Article
Medicine, General & Internal
Claudia Cantoni, Qingqi Lin, Yair Dorsett, Laura Ghezzi, Zhongmao Liu, Yeming Pan, Kun Chen, Yanhui Han, Zhengze Li, Hang Xiao, Matthew Gormley, Yue Liu, Suresh Bokoliya, Hunter Panier, Cassandra Suther, Emily Evans, Li Deng, Alberto Locca, Robert Mikesell, Kathleen Obert, Pamela Newland, Yufeng Wu, Amber Salter, Anne H. Cross, Phillip Tarr, Amy Lovett-Racke, Laura Piccio, Yanjiao Zhou
Summary: This study conducted a six-month longitudinal multi-omics study on multiple sclerosis (MS) patients and healthy controls, revealing multi-system alterations in gut microbiota, immune system, and blood metabolome. The study demonstrated the interactions between gut microbiome and host immune system, metabolism, and diet, and identified microbiome and metabolome features related to the degree of disability in MS patients. Furthermore, a correlation network linking meat intake with gut microbiota and blood metabolites was discovered.
Review
Genetics & Heredity
Alessandro Maglione, Miriam Zuccala, Martina Tosi, Marinella Clerico, Simona Rolla
Summary: Multiple Sclerosis (MS) is a complex disease determined by genetic and environmental factors, with the gut microbiome emerging as an important environmental factor. The interaction between the gut microbiome and host genetics in MS pathogenesis remains unclear. Research has focused on genetic factors, immune system interactions, and the gut microbiome in relation to MS, with future research avenues discussed.
Review
Gastroenterology & Hepatology
Dorota Kujawa, Lukasz Laczmanski, Slawomir Budrewicz, Anna Pokryszko-Dragan, Maria Podbielska
Summary: This article reviews the characteristics of gut dysbiosis in multiple sclerosis (MS), as well as its relevant links with the course of the disease and dysregulated immune response and metabolic pathways in the pathology of MS. The therapeutic implications of these findings, including various interventions targeted at the gut microbiome, are also discussed.
Article
Gastroenterology & Hepatology
Martin Diebold, Marco Meola, Srinithi Purushothaman, Lena K. Siewert, Elisabeth Poessnecker, Tim Roloff, Raija Lp Lindberg, Jens Kuhle, Ludwig Kappos, Tobias Derfuss, Adrian Egli, Anne-Katrin Proebstel
Summary: This study investigated the effects of dimethyl fumarate (DMF) on gut microbiota composition and host/microbial metabolomics in multiple sclerosis (MS) patients. The results revealed longitudinal changes in gut microbiota composition and an increase in citric acid cycle metabolites under DMF treatment. Furthermore, the study found a correlation between DMF-induced lymphopenia and distinct baseline microbiome signatures in MS patients, providing insights into the role of microbiota in mediating clinical side-effects.
Article
Clinical Neurology
Arlette L. Bruijstens, Sandy Molenaar, Yu Yi M. Wong, Robert Kraaij, Rinze F. Neuteboom
Summary: This study investigated the gut microbiota composition and functional pathways in pediatric-onset multiple sclerosis (MS) patients and found that obese children had lower microbiota diversity and higher abundance of certain microbes and functional pathways.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Nutrition & Dietetics
Kristina Hoffman, William J. Doyle, Sean M. Schumacher, Javier Ochoa-Reparaz
Summary: The incidence of multiple sclerosis has increased due to the shift from a whole foods approach to the Western diet. The pathogenesis of multiple sclerosis may involve changes in gut microbiota, gut barrier leakage, and intestinal inflammation. This review discusses the potential of dietary strategies to modulate the gut microbiome as alternative treatments for multiple sclerosis and emphasizes the importance of incorporating gut microbiome analysis in future research.
FRONTIERS IN NUTRITION
(2023)
Review
Neurosciences
Daiki Takewaki, Takashi Yamamura
Summary: Recent studies have identified specific gut microbial species linked to various human diseases, and the gut-brain axis is currently attracting much attention in the field of microbiome science. Researchers are also striving to elucidate how the microbiome regulates the onset and progression of MS. The new findings achieved by analyzing the causal relationship between MS and the gut microbiome will provide a new therapeutic strategy for MS.
