Article
Cell Biology
Yusheng Yao, Daoyi Lin, Yuzhi Chen, Linwei Liu, Yushang Wu, Xiaochun Zheng
Summary: This study tested the hypothesis that fluoxetine can protect against postoperative cognitive dysfunction (POCD) by suppressing hippocampal neuroinflammation. The results showed that fluoxetine pretreatment partially restored cognitive function, downregulated proinflammatory cytokines, restrained microglial activation, alleviated neural apoptosis, and suppressed the TLR4/MyD88/NF-kappa B pathway activation.
INFLAMMATION RESEARCH
(2023)
Article
Neurosciences
Kun Yu, Xue-Kang Zhang, Han-Chun Xiong, Si -Si Liang, Zi-Yun Lu, Yong-Qiang Wu, Yu Chen, Su-Jun Xiao
Summary: Postoperative cognitive dysfunction (POCD) is common in aged patients after major surgery, and the mechanism and clinical management of POCD are still unknown. Recent evidence has shown that stellate ganglion block (SGB) can promote learning and memory. This study suggests that preoperative treatment with SGB could effectively attenuate cognitive decline after surgery.
NEUROSCIENCE LETTERS
(2023)
Article
Chemistry, Medicinal
Jiali Yang, Zhixia Jia, Zhigang Xiao, Jing Zhao, Ye Lu, Li Chu, Hui Shao, Lin Pei, Shaodan Zhang, Yuan Chen
Summary: This study evaluated the beneficial effects of baicalin (BA) on cognitive dysfunction and neurodegeneration in PTZ-induced epileptic rats. Results showed that BA had anti-epileptic effects, improved cognitive dysfunction, and mitigated neurodegeneration in the hippocampus CA3 regions of epileptic rats. The potential mechanism of BA's anti-epileptic effects may involve the activation of the TLR4/MYD88/Caspase-3 pathway.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Medicine, Research & Experimental
Hu-Jun Xu, Xian-Peng Li, Li-Ye Han
Summary: Esketamine effectively mitigates postoperative cognitive dysfunction and inflammation in aged mice by suppressing the TLR4/MyD88/p38 MAPK pathway.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2023)
Review
Medicine, Research & Experimental
Yang Liu, Wei Yang, Jinqi Xue, Juntong Chen, Shiqing Liu, Shijie Zhang, Xiaohui Zhang, Xi Gu, Youjing Dong, Peng Qiu
Summary: The proportion of advanced age patients undergoing surgical procedures is increasing due to advancements in surgical and anesthesia technologies as well as an aging population. Postoperative cognitive dysfunction (POCD) is a common complication in older patients and its development involves multiple factors. Neuroinflammation is considered a leading hypothesis and plays a crucial role in the understanding and treatment of POCD.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cardiac & Cardiovascular Systems
Jian Yang, Zujin Xiang, Jing Zhang, Jun Yang, Yuhong Zhai, Zhixing Fan, Huibo Wang, Jingyi Wu, Yifan Huang, Mengting Xiong, Cong Ma
Summary: Increasing miR-24 levels can attenuate myocardial ischemia/reperfusion injury by reducing infarct area, improving cardiac function, inhibiting inflammatory cell infiltration, and decreasing release of creatine kinase myocardial band and lactate dehydrogenase. Upregulation of miR-24 leads to decreased expression of S100A8, subsequently inhibiting the toll-like receptor 4/MyD-88/nuclear factor-κB signaling pathway.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2021)
Article
Neurosciences
Xiaoxiang Tan, Jiajia Wang, Juan Yao, Jing Yuan, Yuchen Dai, Menghan Sun, Tianhao Zhang, Jiaojiao Yang, Wenlan Cai, Lili Qiu, Jie Sun
Summary: This study found that elderly patients after surgery are prone to cognitive decline, which may be related to the activation of microglia and the increase of complement protein expression in the hippocampus induced by surgery. The study established a model of cognitive decline in aged mice and showed the involvement of microglia and the complement system in cognitive dysfunction. Suppressing microglia activation and the association between microglia and complement can alleviate cognitive dysfunction.
