Involvement of actin cytoskeletal modifications in the inhibition of triple-negative breast cancer growth and metastasis by nimbolide

Molecular Mechanisms and Emerging Therapeutic Targets of Triple-Negative Breast Cancer Metastasis

(2018) Christiana Neophytou et al.   Frontiers in Oncology

Cell Adhesion and Matrix Stiffness: Coordinating Cancer Cell Invasion and Metastasis

(2018) Vasiliki Gkretsi et al.   Frontiers in Oncology

Focal adhesions: a personal perspective on a half century of progress

(2017) Keith Burridge   FEBS Journal

Nimbolide upregulates RECK by targeting miR-21 and HIF-1α in cell lines and in a hamster oral carcinogenesis model

(2017) Jaganathan Kowshik et al.   Scientific Reports

Nimbolide-Induced Oxidative Stress Abrogates STAT3 Signaling Cascade and Inhibits Tumor Growth in Transgenic Adenocarcinoma of Mouse Prostate Model

(2016) Jingwen Zhang et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome

(2016) Edward R. Horton et al.   EXPERIMENTAL CELL RESEARCH

The integrin adhesome network at a glance

(2016) Edward R. Horton et al.   JOURNAL OF CELL SCIENCE

Anticancer properties of nimbolide and pharmacokinetic considerations to accelerate its development

(2016) Lingzhi Wang et al.   Oncotarget

Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition

(2016) Ramadevi Subramani et al.   Scientific Reports

Nimbolide Induces ROS-Regulated Apoptosis and Inhibits Cell Migration in Osteosarcoma

(2015) Ju-Fang Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly

(2015) Edward R. Horton et al.   NATURE CELL BIOLOGY

Movers and shakers: cell cytoskeleton in cancer metastasis

(2014) C M Fife et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mechanotransduction and extracellular matrix homeostasis

(2014) Jay D. Humphrey et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Steering cell migration: lamellipodium dynamics and the regulation of directional persistence

(2014) Matthias Krause et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chemopreventive and therapeutic effects of nimbolide in cancer: The underlying mechanisms

(2014) Lakshmi Narendra Bodduluru et al.   TOXICOLOGY IN VITRO

Overcoming acquired resistance to anticancer therapy: focus on the PI3K/AKT/mTOR pathway

(2013) Howard A. Burris   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Integrins in mechanotransduction

(2013) Tyler D Ross et al.   CURRENT OPINION IN CELL BIOLOGY

Nimbolide, a neem limonoid abrogates canonical NF-κB and Wnt signaling to induce caspase-dependent apoptosis in human hepatocarcinoma (HepG2) cells

(2012) Krishnamurthy Kavitha et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The seed and soil hypothesis revisited-The role of tumor-stroma interactions in metastasis to different organs

(2011) Robert R. Langley et al.   INTERNATIONAL JOURNAL OF CANCER

Nimbolide retards tumor cell migration, invasion, and angiogenesis by downregulating MMP-2/9 expression via inhibiting ERK1/2 and reducing DNA-binding activity of NF-κB in colon cancer cells

(2011) Suboj Babykutty et al.   MOLECULAR CARCINOGENESIS

Triple negative breast cancer - prognostic factors and survival

(2011) Tanja Ovcaricek et al.   Radiology and Oncology

Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents

(2010) Subash C. Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Actin nucleation and elongation factors: mechanisms and interplay

(2009) Melissa A Chesarone et al.   CURRENT OPINION IN CELL BIOLOGY

How ILK and kindlins cooperate to orchestrate integrin signaling

(2009) Ralph T Böttcher et al.   CURRENT OPINION IN CELL BIOLOGY

Mechanisms that regulate adaptor binding to  -integrin cytoplasmic tails

(2009) K. R. Legate et al.   JOURNAL OF CELL SCIENCE

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE