期刊
PHARMACEUTICS
卷 13, 期 2, 页码 -出版社
MDPI
DOI: 10.3390/pharmaceutics13020196
关键词
bacteriocins; nisin; antibiotic resistance
资金
- Ministry of Research and Innovation, CNCS-UEFISCDI within PNCDI III [PN-III-P4-ID-PCCF-2016-0114-10/2018, PN-III-P1-1.1-PD-2016-2137-113/2018, PN-IIIP4-529 ID-PCE-2016-0884, PN-III-P1-1.1-PD-2016-1798-148/2018]
Decades of antibiotic misuse have led to a rise in antibiotic-resistant bacteria, causing a concerning increase in antimicrobial-resistant infections. Bacteriocins, small antimicrobial peptides produced by certain bacteria, show promise as alternatives to traditional antibiotics. The objective of the study was to explore the potential of bacteriocins as antimicrobial therapeutics for infections mainly caused by resistant pathogens.
Decades of antibiotic misuse in clinical settings, animal feed, and within the food industry have led to a concerning rise in antibiotic-resistant bacteria. Every year, antimicrobial-resistant infections cause 700,000 deaths, with 10 million casualties expected by 2050, if this trend continues. Hence, innovative solutions are imperative to curb antibiotic resistance. Bacteria produce a potent arsenal of drugs with remarkable diversity that are all distinct from those of current antibiotics. Bacteriocins are potent small antimicrobial peptides synthetized by certain bacteria that may be appointed as alternatives to traditional antibiotics. These molecules are strategically employed by commensals, mostly Firmicutes, to colonize and persist in the human gut. Bacteriocins form channels in the target cell membrane, leading to leakage of low-molecular-weight, causing the disruption of the proton motive force. The objective of this review was to list and discuss the potential of bacteriocins as antimicrobial therapeutics for infections produced mainly by resistant pathogens.
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