Article
Oncology
Grace Hwei Ching Tan, Claramae Shulyn Chia, Jolene Si Min Wong, Whee Sze Ong, Hong-Yuan Zhu, Chin-Ann Johnny Ong, Melissa Ching Ching Teo
Summary: This study demonstrates that perioperative immunonutrition in patients undergoing CRS-HIPEC can lead to shorter hospital stays and fewer wound infections and postoperative complications.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Xu Tian, Yan-Fei Jin, Xiao-Ling Liu, Hui Chen, Wei-Qing Chen, Maria F. Jimenez-Herrera
Summary: This network meta-analysis investigated the impact of enteral immunonutrition (EIN) on patients undergoing surgery for esophageal cancer (EC) and determined the optimal time of applying EIN. The results showed that postoperative EIN reduced the incidence of infectious complications and pneumonia, and shortened the length of hospitalization. Postoperative EIN should be preferentially utilized in EC patients undergoing esophagectomy.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Nutrition & Dietetics
Hong-Yeul Lee, Jung-Kyu Lee, Hye-Jin Kim, Dal-Lae Ju, Sang-Min Lee, Jinwoo Lee
Summary: Continuous enteral feeding has been shown to be more effective in achieving target nutrition, especially in patients receiving mechanical ventilation.
Article
Pediatrics
Hong Zhao, Yan Han, Ke-Rong Peng, You-You Luo, Jin-Dan Yu, You-Hong Fang, Jie Chen, Jin-Gan Lou
Summary: This study aimed to compare the use of nasogastric (NG) feeding with nasojejunal (NJ) feeding in treating pediatric patients with acute pancreatitis. Results showed that the NG tube feeding group had significantly shorter tube feeding time and length of hospital stay compared to the NJ group, with no significant differences in other outcomes between the two groups.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Dermatology
Houfeng Fu, Bing Li, Zhenxiong Liang
Summary: Enteral immunonutrition did not show significant differences compared to enteral nutrition in surgical wound infection, infectious complications, systemic inflammatory response syndrome, CD8+ level, CD4+ level, CD4+/CD8+, lymphocyte, and transferrin, but had significantly higher levels of proalbumin, IgM, and IgG.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Nutrition & Dietetics
Erin E. Morris, Neely C. Miller, Nicholas A. Marka, Jennifer L. Super, Emily M. Nagel, Juan David Gonzalez, Ellen W. Demerath, Sara E. Ramel
Summary: Retrospective studies show that parenteral nutrition during the first week after birth, providing calories, proteins, and lipids, is associated with improved neurodevelopment. However, an enhanced parenteral nutrition protocol in the early stage did not lead to improved neurodevelopmental outcomes. Instead, higher enteral caloric and protein intake in the first week after birth were associated with improved processing speed.
Article
Surgery
Pablo E. Serrano, Sameer Parpia, Marko Simunovic, Emmanuelle Duceppe, Maria Ines Pinto-Sanchez, Mohit Bhandari, Mark Levine
Summary: This pilot trial aimed to investigate the impact of perioperative nutritional supplementation on surgical outcomes in gastrointestinal cancer patients. The results suggest the feasibility of conducting a larger phase III trial, and postoperative infectious complications were identified as an important outcome of interest.
Article
Nutrition & Dietetics
Ilya Kagan, Moran Hellerman-Itzhaki, Itai Bendavid, Liran Statlender, Guy Fishman, Paul E. Wischmeyer, Elisabeth de Waele, Pierre Singer
Summary: The smART+ platform is a nutrition management feeding platform that improves feeding issues in the ICU by controlling tube positioning, reflux, gastric pressure, and malnutrition. It delivers targeted nutrition and improves outcomes in critically ill patients.
CLINICAL NUTRITION
(2023)
Article
Medicine, Research & Experimental
Yoshinori Takeda, Yoshihiro Mise, Yoji Kishi, Hiroyuki Sugo, Yusuke Kyoden, Kiyoshi Hasegawa, Yu Takahashi, Akio Saiura
Summary: This multicenter randomized controlled trial aims to investigate the benefits of early enteral nutrition (EN) for patients who underwent pancreaticoduodenectomy (PD) under the enhanced recovery after surgery (ERAS) protocol. The study will compare the occurrence of postoperative infectious complications and other complications between the EN group and the peripheral parental nutrition (PPN) group within 90 days of surgery.
