2′-Fluoro-arabinonucleic Acid (FANA): A Versatile Tool for Probing Biomolecular Interactions

Antibacterial FANA oligonucleotides as a novel approach for managing the Huanglongbing pathosystem

(2021) Andrés F. Sandoval-Mojica et al.   Scientific Reports

Use of a Self-Delivering Anti-CCL3 FANA Oligonucleotide as an Innovative Approach to Target Inflammation after Spinal Cord Injury

(2021) Nicolas Pelisch et al.   eNeuro

Targeting the Oncogenic Long Non-coding RNA SLNCR1 by Blocking Its Sequence-Specific Binding to the Androgen Receptor

(2020) Karyn Schmidt et al.   Cell Reports

G-Quadruplexes at Telomeres: Friend or Foe?

(2020) Tracy M. Bryan   MOLECULES

Advances in oligonucleotide drug delivery

(2020) Thomas C. Roberts et al.   NATURE REVIEWS DRUG DISCOVERY

A mechanism for the extension and unfolding of parallel telomeric G-quadruplexes by human telomerase at single-molecule resolution

(2020) Bishnu P Paudel et al.   eLife

2′-Fluoroarabinonucleic Acid Nanostructures as Stable Carriers for Cellular Delivery in the Strongly Acidic Environment

(2020) Qian Wang et al.   ACS Applied Materials & Interfaces

Endogenous antisense RNA curbs CD39 expression in Crohn’s disease

(2020) Rasika P. Harshe et al.   Nature Communications

LET-Dependent Low Dose and Synergistic Inhibition of Human Angiogenesis by Charged Particles: Validation of miRNAs that Drive Inhibition

(2020) Yen-Ruh Wuu et al.   iScience

Crystal structures of a natural DNA polymerase that functions as an XNA reverse transcriptase

(2019) Lynnette N Jackson et al.   NUCLEIC ACIDS RESEARCH

Selection of 2'-Deoxy-2'-Fluoroarabino Nucleic Acid (FANA) Aptamers that Bind HIV-1 Integrase with Picomolar Affinity

(2019) Kevin M. Rose et al.   ACS Chemical Biology

Dual Mechanisms of Action of Self-Delivering, Anti-HIV-1 FANA Oligonucleotides as a Potential New Approach to HIV Therapy

(2019) Mayumi Takahashi et al.   Molecular Therapy-Nucleic Acids

Evaluating the Catalytic Potential of a General RNA‐Cleaving FANA Enzyme

(2019) Yajun Wang et al.   CHEMBIOCHEM

Evaluation of the Stability of DNA i-Motifs in the Nuclei of Living Mammalian Cells

(2018) Simon Dzatko et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Activation of Frataxin Protein Expression by Antisense Oligonucleotides Targeting the Mutant Expanded Repeat

(2018) Liande Li et al.   Nucleic Acid Therapeutics

i-Motif DNA: structural features and significance to cell biology

(2018) Hala Abou Assi et al.   NUCLEIC ACIDS RESEARCH

Manipulating DNA G-Quadruplex Structures Through Guanosine Analogs

(2018) Klaus Weisz et al.   CHEMBIOCHEM

Extensive CRISPR RNA modification reveals chemical compatibility and structure-activity relationships for Cas9 biochemical activity

(2018) Daniel O’Reilly et al.   NUCLEIC ACIDS RESEARCH

Evolution of a General RNA-Cleaving FANA Enzyme

(2018) Yajun Wang et al.   Nature Communications

Mapping the affinity landscape of Thrombin-binding aptamers on 2′F-ANA/DNA chimeric G-Quadruplex microarrays

(2017) Jory Lietard et al.   NUCLEIC ACIDS RESEARCH

2′-Fluoroarabinonucleic acid modification traps G-quadruplex and i-motif structures in human telomeric DNA

(2017) Hala Abou Assi et al.   NUCLEIC ACIDS RESEARCH

Fluorinated Nucleotide Modifications Modulate Allele Selectivity of SNP-Targeting Antisense Oligonucleotides

