Article
Biochemistry & Molecular Biology
Yapeng Lu, Xiaopeng Zhu, Chao Hu, Peng Li, Meihui Zhao, Jinfeng Lu, Guanghua Xia
Summary: A tilapia fish skin gelatin-fucose gum-tannic acid hydrogel wound dressing was designed to promote wound healing. The hydrogel showed excellent properties and could effectively accelerate wound healing while reducing inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Engineering, Biomedical
Lipeng Qiao, Yongping Liang, Jueying Chen, Ying Huang, Saeed A. Alsareii, Abdulrahman Manaa Alamri, Farid A. Harraz, Baolin Guo
Summary: In this study, adhesive self-healing conductive antibacterial hydrogel dressings were prepared for the repair of infected wounds. The hydrogel exhibited self-healing properties, good conductivity, photothermal anti-bacterial properties, and improved wound healing in the infected skin wound repair test. These hydrogels have potential as promising candidates for wound healing dressings for the treatment of infected skin wounds.
BIOACTIVE MATERIALS
(2023)
Article
Materials Science, Biomaterials
Tongtong Leng, Yidan Wang, Wei Cheng, Wensi Wang, Xiaoyan Qu, Bo Lei
Summary: This study reports a multifunctional hydrogel (FEM) formed by self-assembly of poly-L-lysine-F127-poly-L-lysine (EPL-F127-EPL) and metformin for wound repair. The in vivo results showed that FEM dressings accelerated wound healing by stimulating angiogenesis and providing anti-inflammatory effects.
BIOMATERIALS ADVANCES
(2022)
Article
Chemistry, Applied
Erkang Yang, Wen Hou, Kun Liu, He Yang, Wenying Wei, Haifei Kang, Honglian Dai
Summary: A multifunctional hydrogel dressing QCSMA/DAMA/Zn-nWH was developed for the treatment of infected bleeding wounds. It showed good adhesion, antibacterial properties, and biocompatibility, as well as promoting wound healing and hemostasis.
CARBOHYDRATE POLYMERS
(2022)
Article
Biotechnology & Applied Microbiology
Guanhua Lan, Suping Zhu, Dong Chen, Hua Zhang, Lijin Zou, Yuanlin Zeng
Summary: A novel biocompatible polyzwitterionic hydrogel, PolySBMA, was developed for wound healing, showcasing high stretchability, low swelling, strong skin adhesiveness, and antibacterial properties. The hydrogel, cross-linked with natural polymers QCSMA and GelMA, exhibited excellent mechanical flexibility and adhesiveness to skin tissue, along with good antibacterial properties and biocompatibility, making it promising for acute wound dressings.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Materials Science, Multidisciplinary
Quanhong Hu, Xingyi Wan, Shaobo Wang, Tian Huang, Xinyang Zhao, Chuyu Tang, Minjia Zheng, Xueyu Wang, Linlin Li
Summary: This study successfully constructed a Janus nanofiber dressing with comprehensive functions of bacterial killing, piezoelectric stimulation to promote fibroblast migration, and unidirectional liquid delivery for wound exudate removal. The Janus dressing, fabricated through layer-by-layer electrostatic spinning technology, exhibits ultrathin, flexible, breathable, and piezoelectric characteristics. Experimental results indicate that the Janus dressing not only drains excess wound exudate and kills local bacteria, but also generates dynamic piezopotential to accelerate wound healing on mice through fibroblast proliferation and migration, collagen deposition, angiogenesis, and re-epithelialization.
SCIENCE CHINA-MATERIALS
(2023)
Article
Engineering, Biomedical
Yutong Yang, Yongping Liang, Jueying Chen, Xianglong Duan, Baolin Guo
Summary: This study developed a photo-crosslinked multifunctional antibacterial adhesive hemostatic hydrogel dressing that can disinfect drug-resistant bacteria and promote wound healing. Through various tests, it showed good hemostatic and antibacterial properties, and proved to be more effective than current commercially available dressings in treating infected wounds.
