Article
Cardiac & Cardiovascular Systems
Daisuke Nakajima, Satona Tanaka, Tadashi Ikeda, Shiro Baba, Hidefumi Hiramatsu, Takenori Suga, Akihiro Ohsumi, Hiroshi Date
Summary: This study evaluated the outcome of living-donor segmental lung transplantation in pediatric patients. The results showed that the procedure was technically difficult but feasible, with acceptable outcomes. The transplantation was successful in most cases, with only a few complications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Hidenao Kayawake, Satona Tanaka, Yoshito Yamada, Shiro Baba, Hideyuki Kinoshita, Kazuhiro Yamazaki, Tadashi Ikeda, Kenji Minatoya, Yojiro Yutaka, Masatsugu Hamaji, Akihiro Ohsumi, Daisuke Nakajima, Hiroshi Date
Summary: This study compared the preoperative conditions and postoperative outcomes of living-donor lobar lung transplantation (LDLLT) and cadaveric lung transplantation (CLT) in patients with pulmonary hypertension (PH). Despite LDLLT patients having worse preoperative conditions and smaller grafts, LDLLT demonstrated similar perioperative outcomes and prognoses as CLT.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Katsutaka Mineura, Toyofumi F. Chen-Yoshikawa, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Daisuke Nakajima, Akihiro Ohsumi, Masatsugu Hamaji, Toshi Menju, Hiroshi Date
Summary: Native lung complications (NLCs) after native lung-sparing LDLLT had favorable outcomes, and NLCs may occur significantly later in LDLLT recipients than in CLT recipients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cardiac & Cardiovascular Systems
Seiichiro Sugimoto, Hiroshi Date, Kentaroh Miyoshi, Shinji Otani, Megumi Ishihara, Masaomi Yamane, Shinichi Toyooka
Summary: Although LDLLT only involves the implantation of 2 lobes, it provides encouraging long-term outcomes with a high long-term survival rate.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Review
Respiratory System
Usuke Nakajima, Hiroshi Date
Summary: LDLLT is a vital option for patients with severe respiratory disorders, developed to address the shortage of brain-dead donor organs. Precise size matching before surgery can lead to better post-transplant outcomes, with low risk to living donors. Various transplant procedures, such as native upper lobe sparing and single-lobe transplantation, have been developed in LDLLT to address issues of graft size mismatching and have shown favorable results.
JOURNAL OF THORACIC DISEASE
(2021)
Article
Multidisciplinary Sciences
Jesus Garcia-Castillo, Francisca Alcaraz-Perez, Elena Martinez-Balsalobre, Diana Garcia-Moreno, Marlies P. Rossmann, Miriam Fernandez-Lajarin, Manuel Bernabe-Garcia, Ana B. Perez-Oliva, Virginia C. Rodriguez-Cortez, Clara Bueno, Isaac Adatto, Suneet Agarwal, Pablo Menendez, Leonard Zon, Victoriano Mulero, Maria L. Cayuela
Summary: Dyskeratosis congenita (DC) is a rare genetic syndrome caused by mutations in telomerase or telomeric proteins. Research shows that zebrafish terc plays a crucial role in regulating the expression of master myeloid genes, while mutations found in DC patients affect this process.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Ji Hoon Han, Gavin Ryan, Alyson Guy, Lu Liu, Mathieu Quinodoz, Ingrid Helbling, Joey E. Lai-Cheong, Julian Barwell, Marc Folcher, John A. McGrath, Celia Moss, Carlo Rivolta
Summary: The study identified LIPHAK as a previously unrecognized ribosomopathy, where variants in the LTV1 gene result in abnormal splicing and premature termination of the protein it encodes.
