Review
Medicine, Research & Experimental
Prankur Awasthi, Manish Dwivedi, Dhruv Kumar, Saba Hasan
Summary: Epstein-Barr Virus (EBV) infection is associated with various lymphomas, carcinomas, and disorders. The carcinogenic potential of EBV is related to latent membrane protein 1 (LMP1), which plays an essential role in the transformation of fibroblasts and primary lymphocytes. LMP1, a constitutively active transmembrane protein of the tumour necrosis factor receptor (TNFR) superfamily, interferes with and influences numerous host cellular activities and functions, contributing to the pathogenesis of EBV-associated malignancies.
Article
Biochemistry & Molecular Biology
Satoru Kondo, Atsushi Okabe, Takuya Nakagawa, Keisuke Matsusaka, Masaki Fukuyo, Bahityar Rahmutulla, Hirotomo Dochi, Harue Mizokami, Yuki Kitagawa, Tomoya Kurokawa, Masato Mima, Kazuhira Endo, Hisashi Sugimoto, Naohiro Wakisaka, Kiyoshi Misawa, Tomokazu Yoshizaki, Atsushi Kaneda
Summary: Nasopharyngeal carcinoma is a malignancy associated with Epstein-Barr virus and epigenetic abnormalities play important roles in its development. The latent membrane protein 1 (LMP1) is a key factor in inducing aberrant DNA methylation of tumour suppressor genes. This study identified LMP1-inducible methylation genes and demonstrated that DERL3 repression by DNA methylation contributes to the progression of nasopharyngeal carcinoma. The findings suggest potential targets for therapeutic intervention.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Hui-Chen Lin, Yao Chang, Ruo-Yu Chen, Liang-Yi Hung, Paul Chih-Hsueh Chen, Ya-Ping Chen, L. Jeffrey Medeiros, Po-Min Chiang, Kung-Chao Chang
Summary: The study found that EBV-LMP1 enhances autophagy and promotes the viability of HL cells, suggesting that autophagic inhibition may be a potential therapeutic strategy for treating patients with HL, especially EBV-positive cases.
Review
Oncology
Angela Kwok-Fung Lo, Christopher W. Dawson, Hong Lok Lung, Ka-Leung Wong, Lawrence S. Young
Summary: LMP1, as a critical protein in EBV infection, plays an important role in the development of NPC by activating multiple pathways. Targeting LMP1 protein for treatments may be a novel therapeutic strategy for EBV-driven malignancies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Analytical
Han-Yun Hsieh, Jia-Xian Luo, Yi-Hong Shen, Shu-Cheng Lo, Yi-Chiung Hsu, Hidetoshi Tahara, Yu-Jui Fan, Pei-Kuen Wei, Horn-Jiunn Sheen
Summary: This study developed a rapid and highly sensitive EBV screening method using a nanofluidic preconcentrator integrated with a nanoslit Fano resonance biosensor to detect latent membrane protein 1 (LMP1) for EBV diagnosis. Through nanoimprinting and aluminum deposition, a low-cost nanoslit plasmonic sensing chip was mass-produced, achieving a limit of detection of 100 pg/ml and a sensing range of 100 pg/ml to 10 μg/ml.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Immunology
Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
Summary: Chronic active Epstein-Barr virus (CAEBV) disease is a high-mortality disease characterized by persistent infectious mononucleosis-like symptoms. This study analyzed the outcomes of PD-1 inhibitors treatment for CAEBV patients and found that the treatment had a high response rate and tolerable toxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Medicinal
Bo Zhang, Yibo Wang, Cong Lin, Hongyuan Li, Xiaojie Wang, Yinghua Peng, Konstatin S. Mineev, Andrew J. Wilson, Hongshuang Wang, Xiaohui Wang
Summary: This study disrupted the interactions of TMD-5 of LMP-1 from EBV with pentamidine derivatives to inhibit EBV infection. It suggests that the interaction of small molecules with lipids should be considered in addition to the protein target when designing small molecules targeting transmembrane PPIs.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Microbiology
Jun Li, Yan Zhang, Lingling Sun, Song Liu, Menghe Zhao, Bing Luo
Summary: This study found that EBV induces the overexpression of p53 protein in EBVaGC and NPC cells through the H19/miR-675-5p axis, leading to cell proliferation and apoptosis inhibition.
