Review
Medicine, Research & Experimental
Ramadan S. Hussein, Walid Kamal Abdelbasset
Summary: Rosacea is a chronic inflammatory skin disease that affects the central face and eyes, presenting symptoms such as flushing, erythema, and telangiectasia. Recent research has linked rosacea to various diseases and cancer risks. This review discusses the management of rosacea based on different subtypes and new treatment combinations.
INTERNATIONAL JOURNAL OF BIOMEDICINE
(2022)
Article
Dermatology
Nita Katarina Frifelt Wienholtz, Jacob P. P. Thyssen, Casper Emil Christensen, Simon Francis Thomsen, Katrine Elisabeth Karmisholt, Gregor B. E. Jemec, Hans B. B. Lomholt, Michael Heidenheim, Anne Birgitte Simonsen, Carsten Sand, Christian Vestergaard, Diljit Kaur-Knudsen, Elisabeth Ammitzboll, Erik Lorup, Anne G. G. Danielsen, Gitte Strauss, Lone Skov, Peter H. H. Andersen, Marianne Hald, Luise W. W. Idorn, Messoud Ashina, Claus Zachariae, Alexander Egeberg
Summary: This study validates the Rosacea Area and Severity Index (RASI) as an effective tool for evaluating the severity of rosacea, with comparable agreement to the currently used Investigator's Global Assessment (IGA) method. RASI provides a more nuanced evaluation of various rosacea features and the extent of involvement in different facial areas, suggesting its widespread use in clinical and research settings.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Medicine, Research & Experimental
Ana Claïudia Paiva-Santos, Tatiana Goncalves, Diana Peixoto, Patriïcia C. Pires, K. Velsankar, Niraj Kumar Jha, Vivek P. P. Chavda, Imran Shair Mohammad, Letiïcia Caramori Cefali, Priscila Gava Mazzola, Filipa Mascarenhas-Melo, Francisco Veiga
Summary: Rosacea is a chronic inflammatory skin disease characterized by flushing, persistent erythema, papules and pustules, telangiectasia, and phymatous alterations. Its pathophysiology is not fully understood yet and conventional topical treatments have limited efficacy due to the skin barrier. New active ingredients and drug delivery systems, especially nanoparticles, show promise in treating and caring for rosacea. This Review covers the pathophysiology, diagnosis, and prevention measures of rosacea, as well as topical approaches including skin care, cosmetics, and therapies, with an emphasis on future perspectives.
MOLECULAR PHARMACEUTICS
(2023)
Review
Pediatrics
Anca Chiriac, Uwe Wollina
Summary: Rosacea is a facial inflammatory disorder that is more common in older individuals. While it is rare in children, there are specific characteristics and subtypes for pediatric rosacea. Diagnosis is based on clinical symptoms, with laboratory investigations and histopathology used to rule out other conditions. Treatment options include topical and systemic drugs, although oral tetracyclines may have adverse effects on teeth.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Dermatology
Luiz M. C. Almeida, Mayra Ianhez, Taciana Dal'Forno, Fabiola R. Picosse, Flavia Ravelli, Christhine Kamamoto, Priscilla Sarlos, Linda F. S. Gold
Summary: This study aims to discuss and make recommendations on how to treat the main rosacea phenotypes during the long-term maintenance phase. A consensus was reached by a panel of Brazilian and American dermatologists using the Nominal Group Technique. Comprehensive narrative reviews were conducted, and recommendations were made based on 75% agreement among the specialists.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2023)
Article
Multidisciplinary Sciences
Nermin Karaosmanoglu, Pinar Ozdemir Cetinkaya, Ozge Mine Orenay
Summary: This study aims to investigate the inflammatory status of patients with rosacea by evaluating CBC parameters and the systemic immune inflammation (SII) index, and compare them with a control group. The results showed that patients had significantly higher monocyte and platelet count, SII index, ESR, and CRP levels compared to the control group. This suggests the presence of systemic inflammation in the blood of rosacea patients.
SCIENTIFIC REPORTS
(2023)
Article
Dermatology
Caroline Hilbring, Matthias Augustin, Natalia Kirsten, Nicole Mohr
Summary: Rosacea is a common chronic skin condition with increasing prevalence with age in Germany. Patients with rosacea have an increased risk for associated comorbidities.
