Review
Medicine, General & Internal
Dan H. Barouch
Summary: This article reviews the protective effects of vaccination and prior infection on severe Covid-19, and proposes future research directions.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Multidisciplinary Sciences
Dario Palmieri, Amanda Javorina, Jalal Siddiqui, Anne Gardner, Anthony Fries, Richard R. Chapleau, Clarise Starr, Richard Fishel, Wayne O. Miles
Summary: This article introduces a high-throughput sequencing method REMBRANDT, which can simultaneously screen over 100,000 samples and provides a potentially powerful tool for community screening of COVID-19.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Qin Liu, Qi Su, Fen Zhang, Hein M. Tun, Joyce Wing Yan Mak, Grace Chung-Yan Lui, Susanna So Shan Ng, Jessica Y. L. Ching, Amy Li, Wenqi Lu, Chenyu Liu, Chun Pan Cheung, David S. C. Hui, Paul K. S. Chan, Francis Ka Leung Chan, Siew C. Ng
Summary: By integrating clinical features and multi-omics data, the authors identified specific gut microbiome patterns associated with disease severity and development of post-acute COVID-19 syndrome. These findings highlight the potential utility of host phenotype and multi-kingdom microbiota profiling as a prognostic tool for patients with COVID-19.
NATURE COMMUNICATIONS
(2022)
Editorial Material
Immunology
Rustom Antia, M. Elizabeth Halloran
Summary: The article discusses the basic concepts underlying the transition from an epidemic to an endemic state, as well as the implications of this transition for COVID-19.
Review
Chemistry, Physical
Albert D. Luong, Alyah Buzid, Sandeep K. Vashist, John H. T. Luong
Summary: Rapid detection of COVID-19 is urgently needed, with novel electrochemical biosensors being able to detect viral structure proteins and human immune responses quickly. However, developing point-of-care testing devices requires extensive validation, while nanomaterial-based biosensors are also playing a role in fast detection of early viral infections.
CURRENT OPINION IN ELECTROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Marcia C. Castro, Sun Kim, Lorena Barberia, Ana Freitas Ribeiro, Susie Gurzenda, Karina Braga Ribeiro, Erin Abbott, Jeffrey Blossom, Beatriz Rache, Burton H. Singer
Summary: The study found that COVID-19 in Brazil is spreading rapidly across municipalities with distinct spatial and temporal patterns of clustering, trajectories, and speed. Analysis shows that inadequate policy measures have led to high transmission and mortality burdens. The current surge in cases and deaths, along with the circulation of concerning variants, highlights the need for government to strengthen prevention and control measures.
Article
Nanoscience & Nanotechnology
Nicole R. Blumenfeld, Michael Anne E. Bolene, Martin Jaspan, Abigail G. Ayers, Sabin Zarrandikoetxea, Juliet Freudman, Nikhil Shah, Angela M. Tolwani, Yuhang Hu, Terry L. Chern, James Rogot, Vira Behnam, Aditya Sekhar, Xinyi Liu, Bulent Onalir, Robert Kasumi, Abdoulaye Sanogo, Kelia Human, Kasey Murakami, Goutham S. Totapally, Mark Fasciano, Samuel K. Sia
Summary: This study proposes a strategy using plasmonic polymerase chain reaction for multiplexed fluorescence detection of SARS-CoV-2 RNA in human samples, showing potential as a point-of-care approach. The use of small optical components enables rapid and accurate molecular clinical diagnostics in decentralized settings.
