Article
Chemistry, Multidisciplinary
Korath Shivan Sugi, Amritha P. P. Sandra, Nonappa, Debasmita Ghosh, Jyoti Sarita Mohanty, Murugesan Paulthangam Kannan, B. S. Sooraj, Pillalamarri Srikrishnarka, Jayoti Roy, Wakeel Ahmed Dar, Thalappil Pradeep
Summary: Orthogonal self-assembly is used to create complex superstructures from atomically precise silver nanoclusters, and the process is tunable by controlling the molar ratio of the ligand. The resulting nanostructures exhibit enhanced NIR emission due to restricted intramolecular motion.
Article
Engineering, Biomedical
S. Liu, Y. Li, J. Zhang, H. Zhang, Y. Wang, C. Chuah, Y. Tang, J. W. Y. Lam, R. T. K. Kwok, H. Ou, D. Ding, B. Z. Tang
Summary: This study proposed a method for designing Janus NIR-II fluorophores by incorporating different electronic donors into one molecule, resulting in balanced absorption and emission properties in fluorescent dyes. The approach combines the advantages of intense absorption from planar architecture and high fluorescence quantum yield from twisted motif.
MATERIALS TODAY BIO
(2021)
Article
Multidisciplinary Sciences
Gang Xu, Chengwei Li, Chen Chi, Luyan Wu, Yanyan Sun, Jian Zhao, Xing-Hua Xia, Shaohua Gou
Summary: The researchers reported a near-infrared supramolecular photosensitizer, RuDA, which can produce singlet oxygen in aggregate state and induce tumor regression in vivo.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Dingyuan Yan, Miao Wang, Qian Wu, Niu Niu, Meng Li, Ruixiang Song, Jie Rao, Miaomiao Kang, Zhijun Zhang, Feifan Zhou, Dong Wang, Ben Zhong Tang
Summary: A versatile theranostic agent, TPA-BT-DPTQ, was designed and prepared for simultaneous fluorescence imaging, photoacoustic imaging, photothermal imaging, and thermal eradication of tumors. The photothermal therapy mediated by TPA-BT-DPTQ nanoparticles not only destroys the primary tumor but also enhances immunogenicity for further suppressing the growth of distant tumors. Combining photothermal therapy with a PD-L1 antibody prevents cancer metastasis and recurrence.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Multidisciplinary
Wei Zhu, Miaomiao Kang, Qian Wu, Zhijun Zhang, Yi Wu, Chunbin Li, Kai Li, Lei Wang, Dong Wang, Ben Zhong Tang
Summary: A novel NIR-emissive zwitterionic luminogen with AIE features was designed and synthesized for cancer phototheranostics, showing excellent performance in NIR-II fluorescence imaging-guided synergistic phototherapy against cancer, due to its long emission wavelength, effective ROS generation, and high photothermal conversion efficiency.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Zhaoying Liu, Shurui Pei, Kaikai Wen, Aidong Peng, Han Ma, Hui Huang
Summary: A novel fluorescent probe targeting malignant melanoma has been developed for early diagnosis through in vivo imaging. The probe exhibited significant tissue penetration, photostability, and specific targeting properties, making it an excellent nano-platform for early melanoma diagnosis.
SCIENCE CHINA-MATERIALS
(2023)
Article
Engineering, Biomedical
Xiaoxiao Fan, Qiming Xia, Shunjie Liu, Zheng Zheng, Yiyin Zhang, Tianxiang Wu, Yixuan Li, Guping Tang, Ben Zhong Tang, Jun Qian, Hui Lin
Summary: Fluorescence imaging-guided surgery is a significant technique for precision surgery. This study proposes a hybrid navigation surgery using NIR-II and visible fluorescence assisted by aggregation-induced emission nanoparticles (AIE NPs). The combination of NIR-II and visible fluorescence allows for deep tissue localization and easy surgical navigation, improving the surgical process.
MATERIALS TODAY BIO
(2022)
Review
Chemistry, Analytical
Yonghong Tan, Peiying Liu, Danxia Li, Dong Wang, Ben Zhong Tang
Summary: This article summarizes the latest advances in the field of phototheranostics based on NIR-II AIEgens and introduces the strategies for constructing NIR-II AIEgens and their applications in different theranostic modalities. A brief conclusion of perspectives and challenges in the field of phototheranostics is also given at the end.