Review
Nutrition & Dietetics
Beata Jablonska, Slawomir Mrowiec
Summary: SAP patients are at high nutritional risk, and early enteral nutrition can significantly reduce mortality and infectious complications by protecting gut barrier function. The role of parenteral nutrition is limited to cases where EN is not feasible or contraindicated.
Review
Oncology
Lingna Li, Dongying Wang, Ning He, Senjie Dai, Leling Tu, Rongrong Fu, Ping Chen
Summary: This study aimed to investigate the effects of polyunsaturated fatty acids (PUFAs) on patients with colorectal cancer (CRC). Twelve studies involving 702 CRC patients were included. The results showed that preoperative supplementation with PUFAs improved total postoperative infectious complications, shortened the postoperative hospital stay, and reduced inflammation in CRC patients. Moreover, PUFAs supplementation in chemotherapy patients increased albumin and decreased C-reactive protein compared to the control group.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2023)
Article
Pediatrics
Mamta Jajoo, Amitabh Singh, Neha Arora, Vikram Bhaskar, Anirban Mandal
Summary: Early total enteral nutrition starting from the first day of life results in significantly less time to achieve full feeds in hemodynamically stable preterm and VLBW infants.
INDIAN JOURNAL OF PEDIATRICS
(2022)
Review
Surgery
Hongxia Li, Shaofang Zhang, Lin Lin, Sanjay Rastogi
Summary: Enteral immunonutrition (EIN) can enhance the immunity of gastric cancer (GC) patients undergoing gastrectomy, leading to reduced postoperative infections and complications.
VIDEOSURGERY AND OTHER MINIINVASIVE TECHNIQUES
(2023)
Article
Nutrition & Dietetics
Stanislaw Klek, Kamila Kret, Ryszard Choruz, Magdalena Pisarska-Adamczyk, Jerzy Salowka, Tomasz Cegielny, Joanna Welanyk, Mariusz Wilczek, Michal Pedziwiatr
Summary: This study compared the clinical effects of immunomodulating plus high-protein supplements and pure high-protein supplements during the preoperative period in patients undergoing major abdominal surgery. The results showed no significant difference in postoperative complications, length of hospitalization, and mortality between the two groups. Therefore, the routine use of immunomodulating supplements in all surgical patients cannot be recommended.
Article
Nutrition & Dietetics
Emma J. Ridley, Andrew R. Davies, Stephen Bernard, Colin McArthur, Lynne Murray, Eldho Paul, Antony Trapani, D. James Cooper
Summary: In critically ill patients with traumatic brain injury, prophylactic hypothermia reduces energy expenditure by 20% compared to normothermia, leading to higher gastric residual volumes and increased use of prokinetics. Despite enteral nutrition intolerance, patients receiving hypothermia still received 93% of measured energy expenditure over 7 days.
CLINICAL NUTRITION
(2021)
Article
Oncology
Weihua Li, Na Cheng, Zitong Zhao, Bo Zheng, Zhaoyang Yang, Yang Xu, Yang Shao, Yongmei Song, Ning Lu, Liyan Xue
Summary: This study aimed to differentiate between multicentric origin (MO) and intramural metastasis (IMM) in multifocal esophageal squamous cell carcinomas (ESCCs) and explore the tumor immune microenvironment. The research identified complex clonal evolution patterns in IMM cases and found that tumor cells disseminated from primary tumors to IMM tumors were independent of lymph node metastasis. The study also revealed higher immune cell infiltrates and immune pathway activation in large tumors compared to small ones in MO cases. These findings provide comprehensive characterization of the heterogeneity and clonal relationship of multifocal ESCCs, which can aid in distinguishing MO from IMM and interpreting immunotherapy responses.