HUMAN MOLECULAR GENETICS
(2022)
Article
Surgery
Hillary J. Braun, Ana Marie Torres, Finesse Louie, Sandy Weinberg, Sang-Mo Kang, Nancy L. Ascher, John P. Roberts
Summary: Living donor liver transplantation (LDLT) is more common in Asia than in North America, where living donor kidney transplantation, including paired exchanges for ABO-incompatible pairs, is prevalent. The first liver paired exchange (LPE) in the United States, completed over two consecutive days, was initiated by a non-directed donor and benefited an ABO-incompatible pair. This innovative approach demonstrates the feasibility of LPE in centers with experience in LDLT, offering new possibilities for transplantation in cases of ABO incompatibility.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Article
Medicine, General & Internal
Seoung Hoon Kim, Jang Ho Park, Byoung Ho An
Summary: This study introduces how to perform LDLT with minimal manpower and evaluates the outcomes in adult patients. It shows that under the supervision of a single expert surgeon, a team of minimal manpower can successfully perform all the main surgical procedures without compromising the results.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Fumiaki Gochi, Toyofumi Fengshi Chen-Yoshikawa, Hidenao Kayawake, Akihiro Ohsumi, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Daisuke Nakajima, Masatsugu Hamaji, Kimiko Yurugi, Rie Hishida, Hiroshi Date
Summary: The occurrence of dnDSAs was significantly lower and later in LDLLT compared to CLT. dnDSA positivity was significantly associated with worse OS and CLAD-free survival after CLT but not after LDLLT.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Chunhong Cui, Yi Liu, Dennis Gerloff, Christian Rohde, Cornelius Pauli, Marcel Koehn, Danny Misiak, Thomas Oellerich, Schraga Schwartz, Lars-Henning Schmidt, Rainer Wiewrodt, Alessandro Marra, Ludger Hillejan, Frank Bartel, Claudia Wickenhauser, Stefan Huettelmaier, Stefanie Goellner, Fengbiao Zhou, Bayram Edemir, Carsten Mueller-Tidow
Summary: This study reveals the oncogenic role of H/ACA box snoRNPs in NSCLC, suggesting them as potential new biomarkers and therapeutic targets for the disease.
Article
Surgery
Zhihao Li, Ashwin Rammohan, Vasanthakumar Gunasekaran, Suyoung Hong, Itsuko Chih-Yi Chen, Jongman Kim, Kris Ann Hervera Marquez, Shih Chao Hsu, Elvan Onur Kirimker, Nobuhisa Akamatsu, Oren Shaked, Michele Finotti, Marcus Yeow, Lara Genedy, Philipp Dutkowski, Silvio Nadalin, Markus U. Boehnert, Wojciech G. Polak, Glenn K. Bonney, Abhishek Mathur, Benjamin Samstein, Jean C. Emond, Giuliano Testa, Kim M. Olthoff, Charles B. Rosen, Julie K. Heimbach, Timucin Taner, Tiffany CL. Wong, Chung-Mau Lo, Kiyoshi Hasegawa, Deniz Balci, Mark Cattral, Gonzalo Sapisochin, Nazia Selzner, Long Bin Jeng, Dieter Broering, Jae-Won Joh, Chao-Long Chen, Kyung-Suh Suk, Mohamed Rela, Pierre-Alain Clavien
Summary: This study aims to establish benchmark values for adult-to-adult living-donor liver transplantation (LDLT). By analyzing data from 15 high-volume centers, it was found that benchmark LDLT can reduce waitlist mortality, with Asian centers outperforming others and non-benchmark low-volume centers displaying inferior outcomes.
Article
Genetics & Heredity
Michele Callea, Diego Martinelli, Francisco Cammarata-Scalisi, Chiara Grimaldi, Houweyda Jilani, Piercesare Grimaldi, Colin Eric Willoughby, Antonino Morabito
Summary: Dyskeratosis congenita is a genetic syndrome with diverse clinical manifestations, including bone marrow failure and tumors. This review discusses the clinical characteristics, molecular genetics, disease progression, treatment options, and differential diagnosis of the disease, providing personalized medical assessment and family genetic counseling.
Article
Biochemistry & Molecular Biology
Daniela Maiello, Marianna Varone, Rosario Vicidomini, Valentina Belli, Marina De Rosa, Paola Dama, Maria Furia, Mimmo Turano
Summary: In this paper, the authors investigate the effects of dyskerin depletion on cellular physiology and reveal that dyskerin depletion induces the accumulation of unfolded/misfolded proteins in the endoplasmic reticulum and activates the PERK branch of the unfolded protein response. They also demonstrate that dyskerin downregulation triggers a functional autophagic flux through the inhibition of the PI3K/AKT/mTOR pathway.
