Article
Chemistry, Applied
Bowei Zhang, Yingchuan Xu, Huan Lv, Wenwen Pang, Jin Wang, Hui Ma, Shuo Wang
Summary: This study investigated the intestinal pharmacokinetics of resveratrol in mice using HPLC-MS/MS and found that resveratrol and its metabolites were present in significant amounts in the entire intestinal tract and feces, with a peak concentration at 4 hours post-administration. The study also demonstrated the promotion of Lactobacillus reuteri growth by resveratrol-3-O-sulfate during in vitro fermentation and the up-regulation of tight junction and mucin-related proteins mRNA expressions by resveratrol-3-O-sulfate during incubation with Caco-2 cells.
Review
Biochemistry & Molecular Biology
Tao Ke, Andre Rajoo, Alexey A. Tinkov, Anatoly V. Skalny, Yousef Tizabi, Joao B. T. Rocha, Aaron B. Bowman, Michael Aschner
Summary: Methylmercury (MeHg) remains a global public health issue, and the intestinal microbiota plays an important role in its metabolism and elimination. Demethylation by intestinal bacteria is the rate-limiting step in MeHg metabolism, and the intestinal microbiota can protect the host from neurotoxic effects by maintaining intestinal barrier function.
Article
Critical Care Medicine
Silei Sun, Daosheng Wang, Danfeng Dong, Lili Xu, Mengqi Xie, Yihui Wang, Tongtian Ni, Weisong Jiang, Xiaojuan Zhu, Ning Ning, Qian Sun, Shuyuan Zhao, Mengjiao Li, Peili Chen, Meiling Yu, Jian Li, Erzhen Chen, Bing Zhao, Yibing Peng, Enqiang Mao
Summary: This study used microbiome and untargeted metabolomics to analyze stool samples from sepsis patients and identified microbial and metabolic features that may play important roles in disease outcome. Animal model analysis further validated the findings. These findings could help predict the clinical outcome of sepsis patients and provide a basis for exploring new therapies.
Article
Pharmacology & Pharmacy
Ning-Ning Zhang, Zheng-Meng Jiang, Shang -Zhen Li, Xing Yang, E-Hu Liu
Summary: Growing evidence suggests that the status of gut microbiota affects human health, and imbalance of microbiota can lead to various disorders. Natural products are gaining attention due to their therapeutic effects and fewer side effects. Recent studies support that many natural products' activities depend on gut microbiota, while gut microbiota is also modulated by natural products.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Yina Xiao, Fubo Han, Ik-Soo Lee
Summary: Biotransformation of four bioactive phenolic constituents from licorice by Aspergillus niger led to the isolation of 17 metabolites, with 12 compounds previously undescribed. Compounds 1 and 12 showed significant cytotoxic activities against human cancer cell lines, suggesting their potential as cancer chemopreventive agents.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Guangqiang Wang, Hongna Zhang, Jianan Zhang, Katherine Z. Sanidad, Vladimir Yeliseyev, Julie Parsonnet, Thomas D. Haggerty, Haixia Yang, Lianzhong Ai, Minhao Xie, Zongwei Cai, Guodong Zhang
Summary: Metabolic fate of triclocarban in gut tissues was studied in this research, revealing the significant contribution of gut microbiota in mediating the unique metabolic profile of triclocarban in the colon. This highlights the importance of considering the role of gut microbiota in the toxicology evaluation of environmental compounds.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agriculture, Dairy & Animal Science
Junai Zhen, Xueli Yuan, Liping Tao, Huidan Zhang, Yijun Ren, Shengbin Xie, Libo Wang, Hua Shen, Yuqing Chen
Summary: By studying the gut microbiome and metabolic pathways of Pere David's deer with diarrhea, significant changes in gut microbiota diversity and composition, along with considerable alterations in numerous fecal metabolites and several metabolic pathways, were observed.
