Article
Biochemistry & Molecular Biology
Chaozhi Wei, Chuan Zhang, Yuhang Gao, Leilei Yu, Jianxin Zhao, Hao Zhang, Wei Chen, Fengwei Tian
Summary: By studying the bacterium Lactiplantibacillus plantarum CCFM1287, researchers found that it can effectively degrade the mycotoxin patulin in food. The concentration of patulin decreased by 85.09% during the initial growth stages of CCFM1287. The study also investigated the oxidative stress regulation and metabolic changes that occur during patulin degradation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Thais Carbinatti, Marion Regnier, Lucia Parlati, Fadila Benhamed, Catherine Postic
Summary: Carbohydrate response element binding protein (ChREBP) is a glucose responsive transcription factor that plays a critical role in the transcriptional control of glycolysis and de novo lipogenesis. It modulates inter-organ communication through secretion of peptides and lipid factors, ensuring metabolic homeostasis. Dysregulation of ChREBP-mediated interactions is associated with the development of metabolic diseases like type 2 diabetes and non-alcoholic fatty liver disease.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Jialing Gao, Xiaoxue Wu, Shuting Huang, Ziyi Zhao, Weiling He, Mei Song
Summary: This article provides an overview of copper homeostasis and its associated pathological disorders, especially copper metabolism in carcinogenesis. It summarizes the current knowledge of the tumor suppressive mechanisms of elesclomol, with emphasis on cuproptosis. Finally, strategies for better application of elesclomol in cancer therapy are discussed.
Editorial Material
Pharmacology & Pharmacy
Gabriela Reyes-Castellanos, Alice Carrier
Summary: This study reveals that inhibition of mitochondrial complex I promotes anticancer immune surveillance, which has significant implications for metabolic reprogramming in cancer therapy.
TRENDS IN PHARMACOLOGICAL SCIENCES
(2022)
Article
Agriculture, Multidisciplinary
Ruiguo Wang, Na Cui, Alexandros Yiannikouris, Yuan Huang, Wenyu Zhao, Xiaoou Su, Gang Lin, Ronghua Zhu, Zhichao Song, Peilong Wang
Summary: This study investigated the absorption, distribution, metabolism, and excretion patterns of zearalenone (ZEN) in a Chinese miniature pig breed. The results showed that ZEN was mainly metabolized into alpha-zearalenol (alpha-ZOL), and both ZEN and alpha-ZOL were mostly found in conjugated forms in the plasma, urine, and bile. The concentration and composition patterns of ZEN and its metabolites were tissue-specific, suggesting different roles of the small intestine, liver, kidney, and lung in ZEN metabolism. The plasma concentrations of ZEN + alpha-ZOL were highly correlated with ZEN dietary exposure, indicating their potential as a bioindicator for animal exposure and efficacy evaluation of mycotoxin detoxifiers.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Ruiguo Wang, Na Cui, Alexandros Yiannikouris, Yuan Huang, Wenyu Zhao, Xiaoou Su, Gang Lin, Ronghua Zhu, Zhichao Song, Peilong Wang
Summary: Research on the ADME of ZEN in Bama Aroma pigs revealed that ZEN is mainly metabolized into alpha-Zearalenol and both are found in conjugated forms in plasma, urine, and bile. The concentration and composition of ZEN and its metabolites were tissue-specific, suggesting different roles in ZEN metabolism for the small intestine, liver, kidney, and lung.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agronomy
Zhengqing Zhang, Pei Pei, Meng Zhang, Feifei Li, Guanghui Tang
Summary: A chromosome-level genome of Dastarcus helophoroides was assembled using a combination strategy, and 14,890 protein-coding genes and 65.37% repeat sequences were predicted. Phylogenetic analysis showed that Dastarcus helophoroides diverged from related species about 242.9 million years ago. Gene expression analysis identified key genes involved in stress response and detoxification.
PEST MANAGEMENT SCIENCE
(2023)
Article
Engineering, Environmental
Zhu Zhang, Wenqing Chen, Hiutung Chan, Junjie Peng, Peili Zhu, Junkui Li, Xiaoli Jiang, Zhang Zhang, Ying Wang, Zicong Tan, Yungkang Peng, Shiqing Zhang, Kaili Lin, Ken Kin-Lam Yung
Summary: In this study, the systemic toxicity of polystyrene microplastics (MPs) of different sizes was examined in mice. The results showed that the distribution of MPs in the organs is size-dependent, and exposure to different sized MPs results in distinct toxicity pathways and impacts. This study provides important insights into the toxicity of MPs in mammalian models.
