期刊
ANTIOXIDANTS
卷 10, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/antiox10020289
关键词
Bisphenol A; endocrine disruptors; male infertility; oxidative stress; antioxidants; phytochemicals; medicinal plants
资金
- Institute for Biomedicine-iBiMED [UID/BIM/04501/2020]
- FCT of the Portuguese Ministry of Science and Higher Education [SFRH/BD/136896/2018]
- Fundação para a Ciência e a Tecnologia [SFRH/BD/136896/2018] Funding Source: FCT
BPA negatively affects male reproductive system and fertility by disturbing spermatogenesis and seminal parameters, mainly by disrupting hormone signaling and inducing oxidative stress. Studies have shown a negative association between BPA levels and sperm concentration, motility, and DNA damage. Current research focuses on using antioxidants to prevent or reverse BPA-induced testicular toxicity and infertility in men.
Bisphenol A (BPA), a well-known endocrine disruptor present in epoxy resins and polycarbonate plastics, negatively disturbs the male reproductive system affecting male fertility. In vivo studies showed that BPA exposure has deleterious effects on spermatogenesis by disturbing the hypothalamic-pituitary-gonadal axis and inducing oxidative stress in testis. This compound seems to disrupt hormone signalling even at low concentrations, modifying the levels of inhibin B, oestradiol, and testosterone. The adverse effects on seminal parameters are mainly supported by studies based on urinary BPA concentration, showing a negative association between BPA levels and sperm concentration, motility, and sperm DNA damage. Recent studies explored potential approaches to treat or prevent BPA-induced testicular toxicity and male infertility. Since the effect of BPA on testicular cells and spermatozoa is associated with an increased production of reactive oxygen species, most of the pharmacological approaches are based on the use of natural or synthetic antioxidants. In this review, we briefly describe the effects of BPA on male reproductive health and discuss the use of antioxidants to prevent or revert the BPA-induced toxicity and infertility in men.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据