BIOACTIVE MATERIALS
(2022)
Article
Chemistry, Applied
Chuang Li, Tao Jiang, Cong Zhou, Ankang Jiang, Cuifen Lu, Guichun Yang, Junqi Nie, Feiyi Wang, Xiaofan Yang, Zhenbing Chen
Summary: Promoting the healing of diabetic wounds is a major challenge, but Chitosan-based POSS-PEG hybrid hydrogels show excellent healing properties with strong mechanical strength, self-healing efficiency, cytocompatibility, and antibacterial properties.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Multidisciplinary
Ning Tang, Rongjun Zhang, Youbin Zheng, Jing Wang, Muhammad Khatib, Xue Jiang, Cheng Zhou, Rawan Omar, Walaa Saliba, Weiwei Wu, Miaomiao Yuan, Daxiang Cui, Hossam Haick
Summary: The study introduces a novel self-healing, antibacterial, and multifunctional wound dressing for sutureless wound closure and real-time monitoring. The dressing features high mechanical toughness, biocompatibility, and outstanding antibacterial activity, effectively inhibiting bacterial growth and accelerating healing. In vivo tests demonstrate that the dressing can help in wound closure and deposition of collagen, while the integrated sensor array provides real-time monitoring of temperature, pH, and glucose levels in the wound area. Ultimately, this multifunctional dressing would be valuable for personalized monitoring and treatment approaches in wound healing management.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Lingshuang Wang, Lian Duan, Ga Liu, Jianfeng Sun, Mohammad-Ali Shahbazi, Subhas C. C. Kundu, Rui L. L. Reis, Bo Xiao, Xiao Yang
Summary: Polyacrylic acid (PAA) and its derivatives are commonly used as matrices in wound dressings, but their weak wet adhesion limits their clinical application. In this study, a PAA-based coacervate hydrogel with strong wet adhesion capability is created by mixing PAA copolymers with isoprenyl oxy poly(ethylene glycol) ether and tannic acid. The coacervate exhibits solid adhesion to both dry and wet substrates, with an adhesive strength to skin of 23.4 kPa and 70% adhesion underwater. It also possesses desirable self-healing and extensible properties, making it suitable for joints that undergo frequent movement. The coacervate demonstrates antibacterial activity, facilitates fibroblast migration, modulates macrophage polarization, shortens hemostatic time, and promotes collagen deposition, angiogenesis, and epithelialization, suggesting its promising potential as a wound dressing in medical translation.
Article
Engineering, Biomedical
Fei Gong, Nailin Yang, Jiachen Xu, Xiaoyuan Yang, Kailu Wei, Linqian Hou, Bo Liu, He Zhao, Zhuang Liu, Liang Cheng
Summary: This study developed calcium hydride (CaH2)-based dressings with anti-oxidation and anti-inflammation properties for accelerated wound healing. By releasing hydrogen molecules (H-2) and scavenging excess reactive oxygen species (ROS), the CaH2 dressings were able to reduce inflammation levels, promote tissue regeneration and angiogenesis, offering a potential therapeutic option for inflammatory diseases.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Meng Zhang, Guohui Wang, Dong Wang, Yuqi Zheng, Yanxin Li, Wenqiao Meng, Xin Zhang, Feifan Du, Shaoxiang Lee
Summary: This study successfully prepared a bilayer composite dressing for wound healing, with the upper layer possessing antibacterial activity and the lower layer having biocompatibility, the combination of which showed synergistic antibacterial effects and could accelerate wound healing.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Desheng Cai, Yuqin Yang, Jihui Lu, Zhihua Yuan, Yaozhi Zhang, Xiaoyun Yang, Xuemei Huang, Tong Li, Xuehao Tian, Bing Xu, Penglong Wang, Haimin Lei
Summary: This paper introduces the design and efficacy of a small-molecule self-healing antibacterial hydrogel, which exhibits promising antibacterial activities against MRSA and can inhibit proinflammatory cytokines to promote wound healing.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Applied
Guangyao Wang, Junwei Ye, Miao Wang, Ye Qi, Siqi Zhang, Lei Shi, Yueguang Fang, Yiming Tian, Guiling Ning
Summary: In this study, a chitosan membrane loaded with copper boron-imidazolate framework (Cu-BIF) was successfully prepared as a wound dressing. The Cu-BIF/CS membrane showed desirable biocompatibility and exhibited antibacterial activity against bacterial infections. It also accelerated wound closure rate and skin regeneration. This research provides important insights for clinical treatment of bacterial-infected wounds.