JOURNAL OF PATHOLOGY
(2022)
Article
Medicine, Research & Experimental
Chunyue Wang, Zhenlong Zhang, Yulan Sun, Song Wang, Mengmeng Wu, Qiuxiang Ou, Yang Xu, Zhiming Chen, Yang Shao, Hong Liu, Peifeng Hou
Summary: This study depicted the mutational profiles of NSCLC patients with RET fusions at baseline or after resistance to EGFR-TKIs. The results suggest that RET fusions may mediate secondary resistance to third-generation EGFR-TKIs and could be associated with poor prognosis in patients with NSCLC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Andrology
Qing-Lai Tang, Tao Song, You-Feng Han, Bai-Bing Yang, Jian-Huai Chen, Zhi-Peng Xu, Chun-Lu Xu, Yang Xu, Wen Yu, Wei Qiu, Jiong Shi, En-Si Zhang, Yu-Tian Dai
Summary: Selective dorsal neurotomy (SDN) is a surgical treatment for primary premature ejaculation (PE) that lacks a standard surgical procedure for selecting the branches of the dorsal penile nerves. This study aimed to explore the value of intraoperative neurophysiological monitoring (IONM) of penile sensory-evoked potential (PSEP) for standardizing SDN procedures. The results showed that IONM may improve short-term therapeutic effectiveness and reduce complications in SDN surgeries.
ASIAN JOURNAL OF ANDROLOGY
(2023)
Article
Pathology
Xin Zhang, Xiaoxi Fan, Changbo Sun, Liang Wang, Yuan Miao, Liming Wang, Peng Yang, Yang Xu, Xue Ren, Xue Wu, Shun Xu
Summary: In this study, NGS analysis was used to diagnose MLA patients with MPLAs and IPMs. By incorporating a predefined NGS criterion, accurate classification of IPMs was achieved. A refined algorithm was developed that combined NGS and histologic results to correctly diagnose MPLAs and IPMs. This NGS-based algorithm showed promising potential in complementing traditional CHA-based MLA diagnosis and helping determine patient staging and treatment.
JOURNAL OF PATHOLOGY CLINICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Weixin Zhao, Ailing Song, Yang Xu, Qian Wu, Cuicui Liu, Jiani C. C. Yin, Qiuxiang Ou, Xue Wu, Yang Shao, Xinmin Zhao
Summary: This retrospective study analyzed next-generation sequencing (NGS) data from 1025 non-small cell lung cancer (NSCLC) patients with compound epidermal growth factor receptor (EGFR) mutations. Different subtypes of compound EGFR mutations were associated with distinct clinical features, genetic architectures, and prognostic outcomes. Rare mutation-dominant subtypes with variations of uncertain significance (VUSs) residing in the kinase domain had poor clinical outcomes and implied disruptions in kinase domain regulation/function.
Article
Dentistry, Oral Surgery & Medicine
Y. Chen, H. Wang, Q. Ni, T. Wang, C. Bao, Y. Geng, Y. Lu, Y. Cao, Y. Li, L. Li, Y. Xu, W. Sun
Summary: B cells play a crucial role in periodontitis by regulating immune response, inducing tissue destruction, and eliminating periodontal pathogens. However, their role in mesenchymal stem cell (MSC) differentiation to osteoblasts in periodontitis has been poorly studied.
JOURNAL OF DENTAL RESEARCH
(2023)
Article
Medicine, Research & Experimental
Xin Chen, Kaixuan Bai, Yu Zhang, Yang Xu, Yinghao Huo, Sha Wang, Yueli Zou, Xuejiao Qi, Rongyun Guo, Qiuxiang Ou, Dengxiang Liu, Shaohua Yin, Shubo Chen, Hui Bu
Summary: In this study, it was found that cerebrospinal fluid circulating tumor DNA could sensitively detect molecular markers and metastasis-related mechanisms in gastric cancer patients with leptomeningeal metastases, providing new clues for prognosis estimation and clinical assessment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yongkan Bai, Xiang Liu, Limin Zheng, Song Wang, Junli Zhang, Shi Xiong, Pengfei Zhang, Zichen Jiao, Gefei Zhao, Chu Zhou, Jiaohui Pang, Yang Xu, Qiuxiang Ou, Yuan Mao, Louqian Zhang
Summary: In this study, the genomic profiles of NSCLC patients with cEGFR and uEGFR mutations were analyzed using targeted next-generation sequencing. The results showed that uEGFR-positive patients were more likely to have co-occurring genetic alterations in the Hippo pathway and a higher TMB. Smoking-related mutations were also enriched in uEGFR-positive patients. Subgroup analyses revealed potential prognostic biomarkers and significant differences in mutational profiles among patients with different EGFR sub-type mutations.
