Towards clinical application of tau PET tracers for diagnosing dementia due to Alzheimer's disease

The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers

(2021) N. J. Ashton et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Clinical validity of increased cortical uptake of [18F]flortaucipir on PET as a biomarker for Alzheimer’s disease in the context of a structured 5-phase biomarker development framework

(2021) E. E. Wolters et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Diagnostic value of plasma phosphorylated tau181 in Alzheimer’s disease and frontotemporal lobar degeneration

(2020) Elisabeth H. Thijssen et al.   NATURE MEDICINE

Assessment of Demographic, Genetic, and Imaging Variables Associated With Brain Resilience and Cognitive Resilience to Pathological Tau in Patients With Alzheimer Disease

(2020) Rik Ossenkoppele et al.   JAMA Neurology

Regional [18F]flortaucipir PET is more closely associated with disease severity than CSF p-tau in Alzheimer’s disease

(2020) Emma E. Wolters et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Blood phosphorylated tau 181 as a biomarker for Alzheimer's disease: a diagnostic performance and prediction modelling study using data from four prospective cohorts

(2020) Thomas K Karikari et al.   LANCET NEUROLOGY

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   NATURE MEDICINE

Research criteria for the diagnosis of prodromal dementia with Lewy bodies

(2020) Ian G. McKeith et al.   NEUROLOGY

Positron Emission Tomography Imaging With [18F]flortaucipir and Postmortem Assessment of Alzheimer Disease Neuropathologic Changes

(2020) Adam S. Fleisher et al.   JAMA Neurology

Diagnostic Performance of RO948 F 18 Tau Positron Emission Tomography in the Differentiation of Alzheimer Disease From Other Neurodegenerative Disorders

(2020) Antoine Leuzy et al.   JAMA Neurology

Aβ deposition is associated with increases in soluble and phosphorylated tau that precede a positive Tau PET in Alzheimer’s disease

(2020) Niklas Mattsson-Carlgren et al.   Science Advances

18F-MK-6240 PET for early and late detection of neurofibrillary tangles

(2020) Tharick A Pascoal et al.   BRAIN

Longitudinal neuroimaging biomarkers differ across Alzheimer’s disease phenotypes

(2020) Irene Sintini et al.   BRAIN

Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases

(2020) Elizabeth C. Mormino et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Discriminative Accuracy of Plasma Phospho-tau217 for Alzheimer Disease vs Other Neurodegenerative Disorders

(2020) Sebastian Palmqvist et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

One stop shop: Flortaucipir PET differentiates amyloid positive and negative forms of neurodegenerative diseases

(2020) Jochen Hammes et al.   JOURNAL OF NUCLEAR MEDICINE

Synergy between amyloid-β and tau in Alzheimer’s disease

(2020) Marc Aurel Busche et al.   NATURE NEUROSCIENCE

Assessment of 18F-PI-2620 as a Biomarker in Progressive Supranuclear Palsy

(2020) Matthias Brendel et al.   JAMA Neurology

Comparison of regional flortaucipir PET with quantitative tau immunohistochemistry in three subjects with Alzheimer’s disease pathology: a clinicopathological study

(2020) Michael J. Pontecorvo et al.   EJNMMI Research

Spatial Relationships between Molecular Pathology and Neurodegeneration in the Alzheimer’s Disease Continuum

(2020) Leonardo Iaccarino et al.   CEREBRAL CORTEX

Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults

(2020) Matthew R. Scott et al.   NEUROIMAGE

Longitudinal tau accumulation and atrophy in aging and alzheimer disease

(2019) Theresa M. Harrison et al.   ANNALS OF NEUROLOGY

Tau PET imaging in neurodegenerative tauopathies—still a challenge

(2019) Antoine Leuzy et al.   MOLECULAR PSYCHIATRY

Associations between tau, Aβ, and cortical thickness with cognition in Alzheimer disease

(2019) Rik Ossenkoppele et al.   NEUROLOGY

Effect of off-target binding on 18F-Flortaucipir variability in healthy controls across the lifespan

(2019) Suzanne L Baker et al.   JOURNAL OF NUCLEAR MEDICINE

Tau PET in autosomal dominant Alzheimer’s disease: relationship with cognition, dementia and other biomarkers