NEUROSCIENCE RESEARCH
(2021)
Review
Cell Biology
Anna Dunalska, Kamila Saramak, Natalia Szejko
Summary: Multiple sclerosis (MS) is a chronic neuroinflammatory disease with a complex pathophysiology, involving genetic, immunological, and environmental factors. The gut-brain axis has been implicated in the development of MS and related disorders. This paper reviews evidence supporting the role of the gut microbiome in MS and neuromyelitis optica spectrum disorder (NMO-SD), identifying specific bacterial genera involved. Preliminary data suggests that interventions targeting the gut microbiome could potentially have a therapeutic effect on MS/NMO-SD. Understanding the gut microbiome's role in MS is important for disease management and potential treatments.
Article
Genetics & Heredity
Vicente Navarro-Lopez, Maria Angeles Mendez-Miralles, Rosa Vela-Yebra, Ana Fries-Ramos, Pedro Sanchez-Pellicer, Beatriz Ruzafa-Costas, Eva Nunez-Delegido, Humberto Gomez-Gomez, Sara Chumillas-Lidon, Jose A. Pico-Monllor, Laura Navarro-Moratalla
Summary: This study analyzed the gut microbiota of patients with RRMS and found differences compared to a healthy control group. Analysis of the microbiota components revealed the potential of certain genera as predictive factors for RRMS prognosis and diagnosis.
Article
Gastroenterology & Hepatology
Lindsay Devolder, Ayla Pauwels, Ann Van Remoortel, Gwen Falony, Sara Vieira-Silva, Guy Nagels, Jacques De Keyser, Jeroen Raes, Marie B. D'Hooghe
Summary: This study investigated the relationship between gut microbial composition and long-term disability worsening in 111 MS patients. The results showed that the inflammation-associated, dysbiotic Bacteroides 2 enterotype (Bact2) was more prevalent in patients with worsening disability compared to non-worsened patients. This association was independent of confounding factors and Bact2 showed a stronger association with disability worsening than neurofilament light chain (NfL) plasma levels. Additionally, Bact2 was relatively stable over time, suggesting its potential use as a prognostic biomarker in MS clinical practice.
Review
Immunology
Noha S. S. Elsayed, Paula Aston, Vishnu R. R. Bayanagari, Sanjay K. K. Shukla
Summary: Multiple sclerosis is an immune-mediated neurodegenerative disease with complex etiology involving genetic susceptibility, aberrant immune response, and dysbiosis of the gut microbiome. Microbial factors in the gut could potentially trigger neuroinflammation and symptoms of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Saumya Shah, Alberto Locca, Yair Dorsett, Claudia Cantoni, Laura Ghezzi, Qingqi Lin, Suresh Bokoliya, Hunter Panier, Cassandra Suther, Matthew Gormley, Yue Liu, Emily Evans, Robert Mikesell, Kathleen Obert, Amber Salter, Anne H. Cross, Phillip I. Tarr, Amy Lovett-Racke, Laura Piccio, Yanjiao Zhou
Summary: This study revealed alterations in the gut mycobiome of patients with multiple sclerosis compared to healthy controls, with Saccharomyces and Aspergillus being over-represented in the patient group. Different mycobiome profiles were associated with specific bacterial microbiome and immune cell subsets in the blood of patients. Further research is needed to explore the potential causal relationship between the mycobiome and multiple sclerosis, as well as its interactions with bacteria and autoimmunity.
Review
Gastroenterology & Hepatology
Lorrie L. Blais, Theresa L. Montgomery, Eyal Amiel, Paula B. Deming, Dimitry N. Krementsov
Summary: The need for alternative treatments for multiple sclerosis has led to extensive research on microbial therapies targeting the microbiota-gut-brain axis. This comprehensive review evaluates probiotic and commensal gut microbial therapies for MS based on clinical and preclinical evidence, ranking promising therapies and identifying areas needing further research for cheaper, safer, and more durable treatments.
