Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer’s disease

α-Synuclein oligomers in skin biopsy of idiopathic and monozygotic twin patients with Parkinson’s disease

(2020) Samanta Mazzetti et al.   BRAIN

Wide distribution of alpha-synuclein oligomers in multiple system atrophy brain detected by proximity ligation

(2019) Hiroaki Sekiya et al.   ACTA NEUROPATHOLOGICA

A post-translational modification signature defines changes in soluble tau correlating with oligomerization in early stage Alzheimer’s disease brain

(2019) Ebru Ercan-Herbst et al.   Acta Neuropathologica Communications

Tau seeding activity begins in the transentorhinal/entorhinal regions and anticipates phospho-tau pathology in Alzheimer’s disease and PART

(2018) Sarah K. Kaufman et al.   ACTA NEUROPATHOLOGICA

Amyloidogenic cross-seeding of Tau protein: Transient emergence of structural variants of fibrils

(2018) Bartosz Nizynski et al.   PLoS One

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Identification of the Tau phosphorylation pattern that drives its aggregation

(2017) Clément Despres et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wild-Type, but Not Mutant N296H, Human Tau Restores Aβ-Mediated Inhibition of LTP in Tau−/− mice

(2017) Mariana Vargas-Caballero et al.   Frontiers in Neuroscience

Characterization of tau prion seeding activity and strains from formaldehyde-fixed tissue

(2017) Sarah K. Kaufman et al.   Acta Neuropathologica Communications

Phosphorylated Tau: Toxic, Protective, or None of the Above

(2017) Rudy J. Castellani et al.   JOURNAL OF ALZHEIMERS DISEASE

Formation, release, and internalization of stable tau oligomers in cells

(2016) Susanne Wegmann et al.   JOURNAL OF NEUROCHEMISTRY

Tau Prion Strains Dictate Patterns of Cell Pathology, Progression Rate, and Regional Vulnerability In Vivo

(2016) Sarah K. Kaufman et al.   NEURON

Epitope mapping and structural basis for the recognition of phosphorylated tau by the anti-tau antibody AT8

(2016) Thomas J. Malia et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Hippocampal phospho-tau/MAPT neuropathology in the fornix in Alzheimer disease: an immunohistochemical autopsy study

(2016) Edward D. Plowey et al.   Acta Neuropathologica Communications

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

(2016) M. Fá et al.   Scientific Reports

Internalized Tau sensitizes cells to stress by promoting formation and stability of stress granules

(2016) Cecilia A. Brunello et al.   Scientific Reports

Biochemical classification of tauopathies by immunoblot, protein sequence and mass spectrometric analyses of sarkosyl-insoluble and trypsin-resistant tau

(2015) Sayuri Taniguchi-Watanabe et al.   ACTA NEUROPATHOLOGICA

Direct visualization of alpha-synuclein oligomers reveals previously undetected pathology in Parkinson’s disease brain

(2015) Rosalind F. Roberts et al.   BRAIN

Cellular Models of Aggregation-dependent Template-directed Proteolysis to Characterize Tau Aggregation Inhibitors for Treatment of Alzheimer Disease

(2015) Charles R. Harrington et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Determinants of amyloid fibril degradation by the PDZ protease HTRA1

(2015) Simon Poepsel et al.   Nature Chemical Biology

Sensitive Detection of Proteopathic Seeding Activity with FRET Flow Cytometry

(2015) Jennifer L. Furman et al.   Jove-Journal of Visualized Experiments

Conformation Determines the Seeding Potencies of Native and Recombinant Tau Aggregates

(2014) Benjamin Falcon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Proteopathic tau seeding predicts tauopathy in vivo

(2014) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neurofibrillary tangle-bearing neurons are functionally integrated in cortical circuits in vivo

(2013) K. V. Kuchibhotla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum

(2012) Pierre Trifilieff et al.   BIOTECHNIQUES

Identification of oligomers at early stages of tau aggregation in Alzheimer's disease

(2012) Cristian A. Lasagna-Reeves et al.   FASEB JOURNAL

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Propagation of Tau Pathology in a Model of Early Alzheimer's Disease

(2012) Alix de Calignon et al.   NEURON

National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach

(2011) Thomas J. Montine et al.   ACTA NEUROPATHOLOGICA

Understanding the Kinetic Roles of the Inducer Heparin and of Rod-like Protofibrils during Amyloid Fibril Formation by Tau Protein

(2011) Gayathri Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sensitive detection of Aβ protofibrils by proximity ligation - relevance for Alzheimer's disease

(2010) Masood Kamali-Moghaddam et al.   BMC NEUROSCIENCE

Tau in Alzheimer Disease and Related Tauopathies

(2010) K. Iqbal et al.   Current Alzheimer Research

Human Tau Isoforms Assemble into Ribbon-like Fibrils That Display Polymorphic Structure and Stability

(2010) Susanne Wegmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cerebrospinal fluid and plasma biomarkers in Alzheimer disease

(2010) Kaj Blennow et al.   Nature Reviews Neurology