INTERNATIONAL JOURNAL OF DERMATOLOGY
(2022)
Review
Medicine, Research & Experimental
H. Fischer, T. Maleitzke, C. Eder, S. Ahmad, U. Stoeckle, K. F. Braun
Summary: Proximal femur fractures are a leading cause of hospitalization in elderly patients and require careful perioperative management to reduce complications. Special attention should be given to the unique needs and comorbidities of elderly patients for optimal treatment outcomes.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2021)
Article
Dermatology
Jin Seo Park, So Yeon Lee, Jin Cheol Kim, Chun Wook Park, Hye One Kim, Bo Young Chung
Summary: This study investigated the efficacy and safety of transdermal botulinum toxin delivery with fractional microneedling radiofrequency in treating facial erythema associated with rosacea.
DERMATOLOGIC THERAPY
(2023)
Review
Gastroenterology & Hepatology
Sabrina Sidali, Eric Trepo, Olivier Sutter, Jean-Charles Nault
Summary: HCC is the third leading cause of cancer-related death. The Barcelona Clinic Liver Cancer classification is the most widely used staging system for HCC in Western countries. Recent therapeutic advances have led to an updated version of the classification and highlighted the importance of a multidisciplinary approach.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2022)
Article
Dermatology
Zhixiang Zhao, Tangxiele Liu, Yinming Liang, Weiwei Cui, Dong Li, Guohong Zhang, Zhili Deng, Mengting Chen, Ke Sha, Wenqin Xiao, Hongfu Xie, Ji Li
Summary: The polarization of neutrophils in rosacea, particularly towards N2 phenotype, has been found to have anti-inflammatory effects by regulating vascular factors and CD4(+) T cell proliferation.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Dermatology
I Trave, C. Micalizzi, G. Gasparini, E. Cozzani, A. Parodi
Summary: Papulopustular rosacea presents specific dermoscopic findings, but dermoscopy alone is not sufficient for diagnosing Demodex proliferation in rosacea. Different dermoscopic features were observed between patients with different severity of rosacea, but no significant differences were found between patients with and without concomitant Demodex infestation.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Angela Pirillo, Manuela Casula, Alberico L. Catapano
Summary: Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of mortality and morbidity worldwide, and low-density lipoprotein cholesterol (LDL-C) is an important causal factor. The 2019 ESC and EAS guidelines provide guidance for the management of dyslipidaemia, emphasizing the importance of lowering LDL-C and considering other factors associated with cardiovascular risk.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Dermatology
Hanlin Zhang, Keyun Tang, Yuchen Wang, Rouyu Fang, Qiuning Sun
Summary: Rosacea is a chronic and inflammatory skin disease with various characteristic features and secondary manifestations. The update on diagnosis and classification has emphasized the importance of treatment selection for patients with rosacea.
DERMATOLOGY AND THERAPY
(2021)
Article
Dermatology
Martin Schaller, Simon Riel, Rawad Bashur, Nithin Kurup, Harald Schnidar, Birgit Fehrenbacher
Summary: Ivermectin 1% cream is effective in treating papules and pustules as well as improving erythema and invisible skin symptoms in patients with rosacea.
DERMATOLOGIC THERAPY
(2022)
Article
Dermatology
Annelie H. Musters, Conor Broderick, David Prieto-Merino, Andrea Chiricozzi, Giovanni Damiani, Ketty Peris, Sandipan Dhar, Abhishek De, Esther Freeman, Bernd W. M. Arents, Tim Burton, Angela Leigh-Ann L. Bosma, Ching-Chi Chi, Godfrey Fletcher, Aaron M. Drucker, Kenji Kabashima, Emilie F. de Monchy, Maitreyee Panda, Dmitri Robert Wall, Christian Vestergaard, Emmanuel Mahe, Laura Bonzano, Leila Kattach, Maddalena Napolitano, Maria Fernanda Ordonez-Rubiano, Eva Haufe, Cataldo Patruno, Alan D. Irvine, Phyllis Spuls, Carsten Flohr
Summary: Limited data suggest that patients with atopic dermatitis (AD) receiving systemic immunomodulatory treatments have a lower risk of severe COVID-19 complications. Monotherapy with dupilumab is associated with lower hospitalization rates compared to other therapies. However, combination systemic treatments, particularly those including systemic corticosteroids, have the highest risk of severe COVID-19.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Allergy
Conor Broderick, Stefanie Ziehfreund, Karin van Bart, Bernd Arents, Kilian Eyerich, Stephan Weidinger, Joseph Rastrick, Alexander Zink, Carsten Flohr, BIOMAP Consortium
Summary: Biomarkers associated with the development of comorbidities in atopic dermatitis (AD) patients have been inconsistently reported, and there is a lack of high-quality studies. Commonly reported biomarkers include filaggrin mutations and allergen specific-IgE, while promising biomarkers include specific-IgE and/or skin prick tests for predicting asthma development, and genetic polymorphisms for predicting eczema herpeticum occurrence.