(2019) Brian A Gordon et al.   BRAIN

Entorhinal cortex tau, amyloid-β, cortical thickness and memory performance in non-demented subjects

(2019) David S Knopman et al.   BRAIN

Predicting diagnosis and cognition with 18F-AV-1451 tau PET and structural MRI in Alzheimer's disease

(2019) Niklas Mattsson et al.   Alzheimers & Dementia

Early versus late MCI: Improved MCI staging using a neuropsychological approach

(2019) Emily C. Edmonds et al.   Alzheimers & Dementia

Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report

(2019) Peter T Nelson et al.   BRAIN

A multicentre longitudinal study of flortaucipir (18F) in normal ageing, mild cognitive impairment and Alzheimer’s disease dementia

(2019) Michael J Pontecorvo et al.   BRAIN

Association of Amyloid Positron Emission Tomography With Subsequent Change in Clinical Management Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia

(2019) Gil D. Rabinovici et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Progressive tau accumulation in Alzheimer’s disease: two-year follow-up study

(2019) Hanna Cho et al.   JOURNAL OF NUCLEAR MEDICINE

Level of education mitigates the impact of tau pathology on neuronal function

(2019) Merle C. Hoenig et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

[18F]GTP1 (Genentech Tau Probe 1), a radioligand for detecting neurofibrillary tangle tau pathology in Alzheimer’s disease

(2019) Sandra Sanabria Bohórquez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Associations between quantitative [18F]flortaucipir tau PET and atrophy across the Alzheimer’s disease spectrum

(2019) Tessa Timmers et al.   Alzheimers Research & Therapy

The bivariate distribution of amyloid-β and tau: relationship with established neurocognitive clinical syndromes

(2019) Clifford R Jack et al.   BRAIN

Test–retest repeatability of [18F]Flortaucipir PET in Alzheimer’s disease and cognitively normal individuals

(2019) Tessa Timmers et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Tau-positron emission tomography correlates with neuropathology findings

(2019) Val J. Lowe et al.   Alzheimers & Dementia

Evaluation of dosimetry, quantitative methods and test-retest variability of 18F-PI-2620 PET for the assessment of tau deposits in the human brain

(2019) Santiago Bullich et al.   JOURNAL OF NUCLEAR MEDICINE

Amyloid and tau imaging biomarkers explain cognitive decline from late middle-age

(2019) Tobey J Betthauser et al.   BRAIN

Binding of [18F]AV1451 in post mortem brain slices of semantic variant primary progressive aphasia patients

(2019) Jolien Schaeverbeke et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Evidence-based Interpretation of Amyloid-β PET Results

(2018) David Bergeron et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Imaging correlations of tau, amyloid, metabolism, and atrophy in typical and atypical Alzheimer's disease

(2018) Jennifer L. Whitwell et al.   Alzheimers & Dementia

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Longitudinal tau PET in ageing and Alzheimer’s disease

(2018) Clifford R Jack et al.   BRAIN

Comparing18F-AV-1451 with CSF t-tau and p-tau for diagnosis of Alzheimer disease

(2018) Niklas Mattsson et al.   NEUROLOGY

Association of Amyloid Positron Emission Tomography With Changes in Diagnosis and Patient Treatment in an Unselected Memory Clinic Cohort

(2018) Arno de Wilde et al.   JAMA Neurology

Hypometabolism of the posterior cingulate cortex is not restricted to Alzheimer's disease

(2018) Nienke M.E. Scheltens et al.   NeuroImage-Clinical

Evaluation of18F-RO-948 (18F-RO6958948) for quantitative assessment of tau accumulation in the human brain with positron emission tomography

(2018) Hiroto Kuwabara et al.   JOURNAL OF NUCLEAR MEDICINE

Influence of tau PET, amyloid PET, and hippocampal volume on cognition in Alzheimer disease

(2018) Andrew J. Aschenbrenner et al.   NEUROLOGY

Greater tau load and reduced cortical thickness in APOE ε4-negative Alzheimer’s disease: a cohort study

(2018) Niklas Mattsson et al.   Alzheimers Research & Therapy

Correlation of In Vivo [18F]Flortaucipir With Postmortem Alzheimer Disease Tau Pathology

