期刊
ACTA PHYSIOLOGICA
卷 215, 期 4, 页码 177-190出版社
WILEY
DOI: 10.1111/apha.12601
关键词
ageing; exercise; satellite cells
类别
资金
- Natural Sciences and Engineering Research Council of Canada (NSERC) [1455843]
- Labarge Optimal Aging Initiative from McMaster University
- NSERC Canadian Graduate Scholarship (CGS-D)
AimA dysregulation of satellite cells may contribute to the progressive loss of muscle mass that occurs with age; however, older adults retain the ability to activate and expand their satellite cell pool in response to exercise. The modality of exercise capable of inducing the greatest acute response is unknown. We sought to characterize the acute satellite cell response following different modes of exercise in older adults. MethodsSedentary older men (n=22; 674years; 272.6kg*m(-2)) were randomly assigned to complete an acute bout of either resistance exercise, high-intensity interval exercise on a cycle ergometer or moderate-intensity aerobic exercise. Muscle biopsies were obtained before, 24 and 48h following each exercise bout. The satellite cell response was analysed using immunofluorescent microscopy of muscle cross sections. ResultsSatellite cell expansion associated with type I fibres was observed 24 and 48h following resistance exercise only (P?0.05), while no expansion of type II-associated satellite cells was observed in any group. There was a greater number of activated satellite cells 24h following resistance exercise (pre: 1.3 +/- 0.1, 24h: 4.8 +/- 0.5 Pax7+/MyoD+cells/100 fibres) and high-intensity interval exercise (pre: 0.7 +/- 0.3, 24h: 3.1 +/- 0.3 Pax7+/MyoD+cells/100 fibres) (P?0.05). The percentage of type I-associated SC co-expressing MSTN was reduced only in the RE group 24h following exercise (pre: 87 +/- 4, 24h: 57 +/- 5%MSTN+ type I SC) (P<0.001). ConclusionAlthough resistance exercise is the most potent exercise type to induce satellite cell pool expansion, high-intensity interval exercise was also more potent than moderate-intensity aerobic exercise in inducing satellite cell activity.
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