Editorial Material
Rheumatology
Camilla R. L. Machado, Gary S. Firestein
Summary: Rheumatoid arthritis synovium contains fibroblast-like synoviocytes that are phenotypically and functionally heterogeneous. Advanced analyses have identified at least four distinct cell states, which are determined by the cells' location in the synovium, epigenetic imprinting, and the influence of microenvironment mediators.
NATURE REVIEWS RHEUMATOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Sen Lin, Dahao Wang, Chang Xu, Peng Zhang, Kai Gao, Chang Liu, Xifan Mei
Summary: In this study, folic acid modified celastrol-loaded nanoparticles were developed, which can release RA symptoms and have validated anti-inflammatory effects. These nanoparticles modify the polarization of macrophages and significantly reduce inflammation levels in serum and joints.
MATERIALS & DESIGN
(2022)
Article
Chemistry, Multidisciplinary
Yuxuan Ma, Zhangwei Lu, Bin Jia, Ye Shi, Jun Dong, Shuoxing Jiang, Zhe Li
Summary: This study introduces a targeted treatment for rheumatoid arthritis (RA) using folic acid-modified triangular DNA origami nanostructures (FA-tDONs). The FA-tDONs can efficiently scavenge reactive oxygen species (ROS) and nitric oxide (NO), leading to the transition of pro-inflammatory macrophages to an anti-inflammatory phenotype. In an RA mouse model, FA-tDONs treatment effectively alleviates synovial inflammation and cartilage damage, attenuating disease progression.
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Rheumatology
Emilie Sapart, Tatiana Sokolova, Stephanie de Montjoye, Stephanie Dierckx, Adrien Nzeusseu, Aleksandra Avramovska, Patrick Durez
Summary: The study evaluated the use of glucocorticoids in patients with early RA and found that glucocorticoids were more prescribed in seronegative RA patients with higher inflammation levels. However, a 5-year follow-up showed that initiating glucocorticoid treatment did not provide additional benefits for disease control in the short and long term.
Article
Immunology
Juan He, Yu Li, Jian Chen, Qi Wu, Hongying Shan, Xiaocheng Wang, Miaomiao Zhang, Liping Nie, Qingwen Wang
Summary: Different subsets of CD8+ T cells are associated with clinical features and serological parameters in rheumatoid arthritis (RA). Naive CD8+ T cells are negatively correlated with disease activity, while CD8+ CD28-T cells and CD8+ CD27-T cells are positively correlated with disease activity. Activated CD8+ T cells and TCR gamma E+ CD8+ T cells may be involved in inflammation and lipid metabolism in RA.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Rheumatology
Heidi J. Siddle, Lara S. Chapman, Kulveer Mankia, Codruta Zabalan, Marios Kouloumas, Karim Raza, Marie Falahee, Joel Kerry, Andreas Kerschbaumer, Daniel Aletaha, Paul Emery, Suzanne H. Richards
Summary: The study identified the importance of understanding the risk, engaging in preventive interventions, and undergoing predictive testing for individuals at-risk of rheumatoid arthritis. However, barriers to engagement exist, intensified by the burden of uncertainty. It is urgently needed to identify optimal approaches for presenting risk information to support decision-making for individuals at-risk of RA.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Nanoscience & Nanotechnology
Wencui Shang, Quanwei Sun, Chenxu Zhang, Hanmeng Liu, Ye Yang, Yang Liu, Wenheng Gao, Wei Shen, Dengke Yin
Summary: In this study, a hyaluronic acid derivative that can scavenge ROS was developed as a nanocarrier for sinomenine delivery, aiming to remodel the oxidative/inflammatory microenvironment in rheumatoid arthritis (RA) and provide new possibilities for the development of therapeutic polymers and combined therapeutic strategies.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Rheumatology
Gregory McDermott, Ritu Gill, Staci Gagne, Suzanne Byrne, Weixing Huang, Xiaosong Wang, Lauren C. Prisco, Alessandra Zaccardelli, Lily W. Martin, Lucy Masto, Vanessa L. Kronzer, Nancy Shadick, Paul F. Dellaripa, Tracy J. Doyle, Jeffrey A. Sparks
Summary: The study investigates the demographic, lifestyle, and serologic risk factors associated with isolated rheumatoid arthritis (RA)-associated bronchiectasis (RA-BR) that is not caused by interstitial lung disease (ILD). The findings suggest that seropositivity, older age at RA diagnosis, and lower BMI at RA onset are associated with isolated bronchiectasis in RA that is not a result of ILD.
JOURNAL OF RHEUMATOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Chaoxiong Wu, Jiale Cheng, Wei Li, Lingzhi Yang, Haifeng Dong, Xueji Zhang
Summary: A novel polymeric microneedle platform was developed for transdermal delivery of drugs and antioxidants for the treatment of rheumatoid arthritis (RA). This platform shows potential as an ideal choice for RA treatment combining chemotherapy and antioxidative therapy.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Pharmacology & Pharmacy
Shuang Li, Jin Su, Wei Cai, Jian-xin Liu
Summary: Targeting macrophages using nanomaterials is an important therapeutic strategy for rheumatoid arthritis due to the crucial role macrophages play in the pathological process of RA. Manipulating macrophages through intravenous injection, oral administration, percutaneous absorption, etc., has shown significant therapeutic effects, providing new insights and directions for the treatment of RA.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Yuan Qu, Yang Fu, Yuan Liu, Chuanguo Liu, Bing Xu, Qian Zhang, Ping Jiang
Summary: Transient receptor potential cation channel subfamily V member 1 (TRPV1) has been found to play a role in immune regulation and its dysregulation affects the development of rheumatoid arthritis. Understanding the mechanism of TRPV1 can lead to the design of new drugs and improved treatment of RA.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Xuesong Liu, Ruru Guo, Shicheng Huo, Huan Chen, Qingxiang Song, Gan Jiang, Ye Yu, Jialin Huang, Shaowei Xie, Xiaoling Gao, Liangjing Lu
Summary: This study evaluated the potential of HIF-1 alpha siRNA-loaded CaP-rHDL nanoparticles in the treatment of RA. The nanoparticles showed significant anti-inflammatory effects and reduced joint damage and osteoclastogenesis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Materials Science, Multidisciplinary
Cheng Gao, Cheryl H. T. Kwong, Qingfu Wang, Hiotong Kam, Jianwen Wei, Qian Chen, Jian Zhang, Simon M. Y. Lee, Dayong Gu, Ruibing Wang
Summary: A study found that many chemotherapeutic and immunotherapeutic agents are less effective in a hypoxic solid tumor. Current methods of oxygen delivery are limited, but using macrophage membrane coated chlorella can provide sustained oxygen and improve tumor hypoxia, enhancing the effectiveness of chemotherapy and immunotherapy.
Article
Engineering, Environmental
Meng-Wen Ma, Kai-Lin He, Chao-Qing Li, Xiao-Ting Xie, Sui Zhou, Bin Zhang, Xiao-Lin Hou, Cheng Li, Yuan-Di Zhao, Ling-Li Dong, Bo Liu
Summary: In this study, hyaluronic acid-modified platinum-tellurium nanorods (HPT) were synthesized as a targeted therapy for rheumatoid arthritis (RA). HPT effectively removed inflammatory macrophages and reactive oxygen species (ROS), alleviating the inflammatory response and bone erosion. Animal experiments showed a significant reduction in clinical scores and bone erosion in mice treated with HPT and laser irradiation.
CHEMICAL ENGINEERING JOURNAL
(2023)