(2018) Ruben Smith et al.   JAMA Neurology

Flortaucipir tau PET imaging in semantic variant primary progressive aphasia

(2017) Sara J Makaretz et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

[ 18 F]AV-1451 binding in vivo mirrors the expected distribution of TDP-43 pathology in the semantic variant of primary progressive aphasia

(2017) W R Bevan-Jones et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Tau pathology and cognitive reserve in Alzheimer's disease

(2017) Merle Christine Hoenig et al.   NEUROBIOLOGY OF AGING

Associations between [18F]AV1451 tau PET and CSF measures of tau pathology in a clinical sample

(2017) Renaud La Joie et al.   NEUROLOGY

Elevated 18 F-AV-1451 PET tracer uptake detected in incidental imaging findings

(2017) Samuel N. Lockhart et al.   NEUROLOGY

Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease

(2017) Chenjie Xia et al.   JAMA Neurology

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

Cognitive resilience in clinical and preclinical Alzheimer’s disease: the Association of Amyloid and Tau Burden on cognitive performance

(2016) Dorene M. Rentz et al.   Brain Imaging and Behavior

In vivo Patterns of Tau Pathology, Amyloid-β Burden, and Neuronal Dysfunction in Clinical Variants of Alzheimer’s Disease

(2016) Julian Dronse et al.   JOURNAL OF ALZHEIMERS DISEASE

Preclinical Characterization of 18F-MK-6240, a Promising PET Tracer for In Vivo Quantification of Human Neurofibrillary Tangles

(2016) E. D. Hostetler et al.   JOURNAL OF NUCLEAR MEDICINE

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

An autoradiographic evaluation of AV-1451 Tau PET in dementia

(2016) Val J. Lowe et al.   Acta Neuropathologica Communications

Diagnostic impact of CSF biomarkers for Alzheimer's disease in a tertiary memory clinic

(2015) Flora H. Duits et al.   Alzheimers & Dementia

Validating novel tau positron emission tomography tracer [F-18]-AV-1451 (T807) on postmortem brain tissue

(2015) Marta Marquié et al.   ANNALS OF NEUROLOGY

Prevalence of Amyloid PET Positivity in Dementia Syndromes

(2015) Rik Ossenkoppele et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Tau imaging: early progress and future directions

(2015) Victor L Villemagne et al.   LANCET NEUROLOGY

Pathological Tau Disrupts Ongoing Network Activity

(2015) Noa Menkes-Caspi et al.   NEURON

Diagnostic Criteria for Vascular Cognitive Disorders

(2014) Perminder Sachdev et al.   ALZHEIMER DISEASE & ASSOCIATED DISORDERS

Diagnosis and Treatment of Corticobasal Degeneration

(2014) Melissa J. Armstrong   Current Treatment Options in Neurology

Age-specific population frequencies of cerebral β-amyloidosis and neurodegeneration among people with normal cognitive function aged 50–89 years: a cross-sectional study

(2014) Clifford R Jack et al.   LANCET NEUROLOGY

The Intersection of Amyloid Beta and Tau at Synapses in Alzheimer’s Disease

(2014) Tara L. Spires-Jones et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Update on appropriate use criteria for amyloid PET imaging: Dementia experts, mild cognitive impairment, and education

(2013) Keith A. Johnson et al.   Alzheimers & Dementia

[18F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease

(2013) Chun-Fang Xia et al.   Alzheimers & Dementia

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Meta-analysis of amyloid-cognition relations in cognitively normal older adults

(2013) T. Hedden et al.   NEUROLOGY

Impact of molecular imaging on the diagnostic process in a memory clinic

(2012) Rik Ossenkoppele et al.   Alzheimers & Dementia

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Accuracy of the Clinical Diagnosis of Alzheimer Disease at National Institute on Aging Alzheimer Disease Centers, 2005–2010

(2012) Thomas G. Beach et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Age and diagnostic performance of Alzheimer disease CSF biomarkers

(2012) N. Mattsson et al.   NEUROLOGY

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia

(2011) Katya Rascovsky et al.   BRAIN

Age, Neuropathology, and Dementia

(2009) George M. Savva et al.   NEW ENGLAND JOURNAL OF MEDICINE