH17 differentiation and effector function can be separated.
Article
Plant Sciences
Jian-Yu Chen, Xiao-Yun Tian, Shan-Shan Wei, Wen Xu, Rong-Rong Pan, Lin-Lin Chen, Lang-Dong Chen, Li-Hong Nan, Yao-Lin, Shan-Deng, Qian-Qian Wang, Xue-Qin Ma, Ming-Qing Huang
Summary: Magnolol, extracted from Magnolia officinalis, was identified as a potential treatment for multiple sclerosis (MS). It selectively inhibited Th17 differentiation and cytokine expression by blocking STAT3, leading to a decreased ratio of Th17/Treg cells and improvement in MS.
Article
Integrative & Complementary Medicine
Di Hua, Jie Yang, Qinghai Meng, Yuanyuan Ling, Qin Wei, Zhigang Wang, Qingyun Wei, Jiao Chen, Juan Ye, Xuan Han, Kelei Su, Weikang Kong, Chao Xu, Peng Cao, Chunping Hu
Summary: This study demonstrates that the Soufeng sanjie formula (SF) has anti-arthritic effects by reducing arthritis symptoms, inflammation levels, and restoring Th17/Treg cell balance in collagen-induced arthritis (CIA) mice.
Article
Immunology
Tao Wang, Wenjing Feng, Mengwei Ju, Huiyan Yu, Zhiting Guo, Xuejing Sun, Kexin Yang, Miao Liu, Rong Xiao
Summary: Our study found that there was an enhanced level of 27-OHC in the serum of individuals with mild cognitive impairment (MCI). The balance of Th17-related cytokines was altered, with increased levels of IL-17A, IL-12p70, IL-23, GM-CSF, MIP-3 alpha, and TNF-alpha, but decreased levels of IL-13, IL-28A, and TGF-beta 1. Further experiments showed that 27-OHC induced higher immunogenicity, leading to an increase in Th17 cells and a decrease in Treg cells. The amyloidosis was aggravated, cognitive deficits occurred, and the learning and memory performance were worsened in mice treated with 27-OHC. However, by inhibiting ROR gamma t in 27-OHC-loaded mice, the balance of Th17/Treg cells was restored, the amyloidosis was decreased, and the learning and memory decline was improved.
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Immunology
Wen-Hui Qi, Yan-Yan Zhang, Kun Xing, Dong-Xia Hao, Fei Zhang, Rui-Ning Wang, Ming-Yue Bao, Meng-Yuan Tian, Ya-Na Yang, Xing Li, Yuan Zhang
Summary: Using structure-based virtual screening, this study identified a compound called DDC, which is abundant in plants and food, as a potential immunomodulator. DDC inhibits the activity of ROR gamma t, a transcription factor involved in Th17 cell differentiation, thus regulating Th17/Treg balance and showing promise in the treatment of inflammatory diseases like multiple sclerosis, inflammatory bowel disease, and organ transplant rejection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Li Xia, Enming Tian, Mingcheng Yu, Chenglong Liu, Lian Shen, Yafei Huang, Zhongen Wu, Jinlong Tian, Ker Yu, Yonghui Wang, Qiong Xie, Di Zhu
Summary: The study designed a RORγt agonist that enhances the antitumor immune response of PD-1. The agonist increased the migration of CD8(+) T cells and MoDCs in tumors, thereby promoting tumor infiltration. This study provides insights into the mechanism of RORγt agonists in immunotherapy and offers a strategy to improve the efficacy of PD-1 antibodies in cancer treatment.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Ophthalmology
Weijie Ouyang, Yang Wu, Xiang Lin, Shoubi Wang, Yiran Yang, Liying Tang, Zhaolin Liu, Jieli Wu, Caihong Huang, Yueping Zhou, Xiaobo Zhang, Jiaoyue Hu, Zuguo Liu
Summary: Topical application of BAC in C57BL/6 mice induced an increase in CD4(+)CD69(+), CD4(+)IFN-gamma(+), and CD4(+)IL-17(+) cells, leading to corneal barrier dysfunction, goblet cell loss, and decreased tear production. Adoptive transfer of CD4(+) T cells from BAC-treated mice into nude mice resulted in ocular surface manifestations similar to direct topical BAC treatment, suggesting a role of CD4(+) T cells in BAC-induced ocular surface disorder.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Rheumatology
Xiaoxiao Cheng, Meichen Zhou, Jianhua Jiang, Sijia Zhu, Qi Fang, Meirong Liu
Summary: This study aimed to explore the difference in thigh MRI findings between DM patients with and without cancer. It found that honeycomb pattern edema signals in quadriceps but not adductors were more frequently found in cancer-associated DM patients.