(2017) Michael E. Østergaard et al.   Molecular Therapy-Nucleic Acids

Stabilization of i-motif structures by 2′-β-fluorination of DNA

(2016) Hala Abou Assi et al.   NUCLEIC ACIDS RESEARCH

Selection of 2′-deoxy-2′-fluoroarabinonucleotide (FANA) aptamers that bind HIV-1 reverse transcriptase with picomolar affinity

(2015) Irani Alves Ferreira-Bravo et al.   NUCLEIC ACIDS RESEARCH

Telomeric G-quadruplexes are a substrate and site of localization for human telomerase

(2015) Aaron L. Moye et al.   Nature Communications

Catalysts from synthetic genetic polymers

(2014) Alexander I. Taylor et al.   NATURE

Backbone FCH⋅⋅⋅O Hydrogen Bonds in 2′F-Substituted Nucleic Acids

(2013) Nerea Martin-Pintado et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Click conjugated polymeric immuno-nanoparticles for targeted siRNA and antisense oligonucleotide delivery

(2013) Dianna P.Y. Chan et al.   BIOMATERIALS

Molecular Engineering of Guanine-Rich Sequences: Z-DNA, DNA Triplexes, and G-Quadruplexes

(2013) Osman Doluca et al.   CHEMICAL REVIEWS

Dramatic Effect of Furanose C2′ Substitution on Structure and Stability: Directing the Folding of the Human Telomeric Quadruplex with a Single Fluorine Atom

(2013) Nerea Martín-Pintado et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

2′-F-ANA-guanosine and 2′-F-guanosine as powerful tools for structural manipulation of G-quadruplexes

(2012) Christopher Jacques Lech et al.   CHEMICAL COMMUNICATIONS

High-resolution structures of two complexes between thrombin and thrombin-binding aptamer shed light on the role of cations in the aptamer inhibitory activity

(2012) Irene Russo Krauss et al.   NUCLEIC ACIDS RESEARCH

Synthetic Genetic Polymers Capable of Heredity and Evolution

(2012) V. B. Pinheiro et al.   SCIENCE

Antisense 2′-Deoxy, 2′-Fluoroarabino Nucleic Acid (2′F-ANA) Oligonucleotides: In Vitro Gymnotic Silencers of Gene Expression Whose Potency Is Enhanced by Fatty Acids

(2012) Naira Souleimanian et al.   Molecular Therapy-Nucleic Acids

Selection of G-Quadruplex Folding Topology with LNA-Modified Human Telomeric Sequences in K+Solution

(2011) Devranjan Pradhan et al.   CHEMISTRY-A EUROPEAN JOURNAL

Structural insights into G-quadruplexes: towards new anticancer drugs

(2010) Danzhou Yang et al.   Future Medicinal Chemistry

Energetically Important C−H···F−C Pseudohydrogen Bonding in Water: Evidence and Application to Rational Design of Oligonucleotides with High Binding Affinity

(2010) Maryam Yahyaee Anzahaee et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing

(2010) Glen F. Deleavey et al.   NUCLEIC ACIDS RESEARCH

Differential stability of 2′F-ANA•RNA and ANA•RNA hybrid duplexes: roles of structure, pseudohydrogen bonding, hydration, ion uptake and flexibility

(2010) Jonathan K. Watts et al.   NUCLEIC ACIDS RESEARCH

Efficient gene silencing by delivery of locked nucleic acid antisense oligonucleotides, unassisted by transfection reagents

(2009) C. A. Stein et al.   NUCLEIC ACIDS RESEARCH

Studies on the hydrolytic stability of 2′-fluoroarabinonucleic acid (2′F-ANA)

(2009) Jonathan K. Watts et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Probing DNA polymerase activity with stereoisomeric 2′-fluoro-β-D-arabinose (2′F-araNTPs) and 2′-fluoro-β-D-ribose (2′F-rNTPs) nucleoside 5′-triphosphates

(2008) Chang G Peng et al.   CANADIAN JOURNAL OF CHEMISTRY

2′F-Arabinonucleic acids (2′F-ANA) — History, properties, and new frontiers

(2008) Jonathan K Watts et al.   CANADIAN JOURNAL OF CHEMISTRY

Advantageous toxicity profile of inhaled antisense oligonucleotides following chronic dosing in non-human primates

(2008) Alain Guimond et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS