Article
Biochemistry & Molecular Biology
Maryam Asadi Farsani, Ebrahim Banitalebi, Mohammad Faramarzi, Nuredin Bakhtiari, Mostafa Rahimi, Gustavo Duque
Summary: This study explored the effects of ursolic acid and different types of exercise on glycemic control and aging/diabetes-associated complications. The results showed that eight weeks of resistance training could affect miR-133a expression in muscles and the biomarker RUNX2 in aged type 2 diabetes model rats.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Plant Sciences
Yong Zhang, Ruiqi Wang, Yanan Yang, Ning Ma, Zhi Zhou, Yinfeng Tan, Lin Dong, Yiying Li, Weiying Lu, Chongming Wu, Xiaopo Zhang
Summary: This study found that laurolitsine (LL) has potent antidiabetic effects in vitro and in vivo, improving insulin resistance, glucose metabolism, and promoting weight loss. Its mechanisms of actions involve the regulation of the hepatic LKB1/AMPK pathway and gut microbiota.
Review
Medicine, General & Internal
Ehtasham Ahmad, Soo Lim, Roberta Lamptey, David R. Webb, Melanie J. Davies
Summary: Type 2 diabetes accounts for nearly 90% of global diabetes cases, with an increasing number of affected individuals, particularly among young people. Early detection and proactive management are crucial for preventing complications and reducing mortality. Technology and precision medicine offer potential improvements to treatment outcomes but face significant barriers.
Article
Plant Sciences
Jing Bai, Shuai Zhang, Jinjing Cao, Hongbin Sun, Zhiguo Mang, Wei L. Shen, Hao Li
Summary: This study suggests that the natural product HER indirectly activates AMPK by suppressing its dephosphorylation, and has the potential to be a therapeutic option for type 2 diabetes. Oral HER effectively alleviates hyperglycemia and reduces body weight, with a lower risk of cardiac hypertrophy.
Review
Pharmacology & Pharmacy
Abhipree Sharma, Michael Mah, Rebecca H. Ritchie, Miles J. De Blasio
Summary: Diabetes is associated with an increased risk of heart failure known as diabetic cardiomyopathy. Adiponectin, a cardioprotective adipokine, is downregulated in diabetes and obesity, leading to reduced cardioprotection. This review summarizes the evidence linking suppressed adiponectin signaling pathway to cardiac dysfunction in diabetes and discusses potential therapeutic approaches for diabetic cardiomyopathy.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Multidisciplinary Sciences
Valentina V. Miroshnikova, Kseniya V. Dracheva, Roman A. Kamyshinsky, Evgeny V. Yastremsky, Luiza A. Garaeva, Irina A. Pobozheva, Sergey B. Landa, Kristina A. Anisimova, Stanislav G. Balandov, Zarina M. Hamid, Dmitriy I. Vasilevsky, Sofya N. Pchelina, Andrey L. Konevega, Tatiana A. Shtam
Summary: Extracellular vesicles (EVs) are cell-derived membrane vesicles that mediate cell-to-cell communication and physiology by transporting various cargo. In this study, EVs secreted by visceral and subcutaneous adipose tissue of obese patients with type 2 diabetes mellitus (T2DM) were characterized and analyzed using cryo-electron microscopy. The results showed a heterogeneous population of EVs, with single vesicles being the most abundant. Visceral adipose tissue (VAT) EVs had a higher proportion of EVs with internal membrane structures compared to subcutaneous adipose tissue (SAT) EVs. Obese patients with/without T2DM exhibited smaller EVs in SAT compared to VAT, as well as a larger proportion of multilayered EVs and EVs with internal membrane structures secreted by VAT. These findings provide evidence for modified EV biogenesis during obesity and T2DM.
Article
Biotechnology & Applied Microbiology
Weiyan Ren, Yijie Duan, Yih-Kuen Jan, Wenqiang Ye, Jianchao Li, Wei Liu, Hongmei Liu, Junchao Guo, Fang Pu, Yubo Fan
Summary: This study found that higher volumes of exercise are associated with better plantar microcirculation and lower plantar tissue hardness in people with type 2 diabetes. Additionally, weight-bearing exercise appeared to not increase the risk of developing diabetic foot ulcers.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Nutrition & Dietetics
Blanca Alabadi, Miguel Civera, Adrian De la Rosa, Sergio Martinez-Hervas, Mari Carmen Gomez-Cabrera, Jose T. Real
Summary: The study reveals a high prevalence of frailty and elevated levels of oxidative stress in elderly individuals with type 2 diabetes, emphasizing the importance of diagnosing frailty in this population for better management of conditions associated with aging and diabetes.
Article
Biochemistry & Molecular Biology
Jinsoo Kim, Jinyoung Son, Dohee Ahn, Gibeom Nam, Xiaodi Zhao, Hyuna Park, Woojoo Jeong, Sang J. Chung
Summary: Ginkgolic acid analog 1e is a potential therapeutic candidate for type 2 diabetes, as it increases glucose uptake and suppresses insulin resistance through PTPN9 inhibition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Chang Guo, Li Zhao, Yanyan Li, Xia Deng, Guoyue Yuan
Summary: Sedentary lifestyle and high-calorie diets increase the risk of obesity and type 2 diabetes, while exercise and diet control are important treatment options. FGF21 plays a crucial role in regulating glucose and lipid metabolism, and its elevated levels in obesity and diabetes can be used as predictors of diabetes. Clinical antidiabetic drugs can decrease FGF21 levels, potentially improving FGF21 sensitivity.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Haekyung Lee, Hyoungnae Kim, Jin Seok Jeon, Hyunjin Noh, Rojin Park, Dong Won Byun, Hye Jeong Kim, Kyoil Suh, Hyeong Kyu Park, Soon Hyo Kwon
Summary: This study evaluated the effects of empagliflozin, an SGLT2 inhibitor, on mitochondrial function and inflammatory environment in the kidneys of type 2 diabetes patients. The results showed that empagliflozin could attenuate mitochondrial damage and inhibit inflammatory response, explaining the beneficial effects of SGLT2 inhibitors on cardiovascular and renal outcomes.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Kareem Abdelsaid, Varadarajan Sudhahar, Ryan A. Harris, Archita Das, Seock-Won Youn, Yutao Liu, Maggie McMenamin, Yali Hou, David Fulton, Mark W. Hamrick, Yaoliang Tang, Tohru Fukai, Masuko Ushio-Fukai
Summary: Exercise can improve the angiogenic potential of circulating exosomes in patients with type 2 diabetes, and the presence of extracellular superoxide dismutase (SOD3) plays a crucial role in this process. SOD3 increases ATP7A in exosomes, leading to enhanced angiogenesis. Exosomes overexpressing SOD3 show promising results in promoting angiogenesis and wound repair.
Article
Nutrition & Dietetics
Alessio Bellini, Andrea Nicolo, Rocco Bulzomi, Ilenia Bazzucchi, Massimo Sacchetti
Summary: Postprandial exercise, especially aerobic exercise, can significantly improve the glycemic response in patients with type 2 diabetes. The combination of aerobic and resistance exercise shows greater benefits in reducing post-meal blood glucose levels, with aerobic exercise performed alone or before resistance exercise showing the most advantages.
Article
Endocrinology & Metabolism
Amelia S. Wallace, Alex R. Chang, Jung-Im Shin, Jodie Reider, Justin B. Echouffo-Tcheugui, Morgan E. Grams, Elizabeth Selvin
Summary: This study found that the prevalence of obesity is increasing in patients with type 1 diabetes (T1D), and obesity is associated with an increased risk of chronic kidney disease (CKD). After adjusting for age, the burden of CKD in T1D exceeds that in type 2 diabetes (T2D), highlighting the need for increased vigilance and assessment of kidney-protective medications in T1D.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Medicine, Research & Experimental
Hong Wang, Minyi Huang, Weijian Bei, Yiqi Yang, Lixia Song, Dongxing Zhang, Wenjing Zhan, Yuzhen Zhang, Xu Chen, Weixuan Wang, Lexun Wang, Jiao Guo
Summary: FTZ can attenuate NASH by ameliorating steatosis and hepatocyte apoptosis through regulating the AMPK pathway.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Pediatrics
Fernanda Ornellas, Priscila V. Carapeto, Carlos A. Mandarim-de-Lacerda, Marcia B. Aguila
JORNAL DE PEDIATRIA
(2017)
Article
Public, Environmental & Occupational Health
P. V. Carapeto, F. Ornellas, C. A. Mandarim-de-Lacerda, M. B. Aguila
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE
(2018)
Article
Endocrinology & Metabolism
Priscila Viana Carapeto, Carlos A. Mandarim-de-Lacerda, Marcia Barbosa Aguila
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2020)
Article
Endocrinology & Metabolism
Ayush Midha, Hui Pan, Cristian Abarca, Joshua Andle, Priscila Carapeto, Susan Bonner-Weir, Cristina Aguayo-Mazzucato
Summary: Aging pancreatic beta-cells may develop a senescence-associated secretory phenotype (SASP) that can lead to dysfunction of neighboring cells through paracrine actions. The specific secretory profile of senescent beta-cells could have implications in both health and disease.