Article
Microbiology
Martin Muthee Gakuubi, Kuan Chieh Ching, Madhaiyan Munusamy, Mario Wibowo, Zhao-Xun Liang, Yoganathan Kanagasundaram, Siew Bee Ng
Summary: This study investigated the diversity, antimicrobial, and cytotoxic activities of fungal endophytes obtained from different habitats in Singapore. The majority of the identified strains belonged to the phylum Ascomycota, and the most dominant genus was Colletotrichum. Chemical elicitation and variation of fermentation media led to the discovery of more bioactive strains. Active constituents were isolated and characterized, including a known compound and five novel compounds. These compounds showed strong antifungal and antiproliferative activities.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Zheng-Wei Zhang, Lin Cong, Ran Peng, Pei Han, Shu-Rong Ma, Li-Bin Pan, Jie Fu, Hang Yu, Yan Wang, Jian-Dong Jiang
Summary: This study revealed a new transformation mechanism of BBR by demethylation in the gut microbiota through the action of the CYP51 enzyme, shedding light on the enhancement of its intestinal absorption.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2021)
Review
Oncology
Dandan Lin, Bo Hu, Pengfei Li, Ye Zhao, Yang Xu, Depei Wu
Summary: The intestinal microbiota plays a crucial role in the pathogenesis of acute GVHD, with dysbiosis associated with poor prognosis. Intervention strategies targeting the microbiota, such as antibiotics, prebiotics, probiotics, postbiotics, and fecal microbiota transplantation, are potential new treatment options for acute GVHD.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Wei-Jie Li, Le Zhang, Hong-Xia Wu, Miao Li, Tong Wang, Wen-Bing Zhang, Zhen-Yu Du, Mei-Ling Zhang
Summary: This study investigated the effects of gossypol on Nile tilapia and found that it reduced the richness and diversity of the gut microbiota. Gossypol down-regulated the expression of most metabolites, and riboflavin was the key metabolite with significant difference between the control and gossypol-treated groups. Fecal bacteria transplantation experiments demonstrated that the negative effects of gossypol were mediated by the intestinal microbiota and its metabolite.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Lei Yang, Yue Wan, Wenwen Li, Chen Liu, Hui-fang Li, Zhiling Dong, Ke Zhu, Shu Jiang, Erxin Shang, Dawei Qian, Jinao Duan
Summary: This study aimed to clarify the laxative effect of rhubarb by analyzing the metagenome and metabolome of the gut microbiota. The results showed that rhubarb improved the disorder of intestinal microbiota and fecal metabolic profiles in constipated rats. The study suggested that rhubarb's amelioration on constipation might be achieved by modulating the intestinal microflora and its metabolism. Moreover, the application of fecal metabolomics could provide a new strategy to uncover the mechanism of herbal medicines.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Jose M. Landete
Summary: The study found that deglycosylation reactions were the main reactions leading to more bioavailable flavonoids with greater biological activity in most individuals. However, other reactions also occurred, including the partial catabolism of flavonoids.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Abdel-Rahim S. Ibrahim, Mai K. Mansour, Mohammed M. A. Ahmed, Roland Ulber, Ahmed Zayed
Summary: Investigation of xenobiotic metabolism is crucial in drug discovery. Predicting the structure of toxic metabolites during preliminary clinical studies is necessary to avoid harmful effects. Cunninghamella organisms are potential candidates for simulating human metabolism and producing diverse and bioactive metabolites. This review provides a comprehensive literature overview on the use of Cunninghamella as biocatalysts for simulating mammalian metabolism of natural and synthetic compounds.
