Article
Engineering, Environmental
Annika Mangold-Doring, Jan Baas, Paul J. van den Brink, Andreas Focks, Egbert H. van Nes
Summary: This study introduces a new temperature damage model to interpret the thermal stress of ectothermic organisms. The model assumes that damage depends on the balance between temperature-dependent accumulation and constant repair. The model showed good agreement with the measured survival of Gammarus pulex, and it demonstrated the ability to predict temperature effects for various environmental scenarios. The study contributes to the mechanistic understanding of temperature as a single stressor and facilitates the incorporation of temperature as an additional stressor in multistressor effect models.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Andre Gergs, Jutta Hager, Eric Bruns, Thomas G. Preuss
Summary: The ecotoxicological profiles of the insecticides imidacloprid, thiacloprid, and flupyradifurone in Chironomus riparius were analyzed in terms of acute and chronic effects. The toxicokinetic-toxicodynamic modeling revealed that chironomids would die from starvation due to prolonged feeding inhibition under chronic exposures. The study suggests that the additional effect of starvation is not relevant for flupyradifurone.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2021)
Review
Food Science & Technology
Barbara Silva, Jorge Soares, Carolina Rocha-Pereira, Premysl Mladenka, Fernando Remiao
Summary: This review paper summarizes current knowledge on the khat plant from a toxicokinetic and toxicodynamic perspective. The psychoactive effects of khat are primarily caused by its main constituents, cathinone, cathine, and norephedrine. Long-term use of khat is associated with severe physical and psychological complications.
Article
Engineering, Environmental
Yongfei Gao, Weiran Wu, Kexin Qiao, Jianfeng Feng, Lin Zhu, Xiaoshan Zhu
Summary: This study used a novel pulsed-gradient Ag+ (AgNO3) exposure method and a TK-TD model to predict the accumulation and toxicity of Ag+ released from AgNPs in zebrafish larvae, as well as to understand the mechanism of Ag+ release in vivo. The results showed that AgNPs released around twice as much Ag+ in the body compared to a single Ag+ pulse-exposure system, and toxicity was mainly caused by gradually released Ag+ rather than AgNPs themselves.
Article
Environmental Sciences
Barbara Bauer, Alexander Singer, Zhenglei Gao, Oliver Jakoby, Johannes Witt, Thomas Preuss, Andre Gergs
Summary: The study analyzed the performance of toxicokinetic-toxicodynamic (TKTD) models in calibration and validation, highlighting the importance of input data quality. By using a comprehensive dataset with different substances, exposure patterns, and aquatic animal species, the study demonstrated the reduction of parameter uncertainty and improved model predictions through calibration and validation processes.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Ecology
Tjalling Jager, Benoit Goussen, Andre Gergs
Summary: Toxicokinetic-toxicodynamic (TKTD) models are important tools to bridge the gap between laboratory toxicity tests and field conditions. Dynamic energy budget (DEB) theory provides a solid foundation for TKTD modeling. This paper presents a complete TKTD model that includes a standard DEB animal model and a TKTD model that considers damage as the driving force for toxic effects.
ECOLOGICAL MODELLING
(2023)
Article
Marine & Freshwater Biology
T. T. Yen Le, Daniel Grabner, Milen Nachev, Miriam R. Garcia, Eva Balsa-Canto, Willie J. G. M. Peijnenburg, A. Jan Hendriks, Bernd Sures
Summary: A toxicokinetic-toxicodynamic model based on subcellular metal partitioning is presented for simulating chronic toxicity of copper. The study indicates ineffective detoxification at high exposure levels and spill-over effects of detoxification.
AQUATIC TOXICOLOGY
(2021)
Article
Environmental Sciences
Sylvain Bart, Stephen Short, Tjalling Jager, Emily J. Eagles, Alex Robinson, Claire Badder, Elma Lahive, David J. Spurgeon, Roman Ashauer
Summary: The assessment of chemical mixture toxicity is a major challenge in ecotoxicology. In this study, a new approach using toxicokinetic-toxicodynamic modeling was proposed, which accurately simulated synergistic and antagonistic effects of different mixtures on various species. This model can identify interactions throughout the exposure time and provide predictions for untested exposure scenarios.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Chi-Yun Chen, Tien-Hsuan Lu, Chung-Min Liao
Summary: Marine microplastics pose a serious threat to shallow-water corals, necessitating interdisciplinary research. The ecotoxicological effects of MPs on corals are complex and need to be evaluated in a species-specific manner. Toxicokinetic and toxicodynamic modeling can help quantify the impacts of MPs on coral health and growth.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Tjalling Jager, Marie Trijau, Neil Sherborne, Benoit Goussen, Roman Ashauer
Summary: Toxicokinetic-toxicodynamic (TKTD) modeling is crucial for understanding the time dependence of toxic effects and predicting consequences of time-varying exposure, especially in environmental risk assessment of pesticides. However, linking the modeled variables in TKTD models with observations from laboratory ecotoxicity tests, particularly for reproductive endpoints, presents challenges.