NEUROSCIENCE LETTERS
(2023)
Article
Biochemistry & Molecular Biology
Zhihao Xu, Guoqing Zhang, Xiaoyue Zhang, Yu Lei, Yuliang Sun, Ya'nan He, Fen Yang, Wenbin Nan, Xuekun Xing, Yonghai Li, Juntang Lin
Summary: This study found that menstrual blood-derived endometrial stem cells can partially suppress neuroinflammatory reactions by regulating microglia through the TLR4/MyD88/NLRP3/Casp1 signaling pathway. These findings could be very useful for the development of an alternative stem cell-based therapy for neuroinflammation-associated disorders.
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xin Zhao, Jinfan Tian, Yue Liu, Zhishuai Ye, Mingyue Xu, Rongchong Huang, Xiantao Song
Summary: This study investigates the role of toll-like receptor 4-myeloid differentiation factor 88 (TLR4-Myd88) dependent caveolin-1 (Cav-1) expression modulation in coronary artery spasm (CAS) and explores the underlying pathogenic mechanisms. The findings suggest that Cav-1, upregulated by TLR4-Myd88, serves as an important modulator of CAS microenvironment establishment in vivo and in vitro, making it a potential pharmacologic target for the treatment of vasospasm via reduced endothelial cell inflammation.
VASCULAR PHARMACOLOGY
(2022)
Article
Plant Sciences
Xunjie Fan, Yuanyuan Zhang, Yi Song, Yanyan Zhao, Yanan Xu, Feng Guo, Mingwei Shao, Xiaojun Ma, Wei Zhang, Fangyi Wei, Guijun Qin
Summary: This study investigated the mechanism of Compound Danshen Dripping Pills (CDDP) treatment for diabetic cognitive dysfunction through in vivo functional experiments, transcriptomics, metabolomics, and network pharmacology. The results showed that CDDP suppressed inflammation, improved cognition, and attenuated intestinal flora disorder and metabolite increases. The TLR4/MyD88/NF-kappa B signaling pathway was identified as the mechanism of action for CDDP in reversing diabetes-induced cognitive impairment.
Article
Immunology
Yao Wang, Dilinuer Sadike, Bo Huang, Ping Li, Qiao Wu, Na Jiang, Yongkang Fang, Guini Song, Li Xu, Wei Wang, Minjie Xie
Summary: Regulatory T cells alleviate myelin loss and improve cognitive function by inhibiting pyroptosis in microglia in LPC-induced demyelination via the TLR4/MyD88/NF-kappa B pathway.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Immunology
Mengxue Zhang, Yiqing Yin
Summary: Postoperative cognitive dysfunction (POCD) is a common clinical symptom after surgery, characterized by a decline in neurocognitive function. Neuroinflammation mediated by microglia is the key mechanism of POCD. Anesthetics are believed to be a major cause of POCD development, as they activate microglia and induce neuroinflammation. However, the role of anesthetics in POCD remains controversial. Anesthetics can have both anti-inflammatory and pro-inflammatory effects, suggesting their dual roles in the pathogenesis of POCD. This review discusses the mechanisms by which commonly used anesthetics regulate microglial activation through inflammatory signaling pathways, highlighting the anti-inflammatory properties of anesthetics and their potential to improve cognitive performance. The beneficial effects of anesthetics on POCD vary depending on dose, exposure time, and patients' characteristics, emphasizing the need for careful selection of anesthetics to minimize the incidence of POCD.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Jing Lv, Jing Zhu, Peihan Wang, Tongyu Liu, Jiang Yuan, Huan Yin, Yiran Lan, Qiang Sun, Zhifeng Zhang, Guoda Ding, Chenxi Zhou, Huajie Wang, Zihan Wang, Yunfu Wang
Summary: This study investigated the therapeutic effect of artemisinin on Parkinson's disease (PD) and the TLR4/Myd88 signaling pathway through cell and animal experiments. The results showed that artemisinin treatment improved behavioral symptoms, increased the number of dopaminergic neurons in the substantia nigra, and decreased microglial cell activation in the PD mouse model. Cell experiments further revealed that artemisinin reduced BV-2 cell activation and inhibited the TLR4/Myd88 signaling pathway. The effect of artemisinin on BV-2 cells was inhibited by the TLR4 activator LPS.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Xue Han, Xiaolei Cheng, Jiyan Xu, Yujia Liu, Jiawen Zhou, Linhao Jiang, Xiaoping Gu, Tianjiao Xia
Summary: This study investigated the role of TREM2 in postoperative cognitive dysfunction (POCD) and neuroinflammation. The activation of TREM2 attenuated neuroinflammation by modulating PI3K/Akt signaling, thereby alleviating postoperative learning and memory deficits.
