期刊
ACS APPLIED MATERIALS & INTERFACES
卷 13, 期 17, 页码 19710-19725出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.1c03010
关键词
PDT; O-2 self-supply; hypoxic resistance; biomimetic cloaking strategy; nanotheranostics
资金
- National Natural Science Foundation of China [81673376]
- General Program of Natural Science Foundation of Jiangsu Province [BK20201154]
- 62nd batch of General Program of China Postdoctoral Science Foundation [2017M621826]
- Jiangsu Planned Projects for Postdoctoral Research Funds [2018K261C]
- Huai'an Natural Science Foundation [HAB202010]
- Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX20_2461]
This study demonstrates a novel approach to enhance the efficacy of photodynamic therapy by developing a biomimetic nanovehicle that augments oxygen supply. By combining infrared thermal imaging and ultrasound imaging, it achieves a multimodal bioimaging effect for tumor treatment.
Treatment resistance of the tumors to photodynamic therapy (PDT) owing to O-2 deficiency largely compromised the therapeutic efficacy, which could be addressed via modulating oxygen levels by using O-2 self-enriched nanosystems. Here, we report on augmenting the O-2-evolving strategy based on a biomimetic, catalytic nanovehicle (named as N/P@ MCC), constructed by the catalase-immobilized hollow mesoporous nanospheres by enveloping a cancer cell membrane (CCM), which acts as an efficient nanocontainer to accommodate nitrogen-doped graphene quantum dots (N-GQDs) and protoporphyrin IX (PpIX). Inheriting the virtues of biomimetic CCM cloaking, the CCM-derived shell conferred N/P@MCC nano-vehicles with highly specific self-recognition and homotypic targeting toward cancerous cells, ensuring tumor-specific accumulation and superior circulation durations. N-GQDs, for the first time, have been evidenced as a new dual-functional nanoagents with PTT and PDT capacities, enabling the generation of O-1(2) for PDT and inducing local low-temperature hyperthermia for thermally ablating cancer cells and infrared thermal imaging (IRT). Leveraging the intrinsic catalytic features of catalase, such N/P@MCC nanovehicles effectively scavenged the excessive H2O2 to sustainably evolve oxygen for a synchronous O-2 self-supply and hypoxia alleviation, with an additional benefit because the resulting O-2 bubbles could function as an echo amplifier, leading to the sufficient echogenic reflectivity for ultrasound imaging. Concurrently, the elevated O-2 reacted with N-GQDs and PpIX to elicit a maximally increased O-1(2) output for augmented PDT. Significantly, the ultrasound imaging coupled with fluorescence imaging, IRT, performs a tumor-modulated trimodal bioimaging effect. Overall, this offers a paradigm to rationally explore O-2 self-supply strategies focused on versatile nanotheranostics for hypoxic tumor elimination.
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