Article
Biochemistry & Molecular Biology
Zehavit Nitzan, Elsebeth Staun-Ram, Anat Volkowich, Ariel Miller, Serge Nataf
Summary: Microbiome dysbiosis is implicated in immune-mediated disorders, including multiple sclerosis. This study characterizes the MS-associated gut microbiome in Israeli populations and identifies associations with demographic, dietary, and clinical features. The findings suggest that alterations in the microbiota composition are related to disease progression, gender differences, and vitamin D-mediated immunological effects recognized in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Sam Harding-Forrester, Izanne Roos, Ai-Lan Nguyen, Charles B. Malpas, Ibrahima Diouf, Nahid Moradi, Sifat Sharmin, Guillermo Izquierdo, Sara Eichau, Francesco Patti, Dana Horakova, Eva Kubala Havrdova, Alexandre Prat, Marc Girard, Pierre Duquette, Francois Grand Maison, Marco Onofrj, Alessandra Lugaresi, Pierre Grammond, Serkan Ozakbas, Maria Pia Amato, Oliver Gerlach, Patrizia Sola, Diana Ferraro, Katherine Buzzard, Olga Skibina, Jeannette Lechner-Scott, Raed Alroughani, Cavit Boz, Vincent Van Pesch, Elisabetta Cartechini, Murat Terzi, Davide Maimone, Cristina Ramo-Tello, Bassem Yamout, Samia Joseph Khoury, Daniele La Spitaleri, Maria Jose Sa, Yolanda Blanco, Franco Granella, Mark Slee, Ernest Butler, Youssef Sidhom, Riadh Gouider, Roberto Bergamaschi, Rana Karabudak, Radek Ampapa, Jose Luis Sanchez-Menoyo, Julie Prevost, Tamara Castillo-Trivino, Pamela A. McCombe, Richard Macdonell, Guy Laureys, Liesbeth Van Hijfte, Jiwon Oh, Ayse Altintas, Koen de Gans, Recai Turkoglu, Anneke van der Walt, Helmut Butzkueven, Steve Vucic, Michael Barnett, Edgardo Cristiano, Suzanne Hodgkinson, Gerardo Iuliano, Ludwig Kappos, Jens Kuhle, Vahid Shaygannejad, Aysun Soysal, Bianca Weinstock-Guttman, Bart Van Wijmeersch, Tomas Kalincik
Summary: This study compared primary and secondary progressive multiple sclerosis (PPMS, SPMS), and found that SPMS has later onset of the progressive phase and slower disability accrual, but higher baseline disability.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Immunology
Caroline Wasen, Caroline Ospelt, Alessandro Camponeschi, Malin C. Erlandsson, Karin M. E. Andersson, Sofia Toyra Silfversward, Steffen Gay, Maria Bokarewa
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Multidisciplinary Sciences
Panayota Kolypetri, Shirong Liu, Laura M. Cox, Mai Fujiwara, Radhika Raheja, Dvora Ghitza, Anya Song, Dominique Daatselaar, Valerie Willocq, Howard L. Weiner
Summary: This study demonstrates that antibiotic treatment can eliminate certain bacterial families in the gut, leading to a decrease in PRR ligands and affecting the quantity and function of splenic Ly6C(high) monocytes. Addition of PRR ligands can restore the function of these monocytes.
Article
Multidisciplinary Sciences
Thais G. Moreira, Davide Mangani, Laura M. Cox, Jeffrey Leibowitz, Eduardo. L. C. Lobo, Mariana A. Oliveira, Christian D. Gauthier, Brenda N. Nakagaki, Valerie Willocq, Anya Song, Lydia Guo, David C. A. Lima, Gopal Murugaiyan, Oleg Butovsky, Galina Gabriely, Ana C. Anderson, Rafael M. Rezende, Ana Maria C. Faria, Howard L. Weiner
Summary: The dendritic cells (DC) residing in different parts of the gut mucosa, particularly in the upper and lower intestines, exhibit differential PD-L1 and XCR1 expression, driving specific T cell responses to prevent gut inflammation and maintain intestinal homeostasis.