MICROBIOLOGY SPECTRUM
(2022)
Article
Virology
Antonio Santisteban-Espejo, Jose Perez-Requena, Lidia Atienza-Cuevas, Julia Moran-Sanchez, Maria del Carmen Fernandez-Valle, Irene Bernal-Florindo, Raquel Romero-Garcia, Marcial Garcia-Rojo
Summary: The study evaluated the impact of EBV-LMP1 expression on the survival of cHL patients. The prognostic role of EBV in cHL may be influenced by various factors, emphasizing the importance of early identification of prognostic biomarkers for guiding personalized therapeutic decisions.
Article
Oncology
Wing Chung Tang, Sai Wah Tsao, Gareth E. Jones, Xiong Liu, Ming Han Tsai, Henri-Jacques Delecluse, Wei Dai, Chanping You, Jun Zhang, Shaina Chor Mei Huang, Manton Man-hon Leung, Tengfei Liu, Yick Pang Ching, Honglin Chen, Kwok Wai Lo, Xin Li, Chi Man Tsang
Summary: This study reveals the interaction between TNF alpha released by macrophages and EBV-encoded LMP1 in driving the mobilization of invadopodia in EBV-associated nasopharyngeal carcinoma (NPC). The mobilizing invadopodia exhibit lateral movements and enhanced degradative power, transforming from dot-like digestion patterns to dendrite-like patterns. EBV infection sensitizes NPC cells to form mobilizing invadopodia in a TNF alpha-rich tumor microenvironment.
JOURNAL OF PATHOLOGY
(2023)
Article
Virology
Hai-Yu Wang, Lingling Sun, Ping Li, Wen Liu, Zhong-Guang Zhang, Bing Luo
Summary: The distribution of EBV 1/2, F/f, EBER, and LMP1 subtypes in leukemia and MDS in Northern China is similar to that in the general population, suggesting regional specificity rather than association with the pathogenesis of these diseases.
Article
Oncology
Fenggang Yu, Nicholas L. Syn, Yanan Lu, Qing Yun Chong, Junyun Lai, Wei Jian Tan, Boon Cher Goh, Paul A. MacAry, Lingzhi Wang, Kwok Seng Loh
Summary: The Asia Pacific EBV strain Yu103 exhibits a unique capacity to infect and transform both B-lymphocytes and nasopharyngeal epithelial cells, lying midway along the spectrum of EBV strains known to drive lymphomagenesis or carcinogenesis. This EBV isolate is currently the only one shown to drive human nasopharyngeal carcinoma and B-lymphoma, making it a powerful novel platform for research on EBV-driven hematological and epithelial malignancies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Chemistry, Physical
Mengran Guo, Xing Duan, Xingchen Peng, Zhaohui Jin, Hai Huang, Wen Xiao, Qian Zheng, Yongqi Deng, Na Fan, Kepan Chen, Xiangrong Song
Summary: In this study, a lipid-based LMP2-mRNA vaccine was developed and shown to effectively express LMP2 and stimulate antigen-specific T-cell responses in cell assays. It significantly inhibited tumor growth in an LMP2-expressing tumor model after three doses of vaccination.
Article
Microbiology
Hiroyuki Kanno, Tomohiro Osada, Ayako Tateishi
Summary: Chronic active Epstein-Barr virus (EBV) infection (CAEBV) is characterized by chronic or recurrent infectious mononucleosis-like symptoms and is associated with EBV-associated T/natural killer (NK)-cell lymphoproliferative disorders. This study aimed to identify the EBV genes responsible for these diseases and established a gene expression system using plasmid coding sequences of EBV-encoded small RNAs and latent membrane protein 1. The results showed that the currently obtained transformants may be useful for the analyses of the pathophysiology of CAEBV and EBV-positive T/NK-cell lymphoproliferative disorders.
Article
Pharmacology & Pharmacy
Ching-Yi Yiu, Yu-Jhe Chiu, Tsuey-Pin Lin
Summary: The Polygonum cuspidatum ethyl acetate subfraction containing emodin showed a cytotoxic effect on EBV-positive Raji cells, potentially reducing virus gene expression and increasing apoptosis-related protein activity. This suggests that it could be a potential therapeutic drug for EBV-related tumors.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)