Article
Chemistry, Multidisciplinary
Yirun Li, Xiaoxiao Fan, Yuanyuan Li, Liang Zhu, Runze Chen, Yiyin Zhang, Huwei Ni, Qiming Xia, Zhe Feng, Ben Zhong Tang, Jun Qian, Hui Lin
Summary: The study developed hybrid nanovesicles with enhanced NIR-II fluorescence property and PTT functionality, demonstrating excellent biocompatibility and specific targeting ability for tumor diagnosis and PTT.
Article
Polymer Science
Bo Fan, Jing Wan, Jiali Zhai, Nicholas Kai Shiang Teo, Andy Huynh, San H. Thang
Summary: In this study, photoluminescent polymer assemblies with a variety of morphologies were successfully prepared using the efficient RAFT-mediated polymerization-induced self-assembly (RAFT-PISA) process, which is expected to expand the utility of this technique in biomedical applications.
Review
Chemistry, Multidisciplinary
Yan Jin, Chong Zhang, Xi-Yan Dong, Shuang-Quan Zang, Thomas C. W. Mak
Summary: This review summarizes the progress in the preparation and structural determination of monolayer-protected silver clusters, focusing on the strategies and methods for precise modification and hierarchical assembly of silver clusters through shell engineering. The correlations between structure-property and structure-functionality of silver clusters are discussed, with particular emphasis on the structure-luminescence relationship and the potential of silver clusters as lighting materials. The challenges and perspectives of functional silver clusters are also highlighted, aiming to inspire the development of functionality-oriented materials based on nanosized building blocks in the fields of nanotechnology and material science.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Engineering, Biomedical
Yaxi Li, Dehong Hu, Zonghai Sheng, Tianliang Min, Menglei Zha, Jen-Shyang Ni, Hairong Zheng, Kai Li
Summary: In recent decades, research on fluorogens with aggregation-induced emission (AIEgens) has been intensively conducted with a focus on biomedical applications. One efficient strategy involves designing amphiphilic AIEgens that can self-assemble into uniform nanoparticles for high-resolution intravital vascular fluorescence imaging with a significant penetration depth.
Article
Chemistry, Multidisciplinary
Xing Yang, Ting Yang, Qiqi Liu, Xiuwen Zhang, Xinghua Yu, Ryan T. K. Kwok, Luo Hai, Pengfei Zhang, Ben Zhong Tang, Lintao Cai, Ping Gong
Summary: In this study, biomimetic aggregation-induced emission (AIE) photothermal agents with hitchhiking ability (DC@BPBBT dots) were developed by coating the nanoaggregates of the NIR AIE polymeric photothermal agents with dendritic cell (DC) membranes. The DC@BPBBT dots can be hitchhiked on endogenous T cells, leading to enhanced tumor delivery efficiency. Additionally, these dots were found to activate T cells to secrete TNF-alpha, effectively reducing the expression of HSP70 and rendering tumor cells more sensitive to heat.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Review
Chemistry, Multidisciplinary
Wenhan Xu, Dong Wang, Ben Zhong Tang
Summary: NIR-II AIEgens enabled by aggregation-induced emission luminogens have emerged as a promising field for high-performance imaging, overcoming limitations in penetration depth and fluorescence efficiency. Some NIR-II AIEgens demonstrate dual-mode imaging capabilities and guided photothermal therapy, improving diagnostic accuracy and providing an efficient platform for theranostics. This review highlights recent efforts in exploiting NIR-II AIEgens, discussing molecular design strategies, bioapplications, and presenting current challenges and future prospects for diverse applications.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Chemistry, Multidisciplinary
Shunjie Liu, Yuanyuan Li, Ryan T. K. Kwok, Jacky W. Y. Lam, Ben Zhong Tang
Summary: Aggregation-induced emission (AIE) is a cutting-edge technology for developing highly efficient NIR-II emitters and photothermal agents, with the optimization of multi-hierarchical structures and intramolecular motions balancing fluorescence imaging and photothermal therapy functions.
Article
Chemistry, Analytical
Jingya Tang, Guimin Zhang, Feng Li, Rongyu Zeng, Jin Song, Ghulam Abbas, Mengmeng Cui, Wei Zhang, Xian-En Zhang, Dian-Bing Wang
Summary: This article introduces a biological and mild method that combines the genetically encoded SpyTag-SpyCatcher interaction system with the bacterial S-layer for high-quality and homogeneous protein immobilization on a gold surface. This method not only preserves the activity of the proteins but also enhances the detection sensitivity.