NATURE NANOTECHNOLOGY
(2022)
Article
Chemistry, Analytical
Hui Zhao, Feng Liu, Wei Xie, Tai-Cheng Zhou, Jun OuYang, Lian Jin, Hui Li, Chun-Yan Zhao, Liang Zhang, Jia Wei, Ya-Ping Zhang, Can-Peng Li
Summary: The study developed an ultrasensitive electrochemical detection technology using calixarene functionalized graphene oxide for targeting SARS-CoV-2 RNA without the need for nucleic acid amplification and reverse transcription. The biosensor demonstrated high specificity and selectivity, offering a rapid and convenient method for SARS-CoV-2 detection at the point of care.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Review
Public, Environmental & Occupational Health
Sazada Siddiqui, Heba Waheeb Saeed Alhamdi, Huda Ahmed Alghamdi
Summary: COVID-19 is highly contagious and has caused major disruptions around the world. Prevention is crucial through measures such as self-isolation and vaccination.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Medicine, Research & Experimental
William R. Morgenlander, Stephanie N. Henson, Daniel R. Monaco, Athena Chen, Kirsten Littlefield, Evan M. Bloch, Eric Fujimura, Ingo Ruczinski, Andrew R. Crowley, Harini Natarajan, Savannah E. Butler, Joshua A. Weiner, Mamie Z. Li, Tania S. Bonny, Sarah E. Benner, Ashwin Balagopal, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Susan H. Eshleman, Arturo Casadevall, Andrew D. Redd, Oliver Laeyendecker, Margaret E. Ackerman, Andrew Pekosz, Stephen J. Elledge, Matthew Robinson, Aaron A. R. Tobian, H. Benjamin Larman
Summary: This study found strong correlation between the functionality of COVID-19 convalescent plasma and polyclonal antibody targeting of specific peptides in the SARS-CoV-2 spike protein. Antibody responses to specific coronaviruses correlated with the development of highly neutralizing antibodies against CoV-2. Plasma donations reactive to the CoV-2 spike receptor binding domain had higher neutralizing titers.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Microbiology
Xin Li, Jia Chang, Shunmei Chen, Liangge Wang, Tung On Yau, Qiang Zhao, Zhangyong Hong, Jishou Ruan, Guangyou Duan, Shan Gao
Summary: The study identified the recombinant strain RmYN02 across the SARS1 and SARS2 classes within the betacoronavirus subgroup B, which has potential to generate a new strain with similar risk as SARS-CoV and SARS-CoV-2. Recombination, receptor binding abilities, junction furin cleavage sites, among other factors, contribute to the transmission, virulence, and host adaptability of betacoronavirus. The strong recombination ability of coronaviruses integrated with other factors resulted in the emergence of SARS-CoV and SARS-CoV-2, leading to the SARS and COVID-19 pandemics.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zeli Zhang, Jose Mateus, Camila H. Coelho, Jennifer M. Dan, Carolyn Rydyznski Moderbacher, Rosa Isela Galvez, Fernanda H. Cortes, Alba Grifoni, Alison Tarke, James Chang, E. Alexandar Escarrega, Christina Kim, Benjamin Goodwin, Nathaniel Bloom, April Frazier, Daniela Weiskopf, Alessandro Sette, Shane Crotty
Summary: Multiple COVID-19 vaccines have successfully protected against symptomatic cases and deaths. Comparisons of T cell, B cell, and antibody responses to different vaccines can provide insights into protective immunity against COVID-19, particularly immune memory. mRNA vaccines and Ad26.COV2.S induced strong T cell responses, while mRNA vaccines showed substantial declines in antibodies.
Article
Nanoscience & Nanotechnology
Lian C. T. Shoute, Gaser N. Abdelrasoul, Yuhao Ma, Pedro A. Duarte, Cole Edwards, Ran Zhuo, Jie Zeng, Yiwei Feng, Carmen L. Charlton, Jamil N. Kanji, Shawn Babiuk, Jie Chen
Summary: The COVID-19 pandemic presents challenges for existing diagnostic tools, so there is a need to develop portable devices for fast and accurate detection. An impedimetric immunosensor based on microelectrode array has been developed to detect SARS-CoV-2 antibodies. The sensor uses non-Faradaic impedance and has a sensitivity that can be enhanced by adjusting the ionic strength. It has an LOD of 0.4 BAU/ml and can detect anti-spike antibodies in COVID-19 patient sera within 1 hour.
MICROSYSTEMS & NANOENGINEERING
(2023)
Review
Multidisciplinary Sciences
Daniel M. Altmann, Rosemary J. Boyton
Summary: A diverse range of first-generation SARS-CoV-2 vaccines have been successful in controlling the COVID-19 pandemic, although inequitable distribution remains an issue. Future challenges include optimizing immunological boosting strategies and building an immune repertoire that can protect against upcoming viral variants.
Article
Chemistry, Multidisciplinary
Xiong Zhu, Xiaoxia Wang, Shijun Li, Wenkai Luo, Xinping Zhang, Chongzhen Wang, Qian Chen, Shuyi Yu, Jun Tai, Yi Wang
Summary: The study developed a novel diagnostic test for COVID-19, called COVID-19 MCCD, by combining MCDA with CRISPR-Cas12a technology, which is sensitive, rapid, and reliable for the diagnosis of SARS-CoV-2 infection.