INTEGRATED ENVIRONMENTAL ASSESSMENT AND MANAGEMENT
(2022)
Article
Engineering, Environmental
Sylvain Bart, Tjalling Jager, Alex Robinson, Elma Lahive, David J. Spurgeon, Roman Ashauer
Summary: The GUTS model provides a framework for deriving TKTD models that consider the effects of toxicant exposure on survival over time. Experimental studies and previously published data demonstrate the predictive power of the extended GUTS-RED framework for mixture assessment, offering novel diagnostic tools for understanding chemical mode of action in mixtures. Deviations from model predictions can identify interactions between mixture components, such as synergism or antagonism, which are not accounted for by the models, highlighting the importance of TKTD models in mixture hazard assessments.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Huizhen Li, Qingjun Zhang, Hang Su, Jing You, Wen-Xiong Wang
Summary: Species sensitivity to neonicotinoids varies among aquatic invertebrates. Daphnia magna shows high tolerance to imidacloprid in short-term exposure, but delayed and carry-over toxicity present challenges under repeated pulse exposures. Slow damage recovery significantly enhances the toxicity of imidacloprid, despite fast depuration from soft tissues. Integrating delayed and carry-over toxicity quantification is necessary in assessing the risk of neonicotinoids to aquatic invertebrates.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Engineering, Environmental
Lanpeng Yang, Jianfeng Feng, Yongfei Gao, Lin Zhu
Summary: The study developed a subcellular two-compartment toxicokinetic-toxicodynamic model for zebrafish larvae exposed to four metals, showing that copper had the highest toxicity. The results suggest that the observed variation in toxicity of the four metals was mainly determined by toxicodynamic processes.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Article
Environmental Sciences
Chi-Yun Chen, Tien-Hsuan Lu, Ying-Fei Yang, Chung-Min Liao
Summary: This study developed a toxicokinetic/toxicodynamic-based risk assessment framework to examine the health effects of zebrafish and red tilapia in response to environmental concentrations of microplastics. The findings suggest that microplastic pollution is likely to enhance fish health risks and should be considered in evaluations of freshwater fish susceptibility to microplastics.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Review
Biochemistry & Molecular Biology
Khaled Abass, Olavi Pelkonen, Arja Rautio
Summary: Chloro-s-triazines such as atrazine, cyanazine, propazine, simazine, and terbuthylazine are structurally similar herbicides with similar toxicokinetics. By comparing their characteristics, useful structure-activity relationships can be identified to enhance toxicological risk assessment for humans and ecosystems.
CURRENT DRUG METABOLISM
(2021)
Article
Biodiversity Conservation
Coline C. F. Boonman, Mark A. J. Huijbregts, Ana Benitez-Lopez, Aafke M. Schipper, Wilfried Thuiller, Luca Santini
Summary: The study suggests that climate change is likely to significantly alter the global distribution of biomes, with (sub)tropical biomes expanding and tundra as well as temperate broadleaved and mixed forests contracting in size. Additionally, a considerable portion of temperate broadleaved and mixed forests and temperate grasslands are projected to shift northwards. Under extreme climate change scenarios, tundra stands to lose more than half of its current extent. The study also highlights the potential of trait-based correlative approaches as a promising tool to forecast vegetation change and provide additional evidence alongside process-based vegetation models.
DIVERSITY AND DISTRIBUTIONS
(2022)
Article
Multidisciplinary Sciences
Selene Cobo, Angel Galan-Martin, Victor Tulus, Mark A. J. Huijbregts, Gonzalo Guillen-Gosalbez
Summary: This paper assesses the co-benefits and side-effects of DACCS and BECCS for human health and the planet. The health co-benefits of BECCS may exceed those of DACCS, but both technologies may lead to trade-offs between Earth-system processes.
NATURE COMMUNICATIONS
(2022)
Article
Ecology
Erin Henry, Luca Santini, Mark A. J. Huijbregts, Ana Benitez-Lopez
Summary: The intraspecific spatial patterns in body size vary across different species of terrestrial vertebrates, with birds and mammals showing significant correlations between body size and environmental factors. In birds, smaller body size is associated with higher temperature and lower resource seasonality, whereas in mammals, smaller body size is related to lower resource availability and seasonality. However, there is no clear size-environment relationship in reptiles and amphibians.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2023)
Article
Ecology
Maarten Jaap Erik Broekman, Selwyn Hoeks, Rosa Freriks, Merel M. Langendoen, Katharina M. Runge, Ecaterina Savenco, Ruben ter Harmsel, Mark A. J. Huijbregts, Marlee A. Tucker
Summary: Home range is an important measure for understanding animal space use. However, previous macroecological studies have not fully considered the environmental context and intraspecific variation. This study introduces HomeRange, a global database with 75,611 home-range values of 960 mammal species, including terrestrial, aquatic, and aerial species. The database provides detailed information on species traits and methodological aspects.