Article
Biochemistry & Molecular Biology
Yunwei Lu, Renjuan Hao, Yingchao Hu, Yuyan Wei, Yuyan Xie, Yu Shen, Qinglin Rui, Guran Yu
Summary: This study investigated the effect of harpagide on Ang II-induced neuroinflammation and associated neurotoxicity and BBB destruction. The results demonstrated that harpagide alleviated these pathological processes by inhibiting the TLR4/MyD88/NF-kappa B pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Neurosciences
Shun-Mei Lu, Bo Gui, Hong-Quan Dong, Xiang Zhang, Su-Su Zhang, Liu-Qing Hu, Hai-Ling Liu, Jie Sun, Yian-Ning Qian
BRAIN RESEARCH BULLETIN
(2015)
Article
Pharmacology & Pharmacy
Youhua Xu, Rongjian Zhang, Jie Chen, Qichun Zhang, Juejin Wang, Jue Hu, Xiaowei Guan, Lai Jin, Hong Fu, Bo Gui, Yuanyuan Guo, Shengnan Li
BRITISH JOURNAL OF PHARMACOLOGY
(2009)
Article
Cell Biology
Kangyong Liu, Bo Gui, Yinyi Sun, Nan Shi, Zhaohua Gu, Ting Zhang, Xiaojiang Sun
Article
Cell Biology
Bo Gui, Mingyan Su, Jie Chen, Lai Jin, Rong Wan, Yanning Qian
Article
Immunology
Hongquan Dong, Xiang Zhang, Xiaonan Dai, Shunmei Lu, Bo Gui, Wenjie Jin, Susu Zhang, Shu Zhang, Yanning Qian
JOURNAL OF NEUROINFLAMMATION
(2014)
Letter
Medicine, General & Internal
Yang Zhang, Huan-Huan Sha, Peng-Fei Shao, Yong Wang, Bo Gui
CHINESE MEDICAL JOURNAL
(2019)
Correction
Cell Biology
Bo Gui, Fuzhou Hua, Jie Chen, Zeping Xu, Hongbin Sun, Yanning Qian
MEDIATORS OF INFLAMMATION
(2020)
Article
Anesthesiology
Qi Zou, Jindi Jiang, Chonglong Shi, Bianliang Wu, Bo Gui, Xuelong Zhou
Summary: This study found that ultrasound guidance with single or double developing lines improved the first-attempt success rate of radial artery catheterization in obese patients and reduced the procedure time and overall complication rate.
ANAESTHESIA CRITICAL CARE & PAIN MEDICINE
(2023)
Article
Surgery
Xiahao Ding, Jinxing Che, Siyang Xu, Dapeng Chen, Tianming Zha, Gulibositan Abudurousuli, Hui Liang, Bo Gui
Summary: This study developed and validated a prediction model for postoperative nausea and vomiting (PONV) in patients after laparoscopic bariatric surgery (LBS). A risk factor analysis of PONV in patients with diabetes was conducted, providing clinicians with a more precise prophylactic protocol.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Multidisciplinary Sciences
Gulibositan Abudurousuli, Siyang Xu, Jinxing Che, Xiahao Ding, Bo Gui, Linjia Zhu
Summary: Anesthesiologists need to choose and use anesthetics properly to improve the prognosis of patients with organ injuries. Ferroptosis, a new type of cell death, can be modulated by anesthetics to affect multiple organ diseases.
Article
Medicine, Research & Experimental
Hai-Lin Liu, Li-Jun An, Zhen Su, Yang Zhang, Bo Gui
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
(2015)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)