CARBOHYDRATE POLYMERS
(2022)
Review
Nanoscience & Nanotechnology
Rui Yu, Hualei Zhang, Baolin Guo
Summary: This review summarizes the design and application of conductive biomaterials for wound healing and skin tissue engineering. Conductive biomaterials with various structural forms, such as films, nanofibers, membranes, hydrogels, sponges, foams, and acellular dermal matrix, play important roles in electrotherapy, wound dressing, and wound assessment, and possess promising applications in the field.
NANO-MICRO LETTERS
(2022)
Article
Biochemical Research Methods
Kun Xu, Tingting Zhang, Lijun Guo, Ying Xin, Long Zhang, Zhiying Zhang
ANALYTICAL BIOCHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
L. Zhang, T. Zhang, L. Wang, S. Shao, Z. Chen, Z. Zhang
Article
Engineering, Environmental
Long Zhang, Min Wang, Mi Chen, Wen Niu, Wenguang Liu, Tongtong Leng, Wenchen Ji, Bo Lei
Summary: This study developed a safe and efficient biomaterials-based anti-obesity nanosystem, which could deliver miR33 agonist into adipocytes and reduce obesity-related inflammatory factors expression. In obese rat models, the nanosystem effectively reduced body weight without suppressing appetite and inhibited the growth of adipocytes. The system may serve as an ideal platform for RNA drug delivery in anti-obesity therapy for individuals unable to control their diet.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Engineering, Environmental
Meng Luo, Min Wang, Wen Niu, Mi Chen, Wei Cheng, Long Zhang, Chenxi Xie, Yidan Wang, Yi Guo, Tongtong Leng, Xingxing Zhang, Cai Lin, Bo Lei
Summary: A study has developed an injectable self-healing anti-inflammatory, angiogenic europium oxide nanorods reinforced nanocomposites dressing, which demonstrated excellent wound healing and skin regeneration effects in experiments.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Medicine, Research & Experimental
Long Zhang, Hang Peng, Meng Feng, Wan Zhang, Yankun Li
Summary: Gene therapy through oral delivery of IL-1 beta shRNA via yeast microcapsules effectively inhibits inflammatory responses in osteoarthritis and prevents articular cartilage degeneration. This novel strategy holds promise for treating joint degeneration by modulating the immune system.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2021)
Article
Pharmacology & Pharmacy
Li Zhang, Wan Zhang, Hang Peng, Yankun Li, Tongtong Leng, Chenxi Xie, Long Zhang
Summary: The study utilized oral shRNA/yeast microcapsules to treat overweight mice, resulting in reduced body weight and fat weight. The IL-1 beta shRNA/yeast group showed higher food intake but lower energy conversion rate compared to the control group. Improvement in lipid metabolism related cytokines and blood glucose concentration was observed after treatment.
Article
Engineering, Biomedical
Long Zhang, Wan Zhang, Hang Peng, Tianli Shen, Min Wang, Meng Luo, Xiaoyan Qu, Fengyi Qu, Wenguang Liu, Bo Lei, Shuanying Yang
Summary: This study developed a safe and efficient biomaterials-based anti-tumor nanoplatform, which can effectively deliver drugs into cancer cells and inhibit tumor development, with good biocompatibility. It may have significance in reducing the gap between nano-platforms and tumor clinical treatment.
MATERIALS TODAY BIO
(2022)
Article
Engineering, Biomedical
Nan Hu, Li Zhu, Li Zhang, Jing Wang, Yanhua Wang, Jing Luo, Lan He, Zhiming Hao, Long Zhang
Summary: Oral delivery of TNF-alpha shRNA mediated by non-pathogenic yeast can effectively inhibit the inflammatory response in rheumatoid arthritis without toxic effects on peripheral blood and major organs.