GLOBAL ECOLOGY AND BIOGEOGRAPHY
(2023)
Article
Green & Sustainable Science & Technology
Louise Christine Dammeier, Joyce H. C. Bosmans, Mark A. J. Huijbregts
Summary: By combining technological parameters, life-cycle inventory data, and meteorological information, we quantified the greenhouse gas footprint of wind farms globally. Our results indicate a median GHG footprint of 10 g CO(2)eq/kWh for global wind electricity, with a range of 4 to 56 g CO(2)eq/kWh.
JOURNAL OF INDUSTRIAL ECOLOGY
(2023)
Article
Ecology
C. J. Veerkamp, M. Loreti, R. Benavidez, B. Jackson, A. M. Schipper
Summary: The integration of nature into cities promotes sustainable urbanization. To quantify the ecosystem services provided by urban nature, spatially explicit modeling is crucial. However, multi model assessments are needed to understand uncertainties in model outcomes, especially when independent validation data is lacking.
ECOSYSTEM SERVICES
(2023)
Article
Biodiversity Conservation
Hadassa Moreira, Koen J. J. Kuipers, Leo Posthuma, Michiel C. Zijp, Mara Hauck, Mark A. J. Huijbregts, Aafke M. Schipper
Summary: Land use is a significant driver of biodiversity loss globally, and this study estimated the global extinction threat to vascular plant species based on a novel integration of species-area model and relative endemism richness. The results showed that 11% of vascular plant species are threatened with global extinction, with the highest threat in the Neotropic and Palearctic realms due to different intensities of cropland use.
DIVERSITY AND DISTRIBUTIONS
(2023)
Article
Biodiversity Conservation
Sif de Visser, Laura Scherer, Mark Huijbregts, Valerio Barbarossa
Summary: Human activities pose increasing threats to highly biodiverse freshwater ecosystems. Life Cycle Assessment (LCA) is a valuable tool to evaluate the impact of products and services on freshwater biodiversity. The current methodologies in LCA mainly consider the impact of climate change on freshwater fish diversity through changes in average river discharge, but fail to include the importance of water temperature changes and climate extremes. This study introduces new characterization factors that account for climate-driven changes in streamflow and water temperature extremes, and quantifies global freshwater fish extinction risks at different levels of global warming.
ECOLOGICAL INDICATORS
(2023)
Correction
Environmental Sciences
Joyce H. C. Bosmans, Louise C. Dammeier, Mark A. J. Huijbregts
ENVIRONMENTAL RESEARCH LETTERS
(2023)
Article
Biodiversity Conservation
Juan Gallego-Zamorano, Melinda M. J. de Jonge, Katharina Runge, Steven H. Huls, Jiaqi Wang, Mark A. J. Huijbregts, Aafke M. Schipper
Summary: Anthropogenic increases in nitrogen have diverse impacts on terrestrial invertebrate communities, with responses varying depending on species traits, local climate, and feeding guilds. These changes can have negative consequences for ecosystem functions and services, including those important for human food production.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Environmental Studies
Mirza Cengic, Zoran J. N. Steinmann, Pierre Defourny, Jonathan C. Doelman, Celine Lamarche, Elke Stehfest, Aafke M. Schipper, Mark A. J. Huijbregts
Summary: The global expansion of agricultural land is a major contributor to climate change and loss of biodiversity. To address the limitations of current global land change models, we developed high-resolution global maps using artificial neural network models. These maps provide representative estimates of the potential for agricultural land conversion and can facilitate more accurate environmental assessments.
Article
Environmental Studies
Parinaz Rashidi, Sopan D. Patil, Aafke M. Schipper, Rob Alkemade, Isabel Rosa
Summary: This study downscaled the Land Use Harmonization v2 (LUH2) data from their original spatial resolution to 100m and 10m resolutions using the land use allocation tool of the GLOBIO 4 model, and used different reference land cover maps to compare the downscaled outcomes. The results showed that using ESA WorldCover as a reference map provided better agreement with the original LUH2 dataset, and the downscaling approach can provide valuable insights into the potential impacts of land use change on biodiversity and guide local decision-making processes.