期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 45, 期 -, 页码 45-51出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2016.05.013
关键词
Dibutyl phthalate (DBP); Anxiety-like behavior; Oxidative stress (OS); Mangiferin (MAG); Mice
资金
- Science and Technology Research Foundation from Hubei province Education Department [Q20152801]
- Scientific Research Foundation for the PhD Start-up of Hubei University of Science and Technology [BK1412]
Among all phthalate esters, dibutyl phthalate (DBP) is only second to di-(2-ethylhexyl) phthalate (DEHP) in terms of adverse health outcomes, and its potential cerebral neurotoxicity has raised concern in recent years. DBP exposure has been reported to be responsible for neurobehavioral effects and related neurological diseases. In this study, we found that neurobehavioral changes induced by DBP may be mediated by oxidative damage in the mouse brain, and that the co-administration of Mangiferin (MAG, 50 mg/kg/day) may protect the brain against oxidative damage caused by DBP exposure. The results of ethological analysis (elevated plus maze test and open-field test), histopathological examination of the brain, and assessments of oxidative stress (OS) in the mouse brain showed that there is a link between oxidative stress and anxiety-like behavior produced by DBP at higher doses (25 or 125 mg/kg/day). Biomarkers of oxidative stress encompass reactive oxygen species (ROS), glutathione (GSH), malondialdehyde (MDA) and DPC coefficients (DPC). MAG (50 mg/kgiday),administered as an antioxidant,can attenuatetheanxiety-like behavior of the tested mice. (c) 2016 Elsevier By. All rights reserved.
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