Increasing Top-Down Mass Spectrometry Sequence Coverage by an Order of Magnitude through Optimized Internal Fragment Generation and Assignment

Internal fragments generated by electron ionization dissociation enhance protein top-down mass spectrometry

(2020) Muhammad A. Zenaidee et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Identification and Quantification of Proteoforms by Mass Spectrometry

(2019) Leah V. Schaffer et al.   PROTEOMICS

All Ion Differential Analysis Refines the Detection of Terminal and Internal Diagnostic Fragment Ions for the Characterization of Biologics Product-Related Variants and Impurities by Middle-down Mass Spectrometry

(2019) François Griaud et al.   ANALYTICAL CHEMISTRY

Best practices and benchmarks for intact protein analysis for top-down mass spectrometry

(2019) Daniel P. Donnelly et al.   NATURE METHODS

A five-level classification system for proteoform identifications

(2019) Lloyd M. Smith et al.   NATURE METHODS

Top-Down Characterization of Proteins with Intact Disulfide Bonds Using Activated-Ion Electron Transfer Dissociation

(2018) Matthew J. P. Rush et al.   ANALYTICAL CHEMISTRY

Application of Tandem Two-Dimensional Mass Spectrometry for Top-Down Deep Sequencing of Calmodulin

(2018) Federico Floris et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

An integrated native mass spectrometry and top-down proteomics method that connects sequence to structure and function of macromolecular complexes

(2018) Huilin Li et al.   Nature Chemistry

Multiplexed Middle-Down Mass Spectrometry Reveals Light and Heavy Chain Connectivity in a Monoclonal Antibody

(2018) Kristina Srzentic et al.   ANALYTICAL CHEMISTRY

Parsing disease-relevant protein modifications from epiphenomena: perspective on the structural basis of SOD1-mediated ALS

(2017) N. D. Schmitt et al.   JOURNAL OF MASS SPECTROMETRY

Are neutral loss and internal product ions useful for top-down protein identification?

(2017) Kaijie Xiao et al.   Journal of Proteomics

The Ups and Downs of Repeated Cleavage and Internal Fragment Production in Top-Down Proteomics

(2017) Yana A. Lyon et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Defining Gas-Phase Fragmentation Propensities of Intact Proteins During Native Top-Down Mass Spectrometry

(2017) Nicole A. Haverland et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Informed-Proteomics: open-source software package for top-down proteomics

(2017) Jungkap Park et al.   NATURE METHODS

Progress in Top-Down Proteomics and the Analysis of Proteoforms

(2016) Timothy K. Toby et al.   Annual Review of Analytical Chemistry

TopPIC: a software tool for top-down mass spectrometry-based proteoform identification and characterization

(2016) Qiang Kou et al.   BIOINFORMATICS

Targeted analysis of recombinant NF kappa B (RelA/p65) by denaturing and native top down mass spectrometry

(2016) John Paul Savaryn et al.   Journal of Proteomics

Analyzing Internal Fragmentation of Electrosprayed Ubiquitin Ions During Beam-Type Collisional Dissociation

(2015) Kenneth R. Durbin et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

MASH Suite: A User-Friendly and Versatile Software Interface for High-Resolution Mass Spectrometry Data Interpretation and Visualization

(2014) Huseyin Guner et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Complete Protein Characterization Using Top-Down Mass Spectrometry and Ultraviolet Photodissociation

(2013) Jared B. Shaw et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Proteoform: a single term describing protein complexity

(2013) Lloyd M Smith et al.   NATURE METHODS

Characterization of early pathogenesis in the SOD1G93Amouse model of ALS: part II, results and discussion

(2013) Sharon Vinsant et al.   Brain and Behavior

Structural characterization of intact proteins is enhanced by prevalent fragmentation pathways rarely observed for peptides

(2010) Jennifer S. Cobb et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Strategies for stabilizing superoxide dismutase (SOD1), the protein destabilized in the most common form of familial amyotrophic lateral sclerosis

(2010) J. R. Auclair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sensitive and Specific Identification of Wild Type and Variant Proteins from 8 to 669 kDa Using Top-down Mass Spectrometry

(2008) N. Murat Karabacak et al.   MOLECULAR & CELLULAR PROTEOMICS

MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification

(2008) Jürgen Cox et al.   NATURE BIOTECHNOLOGY

A Data-Mining Scheme for Identifying Peptide Structural Motifs Responsible for Different MS/MS Fragmentation Intensity Patterns

(2007) Yingying Huang et al.   JOURNAL OF PROTEOME RESEARCH