MATERIALS TODAY BIO
(2022)
Article
Chemistry, Multidisciplinary
Tianli Shen, Shuanying Yang, Xiaoyan Qu, Zilu Chen, Lizhong Zeng, Xuejun Sun, Yuyao Lin, Meng Luo, Bo Lei, Chenyang Yue, Chunhong Ma, Nan Hu, Wei Wang, Long Zhang
Summary: MiRNA-based gene therapy has shown promising results in experimental cancer treatment, but its application in vivo has been limited due to inefficient delivery. A dual-membrane-camouflaged nanoplatform was developed using cancer cell membrane and macrophage membrane, enabling efficient and targeted therapy for colon cancer and lung metastases. This nanoplatform effectively delivered miR21 antagomir to tumor sites and showed anti-tumor properties, with minimal toxicity and good biosafety. This delivery system holds great potential for future translational research.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biotechnology & Applied Microbiology
Long Zhang, Wen Niu, Yuyao Lin, Junping Ma, Tongtong Leng, Wei Cheng, Yidan Wang, Min Wang, Jingya Ning, Shuanying Yang, Bo Lei
Summary: Large-scale skin damage poses potential risks including skin homeostasis imbalance, inflammation, fluid loss, and bacterial infection. Moreover, multidrug resistant bacteria (MDRB) infection remains a major challenge for skin damage repair. In this study, we developed an injectable self-healing bioactive nanoglass hydrogel (FABA) with strong antibacterial and anti-inflammatory properties for repairing normal and Methicillin-resistant Staphylococcus aureus (MRSA) infected skin wounds. The FABA hydrogel effectively inhibited the growth of Staphylococcus aureus, Escherichia coli, and MRSA in vitro, while demonstrating good compatibility with cells and blood. Additionally, the FABA hydrogel suppressed the expression of proinflammatory factor TNF-a and enhanced the expression of anti-inflammatory factors IL-4/IL-10. The versatile FABA hydrogel efficiently promoted wound closure (75% closure at day 3 for normal wounds, 70% closure at day 3 for MRSA-infected wounds), which was nearly three times higher than the control group, likely attributed to the decreased inflammatory factors in the early stage of wound healing. This work suggests that FABA hydrogel holds promise as a dressing for acute and MRSA-infected wound repair.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenguang Liu, Meng Feng, Chathuraka T. Jayasuriya, Hang Peng, Long Zhang, Yingjie Guan, John A. Froehlich, Richard M. Terek, Qian Chen
Meeting Abstract
Endocrinology & Metabolism
Long Zhang, Hang Peng, Meng Feng, Wan Zhang, Qian Chen
JOURNAL OF BONE AND MINERAL RESEARCH
(2019)
Article
Medicine, Research & Experimental
Long Zhang, Hang Peng, Wan Zhang, Yankun Li, Liang Liu, Tongtong Leng
Article
Engineering, Biomedical
Jianqiu Yang, Zhenzhen Huang, Jiang Tan, Jingye Pan, Shixuan Chen, Wenbing Wan
Summary: By functionalizing a decellularized pomelo peel with an adhesive hydrogel and antibacterial materials, the hybrid wound dressing can effectively inhibit bacterial infection, promote granulation tissue formation and angiogenesis, and reduce scar formation during wound healing.
BIOACTIVE MATERIALS
(2024)
Article
Engineering, Biomedical
Yong Mei, Xiaohua Qin, Zhenyu Yang, Shiyao Song, Xiaoting Liu, Chong Wu, Jieying Qian, Xiaowan Huang, Yunjiao Zhang, Weiling He
Summary: This article presents a novel nanoparticle for treating KRAS-TP53 co-mutation in gastrointestinal cancers. The nanoparticle can degrade mutant p53 proteins (mutp53) and deliver the drug AMG510 to inhibit mutant KRAS and mutp53 signaling pathways. The results show that the nanoparticle can effectively reduce cell proliferation and migration, and demonstrate remarkable therapeutic efficacy in a tumor-bearing mouse model.
BIOACTIVE MATERIALS
(2024)
