Article
Chemistry, Analytical
Jun-Jie Bai, Xuan Zhang, Xing Wei, Yu Wang, Cheng Du, Ze-Jun Wang, Ming-Li Chen, Jian-Hua Wang
Summary: Exosomes are crucial biomarkers for intercellular communication and disease diagnosis and treatment. This study presents a microfluidic chip called DEIC for isolating high-purity exosomes from small-volume biological samples. The chip utilizes elastoinertial separation to remove protein contaminants and achieves a 70.6% recovery and a 91.4% removal rate for proteins. The technique enables individual-vesicle-level biomarker analysis and shows potential for integration with downstream exosome analyses.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Mohammad Moein Naderi, Ludovica Barilla, Jian Zhou, Ian Papautsky, Zhangli Peng
Summary: The study on elasto-inertial focusing highlighted the interaction between elastic force and shear-gradient lift force leading to different particle focusing patterns. Both experimental and simulation studies were conducted to investigate the effects of flowrate, particle size, and shear-thinning extent on focusing patterns, emphasizing the importance of accurately estimating shear-thinning extent in modeling.
Article
Nanoscience & Nanotechnology
Hua Gao, Jian Zhou, Mohammad Moein Naderi, Zhangli Peng, Ian Papautsky
Summary: Particle migration dynamics in viscoelastic fluids in spiral channels for 3D focusing and label-free sorting has been studied extensively, but the underlying mechanism is not fully understood. In this work, we experimentally demonstrate the evolution of particle focusing behavior in spiral microchannels with high blockage ratio and reveal the important roles of flow rate, device curvature, and medium viscosity. Our results provide insights into the design of elasto-inertial microfluidics devices for improved efficiency in cell sorting and cytometry applications.
MICROSYSTEMS & NANOENGINEERING
(2023)
Article
Chemistry, Analytical
Lei Zhao, Mengqi Gao, Yanbing Niu, Jianchun Wang, Shaofei Shen
Summary: A novel microchannel structure was developed for flow-rate and particle-size insensitive inertial focusing; efficient focusing of particles and tumor cells at different flow rates was achieved through enhanced secondary flow; providing important reference for the development of portable inertial microfluidic devices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Mechanics
Mohammad Charjouei Moghadam, Armin Eilaghi, Pouya Rezai
Summary: This study used numerical simulation to investigate elasto-inertial focusing of microparticles in a straight microchannel, proposing a new threshold for particle dispersion prediction. An empirical non-dimensional correlation was developed to predict elasto-inertial particle dispersion in straight square cross-sectional microchannels, reducing the predicted dispersion variation from about 15% to less than about 5%.
Article
Physics, Applied
Di Jiang, Chen Ni, Wenlai Tang, Nan Xiang
Summary: Numerical simulation was used to explore particle elasto-inertial focusing in straight microchannels, revealing that increased flow intensity and particle diameter can accelerate focusing migration, while flow elasticity weakens particle rotation and lateral focusing towards the channel centerline. The competition mechanisms of forces were elucidated under different Reynolds and Weissenberg numbers.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2021)
Article
Mechanics
I. Banerjee, M. E. Rosti, T. Kumar, L. Brandt, A. Russom
Summary: A unique tunable trend in particle focusing is reported in elasto-inertial flows, where particles can be tuned to different focusing bandwidths. Numerical simulations and experimental observations show that particle focusing is affected by minute amounts of elasticity and flow rates. The study provides a new understanding of particle focusing in weakly elastic and strongly inertial flows, with potential applications in microfluidics-based biological sorting.
Article
Biochemical Research Methods
Pablo Rodriguez-Mateos, Bongkot Ngamsom, Charlotte E. Dyer, Alexander Iles, Nicole Pamme
Summary: The early detection of pathogenic microorganisms is crucial for diagnosing and preventing health and safety emergencies. Traditional detection methods rely on time-consuming culturing procedures and biochemical assays, taking over 24 hours for a diagnosis. The main challenge lies in the low concentration of pathogens within complex samples. Inertial microfluidic manipulation in curved glass channels shows promise for automating and parallelizing particle and cell separation.
Article
Chemistry, Multidisciplinary
Jaekyeong Jang, Uihwan Kim, Taehoon Kim, Younghak Cho
Summary: This research utilized soft lithography to fabricate microchannels with various T-shaped cross-sections for particle focusing and separation in viscoelastic solution. The effects of flow rate and geometric shapes on particle focusing were evaluated, and numerical simulation was used to analyze the impacts of corner angle and aspect ratio on the focusing phenomenon.
APPLIED SCIENCES-BASEL
(2022)
Article
Chemistry, Analytical
Haidong Feng, Alexander R. Jafek, Bonan Wang, Hayden Brady, Jules J. Magda, Bruce K. Gale
Summary: This paper studies particle focusing in viscoelastic flow and predicts the focusing position by analyzing the force balance. The research finds that particle separation resolution can be improved in viscoelastic flows.
Article
Engineering, Chemical
Afshin Shiriny, Morteza Bayareh
Summary: A novel microscale device for continuous flow separation of two types of circulating tumor cells from blood cells was proposed in this study. The separation efficiency reached 100% over a range of Reynolds numbers from 90 to 110, achieved through inertial forces.
CHEMICAL ENGINEERING SCIENCE
(2021)
Article
Multidisciplinary Sciences
Masoud Moazzen, Tom Lacassagne, Vincent Thomy, S. Amir Bahrani
Summary: The dynamic properties of elasto-inertial turbulence (EIT) in a Taylor-Couette geometry have been studied. EIT is a chaotic flow state that occurs when both inertia and viscoelasticity are significant. Through direct flow visualization and torque measurement, it has been confirmed that EIT develops earlier than purely inertial instabilities. The scaling of the pseudo-Nusselt number with inertia and elasticity has also been discussed for the first time.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND ENGINEERING SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Taehong Kwon, Kyungyong Choi, Jongyoon Han
Summary: This study demonstrates the successful manipulation of ultra-high-density cells using elasto-inertial microfluidics, achieving stable focusing and clarification under high-flow conditions. The findings open up new opportunities for practical applications of high-particle-density suspension manipulation.
Article
Multidisciplinary Sciences
Tharagan Kumar, Harisha Ramachandraiah, Sharath Narayana Iyengar, Indradumna Banerjee, Gustaf Martensson, Aman Russom
Summary: In this study, high Reynolds number viscoelastic particle focusing and separation in spiral channels was explored. The balance between dominant inertial lift force, dean drag force, and elastic force enables stable 3D particle focusing at dynamically high Reynolds numbers. Effective separation based on size was achieved with high precision.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Electrical & Electronic
Shuang Chen, Zongqian Shi, Jiajia Sun, Shenli Jia, Mingjie Zhong, Yuxin Ma
Summary: Inertial microfluidic is a widely applied technology that uses inertial lift force and Dean Vortices to manipulate particles or bio-samples. This study introduces a split-recombination microchannel for high flow rate particle focusing and separation, utilizing the combined effects of inertial lift force, curvature-induced Dean drag force, and the structure of split and recombination. The designed microchannel not only enhances particle focusing but also enables the separation of different-sized particles with high throughput.
JOURNAL OF MICROMECHANICS AND MICROENGINEERING
(2022)
Article
Engineering, Chemical
Yongxiang Wu, Nguyen Thi Hong Nhung, Deqian Zeng, Nengneng Luo, Akira Otsuki, Gjergj Dodbiba, Toyohisa Fujita
Summary: This study proposed a novel method for synthesizing flower-like vaterite calcium carbonate using nanobubble-containing ethanol and water mixed solution as the solvent and discussed the formation mechanism of vaterite with different shapes. The synthesized vaterite has significant practical interest in the integrated treatment of wastewater contaminated by heavy metals with effective Cd(II) removal, providing a promising field for studying heavy metal and pollutant adsorption in the liquid phase.
ADVANCED POWDER TECHNOLOGY
(2024)
Article
Engineering, Chemical
Jian Gong, Lipo Cheng, Ming Liu, Jie Jiang, Xiaoduo Ou
Summary: This study investigates the effects of particle shape on the collapse of granular columns using the discrete element method. The results show that particle shape has a significant impact on deposition morphology, energy evolution, and mechanical coordination number. Sphericity and angularity are identified as the most important macroscale factors, while roughness has a weaker microscale influence.
ADVANCED POWDER TECHNOLOGY
(2024)