CLINICAL RHEUMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Peng Jin, Jinrong Liu, Liujun Xu, Jun Wang, Xiaoping Ouyang, Jian-Hua Jiang, Jiping Huang
Summary: Thermal metamaterials provide rich control of heat transport by breaking the Onsager reciprocity and introducing thermal convection, leading to a regime beyond effective heat conduction. A continuous switch from thermal cloaking to thermal concentration is demonstrated in a liquid-solid hybrid thermal metamaterial with external tuning. This switch is achieved by tuning the liquid flow, resulting in a topology transition in the virtual space of the thermotic transformation. These findings illustrate the extraordinary heat transport in complex multicomponent thermal metamaterials and pave the way toward an unprecedented regime of heat manipulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Sijia Zhu, Dongxue Ding, Jianhua Jiang, Meirong Liu, Liqiang Yu, Qi Fang
Summary: The study reported a 21-year-old Chinese man with late-onset glutaric aciduria type II (GA II) who presented with muscle weakness, vomiting, and severe pain. Muscle biopsy revealed lipid storage myopathy, and urine organic acid analyses showed an increase in glycolic acid, consistent with GA II. Whole-exome sequencing identified two novel compound heterozygous missense mutations in the ETFDH gene, expanding the list of mutations associated with GA II. Considering the treatability of this disease, GA II should be considered in patients with muscular symptoms and acute metabolism decompensation.
FRONTIERS IN NEUROLOGY
(2023)
Article
Plant Sciences
Xiaojing Dang, Chunyu Jing, Mengyuan Zhang, Xinru Li, Qing Xu, Changmin Hu, Yulong Li, Ying Zhang, Dezheng Wang, Delin Hong, Jianhua Jiang
Summary: We investigated the phenotypic values of panicle elongation length (PEL) in 353 rice accessions across six environments. We identified and validated three significant quantitative trait loci (QTL) associated with PEL, namely qPEL4, qPEL6, and qPEL9, of which qPEL9 is a novel QTL. The allele PEL9(GG) was found to increase the PEL and outcrossing rate in the female parents of hybrid rice, with its frequency gradually increasing with latitude in the Northern Hemisphere. These findings will help improve the PEL of female parents in hybrid rice.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Physics, Applied
Shi-Qiao Wu, Zhi-Kang Lin, Zhan Xiong, Bin Jiang, Jian-Hua Jiang
Summary: In this study, square-root higher-order topological insulator phases were discovered in an acoustic metamaterial with a decorated rectangular lattice. The boundary-dependent topological edge and corner states in both the parent and square-root acoustic metamaterials were explored using acoustic pump-probe techniques. Various simulations were used to validate their higher-order topologies and spectral connections. This work not only confirms the existence of square-root higher-order topology in rectangular lattice systems experimentally but also paves the way for versatile higher-order topological phenomena in photonic, acoustic, and mechanical metamaterials.
PHYSICAL REVIEW APPLIED
(2023)
Article
Clinical Neurology
Lulu Zhang, Shan Wang, Lanfeng Qiu, Juean Jiang, Jianhua Jiang, Yun Zhou, Dongxue Ding, Qi Fang
Summary: This study aimed to investigate the effects of SBI on intracranial HT and clinical outcomes after IVT in patients with AIS. The results showed that SBI had no significant impact on the incidence of HT and favorable clinical outcomes at 3 months. However, SBI remained an independent risk factor for non-excellent functional outcomes at 3 months.
FRONTIERS IN NEUROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Wei Li, Shaoyuan Zhou, Xiaolu Xia, Ying Wang, Kaixuan Yang, Tong Hao, XinYue Zhang, Qi Yang, Zhenyu Ni, Jianhua Jiang, Jia Si, Fujun Zhang, Zhiyong Zhang
Summary: Controllable negative photoconductance (NPC) detectors based on organic-gated carbon nanotube field-effect transistors (OG-CNT FETs) are reported, with the strong influence of light-induced electrostatic doping on the nonconventional photoresponse demonstrated. The optimized OG-CNT FETs exhibit high responsivity of 72.6 A W-1 at 880 nm, along with improved response/recovery times of 7 and 5 ms. Reversible switching between NPC and positive photoconductance (PPC) is observed under the same light illumination, offering a new approach for achieving bidirectional photoresponses and paving the way for multifunctional optoelectronic systems.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Energy & Fuels
Jianhua Jiang, Bo Ming, Qiang Huang, Yi Guo, Jia'nan Shang, Jakub Jurasz, Pan Liu
Summary: This study proposes a comprehensive evaluation framework that optimizes the configuration of hybrid generation systems (HGSs) by integrating renewable power plants with existing hydropower stations. The framework combines long-term and short-term operation models with a techno-economic analysis to simulate and evaluate the HGSs' performance over their lifespan and determine the cost-effective size of the renewable power plant.