NATURE COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Jie Sun, Tanupong Rattanasawatesun, Penghao Tang, Zhaoxia Bi, Santosh Pandit, Lisa Lam, Caroline Wasen, Malin Erlandsson, Maria Bokarewa, Jichen Dong, Feng Ding, Fangzhu Xiong, Ivan Mijakovic
Summary: The study reveals that vertically oriented graphene preferentially grows in areas with stronger local electric fields during plasma-enhanced chemical vapor deposition. The electric field helps accumulate charges on graphene, transforming cohesive graphene layers into separate three-dimensional VG flakes. Additionally, the field attracts charged precursors to protruding areas on the substrate, aiding in the formation of VG.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Immunology
Venkataragavan Chandrasekaran, Nina Oparina, Maria-Jose Garcia-Bonete, Caroline Wasen, Malin C. Erlandsson, Eric Malmhall-Bah, Karin M. E. Andersson, Maja Jensen, Sofia T. Silfverswaerd, Gergely Katona, Maria I. Bokarewa
Summary: The cohesin complex plays an important role in leukocyte maturation and adaptive immunity, affecting genome regulation, hematopoiesis, adipogenesis, and inflammation. It is a key player in immune pathways and is associated with various immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Malin C. Erlandsson, Seval Erdogan, Caroline Wasen, Karin M. E. Andersson, Sofia T. Silfversward, Rille Pullerits, Mats Bemark, Maria Bokarewa
Summary: This study demonstrates the important role of IGF1R in preventing autoimmunity both in experimental models and in patient material, and raises awareness of potential immune tolerance breakdown during therapeutic IGF1R targeting.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Paola Bianchimano, Graham J. Britton, David S. Wallach, Emma M. Smith, Laura M. Cox, Shirong Liu, Kacper Iwanowski, Howard L. Weiner, Jeremiah J. Faith, Jose C. Clemente, Stephanie K. Tankou
Summary: The study found that the antibiotic vancomycin can improve the disease in the mouse model of experimental autoimmune encephalomyelitis (EAE) by modulating the gut microbiota. Meanwhile, the elevated levels of the gut microbiota strain Anaerotruncus colihominis may be associated with recovery in multiple sclerosis patients.
Article
Microbiology
Rafael M. Rezende, Laura M. Cox, Thais G. Moreira, Shirong Liu, Selma Boulenouar, Fyonn Dhang, Danielle S. LeServe, Brenda N. Nakagaki, Juliana R. Lopes, Bruna K. Tatematsu, Luisa Lemos, Julia Mayrink, Eduardo L. C. Lobo, Lydia Guo, Marilia G. Oliveira, Chantal Kuhn, Howard L. Weiner
Summary: This study reveals that the interaction between intestinal gamma delta T cells and gut microbiota is crucial for maintaining mucosal tolerance. Antibiotic treatment disrupts oral tolerance and reduces the number of intestinal gamma delta T cells. Mice deficient in gamma delta T cells exhibit altered microbiota composition, which leads to immune dysregulation and impaired tolerance in the small intestine. Colonizing the deficient mice with normal microbiota restores mucosal immune responses and tolerance.
Article
Clinical Neurology
Lekha Pandit, Laura M. Cox, Chaithra Malli, Anitha D'Cunha, Timothy Rooney, Hrishikesh Lokhande, Valerie Willocq, Shrishti Saxena, Tanuja Chitnis
Summary: This study revealed elevated levels of C bolteae associated with AQP4+ NMOSD among Indian patients, suggesting a possible causal relationship with the immunopathogenesis of the disease. Presence of C bolteae correlated with expression of inflammatory genes associated with innate and adaptive immunities, specifically involved in plasma cell differentiation, B cell chemotaxis, and Th17 activation.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Multidisciplinary Sciences
Fyonn H. Dhang, Howard L. Weiner, Shirong Liu
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2020)
Meeting Abstract
Rheumatology
L. Leifsdottir, C. Wasen, M. C. Erlandsson, K. M. Andersson, R. Heckemann, M. I. Bokarewa
ANNALS OF THE RHEUMATIC DISEASES
(2020)