BIOORGANIC CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Benjamin A. H. Jensen, Jacob B. Holm, Ida S. Larsen, Nicole von Burg, Stefanie Derer, Si B. Sonne, Simone I. Paerregaard, Mads V. Damgaard, Stine A. Indrelid, Aymeric Rivollier, Anne-Laure Agrinier, Karolina Sulek, Yke J. Arnoldussen, Even Fjaere, Andre Marette, Inga L. Angell, Knut Rudi, Jonas T. Treebak, Lise Madsen, Caroline Piercey Akesson, William Agace, Christian Sina, Charlotte R. Kleiveland, Karsten Kristiansen, Tor E. Lea
Summary: The study demonstrates that altering the protein source in diets can modulate the gut microbiota, leading to improvements in glucose regulation, reduced body fat, and diminished hepatic immune infiltration. Supplementation with Methylococcus capsulatus Bath lysates can enhance Parabacteroides abundances and upregulate regulatory T cell populations to improve immunometabolic homeostasis.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Applied
Tomasz Tarko, Magdalena Januszek, Aleksandra Duda-Chodak, Pawel Sroka
Summary: Keeving is a process that involves removing yeast nutrients from apple juice by binding them with pectin, and it is influenced by the concentration of calcium ions. Research shows that Keeving can slow down yeast's use of sugars, leading to lower alcohol levels in ciders, and reduce the concentration of free amino nitrogen, resulting in ciders with higher concentrations of acetates and some terpenoids.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2021)
Article
Food Science & Technology
Katarzyna Petka, Pawel Sroka, Tomasz Tarko, Aleksandra Duda-Chodak
Summary: Under specific conditions, Lactobacillus acidophilus LA-5 has the ability to degrade acrylamide, but this capability disappears under certain conditions. Additionally, the presence of acrylamide in milk can modulate the bacteria metabolism.
Article
Environmental Sciences
Katarzyna Petka, Lukasz Wajda, Aleksandra Duda-Chodak
Summary: This study found that acrylamide can stimulate the growth of Lactic Acid Bacteria and Latin Lactic Yeast, and suggested that Lactobacillus acidophilus LA-5 can utilize acrylamide as a source of carbon and nitrogen. It also indicated that certain strains of bacteria present in fermented milk products may have the potential to diminish acrylamide concentration, hence preventing its harmful impact on the human body and intestinal microbiota.
Review
Biochemistry & Molecular Biology
Aleksandra Duda-Chodak, Tomasz Tarko, Katarzyna Petka-Poniatowska
Summary: This review presents current knowledge on antimicrobial agents that are already used in the food packaging industry, discussing innovative ways of food packaging, and focusing on one group of bioactive components, namely antimicrobial agents. The main antimicrobial agent groups used in packaging materials to extend the shelf life of food, as well as the further development of perspectives and setting of new research directions were described.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Magdalena Franczyk-Zarow, Tomasz Tarko, Anna Drahun-Misztal, Izabela Czyzynska-Cichon, Edyta Kus, Renata B. Kostogrys
Summary: The aim of this study was to evaluate the anti-atherosclerotic effect of pomegranate seed oil containing CLnA compared to LnA and CLA in apoE/LDLR-/- mice. The results showed that CLnA improved the lipid profile and affected lipid metabolism gene expression, but had no impact on the development of atherosclerotic plaque in these mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Tomasz Tarko, Filip Krankowski, Aleksandra Duda-Chodak
Summary: This article discusses the use of different types of wood in the production of wines, beers, and flavored vodkas to improve their quality parameters. The changes that occur in wood during the toasting process and the compounds derived from wood that shape the aroma, taste, and color of alcoholic beverages are described. The influence of wood on the quality of alcoholic beverages, particularly in wine, beer, whisky, and brandy, is emphasized. Furthermore, innovative techniques using wood to enhance the qualitative features of alcoholic beverages are presented.
Review
Biochemistry & Molecular Biology
Aleksandra Duda-Chodak, Tomasz Tarko
Summary: Polyphenols are important components of plant-derived food that have a wide range of beneficial effects on human health. However, they can also have harmful effects, such as blocking iron uptake, inhibiting digestive enzymes, disrupting intestinal microbiota, interacting with drugs, and affecting hormonal balance. Public awareness needs to be raised on the potential side effects of polyphenol supplementation, especially for vulnerable populations.
Review
Biochemistry & Molecular Biology
Krystian Klimczak, Monika Cioch-Skoneczny, Aleksandra Duda-Chodak
Summary: Dry-hopping is a brewing technique where hops are added to the cold side of the brewing process to extract essential oils and achieve unique aromas. It has gained popularity in recent years, especially in the craft beer revolution, and is becoming more useful with the development of new hop varieties.