Editorial Material
Cardiac & Cardiovascular Systems
Kazuhiro Yamazaki, Kenji Minatoya, Motoyuki Kumagai, Tomohiro Handa, Akihiro Ohsumi, Masako Torishima, Hidenori Kawasaki
ANNALS OF THORACIC SURGERY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Akihiro Ohsumi, Jumpei Takamatsu, Itsuki Yuasa, Satona Tanaka, Yojiro Yutaka, Masatsugu Hamaji, Daisuke Nakajima, Kazuhiro Yamazaki, Miki Nagao, Hiroshi Date
Summary: This report describes a case of COVID-19-associated respiratory failure that was successfully treated with urgent living-donor lobar lung transplantation. The patient's respiratory function improved after ECMO support and LDLLTx surgery. LDLLTx is a viable option for patients with endstage respiratory failure following COVID-19.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cell Biology
Naoya Ikegami, Naoki Nakajima, Akihiko Yoshizawa, Tomohiro Handa, Toyofumi Chen-Yoshikawa, Takeshi Kubo, Kiminobu Tanizawa, Akihiro Ohsumi, Yoshito Yamada, Masatsugu Hamaji, Daisuke Nakajima, Yojiro Yutaka, Satona Tanaka, Kizuku Watanabe, Yoshinari Nakatsuka, Yuko Murase, Tomoko Nakanishi, Takafumi Niwamoto, Kazuo Chin, Hiroshi Date, Toyohiro Hirai
Summary: This study evaluated the pathological findings associated with radiological PPFE-like lesions and the clinical and morphological features of patients with pathological PPFE. The results showed that pathological PPFE was related to previous pneumothorax, volume loss in the upper lobes, and a flattened chest. Patients with idiopathic disease and those with secondary disease with pathological PPFE had similar clinical, radiological, and pathological findings. However, fibroblastic foci were more common in idiopathic cases and alveolar septal thickening with elastosis or fibrosis were more common in secondary cases. The post-transplantation survival of patients with pathological PPFE was similar to those with idiopathic pulmonary fibrosis (IPF).
Article
Surgery
Misa Noguchi, Toshi Menju, Naoki Nakajima, Akihiko Yoshizawa, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Hironori Haga, Hiroshi Date
Summary: This study reviewed the clinicopathological characteristics and PD-L1 expression in 46 patients with pulmonary pleomorphic carcinoma, and found that high PD-L1 expression in the carcinomatous components was significantly associated with a poor prognosis after surgery.
Article
Cardiac & Cardiovascular Systems
Daisuke Nakajima, Shunichi Nagata, Hidenao Kayawake, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Akihiro Ohsumi, Masatsugu Hamaji, Toyofumi F. Chen-Yoshikawa, Hiroshi Date
Summary: This article reports successful cases of lung transplantation using ex vivo lung perfusion (EVLP) to evaluate the function of injured donor lungs. After being declined by other transplant centers, the lungs were offered to patients at the authors' hospital. The outcomes of the two cases suggest that EVLP may expand the pool of acceptable donor lungs for transplantation.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Akihiro Ohsumi, Akihiro Aoyama, Hideyuki Kinoshita, Tomoya Yoneda, Kazuhiro Yamazaki, Satona Tanaka, Daisuke Nakajima, Tadashi Ikeda, Kenji Minatoya, Hiroshi Date
Summary: Tapering pretransplant use of epoprostenol may improve perioperative outcomes for patients with severe pulmonary hypertension undergoing lung transplantation, reducing the occurrence of primary graft dysfunction and shortening mechanical ventilation duration.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Misa Noguchi, Toyofumi F. Chen-Yoshikawa, Yasuyuki Arai, Tadakazu Kondo, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Junko Takita, Akifumi Takaori-Kondo, Hiroshi Date
Summary: This study aimed to reassess the indication of lung transplantation for pulmonary complications after HSCT, and found that indications based on estimated recurrence rates and recipients' anti-A/B antibody profiles may increase the use of LT for patients after HSCT.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Daisuke Nakajima, Satona Tanaka, Tadashi Ikeda, Shiro Baba, Hidefumi Hiramatsu, Takenori Suga, Akihiro Ohsumi, Hiroshi Date
Summary: This study evaluated the outcome of living-donor segmental lung transplantation in pediatric patients. The results showed that the procedure was technically difficult but feasible, with acceptable outcomes. The transplantation was successful in most cases, with only a few complications.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Shunichi Nagata, Akihiro Ohsumi, Tomohiro Handa, Yoshito Yamada, Satona Tanaka, Yojiro Yutaka, Daisuke Nakajima, Kiminobu Tanizawa, Toyohiro Hirai, Hiroshi Date
Summary: By analyzing registered lung transplant patients, the study found that a decline of more than 10% in lung function within 6 months and a 6-minute walking distance of less than 250m were associated with a worse prognosis (death or living-donor lobar LT). The ISHLT criteria could appropriately identify ILD patients with potentially poor prognosis.