Editorial Material
Dermatology
Bernd W. M. Arents
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Review
Dermatology
Jerry Tan, Rajeev Chavda, Hilary Baldwin, Brigitte Dreno
Summary: Trifarotene is a recently approved topical retinoid for acne, acting selectively on retinoic acid receptor (RAR) gamma. It reduces hyperkeratinization and inflammation by increasing keratinocyte differentiation, inhibiting leukocyte migration, toll-like receptors, and Activator Protein (AP)-1. Clinical trials have demonstrated its safety and efficacy in reducing comedones and papules/pustules, particularly in truncal acne. This review provides an overview of the data supporting trifarotene's use in acne management.
JOURNAL OF CUTANEOUS MEDICINE AND SURGERY
(2023)
Letter
Dermatology
A. Wollenberg, M. Kinberger, B. Arents, N. Aszodi, S. Barbarot, T. Bieber, H. A. Brough, P. C. Pinton, S. Christen-Zaech, M. Deleuran, M. Dittmann, N. Fosse, K. Gaspar, L. A. A. Gerbens, U. Gieler, G. Girolomoni, S. Gregoriou, C. G. Mortz, A. Nast, U. Nygaard, E. M. Rehbinder, J. Ring, M. Rossi, C. Roxburgh, E. Serra-Baldrich, D. Simon, Z. Z. Szalai, J. C. Szepietowski, A. Torrelo, T. Werfel, C. Flohr
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Editorial Material
Dermatology
Bernd W. M. Arents, Esther J. van Zuuren, Olivia Hughes, Zbys Fedorowicz, Carsten Flohr
Summary: The International League of Dermatological Societies launched the Global Atopic Dermatitis Atlas (GADA) in 2022 to address the disparities in prevalence and disease burden of atopic dermatitis (AD) worldwide, particularly in low- and middle-income settings where data is lacking. The recent Global Report on Atopic Dermatitis serves as a baseline. Moving forward, GADA will serve as a central hub for AD burden data by conducting regular systematic evidence syntheses and fieldwork in understudied populations.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Letter
Infectious Diseases
Chiara van der Worp, Tara Middeldorp, Laura Kuijpers, Jonna Bank, Lisa Dol, Martha van der Beek, Esther J. van Zuuren, Bart Hendriks, Leo Visser, Mark de Boer, Merel Lambregts
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Allergy
Malak Al-Gawahiri, Thomas Rustemeyer, Sylvie M. Franken, Esther J. van Zuuren, Norbertus A. Ipenburg
Summary: This study investigates the frequency and clinical relevance of contact allergy in dental patients through patch testing. Results show that clinically relevant patch test reactions were frequently seen in dental patients. However, further studies are needed to confirm these findings.
CONTACT DERMATITIS
(2023)
Letter
Dermatology
F. L. de Boer, B. W. M. Arents, Z. Kowalska, P. P. G. Simons, N. M. de Roos, P. M. Kemperman, T. Rustemeyer
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Dermatology
Yael Renert-Yuval, Ester Del Duca, Bernd Arents, Robert Bissonnette, Aaron M. Drucker, Carsten Flohr, Emma Guttman-Yassky, Dirkjan Hijnen, Kenji Kabashima, Yael A. Leshem, Amy S. Paller, Jonathan I. Silverberg, Eric L. Simpson, Phyllis Spuls, Christian Vestergaard, Andreas Wollenberg, Alan D. Irvine, Jacob P. Thyssen
Summary: This study evaluated the existing data on the treat-to-target (T2T) approach in dermatology, with a specific focus on atopic dermatitis (AD). The results showed that the T2T approach may be a useful tool in simplifying therapeutic goals and managing AD, but its application in AD is still in the early stages and requires a multidisciplinary approach and involvement of various stakeholders.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Correction
Dermatology
D. Kerob, A. Czermanska, E. M. Karamon
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Dermatology
Delphine Kerob, Anna Czermanska, Ewa M. Karamon, Alain Moga, Guillaume Lecerf, Margot Niore, Guenaelle Le Dantec, Caroline Le Floc'h, Jerry Tan
Summary: This study aimed to assess the benefits of a skincare product for individuals with an allergic background or sensitive skin. The results showed that the product significantly reduced skin intolerance and sensitivity, improved skin hydration, and received high satisfaction and tolerance from users.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Letter
Dermatology
Ewa Karamon, Anna Czermanska, Delphine Kerob, Ann' Laure Demessant, Guenaelle Le Dantec, Caroline le Floc'h, Jerry Tan
JOURNAL OF COSMETIC DERMATOLOGY
(2023)