Article
Thermodynamics
Hongchuan Qin, Zhe Cheng, Bingtao Zhang, Renjie Zhou, Yaowen Yu, Xi Li, Shiping Wen, Jian Li, Jianhua Jiang
Summary: Solid oxide fuel cell (SOFC) is a promising power generation technology with high efficiency, low emission, and fuel adaptability. The performance of a multi-stack SOFC system depends on the stack module configuration and it is crucial to explore its influence on system performance and thermal safety. This study investigates and optimizes the thermoelectrical performance of multi-stack SOFC systems and obtains design principles and optimal stack topology.
ENERGY CONVERSION AND MANAGEMENT
(2023)
Article
Agronomy
Ying Zhang, Jianhua Jiang, Xiaojing Dang, Dezheng Wang
Summary: This study developed a high-yielding two-line restorer line R998 with high blast resistance, good grain quality, and high combining ability. By establishing a library of dominant genic male sterile lines, six restorer lines resistant to rice blast were developed. In addition, nine medium indica rice varieties were bred using R998 and its six derived restorer lines. This study provides an idea for group breeding using dominant genic male sterile polymerized favorable genes.
Article
Transportation Science & Technology
Yangang Ren, Guojian Zhan, Liye Tang, Shengbo Eben Li, Jianhua Jiang, Keqiang Li, Jingliang Duan
Summary: This paper proposes an adversarial learning paradigm to enhance the intelligence and robustness of driving policy for signalized intersections with dense traffic flow. It introduces a static path planner to generate trackable candidate paths for different intersection topologies and builds a constrained optimal control problem considering the uncertainty of the driving environment. Adversarial policy gradient is used to solve the problem by introducing disturbances while the driving policy learns to handle the situation through competition. Simulation results show that the trained policy can handle signal lights flexibly and achieve smooth and efficient passing with a humanoid paradigm, while APG greatly improves the resistance to abnormal behaviors, ensuring a high level of safety for autonomous vehicles.
TRANSPORTATION RESEARCH PART C-EMERGING TECHNOLOGIES
(2023)
Article
Multidisciplinary Sciences
Yanan Wang, Hai-Xiao Wang, Li Liang, Weiwei Zhu, Longzhen Fan, Zhi-Kang Lin, Feifei Li, Xiao Zhang, Pi-Gang Luan, Yin Poo, Jian-Hua Jiang, Guang-Yu Guo
Summary: The authors report the discovery of hybrid topological photonic crystals that simultaneously host quantum anomalous Hall and valley Hall phases in different photonic band gaps. They experimentally realize the hybrid topological photonic crystal and verify its unconventional dual-band gap topological edge states. The dual-band photonic topological edge channels can function as frequency-multiplexing devices, serving as both beam splitters and combiners.
NATURE COMMUNICATIONS
(2023)
Article
Mathematics
Chunguang Bi, Qiaoyun Tian, He Chen, Xianqiu Meng, Huan Wang, Wei Liu, Jianhua Jiang
Summary: This paper proposes an enhanced gray wolf optimization algorithm (EGWO) to address the issues of nonlinear data processing difficulties, high error rates due to local stagnation, and low classification rates caused by premature convergence. The EGWO is tested on benchmark functions and compared with other algorithms, and it is also applied to optimize a multi-layer perceptron (MLP) for disease identification.
Article
Materials Science, Multidisciplinary
Jincheng Lu, Zi Wang, Rongqian Wang, Jiebin Peng, Chen Wang, Jian-Hua Jiang
Summary: Including the phonon-assisted inelastic process can enhance the performance of thermoelectric devices. In this work, we demonstrate that inelastic phonon-thermoelectric devices have a fertile functionality diagram and can perform multiple tasks simultaneously. By studying the efficiencies and coefficients of performance of multitask quantum thermal machines, we emphasize the roles of the inelastic scattering process and multiple biases. Our work provides insights into optimizing phonon-thermoelectric devices.
Article
Astronomy & Astrophysics
Jian-Hua Jiang
Summary: This study proposes an approach to apply the polarization degree of freedom in a 2D photonic crystal, which has potential practical applications in photonic devices.
SCIENTIA SINICA-PHYSICA MECHANICA & ASTRONOMICA
(2023)