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Keiji Yamanashi, Akihiro Ohsumi, Hiromi Oda, Satona Tanaka, Yoshito Yamada, Daisuke Nakajima, Hiroshi Date
Summary: The objective of this study was to investigate the depletion of mononuclear phagocytes and the attenuation of ischemia-reperfusion injury by clodronate-liposome during ex vivo lung perfusion. The experiments determined the number of mononuclear phagocytes in flushed grafts using flow cytometry and administered clodronate-liposome into the perfusate during ex vivo lung perfusion. The results showed a significant reduction in the number of mononuclear phagocytes in the clodronate group, improved lung function, and reduced lung injury.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Yasufumi Goda, Daisuke Nakajima, Satona Tanaka, Yoshito Yamada, Yojiro Yutaka, Kohei Unagami, Mikiko Yoshikawa, Hiroto Egawa, Hiroshi Date
Summary: The antibody response to the SARS-CoV-2 mRNA vaccine was poor in lung transplant recipients, and the vaccination was associated with the development of adverse events such as chronic lung allograft dysfunction (CLAD) or antibody-mediated rejection (AMR).
GENERAL THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Cardiac & Cardiovascular Systems
Satona Tanaka, Daisuke Nakajima, Ryo Sakamoto, Tsuyoshi Oguma, Atsushi Kawaguchi, Akihiro Ohsumi, Keiji Ohata, Satoshi Ueda, Hiroya Yamagishi, Hidenao Kayawake, Yojiro Yutaka, Yoshito Yamada, Masatsugu Hamaji, Satoshi Hamada, Kiminobu Tanizawa, Tomohiro Handa, Takenori Suga, Shiro Baba, Hidefumi Hiramatsu, Tadashi Ikeda, Hiroshi Date
Summary: This study retrospectively analyzed the clinical data of 25 living-donor lung transplantations performed in 24 pediatric recipients aged <= 17 years, evaluating the outcomes of pediatric living-donor lobar lung transplantation (LDLLT) and post-transplant graft growth. The study shows that pediatric LDLLT offers satisfactory long-term survival, with mature adult lobes transplanted into growing children.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Pharmacology & Pharmacy
Ayumi Tsuzawa, Yoshiki Katada, Keisuke Umemura, Mitsuhiro Sugimoto, Asami Nishikawa, Yu-ki Sato, Yuko Yoshida, Noriaki Kitada, Atsushi Yonezawa, Daisuke Nakajima, Hiroshi Date, Tomohiro Terada
Summary: This article discusses a case of a lung transplant patient with COVID-19 who experienced prolonged inhibitory effects of itraconazole on CYP3A during treatment with nirmatrelvir/ritonavir, leading to increased tacrolimus levels. This highlights the importance of drug-drug interaction management for patients on multiple medications.
JOURNAL OF PHARMACEUTICAL HEALTH CARE AND SCIENCES
(2023)
Article
Cardiac & Cardiovascular Systems
Yojiro Yutaka, Toshihiko Sato, Yu Hidaka, Takao Kato, Hidenao Kayawake, Satona Tanaka, Yoshito Yamada, Akihiro Ohsumi, Daisuke Nakajima, Masatsugu Hamaji, Toshi Menju, Hiroshi Date
Summary: This study developed a wireless localization technique for fluoroscopically invisible small lung lesions and compared two marking approaches with or without cone-beam computed tomography (CBCT). The results showed that electromagnetic navigation bronchoscopy-guided radiofrequency identification marking provided a high tumor resection rate with sufficient surgical margins. The use of CBCT for marking resulted in a shorter distance from the marker to the lesion.
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Soh Hosoba, Toshiaki Ito, Makoto Mori, Riku Kato, Koh Kajiyama, Shogo Maeda, Yuji Nakai, Yoshihiro Morishita
Summary: This study describes the approach and perioperative outcomes of totally endoscopic isolated and concomitant surgical aortic valve replacement (AVR) using various valve types. The results demonstrate that endoscopic AVR can safely address concomitant valve diseases.
ANNALS OF THORACIC SURGERY
(2024)