JOURNAL OF HAZARDOUS MATERIALS
(2024)
Article
Agriculture, Dairy & Animal Science
Shun Zhou, Jing Dong, Yongtao Liu, Qiuhong Yang, Ning Xu, Yibin Yang, Xiaohui Ai
Summary: TCCA exposure in goldfish disrupted energy metabolism and detoxification process, induced oxidative stress in the liver, and caused pathological damage in gills. Activation of metabolic enzymes and impairment of antioxidant defense system were observed, contributing to the toxicological influences of TCCA on goldfish.
Article
Multidisciplinary Sciences
Shichen Su, Jia Wang, Ting Deng, Xun Yuan, Jinqiu He, Nan Liu, Xiaomin Li, Ying Huang, Hong-Wei Wang, Jinbiao Ma
Summary: This study revealed the molecular mechanism for the full cycle of ATP-dependent dsRNA processing by Dcr-2-Loqs-PD. The structures of Dcr-2-Loqs-PD in various states during dsRNA processing were determined using cryo-electron microscopy. The study elucidated the conformational changes and interactions between Dcr-2 and Loqs-PD, providing insights into the RNA interference mechanism and potential therapeutic strategies for related diseases.
Article
Environmental Sciences
Zhiwei Bao, Dou Wang, Yao Zhao, Ting Luo, Guilin Yang, Yuanxiang Jin
Summary: The simultaneous exposure to CBZ and PRO, two commonly used fungicides, can have more serious effects on lipid metabolism, causing disorder in the liver. These findings are of significant importance for studying the toxic effects of fungicides.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Leviel Fluhr, Uria Mor, Aleksandra A. Kolodziejczyk, Mally Dori-Bachash, Avner Leshem, Shlomik Itav, Yotam Cohen, Jotham Suez, Niv Zmora, Claudia Moresi, Shahar Molina, Niv Ayalon, Rafael Valdes-Mas, Shanni Hornstein, Hodaya Karbi, Denise Kviatcovsky, Adi Livne, Aurelie Bukimer, Shimrit Eliyahu-Miller, Alona Metz, Alexander Brandis, Tevie Mehlman, Yael Kuperman, Michael Tsoory, Noa Stettner, Alon Harmelin, Hagit Shapiro, Eran Elinav
Summary: Smoking and cessation induce a dysbiotic state in the intestines, leading to weight gain. Depletion of gut microbiota induced by antibiotics prevents weight gain after smoking cessation.
Article
Toxicology
Ana Margarida Araujo, Marcia Carvalho, Vera Marisa Costa, Jose Alberto Duarte, Ricardo Jorge Dinis-Oliveira, Maria de Lourdes Bastos, Paula Guedes de Pinho, Felix Carvalho
Summary: The study revealed metabolic changes induced by MDPV in mice using metabolomics analysis, with kidneys and liver showing the greatest metabolic alterations. Metabolites related to energetic metabolism, antioxidant defenses, and inflammatory response were significantly changed in the liver. Urine metabolites suggested that glutathione-dependent antioxidant pathways may be involved in counteracting oxidative stress induced by MDPV.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Environmental Sciences
Zhongyuan Gao, Luqing Pan, Ruiyi Xu, Yueyao Zhou, Dongyu Li
Summary: This study investigates the mechanism of lipid metabolism interference in aquatic animals during the reproductive period. Transcriptome analysis of the digestive glands of the scallop C. farreri was performed, revealing the pathways and differentially expressed genes involved in lipid metabolism in bivalves. This study provides valuable genomic information on the role of digestive glands in lipid metabolism and reproduction, contributing to further understanding of the functional genomics of bivalves and related species.
ENVIRONMENTAL POLLUTION
(2022)
Article
Environmental Sciences
Yongliang Qiao, Yu Zhang, Shaochun Xu, Shidong Yue, Xiaomei Zhang, Mingjie Liu, Lingling Sun, Xiaoping Jia, Yi Zhou
Summary: This study examined the toxic effects of copper and cadmium on eelgrass at multiple levels. The results showed that copper was more toxic to eelgrass than cadmium. High temperatures increased heavy metal damage, while low temperatures inhibited damage. Copper and cadmium had a synergistic effect on photosynthesis. Transcriptome analysis revealed severe damage to the photosynthetic system under cadmium stress, while copper stress resulted in up-regulation of genes related to glutathione metabolism. Recovery experiments showed that the damage caused by short-term copper and cadmium stress was reversible. These findings provide insights into the heavy metal toxic effects and resistance strategies of eelgrass, highlighting its potential for phytoremediation, especially for cadmium.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