Letter
Oncology
Xueting Qin, Yujun Bai, Shizhen Zhou, Hongjin Shi, Xiaoli Liu, Song Wang, Xiaoying Wu, Jiaohui Pang, Xi Song, Xiaojun Fan, Qiuxiang Ou, Yang Xu, Hua Bao, Li Li, Jun Li, Yang Shao, Shuanghu Yuan
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Letter
Oncology
Kewen He, Li Li, Aijie Li, Yang Xu, Jiaohui Pang, Dianbin Mu, Jie Ma, Hong Ge, Aurian Maleki, Xueting Qin, Xian Zhang, Qiuxiang Ou, Yang Shao, Jinming Yu, Shuanghu Yuan
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Editorial Material
Biochemistry & Molecular Biology
Weidong Wang, Wang Lv, Hui Wang, Yang Xu, Junrong Yan, Han-Ming Shen, Liqun Shan, Jian Hu
Article
Oncology
Jin Li, Xiaohong Xue, Yan Zhang, Fengna Ding, Wenyan Wu, Cuicui Liu, Yang Xu, Hanlin Chen, Qiuxiang Ou, Yang Shao, Xinjun Li, Fei Wu, Xiaohua Wu
Summary: This multi-center study in Chinese cervical cancer patients highlights the immunologic and genomic differences between squamous cell carcinoma (SCC) and adenocarcinoma (AC). The study suggests that SCC may have better immunotherapy efficacy, while AC may be more favorable for targeted therapy. These findings are significant for guiding treatment strategies for different types of cervical cancer.
GYNECOLOGIC ONCOLOGY
(2023)
Article
Dermatology
Meng Tao, Min Li, Yue Zhang, Duoduo Gu, Ruoxin Pan, Yang Xu
Summary: This study found that individuals with rosacea have different facial erythema distribution patterns, which may be related to skin types. The erythema distribution pattern of rosacea was divided into peace signs, wing shapes, and neither of the two patterns. The peace sign pattern was more common in individuals with darker skin tones, while the wing shape pattern was associated with the lateral parts of the cheeks. This has important implications for understanding the pathogenesis and treatment of rosacea.
ARCHIVES OF DERMATOLOGICAL RESEARCH
(2023)
Article
Respiratory System
Yu Yao, Huaping Yang, Bo Zhu, Song Wang, Jiaohui Pang, Xiaoying Wu, Yang Xu, Junli Zhang, Jinfeng Zhang, Qiuxiang Ou, Hui Tian, Zheng Zhao
Summary: This study found that MET tyrosine kinase domain (TKD) mutations were detected in both baseline and patients treated with TKIs in non-small-cell lung cancer (NSCLC) patients. MET-H1094Y may be associated with acquired resistance after recurrent EGFR-TKIs treatment. Preliminary data suggests that EGFR-mutated NSCLC patients who acquired MET-V1092I or MET-H1094Y may benefit from combinatorial therapy with EGFR-TKI and MET-TKI, providing new insights into personalized medical treatment.
RESPIRATORY RESEARCH
(2023)
Article
Medicine, Research & Experimental
Wei Wei, Fangfang Shi, Yang Xu, Yang Jiao, Ying Zhang, Qiuxiang Ou, Xue Wu, Lingyi Yang, Jinhuo Lai
Summary: Next-generation sequencing was used to investigate molecular features in NSCLC patients with pathogenic/likely pathogenic ATM/ATR mutations. The results were validated using an external cohort of NSCLC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)