Article
Materials Science, Multidisciplinary
Ranxue Yu, Alessandro Senocrate, Francesco Bernasconi, Tina Kunniger, Luca Mueller, Robin Pauer, Corsin Battaglia, Xinhou Wang, Jing Wang
Summary: Novel conductive and porous membranes are designed by facile and scalable approach to fabricating conformally coated gold layers on electrospun PVDF fibers. These membranes exhibit high electrical conductivity, low sheet resistance, hydrophobicity, gas permeability, and excellent mechanical durability. They show practical suitability as gas diffusion electrodes for electrochemical CO2 reduction.
MATERIALS & DESIGN
(2023)
Article
Environmental Sciences
Xiaole Zhang, Xiaoxiao Feng, Jie Tian, Yong Zhang, Zhiyu Li, Qiyuan Wang, Junji Cao, Jing Wang
Summary: Millions of premature mortalities are caused by PM2.5 air pollution globally each year. To address this issue, the researchers updated the emission inventories and harmonized the results from source-oriented and receptor models, finding a significant reduction in pollutant emissions in Beijing and successfully identifying temporal changes during the Spring Festival.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Engineering, Chemical
Zhengyuan Pan, Qisheng Ou, Francisco J. Romay, Weiqi Chen, Tianle You, Yun Liang, Jing Wang, David Y. H. Pui
Summary: The microstructure of filter media plays a crucial role in determining its macroscopic properties. This study investigated the dust loading process in structure-resolved filter media using microscale simulations. The results provide insights into the influence of structural factors on the dust holding capacity of the filter media and propose a strategy for designing innovative filters.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Environmental Sciences
Yongsheng Ling, Chengfeng Liu, Qing Shan, Daqian Hei, Xiaojun Zhang, Chao Shi, Wenbao Jia, Jing Wang
Summary: During severe nuclear accidents, radioactive materials are expected to be released into the atmosphere. A deep learning-based method that utilizes field environmental monitoring data was developed to estimate the source term, improving the estimation accuracy compared to traditional methods.
Article
Chemistry, Multidisciplinary
Tiezhu Guo, Di Zhou, Min Gao, Shungui Deng, Mohammad Jafarpour, Jonathan Avaro, Antonia Neels, Erwin Hack, Jing Wang, Jakob Heier, Chuanfang (John) Zhang
Summary: Large-area uniform transparent conductive electrodes (TCEs) with excellent optoelectronic performance have been achieved for the first time using solution-processed Ti3C2Tx MXene aqueous inks. The conductive MXene nanosheets are forced to orientate horizontally during the slot-die coating process, resulting in highly aligned MXene TCEs without percolation issues.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Fuze Jiang, Bei Liu, Yang Yue, Yile Tao, Zhen Xiao, Meng Li, Zheng Ji, Jiukai Tang, Guangyu Qiu, Martin Spillmann, Junji Cao, Lianjun Zhang, Jing Wang
Summary: This study presents a highly specific bioanalysis platform with an extremely low limit of detection and good analytical accordance with RT-qPCR for accurate identification and quantitation of low doses of HCoV-229E and SARS-CoV-2 viruses in urban ambient air. The platform was tested using cultivated coronavirus to simulate the airborne spread of SARS-CoV-2, and it reliably detected airborne coronavirus and revealed transmission characteristics. Real-world HCoV-229E and SARS-CoV-2 concentrations in airborne particulate matters collected from different regions were quantitatively measured and verified by RT-qPCR.
Article
Materials Science, Multidisciplinary
Min Gao, Yi-Bo Zhao, Zhi-Jun Zhao, Guangyu Qiu, Yile Tao, Guochen Bao, Ying Du, Martin Spillmann, Jiukai Tang, Soonhyoung Hwang, Jun-Ho Jeong, Jing Wang
Summary: Multiplex sensing platforms are crucial for various applications such as intelligent diagnosis and environmental monitoring. The development of nanofabrication technologies has greatly improved the performance of these sensors in the past decades. However, there are still challenges in achieving cost-effective and large-scale fabrication processes. Nano-transfer printing and imprinting technology have shown potential in fabricating 100 nm structures efficiently.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Environmental Sciences
V. Agarwal, Y. Yue, X. Zhang, X. Feng, Y. Tao, J. Wang
Summary: Antimicrobial resistance is a serious problem, and animal farms are a major hotspot for AMR. The study found that ARGs and MGEs in the air of a cattle farm mainly originated from cow manure, and farm workers may be at risk of infection with resistant bacteria and respiratory issues.
