期刊
CHEMISTRYSELECT
卷 6, 期 10, 页码 2523-2528出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202100225
关键词
acylation; benzophenone; C− H activation; photocatalysis
资金
- National Natural Science Foundation of China [21376222]
- Natural Science Foundation of Zhejiang Province [LY18B060011]
An efficient and mild C(sp(3))-H acylation method has been developed based on the direct conversion of stable amides. This photoredox cross-coupling of amides and methylbenzenes for aromatic ketones is enabled by cheap benzophenone photocatalyst and nickel catalyst, achieving high yields (up to 90%). The benzophenone catalyst with electron-withdrawing groups promotes hydrogen atom transfer efficiency, contributing to increased yields.
An efficient and benign method of C (sp(3))-H acylation based on the direct conversion of stable amides has been established. This photoredox cross-coupling of amides and methylbenzenes for aromatic ketones is enabled by the cheap benzophenone photocatalyst and nickel catalyst, with high yield (up to 90 %). The benzophenone catalyst having electron-withdrawing group promotes the efficiency of hydrogen atom transfer, which is beneficial to improve the yield.
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