ANALYTICAL CHEMISTRY
(2022)
Article
Green & Sustainable Science & Technology
Bingfang Wu, Fuyou Tian, Miao Zhang, Shilong Piao, Hongwei Zeng, Weiwei Zhu, Junguo Liu, Abdelrazek Elnashar, Yuming Lu
Summary: This study proposes a method based on Earth observations to quantify and refine estimates of global agricultural water appropriation. The results show that agriculture remains the largest user of water worldwide, particularly in terms of irrigation. The study reveals the actual water consumption of global crops and the extent of human intervention in the water cycle, providing support for decision making and sustainable agricultural policies.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Environmental Sciences
Xiwang Zhang, Weiwei Zhu, Nana Yan, Panpan Wei, Yifan Zhao, Hao Zhao, Liang Zhu
Summary: This study developed a classification method based on the Random Forest algorithm and a feature optimization method to identify grassland types, and proposed an approach to quantitatively evaluate the ecosystem service value (ESV) of the grassland ecosystem in Ethiopia. The results showed that the total ESV of grassland ecosystems was USD 105,221.72 million, with ESV4 being the highest. Spatial analysis showed that the differences in ESV were influenced by grassland types, elevation, slope, and rainfall. The zoning map indicated that the areas from approximately the fourth to sixth level have better growth status and development potential.
Article
Chemistry, Physical
Ti Fang, Chaoqun Li, Ao Liang, Hui Zhang, Fan Zhang, Xian-En Zhang, Yi-Yu Yang, Feng Li
Summary: Here, we report a cell membrane integrity probe based on protein nanocage Dps, which can selectively stain cells with damaged membranes, and demonstrate the potential of Dps as a bioimaging platform.
Article
Chemistry, Multidisciplinary
Zhao Chen, Huan Qin, Ya Yin, Dian-dian Deng, Si-Yong Qin, Nan Li, Kai Wang, Yue Sun
Summary: In this study, a series of multi-functionalized luminophores were designed and synthesized based on a carbazole core with different donor and acceptor units. These compounds exhibited full-color emission covering the entire visible light range in the solid state under UV light illumination. One of the derivatives showed rare aggregation-induced near-infrared emission and red-to-near-infrared mechano-fluorochromism, demonstrating potential applications in cell imaging and photodynamic therapy (PDT). This work not only provides insights for the construction of full-color emissive systems but also opens new avenues for multifunctionalized luminophores in near-infrared mechanical-force sensors and PDT fields.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Lei Yang, Zhongyue Sun, Siyun Zhang, Yue Sun, Haibing Li
Summary: In this study, a facile and feasible strategy was employed to construct chiral-modified nanochannels for the transmembrane transport of chiral drugs. The results showed that the constructed nanochannels exhibited improved chiral selectivity compared to other chiral channels. This study is of significant importance for the basic theory research and the construction of artificial channels for the separation of chiral drugs.
Review
Chemistry, Multidisciplinary
Run-Hao Li, Qian Lin, Shu-Lan Li, Yue Sun, Yi Liu
Summary: This review highlights the preparation and applications of MXene materials based on macrocyclic hosts. Functional membranes, photocatalysis, sensing, and adsorption are the main application areas discussed. The unique structural features and recognition ability of macrocyclic hosts provide new inspiration for the design and improvement of MXene-based materials.