ENVIRONMENTAL POLLUTION
(2023)
Article
Multidisciplinary Sciences
Aiwen Wang, Meng Du, Jiaxin Ni, Dongqing Liu, Yunhao Pan, Xiongying Liang, Dongmei Liu, Jun Ma, Jing Wang, Wei Wang
Summary: This study achieves synergistic activation of peroxymonosulfate (PMS) through S-scheme heterojunction regulated by photoexcitation. The enhanced reactive oxygen species generation and increased degradation rate of doxycycline are achieved. The 3D polymer chain spatial structure of chitosan hydrogel facilitates PMS capture and electron transport, reducing the use of transition metal activator and leaching of metal ions.
NATURE COMMUNICATIONS
(2023)
Article
Environmental Sciences
Yi-Bo Zhao, Nathalie Hayeck, Najat A. Saliba, Claudia Schreiner, Markus Zennegg, Fuze Jiang, Renato Figi, Davide Bleiner, Jing Wang
Summary: The long-term effects of the 2020 Beirut port explosion on air quality and public health are inconclusive. This study collected PM10 samples in Beirut one month and three months after the explosion and compared the concentrations of various components with previous years. The results suggest that the explosion had minimal impact on post-explosion PM concentrations, but investigations on chemical contaminations in soil and water are urgently needed.
AEROSOL AND AIR QUALITY RESEARCH
(2023)
Article
Biochemical Research Methods
Xiaobao Cao, Tomas Buryska, Tianjin Yang, Jing Wang, Peter Fischer, Aaron Streets, Stavros Stavrakis, Andrew deMello
Summary: Droplet-based microfluidic systems have become popular in high throughput screening due to their flexibility, high-throughput capabilities, and efficient processing of small volumes. However, the challenges of performing customized operations on user-defined droplets have limited their use in complex screening applications. To address this, the integration of droplet- and valve-based microfluidic technologies provides a solution for controlling droplet manipulations while maintaining analytical throughput. This article presents a microfluidic platform that combines microvalve technology with droplet-based compartmentalization to achieve programmable fluid handling. The platform allows for the execution of user-defined reaction protocols within storage chambers by merging droplets containing specified reagents.
Proceedings Paper
Engineering, Electrical & Electronic
Hangxing Liu, Fuze Jiang, Dongwon Lee, Yuguo Sheng, Adam Wang, Marco Saif, Ying Kong, Zhikai Huang, Thomas Burger, Jing Wang, Hua Wang
Summary: This work presents a fully integrated CMOS electrochemical biosensor chip that detects localized and concurrent electrochemical signals. Each pixel has an individual potentiostat, a current sensor, and three on-chip electrodes, eliminating the need for external electrodes and addressing issues of pixel-to-pixel crosstalk. By using electropolymerization of a conductive polymer film and an intercalating redox compound, this platform achieves an electrode-immobilization-free sensing mechanism, enabling highly sensitive and rapid molecular diagnostic analysis.
IEEE 49TH EUROPEAN SOLID STATE CIRCUITS CONFERENCE, ESSCIRC 2023
(2023)
Review
Chemistry, Multidisciplinary
Guangyu Qiu, Xiaole Zhang, Andrew J. deMello, Maosheng Yao, Junji Cao, Jing Wang
Summary: Airborne pathogens pose a significant threat to public health, and on-site airborne pathogen detection can be an effective non-pharmaceutical intervention strategy. However, there are still challenges that need to be addressed.
CHEMICAL SOCIETY REVIEWS
(2023)
Article
Computer Science, Interdisciplinary Applications
Wenyu Jiang, Yuming Qiao, Guofeng Su, Xin Li, Qingxiang Meng, Hongying Wu, Wei Quan, Jing Wang, Fei Wang
Summary: This paper presents a novel hierarchical convolutional neural network (WFNet) for modeling wildfire spread patterns. By defining the spread spatiotemporal distribution field (SSDF) and implementing a hierarchical State-Condition mechanism, WFNet can efficiently encode high-order features of multimodal elements and exhibits competitive performance in computation time and model accuracy.
ENVIRONMENTAL MODELLING & SOFTWARE
(2023)