Article
Materials Science, Biomaterials
Xuehong Min, Ming Li, Wenjing Zhang, Run-Hao Li, Zhe Zhang, Pingshan Wang, Weide Su, Feng Li, Yue Sun, Yi Liu
Summary: Different from common anti-tumor drugs, organoplatinum(ii) metallacycles can integrate imaging and therapeutic capabilities by incorporating functional donor ligands, enabling potential applications in biomedicine. In this study, an organoplatinum(ii) metallacycle (PtM) was designed and synthesized for use in chemo-photodynamic combination therapy. The PtM molecules were encapsulated in human heavy chain ferritin (HFn) to prepare the active targeting nanoagent HFn-PtM, which exhibited excellent stability and anti-tumor efficiency with negligible systemic toxicity.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Editorial Material
Chemistry, Multidisciplinary
Zhao Chen, Huan Qin, Ya Yin, Dian-dian Deng, Si-Yong Qin, Nan Li, Kai Wang, Yue Sun
Summary: This study successfully prepared eight multifunctional luminophores based on the same core skeleton, exhibiting various colors covering the whole visible light range. Among them, a novel carbazole derivative with dicyano-functionalized triphenylamine unit showed aggregation-induced near-infrared emission and red-to-near-infrared mechano-fluorochromism, making it a promising candidate for cell imaging and photodynamic therapy. This work provides reference for the construction of full-color emissive systems and offers a new avenue for the preparation of multifunctionalized luminophores with potential applications in near-infrared mechanical-force sensors and PDT fields.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Biomedical
Ao Liang, Wei Zhou, Hui Zhang, Juan Zhang, Xian-En Zhang, Ti Fang, Feng Li
Summary: Protein nanocages (PNCs) show promise for developing multifunctional nanomedicines. This study explores the effects of different amino acids on the pharmacokinetics of PNCs. It is found that oligo-lysine, oligo-arginine, and oligo-cysteine can effectively prolong the blood half-life of PNCs through charge neutralization and covalent binding with plasma albumin. These findings provide guidance for surface-engineering biosynthetic PNCs and other nanoparticles.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Engineering, Geological
Weiwei Zhu, Zhiqiang Chen, Yafan Yang, Wenbo Gong, Moran Wang
Summary: It is rarely investigated that the impacts of T-type intersections on the connectivity and flow results in complex fracture networks. The results show that kinematic fracture networks tend to connect more fractures with fewer intersections and yield better connectivity than the original ones. Most kinematic fracture networks have larger permeability in single-phase flow simulation and higher cumulative gas production in two-phase flow simulation than original fracture networks.
ENGINEERING GEOLOGY
(2023)
Article
Geochemistry & Geophysics
Weiwei Zhu, Zhiqiang Chen, Xupeng He, Zhiguo Tian, Moran Wang
Summary: In this study, a discrete element-lattice Boltzmann method was used to simulate the hydro-mechanical behavior in hydraulic fracturing. Different influential factors were considered, and their impacts on the initiation and propagation of hydraulic fractures were evaluated. It was found that factors such as injection rates, heterogeneity of rock strengths, and the presence of natural fractures significantly influenced the complexity of generated fractures.
JOURNAL OF GEOPHYSICAL RESEARCH-SOLID EARTH
(2023)
Review
Materials Science, Multidisciplinary
Ying Han, Zheng-Hong Liu, Chun-Bo Wu, Yu Zhao, Guo-Qing Zu, Wei-Wei Zhu, Xu Ran
Summary: Duplex stainless steels, composed of ferrite and austenite, are widely used for their excellent mechanical properties and corrosion resistance. They outperform ferritic stainless steels in terms of plasticity, toughness, and welding performance, while also exhibiting higher strength and better resistance against stress, pitting, and crevice corrosion compared to austenitic stainless steels. This paper summarizes the important strategy of alloying design in duplex stainless steels, highlighting the role of alloying elements in improving mechanical properties and/or corrosion resistance.
Proceedings Paper
Automation & Control Systems
Xinping Xie, Dandan Li, Weiwei Zhu, Lei Zhang, Xiaodong Du, Hongqiang Wang
Summary: This paper proposes a new method for personalized drug efficacy prediction based on the LOA model, which encodes clinical symptoms and mines hidden features and association patterns to predict tumor drug efficacy. Experimental results show that the proposed method achieved a higher prediction accuracy compared to the PLSA model when combined with SVM classifier.
2022 41ST CHINESE CONTROL CONFERENCE (CCC)
(2022)
Article
Engineering, Electrical & Electronic
Longshan Yang, Junhuan Peng, Yuebin Wang, Linlin Xu, Weiwei Zhu
Summary: In this article, a superpixel-based graph model is proposed for hyperspectral image classification. By utilizing anchor graph regularization, the model is able to extract local and nonlocal spatial information effectively. The approach constructs a scalable anchor graph using a small number of anchor points, which outperforms other semisupervised HSI classification approaches in cases with a limited quantity of labeled samples.
IEEE JOURNAL OF SELECTED TOPICS IN APPLIED EARTH OBSERVATIONS AND REMOTE SENSING
(2022)
